Patent application number | Description | Published |
20100047257 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 02-25-2010 |
20130302316 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 11-14-2013 |
20150274824 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferrentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 10-01-2015 |
Patent application number | Description | Published |
20090138585 | Method and System for Generating Messages - The present invention discloses a method and system for generating Simple Object Access Protocol (SOAP) message, wherein, at least one first information sets are pre-stored and each of the first information sets contains at least one piece of information. The method comprises: generating a first SOAP message which contains a second information set that contains at least one piece of information; retrieving a first information set that corresponds to the second information set; and generating a second SOAP message using the retrieved first information set and the first SOAP message. | 05-28-2009 |
20090327513 | PARSING CONTENTS OF AN E-FORM - A method parses the contents of an e-Form, where the contents of said e-Form have been divided into more than one section with a different content identification code assigned to each section of the e-Form. The method includes scanning an e-Form submitted for processing to determine, based on the content identification codes, which of the sections have a corresponding parsed result already in a cache system; parsing contents of the sections without a parsed result already in the cache system; and combining parsed results from the cache system with parsed results from the parsing of sections without a parsed result already in the cache system. | 12-31-2009 |
20120281170 | COLOR FILTER SUBSTRATE AND PRODUCING PROCESS AND DEVICE FOR MANUFACTURING THE SAME - The embodiments of the disclosed technology disclose a color filter substrate and the producing process and device for the same. The producing process of the color filter substrate according to the embodiments of the disclosed technology comprises: forming a transparent conductive layer on a side of a base substrate; forming a black matrix on the other side of the base substrate; forming a color filer layer within the black matrix; and forming an insulated material layer comprising both post spacers and a protection film formed integrally on the color filer layer. | 11-08-2012 |
20130045942 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF - The present invention provides N | 02-21-2013 |
20130160105 | CONFIGURING IDENTITY FEDERATION CONFIGURATION - A method and apparatus for configuring identity federation configuration. The method includes: acquiring a set of identity federation configuration properties of a first computing system and a set of identity federation configuration properties of a second computing system; identifying one or more pairs of associated properties in the first and the second sets, where the pairs of associated properties include one property from each set of identity federation configuration; displaying, properties that need to be configured manually from the each sets of identity federation configuration properties, where the properties that need to be configured manually do not include the property in any pair of associated properties for which the value can be derived from the value of another property in the pair; automatically assigning a property that can be derived from the value of another property; and providing each computing systems with each set of identity federation properties. | 06-20-2013 |
20130309875 | INTERFACE TREATMENT METHOD FOR GERMANIUM-BASED DEVICE - Disclosed herein is an interface treatment method for germanium-based device, which belongs to the field of manufacturing technologies of ultra large scaled integrated (ULSI) circuits. In the method, the natural oxide layer on ther surface of the germanium-based substrate is removed by using a concentrated hydrochloric acid solution having a mass percentage concentration of 15%˜36%, and dangling bonds of the surface are performed a passivation treatment by using a diluted hydrochloric acid solution having a mass percentage concentration of 5%˜10% so as to form a stable passivation layer on the surface. This method makes a good foundation for depositing a high-K (high dielectric constant) gate dielectric on the surface of the germanium-based substrate after cleaning and passivating, enhances quality of the interface between the gate dielectric and the substrate, and improves the electrical performance of germanium-based MOS device. | 11-21-2013 |
20140013825 | TESTING APPARATUS FOR TESTING AIR PERMEABILITY ON THICKNESS DIRECTION OF PLASTIC MATRIX, AND METHOD THEREFOR - An apparatus for testing the air permeability in the thickness direction of a resin matrix composite material layer includes a mold having a cavity and a covering plate, a loading apparatus, a temperature controlling apparatus, a vacuuming apparatus, and a flow detecting element. An air inlet is connected to the flow detecting element, and an air outlet is connected to the vacuuming apparatus. The covering plate has a through-hole with upper and lower ventilation pieces. The loading apparatus addresses the upper ventilation piece. A test specimen is laid flat between the ventilation pieces. Employment of the present invention allows for accurate testing of air permeability of pre-impregnated material in the thickness direction of the resin matrix composite material layer under different pressure and temperature conditions. | 01-16-2014 |
20140013826 | TESTING APPARATUS FOR TESTING GAS PERMEABILITY ON THICKNESS DIRECTION OF PLASTIC MATRIX - An apparatus for testing the gas permeability on the inward facing direction of a pre-impregnated resin matrix composite material layer includes a mold, a loading apparatus, a temperature control apparatus, a vacuuming apparatus, and a flow detecting element. A test specimen is laid flat inside the mold between airtight sealing elements that leave exposed two ends of the test specimen on the inward facing direction of the layer. An air inlet and an air outlet respectively are arranged on the mold and correspond to the two exposed ends of the test specimen. The inlet is connected to the flow detecting element, and the outlet is connected to the vacuuming apparatus. Air is forced to move in a vacuumed cavity along the inward facing direction of the layer. Testing of air permeability of pre-impregnated material in solidification technique is allowed via adjustments of pressure and temperature. | 01-16-2014 |
20140168621 | Fly Eye Lens and Proximity Exposure Machine Optical System - An embodiment of the present invention provides a fly eye lens which is applied to a proximity exposure machine optical system. The fly lens includes a first lens assembly and a second lens assembly, wherein the first lens assembly includes a plurality of lenses which form a first lens face, and the second lens assembly includes a plurality of lenses which form a second lens face. The first lens face is used to split an incident broad light beam into narrow light beams and then refract the narrow light beams onto the second lens face, and the second lens face is used to dispersively refract the received narrow light beams onto a concave mirror in the optical system. A lens closer to a center of the second lens face has a higher transmittivity, and a lens farther from the center of the second lens face has a lower transmittivity. According to the embodiment of the present invention, since different lenses on the second lens face have different transmittivities, the illuminances of light radiated to different regions of a mask plate through the fly eye lens are different, and thus the uniformity of the critical dimensions of the exposed patterns can be improved to a certain extent. | 06-19-2014 |
20140359739 | VOICE BASED BIOMETRIC AUTHENTICATION METHOD AND APPARATUS - Voice based biometric authentication method, apparatus (system), and computer program product. Provided is voice verification solution with a high accuracy rate that can prevent cheating via recording. The method includes: transmitting to the user a question prompt requiring the user to speak out a voice segment and an answer to a dynamic question, the voice segment having a corresponding text dependent speaker verification model enrolled before the authentication; segmenting, in response to receiving the voice answer, the voice segment part and the dynamic question answer part out from the voice answer; and verifying boundary smoothness between the voice segment and the answer to the dynamic question within the voice answer. With this method, whether a voice answer relates to cheating via recording is determined according to the degree of smoothness at a detected boundary. The apparatus and computer program product carry out the steps of the above-mentioned method. | 12-04-2014 |
20150021251 | DOUBLE-LAYER PERSULFATE SUSTAINED-RELEASE MATERIAL AND ITS PREPARATION METHOD - The present invention involves a persulfate-release material used in the filler of permeable reactive barrier (PRB). This material presents double-layered structure characteristic: inner- and outer-layers are consisted of persulfate, cement, sand and water with different mass ratio. Two different types of moulds are used for the regulation of the shape-of the two-layer structures, which guarantees the stability and reproducibility of its structures and properties. During the whole released process, the released rate become more uniform and stable by the use of this material. During the whole service period, the change of the released rate is very slow, and the service lifetime can be 1-10 years. This invention can both reduce the initial released rate and improve the later released rate, and thus the whole released rate can be more uniform, which can be an important method to promote the efficiency of the persulfate toward engineering application. | 01-22-2015 |
20150030843 | AUTO-REPAIRING COMPOSITIONS FOR OVERCOAT LAYER, METHOD OF PRODUCING THE SAME, AND DISPLAY APPARATUS - Disclosed are an auto-repairing composition for overcoat layer, a method of producing the same, and a display apparatus. The composition for overcoat layer comprising 1-10 wt % of microcapsules based on the total weight of the composition for overcoat layer, said microcapsule including a capsule wall and a capsule core, wherein the capsule wall comprises an alkali-insoluble resin, and the capsule core comprises, based on the total weight of the capsule core, 30-60 wt % of a photo-curable unsaturated oligomer, 30-60 wt % of a photo-polymerizable monomer, 1-10 wt % of a photo-initiator, and 0-5 wt % of additive. | 01-29-2015 |
20150031188 | METHOD FOR ISOLATING ACTIVE REGIONS IN GERMANIUM-BASED MOS DEVICE - Disclosed herein is a method for isolating active regions in a germanium-based MOS device. A surface of a germanium-based substrate is covered by a thin polysilicon layer or a poly-SiGe layer, and an isolation structure of germanium dioxide covered by a silicon dioxide layer or a SiGe oxide layer on top is formed by means of two steps of oxidation in a case of the active regions are protected. Such two steps of oxidation using the polysilicon layer or the poly-SiGe layer as a sacrificial layer is advantageous to improve the isolation quality of a fabricated germanium dioxide and to reduce a beak effect occurred during a local field oxygen oxidation so as to dramatically elevate the performance of the germanium device. | 01-29-2015 |
20150085216 | ARRAY SUBSTRATE AND FABRICATION METHOD THEREOF, DISPLAY PANEL AND FABRICATION METHOD THEREOF - Embodiments of the disclosure provide an array substrate and a fabrication method thereof, and a display panel and a fabrication method thereof. A passivation layer of the array substrate is made of a black insulation material and the passivation layer is provided with an opening at a pixel display region of the array substrate. The passivation layer is simultaneously used as a black matrix, and thus the aperture ratio of the display panel is effectively increased. | 03-26-2015 |
20150124200 | COLOR FILTER SUBSTRATE, METHOD FOR FABRICATING THE SAME AND LIQUID CRYSTAL DISPLAY SCREEN - A color filter substrate and its fabrication method as well as a LCD screen are disclosed. The color filter substrate includes a base substrate, a plurality of color filter elements, and a microlens structure. The plurality of color filter elements are disposed on the base substrate, and the microlens structure is disposed on the plurality of color filter elements. | 05-07-2015 |
20150154392 | SECURE FACE AUTHENTICATION WITH LIVENESS DETECTION FOR MOBILE - An authentication method can include, a random expression prompt, recording of the user's expression actions, and an authentication result. This is completed using a terminal device configured to display authentication information, record the user's inputted information, and send an authentication result. The terminal device may be further configured to package an authentication result, and send it to an authentication server. Subsequent actions of the user are allowed or denied based on the authentication result. | 06-04-2015 |
20150179439 | METHOD FOR PROCESSING GATE DIELECTRIC LAYER DEPOSITED ON GERMANIUM-BASED OR GROUP III-V COMPOUND-BASED SUBSTRATE - The present invention discloses a method for processing a gate dielectric layer deposited on a germanium-based or Group III-V compound-based substrate, belonging to a semiconductor device field. The method comprises the steps of depositing a high-K gate dielectric layer on the germanium-based or Group III-V compound-based substrate, and then performing a plasma process to the high-K gate dielectric layer by using fluorine plasma, wherein during the plasma process, a guiding electric field is applied so that fluorine ions, when being accelerated to a surface of the gate dielectric layer, has an energy of | 06-25-2015 |
20150205208 | DEVELOPER COMPOSITION - A developer composition including 0.01 to 5.0 parts by weight of inorganic or organic acids, 0.01 to 5.0 parts by weight of surfactant, 0.1 to 10.0 parts by weight of water-soluble organic solvent, 85 to 99 parts by weight of water, and 0 to 2 parts by weight of additives, based on 100 parts by weight of the developer composition. | 07-23-2015 |
20150248761 | PATTERN RECOGNITION BASED ON INFORMATION INTEGRATION - A method for recognizing a primitive in an image includes recognizing at least one primitive in the image to obtain at least one candidate shape of the at least one primitive, which at least one candidate shape has a respective confidence; determining whether the recognizing of the at least one primitive has a potential error based on the confidence; obtaining auxiliary information about the at least one primitive from a user in response to determining that the recognizing has the potential error; and re-recognizing the at least one primitive at least in part based on the auxiliary information. | 09-03-2015 |
20150253681 | EXPOSURE APPARATUS AND EXPOSURE SYSTEM - An exposure apparatus is provided. It comprises: a substrate stage on which a holding region is provided to hold a substrate to be exposed, the holding region being provided with a support portion thereon for supporting the substrate to be exposed; a supporter configured to support a mask; a light source system configured to provide an exposure light which is illuminated on the substrate to be exposed via the mask to reproduce a pattern of the mask onto the substrate, wherein the support portion has a height which decreases gradually from an outer periphery of the holding region to a center of the holding region, such that an exposure distance is constant at all of positions on the holding region. With the above structure, the graph dimension may be kept uniform on the substrate even if the mask becomes bent. | 09-10-2015 |
20150285968 | COLOR FILTER SUBSTRATE, PREPARING METHOD THEREOF, AND DISPLAY DEVICE - A color filter substrate, a preparing method thereof and a display device are provided. The method includes: preparing a black matrix pattern and a color filter pattern on a substrate; preparing planarization layer and spacers including primary spacers and secondary spacers. The black matrix pattern includes primary areas and secondary areas, and the primary area has a width in the column direction of the black matrix pattern greater than the width of the secondary area in the column direction of the black matrix pattern. The primary spacers are located on primary areas of the black matrix pattern; and the secondary spacers are located on secondary areas of the black matrix pattern, the primary spacers have a height greater than that of the secondary spacers. | 10-08-2015 |
20150294184 | PATTERN RECOGNITION BASED ON INFORMATION INTEGRATION - A method for recognizing a primitive in an image includes recognizing at least one primitive in the image to obtain at least one candidate shape of the at least one primitive, which at least one candidate shape has a respective confidence; determining whether the recognizing of the at least one primitive has a potential error based on the confidence; obtaining auxiliary information about the at least one primitive from a user in response to determining that the recognizing has the potential error; and re-recognizing the at least one primitive at least in part based on the auxiliary information. | 10-15-2015 |
20150301241 | COLOR FILTER SUBSTRATE AND MANUFACTURING METHOD THEREOF, AND DISPLAY DEVICE - Embodiments of the invention provide a color film substrate and a manufacturing method thereof, and a display device, which are used in the field of display technology, and can improve the product quality, reduce costs, and improve production capacity. The color film substrate includes a plurality of first and second black matrixes which are arranged to intersect, and a color filter structure; wherein, the color filter structure includes at least first, second and third color filters, each of the first, second and third color filters includes a first and a second openings, area of a first region between a second opening of the first color filter and a first opening of the second color filter is not the same as that of a second region between a second opening of the second color filter and a first opening of the third color filter. | 10-22-2015 |
20150309221 | COLOR FILTER SUBSTRATE, MANUFACTURING METHOD THEREOF AND DISPLAY DEVICE - A color filter substrate, a manufacturing method thereof and a display device are provided. The color filter substrate includes a substrate; a black matrix dividing the substrate into a plurality of sub-pixel areas arranged in matrix; a color filter layer including color photoresist patterns with N different colors, N≧3, arranged cyclically in discontinuous sub-pixel areas in adjacent N rows/columns, the color photoresist patterns in M adjacent sub-pixel areas of a single color in at least one line/column in the color filter layer extending to regions over the black matrix corresponding to regions between adjacent sub-pixel areas, to form continuous strip-like color photoresist patterns, wherein M≧2; and spacers including main spacers disposed over regions between adjacent discontinuous color photoresist patterns corresponding to the black matrix and secondary spacers disposed over regions of the continuous strip-like color photoresist patterns corresponding to the black matrix. | 10-29-2015 |
20150347742 | CONFIGURING IDENTITY FEDERATION CONFIGURATION - A method and apparatus for configuring identity federation configuration. The method includes: acquiring a set of identity federation configuration properties of a first computing system and a set of identity federation configuration properties of a second computing system; identifying one or more pairs of associated properties in the first and the second sets, where the pairs of associated properties include one property from each set of identity federation configuration; displaying, properties that need to be configured manually from the each sets of identity federation configuration properties, where the properties that need to be configured manually do not include the property in any pair of associated properties for which the value can be derived from the value of another property in the pair; automatically assigning a property that can be derived from the value of another property; and providing each computing systems with each set of identity federation properties. | 12-03-2015 |
20150362840 | MASK PLATE AND METHOD FOR MANUFACTURING COLOR FILTER UNIT OF COLOR FILTER SUBSTRATE - A mask plate used for manufacturing a color filter unit of a color filter substrate, the followings are formed thereon: an un-blocked area, corresponding to a first area of positive photoresist surrounding the color filter unit forming area of the color filter unit; at least one partially blocked area through which the light is able to pass partially, the at least one partially blocked area corresponding to a second area of the positive photoresist, the second area is a part of the color filter unit forming area, the at least one partially blocked area is adjacent to the un-blocked area at a common edge; an entirely blocked area, corresponding to a third area of the positive photoresist, the third area is another part of the color filter unit forming area; the reserved photoresist in the second area and the third area form the color filter unit. | 12-17-2015 |
20150368526 | MODIFIED ACRYLATE ADHESIVE RESIN AND PRODUCTION PROCESS OF THE SAME, PHOTOSENSITIVE RESIN COMPOSITION, DISPLAY SUBSTRATE, LIQUID CRYSTAL PANEL - The invention discloses a modified acrylate adhesive resin and a production process of the same, a photosensitive resin composition, a display substrate, and a liquid crystal panel. This resin can improve the compression displacement and elastic recovery rate of the column-like spacers between two substrates of the liquid crystal display. The modified acrylate adhesive resin disclosed by the invention is an acrylate adhesive resin modified by a terminal hydroxyl-containing polybutadiene polymer, and has the following general structural formula: | 12-24-2015 |
20150370163 | GRAYSCALE MASK PLATE, COLOR FILM SUBSTRATE, RELATED FABRICATING METHODS, AND DISPLAY DEVICE - A grayscale mask plate and method of fabricating the same, a color film substrate and method of fabricating the same, and a display device are disclosed. The grayscale mask plate comprises a transparent substrate and a light blocking layer on the transparent substrate. The light blocking layer comprises an exposure region with an optical translucent film which has a light blocking ratio decreasing gradually or stepwise from a center of the optical translucent film to an edge of the optical translucent film. As a result, the intensity of light transmitted through the exposure region is uniform, such that a post spacer fabricated by the grayscale mask plate has a relatively flat top face. Thus, the post spacer exhibits a linear variation in its hardness under the action of an external force. | 12-24-2015 |
20150371029 | ANTI-PEEPING DISPLAY SYSTEM AND METHOD, ANTI-PEEPING DISPLAY AND ANTI-PEEPING GLASSES - The present disclosure discloses an anti-peeping display system includes an anti-peeping display, anti-peeping glasses and a controller. The anti-peeping display includes a first polarizer and a first driving device driving the first polarizer to rotate. The anti-peeping glasses include a second polarizer and a second driving device driving the second polarizer to rotate. When judging that both of the obtained display password and the obtained glasses password are correct, the controller is configured to control the first polarizer and the second polarizer to rotate at a same angular velocity; otherwise, control the first driving device and the second driving device to rotate at different angular velocities. | 12-24-2015 |
20150379677 | RADIATION IMAGE INSPECTION SYSTEM AND METHOD BASED ON B/S ARCHITECTURE - The present disclosure provides a radiation image inspection system based on B/S architecture. The system comprises: at least one client terminal, configured to initiate an image operation request to a Web server, and display an image operation result on a browser of the client terminal upon receiving a response from the Web server; an image processing assembly, configured to query, based on the image operation request from the client terminal and forwarded by the Web server, an image which the client terminal desires to process, perform an operation on an image as requested by the client terminal, convert the resulted image into an image in a designated format and quality and return the converted image to the browser of the client terminal via the Web server for displaying; and the Web server, configured to receive the image operation request from the client terminal, forward the image operation request to the image processing assembly, and return the image operation result from the image processing assembly to the client terminal. | 12-31-2015 |
Patent application number | Description | Published |
20110268789 | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH ANTICANCER AGENTS - This invention relates to methods and compositions for the treatment, management or prevention of injuries to one or more of the organs of the body, such as the brain, heart, lung, kidneys, liver, and gastrointestinal tract, of humans or other mammals caused by one or more anticancer agents. The methods of this invention consist of the administration of an effective amount of one or more pituitary adenylate cyclase-activating polypeptide (PACAP)-like compounds, which includes native human PACAP38, native human PACAP27, native human vasoactive intestinal peptide (VIP), their agonists, analogs, fragments, and derivatives, with activities toward one or more of the PACAP/VIP receptors, including all of their various isoforms. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents useful for the treatment, management or prevention of injuries to the organs of the body of humans or other mammals undergoing cancer chemotherapy. Combination therapy with one or more PACAP-like compounds plus one or more anticancer agents can be used in the treatment of hematological cancers. | 11-03-2011 |
20130065816 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE - This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents. | 03-14-2013 |
20140314838 | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS FOR TREATING CONTRAST-INDUCED NEPHROPATHY - Featured are methods and compositions for treating, managing, preventing, or reducing injury to the kidney of a mammal (e.g., a human) caused by one or more iodinated radiocontrast media. The methods include administering an effective amount of one or more pituitary adenylate cyclase-activating polypeptide (PACAP)-like compounds, which includes native human PACAP38, native human PACAP27, native human vasoactive intestinal peptide (VIP), their agonists, analogs, fragments, and derivatives, with activities toward one or more of the PACAP/VIP receptors, including all of their various isoforms. Also provided are pharmaceutical compositions of one or more PACAP-like compounds, either alone or in combination with one or more other prophylactic/therapeutic agents useful for treating, managing, or preventing injury to the kidney of a mammal (e.g., a human) undergoing treatment with one or more iodinated radiocontrast media. Also featured is an in vivo mouse model for testing the efficacy of cytoprotective agents against contrast-induced nephropathy. | 10-23-2014 |
20150104388 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE - This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents. | 04-16-2015 |
Patent application number | Description | Published |
20120205757 | Pinning field in MR devices despite higher annealing temperature - The pinning field in an MR device was significantly improved by using the Ru 4A peak together with steps to minimize interfacial roughness of the ruthenium layer as well as boron and manganese diffusion into the ruthenium layer during manufacturing. This made it possible to anneal at temperatures as high as 340° C. whereby a high MR ratio could be simultaneously achieved. | 08-16-2012 |
20120295133 | Writer with an AFM write gap - A perpendicular magnetic recording (PMR) head is fabricated with main pole and a trailing edge shield antiferromagnetically coupled across a write gap by either having the write gap layer formed as a synthetic antiferromagnetic tri-layer (SAF) or formed as a monolithic layer of antiferromagnetic material. The coupling improves the write performance of the writer by enhancing the perpendicular component of the write field and its gradient. Methods of fabricating the writer are provided. | 11-22-2012 |
20130027809 | HIGH DATA RATE MAGNETIC WRITER DESIGN - A high speed magnetic data writer containing a stitched pole tip that works in conjunction with the main pole is disclosed, together with a process for their manufacture. The material composition of each of these two sub-structures is slightly different; one sub-structure is optimized for high magnetic damping while the other sub-structure is optimized for high saturation magnetization. | 01-31-2013 |
20130029035 | CoFe/Ni Multilayer Film with Perpendicular Anisotropy for Microwave Assisted Magnetic Recording - A spin transfer oscillator with a seed/SIL/spacer/FGL/capping configuration is disclosed with a composite seed layer made of Ta and a metal layer having a fcc(111) or hcp(001) texture to enhance perpendicular magnetic anisotropy (PMA) in an overlying (A1/A2) | 01-31-2013 |
20130029182 | CoFe/Ni Multilayer Film with Perpendicular Anisotropy for Microwave Assisted Magnetic Recording - A spin transfer oscillator with a seed/SIL/spacer/FGL/capping configuration is disclosed with a composite seed layer made of Ta and a metal layer having a fcc(111) or hcp(001) texture to enhance perpendicular magnetic anisotropy (PMA) in an overlying (A1/A2) | 01-31-2013 |
20130069626 | Perpendicular spin torque oscillator FMR frequency measurement method - A method for measuring the frequency in a spin torque oscillator having at least a magnetic oscillation layer (MOL), junction layer, and magnetic reference layer (MRL) is disclosed. In a first embodiment, a small in-plane magnetic field is applied to the STO after a DC current is applied to excite the MOL into an oscillation state. The MRL has a perpendicular magnetization that is tilted slightly to give an in-plane magnetization component to serve as a reference layer for measuring the oscillation frequency of the MOL in-plane magnetization component. An AC voltage change is produced in the DC current as a result of variable STO resistance and directly correlates to MOL oscillation frequency. Alternatively, a field having both perpendicular and in-plane components may be applied externally or by forming the STO between two magnetic poles thereby producing an in-plane magnetization reference component in the MRL. | 03-21-2013 |
20130082787 | Spin injection layer robustness for microwave assisted magnetic recording - A spin transfer (torque) oscillator (STO) with a non-magnetic spacer formed between a spin injection layer (SIL) and a field generation layer (FGL), and with an interfacial layer comprised of Fe | 04-04-2013 |
20130084452 | Very thin high coercivity film and process for making it - High Hc (>4,000 Oe) and high Hk (>1 Tesla) has been achieved in FePt films as thin as 70 Angstroms. This was accomplished by starting with a relatively thick film having the required high coercivity, coating it with a suitable material such as Ta, and then using ion beam etching to remove surface material until the desired thickness was reached. | 04-04-2013 |
20130277780 | TMR Device with Low Magnetoresistive Free Layer - A high performance TMR sensor is fabricated by employing a free layer with a trilayer configuration represented by FeCo/CoFeB/CoB, FeCo/CoB/CoFeB, FeCo/CoFe/CoB, or FeCo/FeB/CoB may also be employed. Alternatively, CoNiFeB or CoNiFeBM formed by co-sputtering CoB with CoNiFe or CoNiFeM, respectively, where M is V, Ti, Zr, Nb, Hf, Ta, or Mo may be included in a composite free layer or as a single free layer in the case of CoNiFeBM. A 15 to 30% in improvement in TMR ratio over a conventional CoFe/NiFe free layer is achieved while maintaining low Hc and RA<3 ohm-um | 10-24-2013 |
20130286508 | Perpendicular Magnetic Recording Write Head with Milling Defined Track Width - A main pole layer having at least a leading taper and trimmed pole tip portion is described. The leading taper increases head field up to ≧15000 Oe even for narrow track widths approaching 50 nm. For MAMR applications, a STO and trailing shield are sequentially formed on a trailing pole tip side. Furthermore, full side shields may be added to reduce fringing field. A preferred embodiment includes both of a leading taper and trailing taper at the pole tip where leading taper angle is between 20° and 60° and trailing taper angle is from 10° to 45°. A method is provided for forming various embodiments of the present invention. A key feature is that milling depth at an effective neck height distance is greater than or equal to the pole tip thickness. A self aligned STO may be formed by the same ion milling step that defines track width. | 10-31-2013 |
20140078620 | MICROWAVE-ASSISTED MAGNETIC RECORDING HEAD, METHOD OF MANUFACTURING THE SAME, MAGNETIC HEAD ASSEMBLY USING THE SAME, AND MAGNETIC RECORDING/REPRODUCTION APPARATUS - According to one embodiment, a magnetic recording head manufacturing method includes forming a spin torque oscillator layer on a main magnetic pole layer, forming a mask on the spin torque oscillator layer, processing the spin torque oscillator layer by performing ion beam etching through the mask, and partially modifying the main magnetic pole layer through the mask. The partially modifying the main magnetic pole layer makes it possible to decrease the saturation flux density of the main magnetic pole layer in the modified portion, and form an unmodified main magnetic pole portion covered with the mask, and a modified portion around the main magnetic pole. | 03-20-2014 |
20140106182 | High Coercivity Magnetic Film for Use as a Hot Seed in a Magnetic Write Head and Method to Grow It - A sub-structure, suitable for use as a hot seed on which to form a perpendicular magnetic main write pole, is described. It is made up of a buffer layer of atomic layer deposited alumina on which there are one or more seed layers having a body-centered cubic (bcc) crystal structure. Finally, the high coercivity magnetic film lies on the seed layer(s). It is critical that the high coercivity magnetic film be deposited at a very low deposition rate (around 1 Angstrom per second). | 04-17-2014 |
20140116984 | Two Step Method to Fabricate Small Dimension Devices for Magnetic Recording Applications - A two part ion beam etch sequence involving low energy (<300 eV) is disclosed for fabricating a free layer width (FLW) as small as 20-25 nm in a MTJ element. A first etch process has one or more low incident angles and accounts for removal of 70% to 100% of the MTJ stack that is not covered by an overlying photoresist layer. The second etch process employs one or more high incident angles and a sweeping motion that is repeated during a plurality of cycles. Sidewall slope may be adjusted by varying the incident angle during either of the etch processes. FLW is about 30 nm less than an initial critical dimension in the photoresist layer while maintaining a MR ratio over 60% and low RA (resistance×area) value of 1.0 ohm-μm | 05-01-2014 |
20140183673 | Magnetic Read Head with MR Enhancements - A TMR stack or a GMR stack, ultimately formed into a sensor or MRAM element, include insertion layers of Fe or iron rich layers of FeX in its ferromagnetic free layer and/or the AP1 layer of its SyAP pinned layer. X is a non-magnetic, metallic element (or elements) chosen from Ta, Hf, V, Co, Mo, Zr, Nb or Ti whose total atom percent is less than 50%. The insertion layers are between 1 and 10 angstroms in thickness, with between 2 and 5 angstroms being preferred and, in the TMR stack, they are inserted adjacent to the interfaces between a tunneling barrier layer and the ferromagnetic free layer or the tunneling barrier layer and the AP1 layer of the SyAP pinned layer in the TMR stack. The insertion layers constrain interdiffusion of B and Ni from CoFeB and NiFe layers and block NiFe crystalline growth. | 07-03-2014 |
20140210022 | Magnetic Seed for Improving Blocking Temperature and Shield to Shield Spacing in a TMR Sensor - The blocking temperature of the AFM layer in a TMR sensor has been raised by inserting a magnetic seed layer between the AFM layer and the bottom shield. This gives the device improved thermal stability, including improved SNR and BER. | 07-31-2014 |
20140220385 | MR Enhancing Layer (MREL) For Spintronic Devices - The performance of an MR device has been improved by inserting one or more Magneto-Resistance Enhancing Layers (MRELs) into approximately the center of one or more of the magnetic layers such as an inner pinned (AP1) layer, spin injection layer (SIL), field generation layer (FGL), and a free layer. An MREL is a layer of a low band gap, high electron mobility semiconductor such as ZnO or a semimetal such as Bi. The MREL may further comprise a first conductive layer that contacts a bottom surface of the semiconductor or semimetal layer, and a second conductive layer that contacts a top surface of the semiconductor or semimetal layer. | 08-07-2014 |
20140220708 | MR Enhancing Layer (MREL) For Spintronic Devices - The performance of an MR device has been improved by inserting one or more Magneto-Resistance Enhancing Layers (MRELs) into approximately the center of one or more of the magnetic layers such as an inner pinned (AP1) layer, spin injection layer (SIL), field generation layer (FGL), and a free layer. An MREL is a layer of a low band gap, high electron mobility semiconductor such as ZnO or a semimetal such as Bi. The MREL may further comprise a first conductive layer that contacts a bottom surface of the semiconductor or semimetal layer, and a second conductive layer that contacts a top surface of the semiconductor or semimetal layer. | 08-07-2014 |
20140252517 | Thin Seeded Antiferromagnetic Coupled Side Shield for Sensor Biasing Applications - A composite side shield structure is disclosed for providing biasing to a free layer in a sensor structure. The sensor is formed between a bottom shield and top shield each having a magnetization in a first direction that is parallel to an ABS. The side shield is stabilized by an antiferromagnetic (AFM) coupling scheme wherein a bottom (first) magnetic layer is AFM coupled to a second magnetic layer which in turn is AFM coupled to an uppermost (third) magnetic layer. First and third magnetic layers each have a magnetization aligned in the first direction and are coupled to bottom and top shields, respectively, for additional stabilization. The top shield may be modified to include an AFM scheme for providing additional stabilization and guidance to magnetic moments within AFM coupled magnetic layers in the top shield, and to the third magnetic layer in the side shield. | 09-11-2014 |
20140252518 | High Moment Wrap-Around Shields for Magnetic Read Head Improvements - A wrap around shield structure is disclosed for biasing a free layer in a sensor and includes a bottom shield, side shields, and top shield in which each shield element comprises a high moment layer with a magnetization saturation greater than that of Ni | 09-11-2014 |
20140264665 | Reader Sensor Structure and its Method of Construction - A TMR (tunneling magnetoresistive) read sensor is formed in which a portion of the sensor stack containing the ferromagnetic free layer and the tunneling barrier layer is patterned to define a narrow trackwidth, but a synthetic antiferromagnetic pinning/pinned layer is left substantially unpatterned and extends in substantially as-deposited form beyond the lateral edges bounding the patterned portion. The narrow trackwidth of the patterned portion permits high resolution for densely recorded data. The larger pinning/pinned layer significantly improves magnetic stability and reduces thermal noise, while the method of formation eliminates possible ion beam etch (IBE) or reactive ion etch (RIE) damage to the edges of the pinning/pinned layer. | 09-18-2014 |
20140268423 | Dual-Piece Heat Sink Layer for Robust Reader in Magnetic Recording Head - A read head structure is disclosed with a dual piece heat sink layer having a front piece formed over a front portion of a dynamic flying height (DFH) element and a back piece above a back portion of the DFH element. A first (S1) shield is formed on the front piece and between the front piece and air bearing surface (ABS). Front and back pieces are separated by an insulator gap. The front piece is used to help control read gap protrusion. As a result, a bottom portion of the S1 shield protrudes to a greater extent than a top portion adjacent to the sensor thereby protecting the sensor from unwanted contact with the magnetic media. The dual piece heat sink layer also enables an improved Figure of Merit in terms of temperature rise in the reader per unit of actuation (nm) delivered by the DFH element. | 09-18-2014 |
20140287267 | TMR Device with Novel Free Layer - A TMR sensor with a free layer having a FL1/FL2/FL3 configuration is disclosed in which FL1 is FeCo or a FeCo alloy with a thickness between 2 and 15 Angstroms. The FL2 layer is made of CoFeB or a CoFeB alloy having a thickness from 2 to 10 Angstroms. The FL3 layer is from 10 to 100 Angstroms thick and has a negative λ to offset the positive λ from FL1 and FL2 layers and is comprised of CoB or a CoBQ alloy where Q is one of Ni, Mn, Tb, W, Hf, Zr, Nb, and Si. Alternatively, the FL3 layer may be a composite such as CoB/CoFe, (CoB/CoFe) | 09-25-2014 |
20140315045 | Supermalloy and Mu Metal Side and Top Shields for Magnetic Read Heads - The use of supermalloy-like materials for the side and top shields of a magnetic bit sensor is shown to provide better shielding protection from stray fields because of their extremely high permeability. | 10-23-2014 |
20150108593 | Magnetic Seed for Improving Blocking Temperature and Shield to Shield Spacing in a TMR Sensor - The blocking temperature of the AFM layer in a TMR sensor has been raised by inserting a magnetic seed layer between the AFM layer and the bottom shield. This gives the device improved thermal stability, including improved SNR and BER. | 04-23-2015 |
20150187375 | CoFe/Ni Multilayer Film with Perpendicular Anisotropy for Microwave Assisted Magnetic Recording - A spin transfer oscillator with a seed/SIL/spacer/FGL/capping configuration is disclosed with a composite seed layer made of Ta and a metal layer having a fcc(111) or hcp(001) texture to enhance perpendicular magnetic anisotropy (PMA) in an overlying (A1/A2) | 07-02-2015 |
20150235660 | TMR Device with Low Magnetostriction Free Layer - A high performance TMR sensor is fabricated by employing a free layer comprised of CoNiFeB or CoNiFeBM where M is V, Ti, Zr, Nb, Hf, Ta, or Mo and the M content in the alloy is <10 atomic %. The free layer may have a FeCo/FeB/CoNiFeB, FeCo/CoFe/CoNiFeB, FeCo/CoFeB/CoNiFeB, or FeCo/CoNiFeB/CoFeB configuration. A CoNiFeBM layer may be formed by co-sputtering CoB with CoNiFeM. A 15 to 30% in improvement in TMR ratio over a conventional CoFe/NiFe free layer is achieved while maintaining low Hc and RA<3 ohm-um | 08-20-2015 |
20150295168 | Magnetic Read Head with MR Enhancements - A TMR stack or a GMR stack, ultimately formed into a sensor or MRAM element, include insertion layers of Fe or iron rich layers of FeX in its ferromagnetic free layer and/or the AP1 layer of its SyAP pinned layer. X is a non-magnetic, metallic element (or elements) chosen from Ta, Hf, V, Co, Mo, Zr, Nb or Ti whose total atom percent is less than 50%. The insertion layers are between 1 and 10 angstroms in thickness, with between 2 and 5 angstroms being preferred and, in the TMR stack, they are inserted adjacent to the interfaces between a tunneling barrier layer and the ferromagnetic free layer or the tunneling barrier layer and the AP1 layer of the SyAP pinned layer in the TMR stack. The insertion layers constrain interdiffusion of B and Ni from CoFeB and NiFe layers and block NiFe crystalline growth. | 10-15-2015 |
20150325259 | High Coercivity Magnetic Film for Use as Hot Seed in a Magnetic Write Head and Method to Grow it - A sub-structure, suitable for use as a hot seed on which to form a perpendicular magnetic main write pole, is described. It is made up of a buffer layer of atomic layer deposited alumina on which there are one or more seed layers having a body-centered cubic (bcc) crystal structure. Finally, a magnetic film made of FeCo or FeNi with an as deposited coercivity of 60-110 Oe lies on the seed layer(s). Coercivity is lowered somewhat after the annealing step. It is critical that the high coercivity magnetic film be deposited at a very low deposition rate of around 1 Angstrom per second. The magnetic film is preferably annealed at 220° C. for 2 hours in a 250 Oe applied magnetic field. | 11-12-2015 |
20160035378 | Reader Designs of Shield to Shield Spacing Improvement - A MR sensor is disclosed with an antiferromagnetic (AFM) layer recessed behind a first stack of layers including a free layer and non-magnetic spacer to reduce reader shield spacing and enable increased areal density. The AFM layer may be formed on a first pinned layer in the first stack that is partially embedded in a second pinned layer having a front portion at an air bearing surface (ABS) to improve pinning strength and avoid a morphology effect. In another embodiment, the AFM layer is embedded in a bottom shield and surrounds the sidewalls and back side of an overlying free layer in the sensor stack to reduce reader shield spacing. Pinning strength is improved because of increased contact between the AFM layer and a pinned layer. The free layer is aligned above a bottom shield center section. | 02-04-2016 |