Patent application number | Description | Published |
20090047742 | Inhibition of mRNA Interferase-Induced Apoptosis in BAK-Deficient and BAK- and Bax-Deficient Mammalian Cells - Ribonucleases, antibiotics, bacterial toxins and viruses inhibit protein synthesis, which results in apoptosis in mammalian cells. How the BCL-2 family of proteins regulates apoptosis in response to shutoff of protein synthesis is not known. According to the present invention, an | 02-19-2009 |
20090215120 | The Use of Protein S Fusion for Protein Solubilization - The invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from | 08-27-2009 |
20100035346 | SINGLE PROTEIN PRODUCTION IN LIVING CELLS FACILITATED BY A MESSENGER RNA INTERFERASE - The present invention describes a single-protein production (SPP) system in living | 02-11-2010 |
20100120118 | MRNA Interferase from Myxococcus Xanthus - A deployment of a toxin gene for developmental programmed cell death in bacteria is described. | 05-13-2010 |
20100196951 | Antitoxin Destabilization Technology - Disclosed are methods for purifying toxin proteins which avoid denaturation and renaturation procedures. | 08-05-2010 |
20100228009 | Labeled Biomolecular Compositions and Methods for the Production and Uses Thereof - Disclosed herein is a set of | 09-09-2010 |
20110097722 | Cold Shock Protein Compositions and Methods and Kits for the Use Thereof - The present invention provides cold shock protein-containing compositions for improved DNA synthesis reactions with improved reactivity, methods for synthesizing DNA using such compositions, kits for use in such methods, and DNA compositions yielded by such methods. The present invention further provides cold shock protein-containing compositions for the identification of endoribonuclease cleavage sites, methods for identifying endoribonuclease cleavage sites using such compositions, and kits for use in such methods. | 04-28-2011 |
20110217282 | Novel Toxin-Antitoxin System - Disclosed in certain embodiments is a method of inhibiting cell function comprising inducing the expression of a mRNA interferase that cleaves mRNA at GCU. | 09-08-2011 |
20110306751 | Independently Inducible System of Gene Expression - The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system. | 12-15-2011 |
20120045789 | Method for Screening of Antiviral Agents - A method for screening for an antiviral agent capable of blocking a viral viroporin by determining whether a test agent can rescue expression of a fragment of a viral viroporin in a Single Protein Production system of | 02-23-2012 |
20120116053 | EXPRESSION OF TRIPLE-HELICAL COLLAGEN-LIKE PRODUCTS IN E.COLI - Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications | 05-10-2012 |
20130029426 | Dual Inducible System for the cSPP System - The present invention provides a dual inducible system for single protein production, as well as a method of inducing high level protein expression using amino acids. | 01-31-2013 |
20130071374 | RNA Interferases and Methods of Use Thereof - The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials. | 03-21-2013 |
20140193878 | MRNA Interferase from Myxococcus Xanthus - A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. | 07-10-2014 |
20140234258 | RNA Interferases and Methods of Use Thereof - The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials. | 08-21-2014 |
20140294801 | SEQUENCE-SPECIFIC MRNA INTERFERASE AND USES THEREOF - The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference. | 10-02-2014 |