Patent application number | Description | Published |
20150100503 | SYSTEMS AND METHODS FOR ENTERPRISE MANAGEMENT USING CONTEXTUAL GRAPHS - The disclosed technology provides a unified collaborative tool and workspace to access people, content, and tools within the context of completing a project or task. The system streamlines the way that projects or tasks get done, while providing a system of record for the project or task that is neatly and intuitively organized within the context of that project or task. The collaborative workspace with context is customized for each user at an enterprise. Portions of the collaborative workspace accessible to a given user are shared with a designated set of other users, allowing all users with access to contribute and share information, documents, and resources within a particular context, such as a particular project or task. | 04-09-2015 |
20150120577 | SYSTEMS AND METHODS FOR ENTERPRISE MANAGEMENT USING CONTEXTUAL GRAPHS - The disclosed technology provides a unified collaborative tool and workspace to access people, content, and tools within the context of completing a project or task. The system streamlines the way that projects or tasks get done, while providing a system of record for the project or task that is neatly and intuitively organized within the context of that project or task. The collaborative workspace with context is customized for each user at an enterprise. Portions of the collaborative workspace accessible to a given user are shared with a designated set of other users, allowing all users with access to contribute and share information, documents, and resources within a particular context, such as a particular project or task. | 04-30-2015 |
Patent application number | Description | Published |
20090300609 | Combining system blueprints, functional layer, and software bits in parallel development of machines - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. A source code management tool stored in the distributable self-contained repository is configured to develop each virtual machine independently from each other in parallel, and to merge back the developments to a corresponding parent virtual machine. | 12-03-2009 |
20090300610 | Self-replicating machines - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. | 12-03-2009 |
20090300619 | Product independent orchestration tool - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. A configuration management tool is configured to orchestrate and automate a deployment process, and to interface with an underlying product having a corresponding functionality. | 12-03-2009 |
Patent application number | Description | Published |
20090194910 | Two Stage Spring Pack Device for Hot Runner Sealing - A two stage spring pack device comprising a nozzle or back up insulator, surrounded by a first stage spring for applying an initial force, and a plurality of Belleville springs to exert a secondary force against a thermally expanding hot runner manifold in an injection molding system, precludes resin leakage between a manifold and nozzle or between mating manifolds in a cross manifold system. The first stage spring imparts a relatively low initial force against the hot runner components while the system heats up from ambient temperature to prevent plate bowing and component hobbing, until it is fully compressed, at which point a subsequently larger sealing force is exerted by the constant force Belleville springs to prevent leakage between the mating components at operating temperature and injection pressure. | 08-06-2009 |
20110027410 | Back-Up Device for Use in a Melt Distribution Apparatus of an Injection Molding System - Disclosed, amongst other things, is a back-up device that is configured to provide a structural support, in use, between a manifold and a housing member within a melt distribution apparatus of an injection molding system. The back-up device is associated, in use, with a valve-gate apparatus within a nozzle drop. The back-up device includes a cold-side member formed from a first material and a hot-side member formed from a second material. The first material is more thermally conductive than the second material. The cold-side member is configured to be thermally connectable, in use, with the housing member and the hot-side member. The hot-side member is configured to be thermally connectable, in use, with the manifold and the cold-side member. The hot-side member is also configured to prevent the cold-side member from directly contacting the manifold. | 02-03-2011 |
20120045537 | Mold-Tool System having Valve Stem Slide Supported by Nozzle Housing - A mold-tool system ( | 02-23-2012 |
20120156323 | Hot-Runner System Including Melt-Flow Control Structure Integrally Formed with the Manifold Body - A hot-runner system is provided with a manifold body including a manifold melt channel, and a melt-flow control structure communicating with the manifold melt channel. The melt-flow control structure is integrally formed with the manifold body. | 06-21-2012 |
20120156324 | Mold-Tool System having Melt Splitting Device Including Uninterrupted Melt Channels Extending from Inlet and Outlets - A mold-tool system is provided which includes a melt distribution device and a melt splitting device configured to interact with the melt distribution device. The melt splitting device includes a single inlet and multiple outlets spaced from the single inlet. The outlets are configured for fluid communication with the melt distribution device. The melt splitting device further includes a plurality of uninterrupted melt channels, where each melt channel extends from the inlet to an associated one of the outlets. | 06-21-2012 |
20130064922 | Injection Molding System having Dynamic Mixer - A dynamic mixer and associated injection molding system for mixing a melt flow. The injection molding system includes: a hot runner assembly having a plurality of splits; an injection unit that delivers a melt flow to the plurality of splits in the hot runner assembly via a melt channel; and a dynamic mixer incorporated into the melt channel upstream from the plurality of splits, wherein the dynamic mixer includes a rotor assembly configured to be rotationally driven by the melt flow, and wherein the rotor assembly is further configured to mix the melt flow passing through the melt channel. | 03-14-2013 |
20130287887 | Valve-Stem Assembly Removable from Runner System While Valve-Actuator Assembly Remains Connected with Manifold Assembly - A mold-tool system ( | 10-31-2013 |
20130316039 | Mold-Tool System Including Cooling-Insert Assembly being Positioned Proximate to Nozzle Assembly - A mold-tool system ( | 11-28-2013 |
20130316040 | Mold-Tool System Includes One-Piece Manifold Assembly having Each Inlet in Fluid Communication with Outlets - A mold-tool system ( | 11-28-2013 |
20140271963 | POST-MOLD SYSTEM - Disclosed herein, amongst other things, is a post-mold system ( | 09-18-2014 |
Patent application number | Description | Published |
20130227067 | METHOD AND SYSTEM FOR SHARING WEB COMPONENTS BETWEEN WEB SITES - The sharing of objects may be executed by performing various share type administrations. Objects may be shared directly to a site or may be made available indirectly for reuse by a site. The objects shared and made available for reuse may be added to the site to which they are shared and made available for reuse. References to the objects shared and made available for reuse are stored in repositories in response to, and in accordance with, the share type administration performed. The storage of the references to objects is based on privileges associated with at least one of a repository, a site and a user. Objects made available for reuse by, and shared to, a site may be made unavailable for reuse by, and unshared to, the site through the execution of a share type administration. | 08-29-2013 |
20140201190 | Method and system to provide composite view of components - Systems and methods for defining a composite view and using the definition of the composite view to obtain, aggregate, analyze, and present data from a variety of data sources to a user. These systems and methods may allow for the definition of a visual framework to aggregate and display related data. This visual framework, or composite view, may in turn be composed of a master view and a set of subviews, each of which may display data collected from a particular data source according to a particular format. By interacting with the master view data from a variety of data sources can be displayed. | 07-17-2014 |
20150234797 | METHOD AND SYSTEM FOR SHARING DIFFERENT WEB COMPONENTS BETWEEN DIFFERENT WEB SITES IN A PORTAL FRAMEWORK - The sharing of objects may be executed by performing various share type administrations. Objects may be shared directly to a site or may be made available indirectly for reuse by a site. The objects shared and made available for reuse may be added to the site to which they are shared and made available for reuse. References to the objects shared and made available for reuse are stored in repositories in response to, and in accordance with, the share type administration performed. The storage of the references to objects is based on privileges associated with at least one of a repository, a site and a user. Objects made available for reuse by, and shared to, a site may be made unavailable for reuse by, and unshared to, the site through the execution of a share type administration. | 08-20-2015 |
20150310064 | METHOD AND SYSTEM TO PROVIDE COMPOSITE VIEW OF DATA FROM DISPARATE DATA SOURCES - Systems and methods for defining a composite view and using the definition of the composite view to obtain, aggregate, analyze, and present data from a variety of data sources to a user. These systems and methods may allow for the definition of a visual framework to aggregate and display related data. This visual framework, or composite view, may in turn be composed of a master view and a set of subviews, each of which may display data collected from a particular data source according to a particular format. By interacting with the master view data from a variety of data sources can be displayed. | 10-29-2015 |
Patent application number | Description | Published |
20110117030 | Aerosolized Fosfomycin/Aminoglycoside Combination for the Treatment of Bacterial Respiratory Infections - A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass median aerodynamic diameter predominantly between 1 to 5μ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler. | 05-19-2011 |
20110189103 | Aerosolized Fosfomycin/Aminoglycoside Combination for the Treatment of Bacterial Respiratory Infections - A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5μ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler. | 08-04-2011 |
20110230431 | FOSFOMYCIN/TOBRAMYCIN COMBINATIONS FOR THE TREATMENT AND PREVENTION OF OPHTHALMIC, OTOLOGICAL AND DERMATOLOGICAL INFECTIONS - Provided are topical fosfomycin-tobramycin compositions for the treatment and/or prevention of ophthalmic, otological, and dermatologic inflammation and/or bacterial infections and methods of treating ophthalmic, otological and dermatological inflammation and/or bacterial infections. | 09-22-2011 |
20130071442 | Aerosolized Fosfomycin/Aminoglycoside Combination for the Treatment of Bacterial Respiratory Infections - A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5μ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler. | 03-21-2013 |
Patent application number | Description | Published |
20100019431 | METHODS OF VERIFYING EFFECTIVENESS OF A PUT OF A SUBSTRATE ONTO A SUBSTRATE SUPPORT - In a first aspect, a method of manufacturing a substrate is provided wherein an end effector mounted substrate is attempted to be placed, that is put, onto a substrate support, such as a pedestal or slotted support of a substrate carrier, and the effectiveness of the put is verified by a sensor associated with the end effector. In one embodiment, the verification takes place during the retraction motion of the end effector and is accomplished by sensing the presence, absence, or location of the substrate on the substrate support. The sensor may be a through beam sensor, and may be mounted on, coupled to or otherwise move with the end effector adapted to carry the substrate. Numerous other aspects are described. | 01-28-2010 |
20150022821 | CARRIER ADAPTER INSERT APPARATUS AND CARRIER ADAPTER INSERT DETECTION METHODS - Methods, apparatus, and assemblies are provided for an adapter insert including an adapter frame including a support rail adapted to support one or more substrates in a substrate carrier, a frame extension coupled to, or integral with, the adapter frame, and a mapping feature formed on the frame extension and disposed to be detected by a sensor for determining whether an adapter insert is present or absent in a substrate carrier. Numerous additional features are disclosed. | 01-22-2015 |
20160118279 | SYSTEMS, APPARATUS, AND METHODS FOR PURGING A SUBSTRATE CARRIER AT A FACTORY INTERFACE - Embodiments of the present invention provide systems, apparatus, and methods for purging a substrate carrier. Embodiments include a frame configured to sit proximate to a load port door without interfering with operation of a factory interface or equipment front end module robot; one or more inter-substrate nozzle arrays supported by the frame and configured to spray gas into a substrate carrier; and one or more curtain nozzle arrays supported by the frame and configured to spray gas across an opening of the substrate carrier. Numerous additional aspects are disclosed. | 04-28-2016 |
Patent application number | Description | Published |
20110066390 | Systems and Methods For Determining Geologic Properties Using Acoustic Analysis - Systems and methods which determine geologic properties using acoustic analysis are shown. Acoustic signals are collected during processing (e.g., crushing, shearing, striking, compressing, etc.) of geologic media, such as rock samples, for determining geologic properties according to embodiments. The acoustic signals collected may include frequency information, amplitude information, time information, etc. which may be utilized in determining geologic properties, such as geologic media properties (e.g., mineralogy, porosity, permeability, sealing capacity, fracability, compressive strength, compressibility, Poisson's Ratio, Youngs Modulus, Bulk Modulus, Shear Modulus), geologic structure properties (e.g., lithology, seal quality, reservoir quality), geologic acoustic properties (e.g., acoustic logging effectiveness, acoustic response, natural or harmonic frequencies, etc.). Embodiments may be used to provide determination of geologic properties from a variety of geologic media samples, such as cuttings, core samples, etc. | 03-17-2011 |
20130037707 | MEASUREMENT OF ISOTOPE RATIOS IN COMPLEX MATRICES - The present techniques are directed to a method for microprobe analyses of isotope ratios in inhomogeneous matrices. The method includes selecting matrix standards that have matrices that resemble a target matrix. A bulk isotope analysis is run on each of the matrix standards to determine a bulk isotope ratio value. A microprobe analysis is run on each of the matrix standards to determine a microprobe isotope ratio values for each of the plurality of matrix standards. Spurious values are eliminated from the microprobe isotope ratio values. The microprobe isotope ratio values are averaged for each of the matrix standards to create an average microprobe isotope ratio value associated with each of the matrix standards. The bulk isotope ratio value for each of matrix standards is plotted against the average microprobe isotope ratio value associated with each of the matrix standards to create a matrix corrected calibration curve. | 02-14-2013 |
20140283609 | Systems and Methods For Determining Geologic Properties Using Acoustic Analysis - Systems and methods which determine geologic properties using acoustic analysis are shown. Acoustic signals are collected during processing (e.g., crushing, shearing, striking, compressing, etc.) of geologic media, such as rock samples, for determining geologic properties according to embodiments. The acoustic signals collected may include frequency information, amplitude information, time information, etc. which may be utilized in determining geologic properties, such as geologic media properties (e.g., mineralogy, porosity, permeability, sealing capacity, fracability, compressive strength, compressibility, Poisson's Ratio, Youngs Modulus, Bulk Modulus, Shear Modulus), geologic structure properties (e.g., lithology, seal quality, reservoir quality), geologic acoustic properties (e.g., acoustic logging effectiveness, acoustic response, natural or harmonic frequencies, etc.). Embodiments may be used to provide determination of geologic properties from a variety of geologic media samples, such as cuttings, core samples, etc. | 09-25-2014 |
Patent application number | Description | Published |
20100094531 | Personalized traffic reports - A method and system are disclosed for providing personalized traffic reports. A personalized traffic report is a relatively short, audio-visual presentation that includes an audio narrative by an announcer describing the traffic conditions along a user's selected route, synchronized with a video presentation that includes maps with animations showing the traffic conditions and a visual representation of the announcer. A traffic data services provider determines traffic conditions that pertain to a user's identified particular route, i.e. from an origin to a destination. Then, the traffic data services provider forms an audio-video file that includes an audio narrative in the voice of an announcer that describes the traffic conditions along the user's route, along with a visual map representation of the user's route, a graphical indication of the traffic conditions along the route, and a visual representation of the announcer. The traffic data services provider transmits the audio-video file of the personalized traffic report to the user, who then plays it back on a computing device. | 04-15-2010 |
20150162999 | Systems and Methods for Delivering Contextually Relevant Media Content Stream Based on Listener Preference - The present disclosure provides a system for delivering contextually relevant streaming media content embodied in a mobile device, wherein the media stream includes one or more media content segments content selected from a plurality of media content segments content based on the current location of the mobile device and received listener preferences. | 06-11-2015 |
20150163636 | Systems and Methods for Delivering Relevant Media Content Stream Based on Location - The present disclosure provides a system for delivering contextually relevant streaming media content embodied in a mobile device, wherein the media stream includes one or more media content segments content selected from a plurality of media content segments content based on the current location of the mobile device. | 06-11-2015 |
Patent application number | Description | Published |
20140240146 | Wireless Vehicle Detector Aggregator and Interface to Controller and Associated Methods - Embodiments of systems and methods of the present invention include efficient, reliable aggregation and transfer of one or more sensor pods detect status to the base station and then the traffic controller. An embodiment of an access point maintains a sensor state array, which is the current status of the sensor pods in communication with the access point. The access point can maintain the sensor state array in its memory and relay the sensor state array to the base station. An embodiment of a base station can use the sensor state array information to generate and update a vehicle detector array, which is the current status of all the sensor pods in the wireless vehicle detector network. An embodiment of the base station emulates one or more bus interface units and uses the vehicle detector array to relay detector information to the traffic controller periodically or when polled. | 08-28-2014 |
20140244145 | WIRELESS VEHICLE DETECTION SYSTEM AND ASSOCIATED METHODS HAVING ENHANCED RESPONSE TIME - Embodiments of the invention include a wireless vehicle detection systems and associated methods with extended range and battery life. The wireless vehicle detection system can include a plurality of sensor pods in communication with an access point without repeaters. Embodiments of the sensor pod can include a vehicle detector controller adapted to determine the presence of vehicles and a communication controller connected to the vehicle detector and adapted to transmit data 300 feet or more to an access point, which in turns communicates with the base station. To extend the battery life of the sensor pod, the sensor pod can be adapted to detect received communication signal strength and adjust transmitting power based upon said strength to thereby conserve power. Embodiments of the sensor pod can also include a battery connected in parallel to an HLC capacitor to further extend the life of the battery. | 08-28-2014 |
20150046075 | WIRELESS VEHICLE DETECTION SYSTEM AND ASSOCIATED METHODS HAVING ENHANCED RESPONSE TIME - Embodiments of the invention include a wireless vehicle detection systems and associated methods with extended range and battery life. The wireless vehicle detection system can include a plurality of sensor pods in communication with an access point without repeaters. Embodiments of the sensor pod can include a vehicle detector controller adapted to determine the presence of vehicles and a communication controller connected to the vehicle detector and adapted to transmit data 300 feet or more to an access point, which in turns communicates with the base station. To extend the battery life of the sensor pod, the sensor pod can be adapted to detect received communication signal strength and adjust transmitting power based upon said strength to thereby conserve power. Embodiments of the sensor pod can also include a battery connected in parallel to an HLC capacitor to further extend the life of the battery. | 02-12-2015 |
20150194056 | WIRELESS VEHICLE DETECTION SYSTEM AND ASSOCIATED METHODS HAVING ENHANCED RESPONSE TIME - Embodiments of the invention include a wireless vehicle detection systems and associated methods with extended range and battery life. The wireless vehicle detection system can include a plurality of sensor pods in communication with an access point without repeaters. Embodiments of the sensor pod can include a vehicle detector controller adapted to determine the presence of vehicles and a communication controller connected to the vehicle detector and adapted to transmit data 300 feet or more to an access point, which in turns communicates with the base station. To extend the battery life of the sensor pod, the sensor pod can be adapted to detect received communication signal strength and adjust transmitting power based upon said strength to thereby conserve power. Embodiments of the sensor pod can also include a battery connected in parallel to an HLC capacitor to further extend the life of the battery. | 07-09-2015 |
Patent application number | Description | Published |
20130168205 | Accumulator for a Sheet Handling System - An apparatus for accumulating sheet material in a sheet handling system including a first conveyance, a second conveyance, an auxiliary conveyance and a processor to control the conveyances based upon a selected operating mode. The first conveyance receives singulated sheets and conveys the sheets to an accumulator station to produce completed collations. The second conveyance is operative to dispense completed collations from the accumulator station and, receives the completed collations from the first conveyance, in one operating mode, and from the auxiliary conveyance in another operating mode when the first conveyance is inoperative. The processor is responsive to a next collation signal, to control the conveyances based upon a selected one of the operating modes. | 07-04-2013 |
20130168914 | SYSTEM AND METHOD FOR MINIMIZING THE CONVEYANCE FEED PATH OF A SHEET MATERIAL HANDLING SYSTEM - A method for operating a sheet handling system including the steps of: determining a location of a next collation mark on select sheets of the stack of material, selecting an operating mode based upon the proximity of the next collation mark relative to a leading or trailing edge of each of the select sheets, processing the singulated sheets in a first operating mode when the next collation mark is proximal to the leading edge of each of the select sheets, and in a second operating mode, when the next collation mark is proximal to a trailing edge of each of the select sheets. Each of the select sheets is buffered to change the spatial relationship between each of the select sheet and each completed collation of sheets along the feed path. By selectively processing the sheets based upon the location of the next collation mark, the conveyance feed path is minimized. | 07-04-2013 |
20130168918 | VACUUM ROLLER ASSEMBLY - A vacuum roller assembly adapted to singulate a sheet from a stack of sheets. The vacuum roller assembly comprising a stationary inner plenum having a substantially linear plenum slot disposed in fluid communication with the vacuum source and a rotating vacuum roller disposed over the stationary inner plenum and rotating about a rotational axis. The vacuum roller includes a plurality of apertures disposed in fluid communication with the substantially linear plenum slot and about the periphery in at least one region of the roller. Furthermore, each of the apertures is substantially slot-shaped and defines a major axis. The major axis is off-axis with respect to the substantially liner plenum slot of the inner plenum to reduce audible noise levels produced by the rotating vacuum roller as air flows through each rotating aperture into the stationary linear plenum slot. | 07-04-2013 |
Patent application number | Description | Published |
20100160765 | THERAPEUTIC SUCCESS PREDICTION FOR ATRIAL FIBRILLATION - Certain embodiments of the invention provide methods of assessing a patient's risk for atrial fibrillation (AF) recurrence after receiving treatment with an AF treatment modality, that include determining, from left atrium (LA) tissue image data of a patient, a level of a parameter that is positively proportional to an amount of unhealthy tissue in a wall of the LA of the patient; and outputting, to an output device, an indicator of a comparison between (i) the determined level and (ii) a first threshold level of the parameter, the first threshold level derived from LA tissue image data of at least one other patient, who experienced an AF recurrence after treatment with the AF treatment modality. In certain embodiments, levels of the parameter equal to or greater than the first threshold level are indicative of a significant risk of AF recurrence after treatment with the AF treatment modality. | 06-24-2010 |
20100160768 | THERAPEUTIC OUTCOME ASSESSMENT FOR ATRIAL FIBRILLATION - Certain embodiments provide a method of assessing an outcome of an ablative atrial fibrillation (AF) treatment modality administered to a patient, the method including: determining, from left atrium (LA) tissue image data of a subject patient that has undergone an ablative AF treatment with the modality, at least one of: a level of a parameter that is positively proportional or negatively proportional to an amount of ablated tissue in a wall of the LA of the subject patient; and a spatial distribution, in the LA wall, of a variable indicative of ablated LA tissue; and outputting, to an output device, a machine-readable indicator of at least one of: (i) a comparison between the determined level and a threshold level of the parameter; and (ii) a map of the spatial distribution. | 06-24-2010 |
20100298694 | STROKE RISK ASSESSMENT - Certain embodiments provide a method of assessing a risk of thromboembolic stroke in a patient. The method comprises acquiring image data and determining an indicator of a degree of fibrosis of a patient's left atrium (LA) based on the image data. The method also comprises estimating a level of risk of thromboembolic stroke of the patient based on the indicator. | 11-25-2010 |
Patent application number | Description | Published |
20120083522 | MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI - Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI. | 04-05-2012 |
20120277284 | MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3)EXPRESSION - Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases. | 11-01-2012 |
20130237585 | MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof. | 09-12-2013 |
20140206745 | METHODS FOR MODULATING KALLIKREIN (KLKB1) EXPRESSION - Disclosed herein are methods for decreasing kallikrein and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to kallikrein include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism. | 07-24-2014 |
20140213631 | METHODS FOR MODULATING KALLIKREIN (KLKB1) EXPRESSION - Disclosed herein are methods for decreasing kallikrein and treating or preventing inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to kallikrein include hereditary angioedema (HAE). Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for developing an inflammatory condition, such as, hereditary angioedema. | 07-31-2014 |
20140336237 | MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION - Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases. | 11-13-2014 |
20140371296 | METHODS FOR MODULATING METASTASIS-ASSOCIATED-IN-LUNG-ADENOCARCINOMA-TRANSCRIPT-1 (MALAT-1) EXPRESSION - The present embodiments provide compounds and methods for reducing expression of Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) RNA and/or protein in an animal. Such methods are useful for treating cancer, such as colon cancer, intestinal cancer, lung cancer (e.g. non-small cell lung cancer), liver cancer, and/or prostate cancer. In various aspects, the cancer is a primary cancer. | 12-18-2014 |
20160068845 | MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof. | 03-10-2016 |
Patent application number | Description | Published |
20130331434 | METHODS FOR MODULATING FACTOR 12 EXPRESSION - Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism. | 12-12-2013 |
20140107180 | MODULATION OF ANDROGEN RECEPTOR EXPRESSION - Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation. | 04-17-2014 |
20160068846 | MODULATION OF ANDROGEN RECEPTOR EXPRESSION - Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation. | 03-10-2016 |
Patent application number | Description | Published |
20090036404 | OPHTHALMIC COMPOSITIONS COMPRISING A CARBOXYL-MODIFIED FRUCTAN OR A SALT THEREOF - Ophthalmic composition including a carboxyl-modified fructan or a salt thereof. The ophthalmic composition can be used in an eye care product or a contact lens care product such as a contact lens packaging solution or contact lens disinfecting solution. | 02-05-2009 |
20090092575 | OPHTHALMIC COMPOSITIONS WITH A DISUCCINATE - The invention is directed to an ophthalmic composition comprising a disuccinate of formula I or a corresponding salt thereof; | 04-09-2009 |
20090304811 | Pharmaceutical Formulations Comprising Stabilized Polysaccharides and Source of Hydrogen Peroxide - A pharmaceutical formulation that is effective in adversely affecting the viability of microorganisms or in inhibiting their growth and that provides better safety and/or comfort to the users comprises a polysaccharide, a source of hydrogen peroxide, and an anti-oxidant. The formulation can further comprise a chelating agent and/or an ophthalmically active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses. | 12-10-2009 |
20100247666 | Method for Preparing Suspensions of Low-Solubility Materials - A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient (“API”) having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process. | 09-30-2010 |
20150038439 | METHOD FOR PREPARING SUSPENSIONS OF LOW-SOLUBILITY MATERIALS - A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient (“API”) having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process. | 02-05-2015 |
Patent application number | Description | Published |
20150042283 | BATTERY STACK WITH DISTRIBUTED CONTROL OF CELLS DRIVING EVENTS - Embodiments of the present invention relate to a battery stack controller system. The system may include a plurality of battery cell stages with cell controller systems (as described above with respect to the first embodiment). The system may also include a stack controller to send charge/discharge commands to the battery stack via a communication network. The stack controller may send the commands to the battery stack based on the requirements of a load or the state of the battery cell stages. The battery cell stages may either comply with the commands or send the commands to neighboring cells via the communication network. | 02-12-2015 |
20150044515 | BATTERY PACK WITH LOCALLY CONTROLLED DISCONNECT SAFEGUARDS - Embodiments of the present invention are directed to an improved battery packaging design. The battery pack design may include a battery cell, a plurality of transistors, and a controller. The transistors may be coupled to the terminals of the battery cell in an H-bridge configuration. The controller may control the transistors to bypass the battery cell based on the current flowing between the output terminals of the battery pack. In such a manner, the controller may prevent damage to the battery cell and improve the overall safety of the battery pack in hazardous conditions. | 02-12-2015 |
20150044521 | BATTERY CELL WITH DISCRETION TO DRIVE LOADS WITHIN BATTERY STACK - Embodiments of the present invention are directed to improved battery packaging designs. The battery pack design may include a battery cell, a plurality of transistors, and a controller. The transistors may be coupled to the terminals of the battery cell in an H-bridge configuration. The controller may control the transistors to bypass the battery cell based on the current flowing between the output terminals of the battery pack. In such a manner, the controller may prevent damage to the battery cell and improve the overall safety of the battery pack in hazardous conditions. Moreover, the design may allow for more efficient charging/discharging of the cells that are most ready to accept/supply current. | 02-12-2015 |
20150044522 | BATTERY STACK WITH LEAPFROGGING PROTOCOL - Embodiments of the present invention are directed to a battery stack with a leapfrogging communication network. Each cell stage may include a controller, a transmitter, and a pair of receivers. The cell stage in the battery stack may be coupled to the closest two preceding battery cell stages in the stack. In this manner, each cell stage may be able to determine if a fault is present in an immediately preceding cell stage in the stack by monitoring the first preceding cell stage and the second preceding cell stage. If discharge/charge commands transmitted by the second preceding cell stage are not reaching the battery cell stage at issue, the controller may determine that there is a fault in the first preceding cell stage and discharge/charge the cell stage based on the commands transmitted by the second preceding cell stage. | 02-12-2015 |