Patent application number | Description | Published |
20080200679 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES - The present invention relates to a method for preparing α-hydroxy, α-substituted methylenebisphosphonates and phosphonoacetates via addition of Grignard or organoindium reagents to tetraalkyl carbonylbisphosphonates and trialkyl carbonylphosphonoacetates. Also disclosed are compounds so synthesized. | 08-21-2008 |
20110263535 | TYROSINE-BASED PRODRUGS OF ANTIVIRAL AGENTS - A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine or its cytosine analogue. A method of synthesizing such conjugates based on Boc-protected amino acid or dipeptides is also provided. In addition, a method of isomerizing an (S,S)-diastereoisomer to an (S,R)-diastereoisomer of an amino acid-based or dipeptide-based conjugate by a process including transesterification is provided. A method of inhibiting viral infection and a method of treating viral infection based on (phosphonylmethoxyalkyl)purine or -pyrimidine conjugates is also provided. | 10-27-2011 |
20140100186 | METHOD TO IMPROVE ANTIVIRAL ACTIVITY OF NUCLEOTIDE ANALOGUE DRUGS - A method of modifying a nucleotide or a nucleotide analogue to increase its overall effectiveness in treating an antiviral disease is provided. In some cases, a compound comprising a base, sugar, phosphonate moiety, and amino acid residue is provided, where the base-sugar may be a nucleoside, and the amino acid residue may be a tyrosine residue. In certain cases, the tyrosine residue contains a long chain alkyl group on the carboxamide group of the residue. Methods of inhibiting viral replication and methods of treating a viral infection are also provided. | 04-10-2014 |
Patent application number | Description | Published |
20090282019 | Sentiment Extraction from Consumer Reviews for Providing Product Recommendations - A system and method for recommending a product to a user in response to a query for a product with a feature wherein the recommendation is accompanied by a quotation expressing a sentiment about the feature or the product. | 11-12-2009 |
20100011205 | SECURE DATA EXCHANGE TECHNIQUE - Techniques utilizing common encryption approaches for data from multiple parties enable those parties to discover information that is held in common by the parties without disclosing to any party information that is not held in common by the parties. Encrypted information for each party can be compared to determine which encrypted values match, and those encrypted values can be returned to any of the parties such that a party can determine which corresponding data the parties have in common, without having access to any other data of any other parties. | 01-14-2010 |
20110271093 | SECURE DATA EXCHANGE TECHNIQUE - Techniques utilizing common encryption approaches for data from multiple parties enable those parties to discover information that is held in common by the parties without disclosing to any party information that is not held in common by the parties. Encrypted information for each party can be compared to determine which encrypted values match, and those encrypted values can be returned to any of the parties such that a party can determine which corresponding data the parties have in common without having access to any other data of any other parties. | 11-03-2011 |
20130212697 | SECURE DATA EXCHANGE TECHNIQUE - Techniques utilizing common encryption approaches for data from multiple parties enable those parties to discover information that is held in common by the parties without disclosing to any party information that is not held in common by the parties. Encrypted information for each party can be compared to determine which encrypted values match, and those encrypted values can be returned to any of the parties such that a party can determine which corresponding data the parties have in common without having access to any other data of any other parties. | 08-15-2013 |
20150312221 | SECURE DATA EXCHANGE TECHNIQUE - Techniques utilizing common encryption approaches for data from multiple parties enable those parties to discover information that is held in common by the parties without disclosing to any party information that is not held in common by the parties. Encrypted information for each party can be compared to determine which encrypted values match, and those encrypted values can be returned to any of the parties such that a party can determine which corresponding data the parties have in common without having access to any other data of any other parties. | 10-29-2015 |
Patent application number | Description | Published |
20100004237 | 2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones - Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases. | 01-07-2010 |
Patent application number | Description | Published |
20090012716 | Diabetes-related biomarkers and methods of use thereof - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 01-08-2009 |
20090271124 | DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 10-29-2009 |
20110008805 | Markers Associate with Arteriovascular Events and Methods of Use Thereof - Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease. | 01-13-2011 |
20110098187 | SYSTEMS AND METHODS FOR DEVELOPING DIAGNOSTIC TESTS BASED ON BIOMARKER INFORMATION FROM LEGACY CLINICAL SAMPLE SETS - Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 μL or less of a legacy clinical sample. | 04-28-2011 |
20120179484 | DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 07-12-2012 |
20140072571 | OSTEOPOROSIS ASSOCIATED MARKERS AND METHODS OF USE - Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness of osteoporosis treatments in subjects with osteoporosis or osteopenia, and methods of selecting therapies for treating osteoporosis or osteopenia, using biomarkers. | 03-13-2014 |
20140147850 | DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 05-29-2014 |
20150346218 | MARKERS ASSOCIATED WITH ARTERIOVASCULAR EVENTS AND METHODS OF USE THEREOF - Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease. | 12-03-2015 |
Patent application number | Description | Published |
20110035368 | System And Method For Processing Database Queries - A system and/or method are implemented to process queries to a database. In particular, the processing of queries to the database is enhanced by enhancing the determination of join orders of tables implicated in queries. Join orders between relatively large numbers of tables are determined by dividing the set of tables to be ordered into a plurality of subsets of tables, and ordering the individual subsets of tables. | 02-10-2011 |
20120278307 | SYSTEM AND METHOD FOR PROCESSING DATABASE QUERIES - A system and/or method are implemented to process queries to a database. In particular, the processing of queries to the database is enhanced by enhancing the determination of join orders of tables implicated in queries. Join orders between relatively large numbers of tables are determined by dividing the set of tables to be ordered into a plurality of subsets of tables, and ordering the individual subsets of tables. | 11-01-2012 |
20140089291 | System and Method for Processing Database Queries - A system and/or method are implemented to process queries to a database. In particular, the processing of queries to the database is enhanced by enhancing the determination of join orders of tables implicated in queries. Join orders between relatively large numbers of tables are determined by dividing the set of tables to be ordered into a plurality of subsets of tables, and ordering the individual subsets of tables. | 03-27-2014 |
20150149435 | Limiting Plan Choices For Database Queries Using Plan Constraints - A database system allows users to specify plan constraint specification that limit choices of execution plans considered by an optimizer of the database system for optimizing database queries. The plan constraint specification specifies attributes of execution plans. The plan constraint specification may identify tables/intermediate results that the plan constraint is applicable to using table names or aliases. The database system applies the plan constraint specification to database queries that match the tables/aliases specified in the plan constraint specification. The database system limits the choice of execution plans evaluated for a database query to execution plans satisfying the attributes specified in an applicable plan constraint specification. The plan constraint specification may specify distribution of a table, a join order for tables, the join mechanism, cardinality of a table or intermediate result, and so on. | 05-28-2015 |
20150149436 | Rewrite Constraints For Database Queries - A database system rewrites database queries based on rewrite constraints specification. The rewrite constraints specification provides directives to the database system to generate temporary tables for storing intermediate results of database queries and rewrite the corresponding database queries in terms of the temporary tables. The subqueries for matching the rewrite constraints specification may be specified in various ways. For example, the rewrite constraints specification may identify the subqueries by using one or more aliases. The rewrite constraints specification may specify a list of tables such that all database queries that join the database tables specified in the rewrite constraints specification are determined to match. The optimizer is able to optimize the rewritten database queries better by getting a better estimate for the statistics describing the temporary tables. | 05-28-2015 |
20150154256 | Physical Planning of Database Queries Using Partial Solutions - A database system determines execution plans for database queries by evaluating a number of partial solutions for each database query. The database system determines a partial solutions limit on the number of partial solutions to be evaluated for determining the execution plan of the query. The database system determines a plurality of partial solutions, each partial solution corresponding to a portion of the execution plan for processing the database query. The database system evaluates a number of candidate partial solutions for determining a partial solution. The number of candidate partial solutions evaluated is determined based on the partial solutions limit. The database system combines the plurality of partial solutions to obtain an execution plan for the database query. The database system executes the database query by executing the execution plan. | 06-04-2015 |