Mcdunn
Jonathan Mcdunn, University City, MO US
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20090012025 | Methods and Compositions for Treatment of Sepsis - Methods of treatment of sepsis are disclosed. These methods comprise administering to a subject a composition comprising at least one siRNA directed against at least one gene encoding a pro-apoptotic polypeptide. The pro-apoptotic polypeptide, in some aspects, can be other than Fas or caspase-8. In some embodiments, an siRNA can be directed against a pro-apoptotic component of the mitochondrial pathway, such as a pro-apoptotic bcl-2 protein. In some aspects, an siRNA can be directed against a BH3-only bcl-2 protein, while in other aspects, siRNAs can be directed against multi BH domain Bcl-2 family members such as bax and bak. In some embodiments, an siRNA can be directed against a death receptor pathway molecule such as FADD. In various configurations, a composition can also comprise a cationic lipid such as DOTAP, or nanoparticles comprising a cyclodextrin-containing polycation and a polymer such as a poly(ethylene glycol). | 01-08-2009 |
20100121031 | MEMBRANE-PERMEANT PEPTIDE COMPLEXES FOR TREATMENT OF SEPSIS - Methods and compositions for treating sepsis and diseases and conditions involving cellular apoptosis using cell membrane-permeant peptide conjugates of a cell membrane permeant peptide together with anti-apoptotic domains of the TCL1 protein are provided. | 05-13-2010 |
Jonathan E. Mcdunn, University City, MO US
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20090176705 | MODULAR PLATFORM FOR TARGETED THERAPEUTIC DELIVERY - Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant K | 07-09-2009 |
Jonathan E. Mcdunn, Cary, NC US
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20130217647 | Biomarkers for Prostate Cancer and Methods Using the Same - Biomarkers (and suites of biomarkers) relating to prostate cancer are provided, as well as methods for using such biomarkers (ans suites thereof), including early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy. | 08-22-2013 |
20150065366 | Biomarkers for Bladder Cancer and Methods Using the Same - Methods for identifying and evaluating biochemical entities useful as biomarkers for bladder cancer, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for bladder cancer. | 03-05-2015 |
Kevin J. Mcdunn, Lake In The Hills, IL US
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20150082255 | METHODS AND APPARATUS FOR DISPLAYING NOTIFICATION INFORMATION - Methods and apparatus for displaying notification information are disclosed. A computing device that is showing a breathing view on its touch screen display, detects a peek request event, such as a press and hold on the display. If the user then swipes one direction (e.g., up to a notification target), the computing device launches the notification intent (e.g., the full text message in the text messaging application). However, if the user swipes another direction (e.g., down to a plurality of notification icons), the computing device displays a notification curtain (e.g., a list of various notifications and links to each associated application). | 03-19-2015 |
Todd Robert Mcdunn, Woodlawn, TN US
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20080235841 | QUICK RELEASE SYSTEM FOR ARMOR PLATES IN A BALLISTIC RESISTANT VEST AND METHOD - A quick release system for releasing armor plates from a vest or other garment including a pocket associated with the front torso portion of the vest for selectively receiving a first armor plate, a pocket associated with the rear torso portion of the vest for selectively receiving a second armor plate, and a flexible retainer element in conjunction with at least one connector element associated with each of the front and rear pockets for selectively retaining the first and second armor plates therewithin, pulling the flexible retainer element releasing the armor plates from their respective pockets. A release handle is located on the front of the vest and is attached to the retainer element for facilitating pulling of the retainer element to release the front and rear armor plates in one easy motion. | 10-02-2008 |