Marc F.
Marc F. Bolliger, Brittanu CH
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20090170950 | Inhibitors Of Neurotrypsin - The invention relates to a method for determining whether a compound is a neurotrypsin inhibitor, characterized in that the compound is incubated together with neurotrypsin, a variant thereof or a fragment comprising the protease domain and with a protein or peptide comprising agrin, a variant thereof or a fragment comprising the α- or the β-cleavage site of agrin, in an aqueous buffer solution, and the amount of cleavage of agrin is measured. Additionally, the invention relates to inhibitors of neurotrypsin found by this method, in particular to compounds of formula | 07-02-2009 |
Marc F. Schetelig, Gottingen DE
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20110088105 | DEVELOPMENT STAGE-SPECIFIC LETHALITY SYSTEM FOR INSECT POPULATION CONTROL - The application describes a transgenic insect comprising a developmental stage-specific lethality system. The developmental stage-specific lethality system comprises a first gene expression cassette comprising a first promoter/enhancer element of a developmental stage-specific gene derived from an insect pest species, preferably from a member of the family Tephritidae, a first component of a transactivating system, a second gene expression cassette comprising a second component of the transactivating system, a second promoter responsive to the activity of the transactivating system, and a lethality inducing system. Also, the application describes a method of controlling reproduction in an insect population of interest, comprising providing a plurality of insects according to the invention and allowing the insects to interbreed with insects of the population of interest. Further, the application describes a method for producing transgenic insects comprising a developmental stage-specific lethality system comprising providing a set of insects comprising gene expression cassettes according to the invention, and further evaluating the insects or offspring thereof for functionality of the developmental stage-specific lethality system. Also, the application describes the use of a transgenic insect according to the invention for controlling reproduction in an insect population of interest. Further, the application describes a developmental stage-specific lethality system for use in a transgenic insect comprising gene expression cassettes according to the invention. | 04-14-2011 |
Marc F. Sinovich, Maryland Heights, MO US
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20100279802 | BASES FOR BASEBALL AND SOFTBALL - A base for baseball or softball including a bottom surface wherein at least a portion of the bottom surface includes a prepared surface having a higher coefficient of friction than the surface in its unprepared state and wherein the base will move from its resting position when a human body applies a lateral force thereto, the force being low enough to avoid substantial injury to the human body, but will remain in position when a force applied to the base includes a downward force component that is substantial in comparison to the lateral force component. | 11-04-2010 |
Marc F. Sobas, Chicago, IL US
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20110062276 | APPARATUS AND METHOD FOR DISTRIBUTION OF A FLOOR COVERING - An apparatus includes a frame and a roller. The frame has a first portion and a second portion. The first portion is configured to be coupled to a vehicle configured to move along a surface, such as for example, an industrial utility vehicle, scooter or the like. The roller is coupled to the second portion of the frame such that when the first portion of the frame is coupled to the vehicle the second portion of the frame and the roller are spaced apart from the surface, and the roller is configured to contact a portion of a substantially cylindrical roll. The portion of the substantially cylindrical roll is disposed between the surface and a horizontal center line of the substantially cylindrical roll. | 03-17-2011 |