Mcvey
Andrew Mcvey, Bristol GB
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20150053663 | PANEL FOR AN AIRCRAFT - A panel for an aircraft is disclosed. The panel has a body with an integral conductor for the transmission of electrical power and/or signals therethrough. | 02-26-2015 |
John Mcvey, London GB
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20110104788 | Modulation of Adenoviral Tropism - The invention provides materials and methods for modulating adenoviral tropism for hepatocytes and other cell types such as splenocytes. It relates to the findings that hypervariable regions (HVRs) of the viral hexon protein interact with the Gla domain of the blood clotting factor FX as part of the infective process in vivo. The invention provides means to disrupt the interaction between hexon and FX, thus reducing infection of hepatocytes and splenocytes, as well as use of targeting agents comprising the Gla domain or a fragment thereof to direct adenoviral vectors to desired target cell or tissue types. | 05-05-2011 |
20150273082 | OPTIMISED CODING SEQUENCE AND PROMOTER - An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocyte biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. | 10-01-2015 |
John Mcvey, Beaconsfield GB
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20130024960 | OPTIMISED CODING SEQUENCE AND PROMOTER - An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. | 01-24-2013 |
Thomas Michael Mcvey, Malmesbury GB
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20140033473 | FLOOR TOOL FOR A VACUUM CLEANING APPLIANCE - A floor tool for a vacuum cleaning appliance, the floor tool comprising a main body including a suction nozzle comprising a surface engaging skirt that depends downwardly to define an outer periphery of a suction chamber having a suction chamber outlet, the surface engaging skirt including a leading edge, a trailing edge, and side edges extending between the leading edge and the trailing edge, and wherein the trailing edge depends downwardly from the suction nozzle by a first distance and the leading edge depends downwardly from the suction nozzle by a second distance that is less than the first distance so as to define a predetermined gap with a floor surface, in use. | 02-06-2014 |
Thomas Michael Mcvey, Bristol GB
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20150033498 | CLEANER HEAD FOR A VACUUM CLEANER - A cleaner head for a vacuum cleaner, comprising an agitator; and a housing defining a chamber which at least partially surrounds the agitator, a dirty air inlet in a lower part of the chamber and a dirty air outlet, wherein a partition is disposed between the agitator and the dirty air outlet such that the partition and the housing define a settling region of the chamber adjacent the dirty air outlet, the partition is provided with a first debris opening and a second debris opening disposed above the first debris opening such that, in use, debris swept past the first debris opening by the agitator is swept towards the second debris opening. | 02-05-2015 |
William J. Mcvey, Granby CT
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20150315976 | GAS TURBINE ENGINE VARIABLE AREA FAN NOZZLE CONTROL - A method of managing a gas turbine engine includes the steps of detecting an airspeed and detecting a fan speed. A parameter relationship is referenced related to a desired variable area fan nozzle position based upon at least airspeed and fan speed. The detected airspeed and detected fan speed is compared to the parameter relationship to determine a target variable area fan nozzle position. An actual variable area fan nozzle position is adjusted in response to the determination of the target area fan nozzle position and at least one threshold. | 11-05-2015 |