Patent application number | Description | Published |
20080293594 | SOLID PHASE FOR CAPTURE OF NUCLEIC ACIDS - A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer. | 11-27-2008 |
20090170717 | RE-SEQUENCING PATHOGEN MICROARRAY - The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample. | 07-02-2009 |
20100070195 | COMPUTER-IMPLEMENTED BIOLOGICAL SEQUENCE IDENTIFIER SYSTEM AND METHOD - A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen. | 03-18-2010 |
20100112643 | METHOD FOR DIRECT CAPTURE OF RIBONUCLEIC ACID - A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a target ribonucleic acid; denaturing the target ribonucleic acid; and incubating the sample to allow hybridization of the denatured ribonucleic acid to the probe nucleic acids. The target ribonucleic acid is complementary to the probe nucleic acid. | 05-06-2010 |
20110183856 | Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood - The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved. | 07-28-2011 |
20140275628 | Large scale preparation method for functionalizing the surface of magnetic microparticles with an inorganic phosphorous dendrimer - A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method. | 09-18-2014 |
Patent application number | Description | Published |
20110300552 | Systems and Methods for Determining Drug Resistance in Microorganisms - The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum of the intact microorganism or one or more isolated biomarkers from the microorganism grown in non-labeled media without the drug present. Drug resistance is determined by predicting and detecting a characteristic mass shift of one or more biomarkers using algorithms. The characteristic mass shift is indicative that the microorganism is growing in the presence of the drug and incorporating the isotopic label into the one or more biomarkers, resulting in change in mass. | 12-08-2011 |
20150024378 | Analysis of DNA-Containing Samples and Resolution of Mixed Contributor DNA Samples - Methods for analyzing DNA-containing samples are provided. The methods can comprise isolating a single genomic equivalent of DNA from the DNA-containing sample to provide a single isolated DNA molecule. The single isolated DNA molecule can be subjected to amplification conditions in the presence of one or more sets of unique molecularly tagged primers to provide one or more amplicons. Any spurious allelic sequences generated during the amplification process are tagged with an identical molecular tag. The methods can also include a step of determining the sequence of the one or more amplicons, in which the majority sequence for each code is selected as the sequence of the single original encapsulated target. The DNA-containing sample can be a forensic sample (e.g., mixed contributor sample), a fetal genetic screening sample, or a biological cell. | 01-22-2015 |
20150079115 | Compositions and Methods for Preventing or Relieving Symptoms of Infections - Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection. | 03-19-2015 |
Patent application number | Description | Published |
20090263366 | Effects of probiotics on humans and animals under environmental or biological changes - An exemplary embodiment providing one or more improvements includes probiotic compositions comprising probiotic microorganisms with dried vegetable, fruit, cereal, or herb powder. Feeding human or animals either having biological or environmental changes with probiotic compositions has a positive effect in relieving the changes. Positive effects has been demonstrated in humans, dogs, and fish. | 10-22-2009 |
20110038838 | Probiotic enhancement of steroid and immune suppressor activity in mammals with chronic diseases - Embodiment include methods for treating cats and dogs with inflammatory bowl disease or inflammatory-like bowl disease or immune mediated hemolytic anemia or atopic dermatitis which are being treated with steroids or immune suppressors which involves the step of administering to the animal a probiotic comprised of | 02-17-2011 |
20110129518 | Probiotic products for pet applications - An exemplary embodiment providing one or more improvements includes feeding animals with probiotic microbes encapsulated in a mixture of xanthan gum and chitosan, or in gelatin, specifically | 06-02-2011 |
20110129529 | Probiotic products for pet applications - An exemplary embodiment providing one or more improvements includes feeding animals with probiotic microbes encapsulated in a mixture of xanthan gum and chitosan, or in gelatin, specifically | 06-02-2011 |
20110151511 | RAPID GROWING MICROORGANISMS FOR BIOTECHNOLOGY APPLICATIONS - The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in molecular biology and thus provide a significant improvement in in vitro cloning methods used extensively in molecular biology. The invention also relates to kits and compositions used in the methods of the invention. | 06-23-2011 |
20140193464 | EFFECTS OF PROBIOTICS ON HUMANS AND ANIMALS UNDER ENVIRONMENTAL OR BIOLOGICAL CHANGES - A dry, stable and viable probiotic composition comprising, a probiotic microorganism and a dried plant powder, with the proviso that said composition is not a blended mixture of at least one biologically pure | 07-10-2014 |
20150246082 | Pediococcus-Based Probiotics for Body Weight Control - A method of augmenting a weight-loss regimen composition comprising administering at least one billion | 09-03-2015 |
Patent application number | Description | Published |
20090123928 | Genomic Landscapes of Human Breast and Colorectal Cancers - Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. | 05-14-2009 |
20100316995 | CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS - Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. | 12-16-2010 |
20130196312 | GENOMIC LANDSCAPES OF HUMAN BREAST AND COLORECTAL CANCERS - Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. | 08-01-2013 |
Patent application number | Description | Published |
20110229479 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 09-22-2011 |
20120115735 | Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene - There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. | 05-10-2012 |
20120202207 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 08-09-2012 |
20140187764 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 07-03-2014 |
20140377754 | Genomic Landscapes of Human Breast and Colorectal Cancers - Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. | 12-25-2014 |
Patent application number | Description | Published |
20090033493 | Method, System and Apparatus for Writing Common Information to a Plurality of Radio Frequency Identification (RFID) Tags - RFID methods, systems and apparatus for writing common data (RFID information) to a plurality of RFID tags, include transmitting a common-write data signal including the common data to a plurality of RFID tags located in a broadcast field, where the plurality of RFID tags receive and respectively write the common data in internal memory of the plurality of RFID tags in accordance with a common algorithm. A common-write data signal may include common identifier data. Each of a plurality of RFID tags may generate common identifier data by controlling a random number generator of the tag. Each of a plurality of RFID tags may be pre-configured (initialized) for receiving common data and writing the common data to memory in accordance with a common algorithm. Each of a reader and a plurality of RFID tags may include common algorithm for transmitting/receiving and executing a common-write-enable command that enables a common write capability of a tag (e.g., initializes a tag for receiving a common-write data signal), and for transmitting/receiving a common-write-disable command that disables common-write capability of a tag. | 02-05-2009 |
20100148985 | Association Based Locationing for RFID - An apparatus, system and techniques for determining a location of an RFID tag among a population of tags are disclosed. The system includes an RFID reader with at least one antenna port and a population of RFID tags. The population of tags can be homogenous or heterogeneous. The RFID reader varies its transmit power through one or more antenna ports resulting in a grouping of the RFID tags into clusters. In one embodiment, the reader utilizes multiple antennas to further define RFID tag clusters among the population. Each read tag is then uniquely associated with a defined cluster. Tag agents also can be provided among the population of tags facilitating definition of the clusters. | 06-17-2010 |
20100156601 | LLRP-Based Flexible Reader System And Method - A system includes a host computing device, a first RFID transceiver, and at least one second RFID transceiver. The host computing device executes an application according to a predetermined RFID communication protocol. The predetermined RFID communication protocol supports communication only with a single RFID transceiver. The first RFID transceiver communicates with the host computing device according to the predetermined RFID communication protocol. The at least one second RFID transceiver communicates with the first RFID transceiver. The at least one second RFID transceiver provides data to the host computing device only via the first RFID transceiver. | 06-24-2010 |
20110102149 | SYSTEM AND METHOD FOR OPERATING AN RFID SYSTEM WITH HEAD TRACKING - A method of transmitting radiofrequency identification (RFID) interrogation signals is disclosed. The method comprises detecting a first movement of a user in a first direction, determining a command from the first movement, and transmitting a RFID interrogation signal in response to the command. | 05-05-2011 |
20120127976 | RADIO FREQUENCY IDENTIFICATION SYSTEM AND RELATED OPERATING METHODS - A method of operating a radio frequency identification (RFID) system is provided. The method interrogates RFID tags with an RFID reader and provides at least some of the collected tag data to a mobile device that is unable to communicate with RFID tags using the over-the-air interface. In some situations, the RFID system obtains the current location of the mobile device and determines the location of a target tag relative to the current location of the mobile device. Locating the target tag in this manner involves the interrogation of a reference tag located at the mobile device, along with the target tag, using one RFID reader. The position of the target tag relative to the reference tag is calculated in response to the tag response signals obtained from the target and reference tags. Moreover, location of the target tag can be independently determined relative to the location of a mobile reader, by using a reference tag attached to a fixed reader or to the mobile reader. | 05-24-2012 |
20130267250 | Method and system for integrated consumer experience and social networking - Methods and systems for integrated consumer experience and social networking are disclosed comprising the function of presenting a communication function to facilitate communication among multiple users wherein different modes of communication are achieved through a unified process utilizing a context information. The methods and systems further comprise the functions of causing two images to be displayed wherein the two images overlap with each other, and presenting a logic to determine which one of the two images a gesture control signal is directed to. Additionally, the methods and systems can also comprise the functions of receiving a location information of a first device, receiving a location information of a second device, receiving a distance limitation from the first device, determining if the second device is within the distance limitation, and delivering a message from the first device to the second device if the second device is within the distance limitation. | 10-10-2013 |
20150014407 | System Utilizing Light Signals with Wavelengths Approximately Beyond Human Sensitive Light Spectrum - Identification systems and methods for utilizing light signals with wavelengths approximately above or below human sensitive light spectrum are disclosed comprising a special mark, wherein the special mark emits or absorbs light signals in light spectrums approximately below or above the visible light spectrum, a server comprising a processing unit, and a storage area, wherein the special mark is capable of being detected by the photographic instrument, and wherein a digital file is saved in the storage area, and wherein the special mark carries information which identifies the digital file saved in the storage area. | 01-15-2015 |
Patent application number | Description | Published |
20090099107 | Methods and Compositions for Inhibition of Nuclear Factor kappaB - A series of p105-based NF-κB super repressors, designated p-105(sr), have been designed. The p105(sr), no longer generates p50 and undergoes signal-induced degradation, effectively inhibiting all NF-κB activities. Additionally, p105(sr) significantly enhances tumor necrosis factor alpha (TNF-α)-mediated killing of MT1/2 skin papilloma cells when p50 homodimer activity is elevated. p105(sr) is an effective NF-κB super repressor with a broader range than other currently available IkBα super repressors. The novel repressor can be used in cells where a noncanical NF-κB activity is dominant or multiple NF-κB activities are activated. | 04-16-2009 |
20100173307 | NUCLEIC ACID MODULES FOR EXPRESSION AND TAGGING OF MEMBRANE PROTEINS AND METHODS OF USE - Described herein are nucleic acid modules for cloning, expression and tagging of eukaryotic membrane proteins. The nucleic acid modules include a receptor for advanced glycation end products (RAGE) signal sequence, a nucleic acid sequence encoding a tag and a multiple cloning sequence (MCS). Any membrane protein of interest can be cloned into the MCS for expression in cells. The nucleic acid modules can encode any type of tag, such as an epitope tag or affinity tag. The nucleic acid modules disclosed herein can be used to express any type of membrane protein and are particularly suited to the expression and tagging of Type I and Type III membrane proteins. | 07-08-2010 |
20150051136 | HUMAN SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (sRAGE), METHODS OF PREPARING HUMAN sRAGE, AND TREATMENT METHODS USING sRAGE - The present disclosure provides a method for recombinant production of human sRAGE in mammalian cells, as well as a human sRAGE having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human sRAGE having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal. | 02-19-2015 |
Patent application number | Description | Published |
20110170737 | METHOD FOR CONSTRUCTING INNER CODES FOR ANTI-COLLUSION FORRENSIC CODE FOR WATERMARKING DIGITAL CONTENT - A method and apparatus are described including generating a unique code for each of a plurality of users using a plurality of symbols, generating a plurality of codes representing the plurality of symbols, substituting the plurality of codes into the unique code for each of the plurality of users, permuting the code resulting from the substitution to produce a codeword for each of the plurality of users and embedding the codeword into digital content. The second generating act further includes generating a string of first symbols followed by second symbols, wherein the first symbols are all ones and the second symbols are all negative ones, wherein a number of first symbols is equal to a number of the second symbols, and wherein if a length of the first symbols followed by the second symbols is less than a length of the code, then the first symbols followed by the second symbols are repeated until the code length is filled. | 07-14-2011 |
20110182466 | METHOD FOR PROTECTING DIGITAL CONTENT AGAINST MINORITY COLLUSION ATTACKS - A method and system of detecting colluders conducting a collusion attack including a minority-type collusion attack on a digital product includes the generation of codewords used as watermarks in the digital product. The inner code of the codewords is generated using permutations of rows in a Hadamard matrix and concatenating them together. A typical outer code of the codeword is the Reed Solomon code. An adaptive detector is able to accurately detect one of three or more colluders of a minority-type attack. Prior art schemes using an error correcting code-based watermarking mechanism with an inner code fail to detect colluders with a minority-type collusion attack which includes three colluders. | 07-28-2011 |
20130159722 | ACTIVE SENSING FOR DYNAMIC SPECTRUM ACCESS - Various communication systems may benefit from physical layer watermarking. For example, active sensing for dynamic spectrum access may be performed using physical layer watermarking, such as watermarking based on channel effects and/or receiver distortion. A method may include, for example, obtaining an original signal to be transmitted to at least one receiver. The method may also include watermarking the original signal with at least one of authentication data or ancillary data to provide an enhanced signal. The watermarking can include a physical layer watermark. The physical layer watermark can be configured to emulate at least one a channel effect or a receiver distortion. The method can further include transmitting the enhanced signal to the at least one receiver. | 06-20-2013 |
Patent application number | Description | Published |
20110248653 | CONTROLLED POWER FADE FOR BATTERY POWERED DEVICES - A method is provided for operating a power tool having a motor powered by a battery. The method includes: delivering power from the battery to the motor in accordance with an operator input; detecting a condition of the power tool indicating a shutdown of the power is imminent; and fading the power delivered from the battery to the motor, in response to the detected condition, through the use of a controller residing in the power tool. | 10-13-2011 |
20110254472 | POWER TOOL HAVING A NON-LINEAR TRIGGER-SPEED PROFILE - A power tool including a motor, an input unit such as a variable-speed trigger switch, and a controller is provided. The controller controls the speed of the motor as a function of the input level indicated by the electrical signal from the input unit. The function is a first expression within a first predetermined range of the input level and a second expression within a second predetermined range of the input level, where the second expression corresponds to a polynomial of a second degree or higher and is different from the first expression | 10-20-2011 |
20150137715 | Controlled Power Fade For Battery Powered Devices - A method is provided for operating a power tool having a motor powered by a battery. The method includes: delivering power from the battery to the motor in accordance with an operator input; detecting a condition of the power tool indicating a shutdown of the power is imminent; and fading the power delivered from the battery to the motor, in response to the detected condition, through the use of a controller residing in the power tool. | 05-21-2015 |