Lu, MD
Alan Y. Lu, Baltimore, MD US
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20130123330 | Dual Targeted siRNA Therapeutics for Treatment of Diabetic Retinopathy and Other Ocular Neovascularization Diseases - The present invention relates to compositions and methods for treating diabetic retinopathy and other ocular neovascularization diseases. In one embodiment, the composition comprises at least two different siRNA duplexes and a pharmaceutically acceptable carrier. One of the duplexes binds to an mRNA molecule that encodes VEGF, and the other binds to an mRNA molecule that encodes VEGFR2. In another embodiment, the composition further comprises an siRNA duplex that binds to an mRNA molecule that encodes TGFβ1. | 05-16-2013 |
20160068843 | Compositions and Methods for "Resistance-Proof" SiRNA Therapeutics for Influenza - The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle. | 03-10-2016 |
Alan Y. Lu, Lutherville-Timonium, MD US
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20130345284 | siRNA Compositions and Methods for Treatment of HPV and Other Infections - The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections. | 12-26-2013 |
Bai Lu, Bethesda, MD US
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20100105623 | SCHIZOPHRENIA-RELATED ISOFORM OF KCNH2 AND DEVELOPMENT OF ANTIPSYCHOTIC DRUGS - The invention is related to a novel primate specific brain isoform of the potassium channel KCNH2 and genetic association with risk for schizophrenia. | 04-29-2010 |
Chi-Hung Lu, Gaithersburg, MD US
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20120317171 | System and Method for Sharing Web Contents for Building Rich Internet Applications - An Internet-based system and application includes both a server and a plurality of client hardware platforms for executing the server as well as the client software. The current invention provides both bottom-up and top-down approaches in modeling information while all other existing systems provide only bottom-up approach. The system and application provide a set of pre-build widgets, also called “molecules”, that spare users from the details and complexity of the underlying web technologies while allowing them to build end applications from intermediary components called droplets by simply assembling and connecting existing molecules. Droplets are stored in a centralized repository wherein all other droplets that have been previously created by this user or others are also stored. Droplets can be selectively shared with others by assigning read/write privileges on creation or on the fly. Multiple droplets can be saved as a single HTML file called a formation. Multiple formations arranged in a pre-determined sequential order typical of a presentation can be packaged as an application. Molecules, droplets, formations, and applications are all sharable units within the system. | 12-13-2012 |
Claire Lu, Gaithersburg, MD US
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20160067707 | PACKAGING FOR MULTIPLEXED ASSAYS - The invention relates to kits and components thereof used in the conduct of solid-phase binding assays. | 03-10-2016 |
Enriquito Lu, Baltimore, MD US
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20140350535 | Cryotherapy Device And Method For The Treatment Of Cervical Precancerous Lesions - A device for providing a cryotherapy ablation treatment includes a piping assembly and a snow horn adapted to create a spray of snow from a pressurized source of a low-temperature liquid, a tubular applicator for collecting a mass of snow at a prescribed density that is sufficient to allow the mass to serve as the needed, low temperature, thermal reservoir for the device after the applicator's distal end has been disconnected from the snow horn end so that it can to be used during the treatment process, and an applicator tip adapted to allow it to connect to the applicator's distal end and be used to treat those specific locations which are to receive this treatment. | 11-27-2014 |
Hang Lu, Gaithersbyrg, MD US
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20110027321 | Chlamydia Vaccine Comprising HtrA Polypeptides - The present invention provides vaccine compositions useful in prevention and treatment of | 02-03-2011 |
Hang Lu, Gaithersburg, MD US
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20100310593 | Vaccines Against Chlamydia Infection - The present invention is directed to providing a vaccine to enhance the immune response of an animal in need of protection against a | 12-09-2010 |
Jeff Zhiqiang Lu, Towson, MD US
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20090215983 | Compounds and methods for inhibiting hepatitis C virus replication - The inventors have discovered that an ATPase-deficient dominant-negative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal structure of a multi-enzyme NS3 complex on a DNA substrate is also provided. The inventors have tested a peptide matching the sequence of a portion of NS3 that interacts with another NS3 molecule for inhibiting HCV replication. The peptide inhibits HCV replication. Accordingly, the invention provides a method of inhibiting HCV replication in cells infected with HCV involving transforming the cells with a vector expressing a dominant-negative mutant NS3 gene. The invention also provides a method of inhibiting HCV replication in cells infected with HCV involving administering to the cells a dominant-negative mutant NS3 protein. The invention also provides peptides and agents that inhibit HCV replication and methods of identifying agents that inhibit HCV replication. | 08-27-2009 |
Jianming Lu, North Potomac, MD US
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20110086374 | Novel Cell-Based Phosphodiesterase Assays - The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds. | 04-14-2011 |
Li Lu, Beltsville, MD US
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20120213780 | Efficient mucosal vaccination mediated by the neonatal Fc receptor - The present invention relates to methods and compositions for enhancing delivery of vaccine antigens to the mucosal epithelium, the composition comprising an antigen from an infectious agent fused with an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn). The composition is effective in eliciting a protective long-term memory T cell immune response against infection at a distant mucosal site. | 08-23-2012 |
Lili Lu, Baltimore, MD US
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20140314740 | COMPOSITIONS AND METHODS FOR THE PREVENTION OR TREATMENT OF DIABETIC COMPLICATIONS - The invention provides compositions and methods for the prevention, amelioration, and/or treatment of diabetes complications, including ocular diseases associated with increased glucose transport and/or oxidative stress. | 10-23-2014 |
Maohua Lu, Greenbelt, MD US
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20120030260 | SCALABLE AND PARALLEL GARBAGE COLLECTION METHOD AND SYSTEM FOR INCREMENTAL BACKUPS WITH DATA DE-DUPLICATION - In accordance with exemplary embodiments, a scalable and parallel garbage collection system for incremental backups with data de-duplication may be implemented with a memory and a processor. The memory may store a changed list at a current time, a before-image list including previous versions of the first overwrite at a current time for each of a plurality of overwritten physical blocks in said storage system, a garbage collection related change list and a recycle list. With these lists configured in the memory, the processor limits the garbage collection to incremental changes and distributes garbage collection tasks to a plurality of participating nodes. For garbage collection, each physical block may associate with an expiration time and a reference count. When the reference count drops to zero, the physical blocks are recycled based on the expiration time. | 02-02-2012 |
20120030477 | SCALABLE SEGMENT-BASED DATA DE-DUPLICATION SYSTEM AND METHOD FOR INCREMENTAL BACKUPS - A system in accordance with exemplary embodiments may provide a scalable segment-based data de-duplication for incremental backups. In the system, a master device on a secondary-storage node side may receive at least incremental changes, fingerprints, mapping entities, and distribute de-duplication functionality to at least a slave device, and performs data de-duplication on said plurality of segments via a way to cluster a plurality of fingerprints in a data locality unit called container for the incremental changes, varied sampling rates of a plurality of segments by having a fixed sampling rate for stable segments and by assigning a lower sampling rate for a plurality of unstable target files of de-duplication, and a per-segment summary structure to avoid unnecessary I/Os involved in de-duplication. | 02-02-2012 |
Patrick Lu, Rockville, MD US
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20090069257 | Method of achieving persistent Transgene expression - Non-inflammatory vector compositions are provided that are suitable for repeated transgene delivery and that result in persistent transgene expression. The compositions are non-inflammatory, the present compositions are suitable for readministration and do not induce expression-limiting immune or inflammatory responses. Thus, these compositions are useful in methods of repeated administration to achieve persistent transgene expression, and are especially suited to treating genetic, acquired and inflammation-associated conditions. | 03-12-2009 |
Patrick Y. Lu, Potomac, MD US
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20160068843 | Compositions and Methods for "Resistance-Proof" SiRNA Therapeutics for Influenza - The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle. | 03-10-2016 |
Rongjian Lu, Gaithersburg, MD US
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20110182854 | HCV PROTEASE INHIBITORS - Novel compounds that are potent inhibitors of hepatitis C virus protease are provided. Pharmaceutical compositions containing one or more of these inhibitors, methods of preparing the inhibitors and methods of using the inhibitors to treat hepatitis C and related disorders also are provided. | 07-28-2011 |
Rongjuan Lu, Gaithersburg, MD US
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20120141414 | Bimacrocylic HCV NS3 Protease Inhibitors - Inhibitors of the hepatitis C virus (HCV) NS3 protease are provided. In particular, bimacrocyclic compounds and their pharmaceutical compositions for the treatment of HCV infections are provided. Methods of making the bimacrocyclic compounds and their pharmaceutical compositions, and methods of using the compounds for treating HCV infections are also provided. | 06-07-2012 |
Ruiliang Lu, Nottingham, MD US
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20110105385 | Antibacterial lactobacillus GG peptides and methods of use - The present invention provides antibacterial peptides isolated from | 05-05-2011 |
Shude Lu, Woodstock, MD US
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20100017563 | MICROCONTROLLER BASED FLASH MEMORY DIGITAL CONTROLLER SYSTEM - Some embodiments includes a digital control system having a microcontroller for handling timed events, a command decoder for interpreting user commands, a separate burst controller for handling burst reads of the Flash memory, a program buffer for handling page writes to the Flash memory, a page transfer controller for handling data transfers from the Flash core to the program buffer as well as address control for page writes from the program buffer to the Flash memory, a memory control register block for storing and adjusting memory control, and memory test mode signals, a memory plane interface for multiplexing addresses into the Flash memory and accelerating program, erase, and recovery verification, and an I/O Mux module for multiplexing data out of the system, and a general purpose I/O port (GPIO) that can be read and written by the microcontroller for use in test and debug. Other embodiments are described. | 01-21-2010 |
Wenjun Lu, Greenbelt, MD US
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20120300926 | VALID REPLACEMENT DATA IN ENCODED VIDEO - A security method for H.264 video streams and the like is provided that comprises: coding video data with incorrect or missing bytes, whereby the coded video is corrupted or distorted; generating replacement data that corrects the coded video during decoding; and distributing the replacement data to users. | 11-29-2012 |
Wuyuan Lu, Ellicottt City, MD US
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20110183917 | P53 Activator Peptides - The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides as well as methods of treating abnormal conditions, such as malignant tumors, with the methods comprising administering the pharmaceutical compositions of the present invention to a subject in need of treatment thereof. | 07-28-2011 |
Wuyuan Lu, Ellicott City, MD US
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20090214662 | SURFACE-LAYER PROTEIN COATED MICROSPHERES AND USES THEREOF - The invention provides surface-layer protein coated microspheres for delivery of a therapeutic agent to the intestine. These surface-layer protein coated microspheres generally include a core encapsulated by a microsphere which is coated by surface layer protein. The core includes a therapeutic agent, such as a defensin. The invention also includes methods of making and using the surface-layer protein coated microspheres of the invention for administering therapeutic agents to a subject in need thereof. The invention also includes pharmaceutical dosage units that include the surface-layer protein coated microspheres of the invention. The invention further includes various labeled defensins for use in the study of the properties and actions of defensins, and further includes the use of defensins, particularly HD5α in the treatment of inflammatory conditions of the bowel, such as Crohn's disease. | 08-27-2009 |
20120328692 | POTENT D-PEPTIDE ANTAGONISTS OF MDM2 AND MDMX FOR ANTICANCER THERAPY - The present invention relates to a group of MDM2 and MDMX antagonists, namely, D-peptides, variants thereof, and stapled D-peptides, along with pharmaceutical compositions comprising the antagonists, and methods of treating conditions such as cancer using the antagonists. | 12-27-2012 |
Xiaobin Lu, Germantown, MD US
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20150030627 | Trans-complementing, replication deficient lentiviral vectors and methods for making and using them - The present invention relates to multiple novel approaches for the generation of an immune response in an animal, such as a human, using lentivirus-based vector technology. The invention provides for the ability to mimic the efficacy of a live attenuated (LA) vaccine, without exposing the patient to the risk of disease as possible with some LA vaccines. The invention thus provides for systems of complementary conditionally replicating vectors, vectors that produce replication deficient virus like particles, and multi-antigen constructs that target a virus or microbial pathogen. The use of these materials in the practice of the invention permits the generation of robust cellular and humoral responses to the antigens presented thereby. | 01-29-2015 |
Xi-Chun May Lu, Laurel, MD US
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20130042332 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 02-14-2013 |
20140343458 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 11-20-2014 |
20150057193 | ENDOTHELIAL-MONOCYTE ACTIVATING POLYPEPTIDE II (EMAP-II), A BIOMARKER FOR USE IN DIAGNOSIS AND TREATMENT OF BRAIN INJURY - A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP II) and comparing to a control. An increase of EMAP II indicates the presence of traumatic brain injury and a decrease of EMAP II indicates the presence of ischemic brain injury. Detection of EMAPII can be done in brain tissue, biofluids such as cerebrospinal fluid or blood (including plasma and serum) | 02-26-2015 |
Yang Lu, Rockville, MD US
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20100028848 | Compositions and Methods of Using siRNA to Knockdown Gene Expression and to Improve Solid Organ and Cell Transplantation - This invention describes compositions and methods using siRNA to target various genes expressed in cells of transplanted organs or tissues and/or genes expressed in the host to improve the success of the transplantation. | 02-04-2010 |
Yunyi Lu, Cockeysville, MD US
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20120136148 | Photochromic Compounds Having At Least Two Photochromic Moieties - The present invention relates to photochromic compounds that include at least two photochromic moieties that are linked together by a multivalent linking group. The multivalent linking group can be selected so as to be flexible and/or substantially prevent electronic interaction between any two photochromic moieties through the multivalent linking group. The present invention also relates to photochromic compositions and articles that include at least a photochromic amount of one or more photochromic compounds of the present invention. | 05-31-2012 |