Mark Phillip
Mark Phillip Hogarth, Victoria AU
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20100112080 | MULTIMERIC Fc RECEPTOR POLYPEPTIDES INCLUDING A MODIFIED Fc DOMAIN - A soluble multimeric polypeptide or protein is disclosed that is able to inhibit interaction of leukocyte Fcγ receptors (FcγR) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more Fc binding regions linked in a head to tail arrangement, at least one of which is derived from an FcγR type receptor, and an Fc domain of an immunoglobulin which has been modified to reduce or prevent binding to the said Fc binding regions and/or to alter effector function. Also described are polynucleotide molecules encoding the polypeptide or protein and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease. | 05-06-2010 |
Mark Phillip Hogarth, Williamstown AU
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20110144170 | Fc RECEPTOR MODULATING COMPOUNDS AND COMPOSITIONS - The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor. | 06-16-2011 |
Mark Phillip Speechley, New South Wales AU
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20100146891 | SPACER | 06-17-2010 |
Mark Phillip Vano, Houston, TX US
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20120168352 | SYSTEMS AND METHODS FOR PROCESSING HYDROCARBON FEEDSTOCKS - Systems and methods for processing a hydrocarbon feedstock are provided. The method can include removing a portion of one or more impurities from a non-phenolic sour water to produce a treated sour water and a waste byproduct. The non-phenolic sour water can have a total concentration of impurities ranging from about 100 ppmw to about 125,000 ppmw. The treated sour water can have a total concentration of impurities ranging from about 1 ppmw to about 4,000 ppmw. The treated sour water can be heated to produce steam. A hydrocarbon feedstock can be contacted with the steam at conditions sufficient to separate the hydrocarbon feedstock into at least a first hydrocarbon product and a second hydrocarbon product. | 07-05-2012 |
Mark Phillip Vonderwell, Franklin, WI US
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20110289911 | HYDRAULIC SYSTEM AND METHOD OF ACTIVELY DAMPING OSCILLATIONS DURING OPERATION THEREOF - A hydraulic system and a method of actively damping oscillations during actuation of a hydraulic cylinder in a hydraulic system is disclosed. The hydraulic cylinder is actuated by energizing a motor that rotatably drives a pump. The pump supplies a fluid to the hydraulic cylinder to actuate the cylinder. A pressure of the fluid is sensed during actuation of the hydraulic cylinder. A rotational speed of the motor is varied in response to the sensed pressure of the fluid. This varying of the rotational speed of the motor actively damps pressure oscillations during actuation of the hydraulic cylinder. | 12-01-2011 |
20120055149 | SEMI-CLOSED HYDRAULIC SYSTEMS - A semi-closed hydraulic system for use with heavy equipment includes a double-acting cylinder, a reservoir, first and second electric motors, first and second electric pumps, a pressure sensor, and a controller. The double-acting cylinder has a rod end and a cap end, and the reservoir is designed to provide hydraulic fluid to and receive hydraulic fluid from the cap end of the double-acting cylinder. The first pump is connected to and designed to be driven by the first electric motor. Furthermore, the first pump is bi-directional and is intermediate to the rod end and the cap end of the double-acting cylinder, such that the first pump is designed to provide hydraulic fluid to the rod end from the cap end, and to the cap end from the rod end. In addition, the second pump is coupled to and designed to be driven by the second electric motor, where the second pump is intermediate to the cap end of the double-acting cylinder and the reservoir. The second pump is also bi-directional and designed to provide hydraulic fluid to the cap end from the reservoir, and to the reservoir from the cap end. The pressure sensor provides an output signal related to the pressure of hydraulic fluid of the rod end of the double-acting cylinder, and the controller is connected to the pressure sensor. The controller operates the first pump at least partially as a function of the output signal provided by the pressure sensor during operation of the semi-closed hydraulic system. | 03-08-2012 |
Mark Phillip Wakem, Chester Cheshire GB
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20090209793 | USE OF A PARAFFINIC BASE OIL FOR THE REDUCTION OF NITROGEN OXIDE EMISSIONS - The present invention relates to the use of a paraffinic base oil in a lubricant for the reduction of nitrogen oxide emissions of compression ignition engines, wherein the paraffinic base oil comprises (i) a continuous series of iso-paraffins having n, n+1, n+2, n+3 and n+4 carbon atoms, wherein n is between 15 and 40. | 08-20-2009 |