Patent application number | Description | Published |
20090317390 | NOVEL TISSUE FACTOR TARGETED ANTIBODIES AS ANTICOAGULANTS - This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, and inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including, but not limited to, deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome. | 12-24-2009 |
20100210630 | Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase - This invention is directed to compounds of formula (I): | 08-19-2010 |
20110027268 | ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF - The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. | 02-03-2011 |
20110104058 | DIMERIC MOLECULAR COMPLEXES - Dimeric molecular complexes comprising an IgE CH4 dimerization domain useful for diagnostics and therapeutics. | 05-05-2011 |
20110229476 | MONOSPECIFIC AND MULTISPECIFIC ANTIBODIES AND METHOD OF USE - This invention relates to monospecific and multispecific antibodies that may be utilized for the diagnosis and treatment of various diseases. In addition, these antibodies may be modified by protease cleavage. Protease control or regulation may be provided by a protease site located in, for example, a linker. These protease-regulated antibodies may also be utilized for the diagnosis and treatment of various diseases. | 09-22-2011 |
20130123243 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE - This invention is directed to compounds of formula (I): | 05-16-2013 |
20130259806 | DIMERIC MOLECULAR COMPLEXES WITH FREE CYSTEINE RESIDUES AND CONJUGATES THEREOF - The invention relates generally to dimeric molecular complexes comprising two fusion proteins. Each fusion protein comprises a biological effector moiety, a polypeptide spacer sequence, and an IgE CH4 dimerization domain. The dimeric molecular complexes may be conjugated, at a defined site, to other molecules including drug moieties, cytotoxic agents, labels (such as detectable labels), or biocompatible polymers. | 10-03-2013 |
20150080382 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE - This invention is directed to compounds of formula (I): | 03-19-2015 |
20150259433 | ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF - The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. | 09-17-2015 |
Patent application number | Description | Published |
20130143420 | Electrical Connector and Method of Making It - The present invention is an electrical connector in which a substrate (such as a printed circuit board or PCB) includes a plurality of apertures (or vias) and some of those apertures are filled with two materials to improve the characteristics of the electrical interconnection. The preferred process of crating the filled vias includes the steps of plating the vias with an electrically-conductive material to create an electrically-conductive path between portions of the substrate and components associated with the substrate and partially filling the apertures, then filling at least a portion of the apertures or vias with a second or different filling material to seal at least apart of the electrically conductive path through the plating. The second filling material may be chosen to provide thermal compensation for the connection. | 06-06-2013 |
20140154893 | ELECTRICAL CONNECTOR AND METHOD OF MAKING IT - The present invention is an electrical connector in which a substrate (such as a printed circuit board or PCB) includes a plurality of apertures (or vias) and some of those apertures are filled with two materials to improve the characteristics of the electrical interconnection. The preferred process of crating the filled vias includes the steps of plating the vias with an electrically-conductive material to create an electrically-conductive path between portions of the substrate and components associated with the substrate and partially filling the apertures, then filling at least a portion of the apertures or vias with a second or different filling material to seal at least apart of the electrically conductive path through the plating. The second filling material may be chosen to provide thermal compensation for the connection. | 06-05-2014 |
20140273641 | Electrical Connector with Electrical Contacts Protected by a Layer of Compressible Material and Method of Making It - Disclosed is an electrical connector having a substrate and movable electrical contacts which are mounted to the substrate and extend a distance D from the substrate. A layer of compressible material (such as a foam or elastomeric material) is positioned on the substrate adjacent at least some of the electrical contacts and ideally has an uncompressed thickness slightly greater than the distance D to provide for protection of the electrical contacts. When a mating electrical device such as an electrical connector or other circuit member is mated to the electrical connector with its electrical contacts and its layer of compressible material, the layer of compressible material is compressed to a thickness less than the distance D, allowing the contacts to make a suitable electrical interconnection to the mating electrical device. The compressible material may be selected which has a force-to-compression plot which includes at least one inflection, defining a first region on one side of the inflection where a given increment of force provides a larger increment of compression and a second region on the other side of the inflection where the same increment of compressive force provides a substantially smaller increment of compression. The compressible material can function to prevent damage to the movable electrical contacts from handling, packing, shipping, assembly, testing, connection and/or mating of the connector. | 09-18-2014 |
Patent application number | Description | Published |
20090092399 | MONOLITHIC SHELL FOR AN OPTICAL ELECTRICAL DEVICE - An optoelectronic transceiver module. The optoelectronic module is a monolithic, one-piece module shell that includes a top portion, a bottom portion, a first side portion, a second side portion, and a front portion. The top portion, bottom portion, first side portion, second side portion and the front portion define a cavity configured to enclose electro-optical circuitry. In addition, the top portion and the bottom portion are configured such that the top portion is not separable from the bottom portion. Further, the front portion defines at least one of an optical transmit port or an optical receive port. | 04-09-2009 |
20090148106 | LINE-SIDE OUT-OF-BAND ELECTRICAL INTERFACE FOR OPTOELECTRONIC MODULES - Electrical connections from the printed circuit board (“PCB”) of an optoelectronic device through the front or line-side of the device enable a microcontroller or other component on the PCB to electrically communicate with an optical connector or other line-side device. The electrical connections can be integrated within a lead frame and trace structure providing mechanical support for the electrical connections and the PCB, with each electrical connection including a PCB-side contact and a line-side contact supported by the integrated structure. Alternately, the electrical connections can be integrated within one or more flex circuits. The optical connector can include traces and contacts configured to be electrically coupled to corresponding line-side contacts when the optical connector is received within the device. | 06-11-2009 |
20090261955 | INTELLIGENT BAIL - An identification device is configured to be coupled externally to an optoelectronic device to provide connectivity and/or identification information in an optical network in which the optoelectronic device is implemented. The identification device may include an integrated circuit with unique identification information and a plurality of contacts coupled to the integrated circuit and configured to be coupled to an outside identification system. The outside identification system communicates with the identification device via the plurality of contacts to collect unique identification information, the ability to retrieve the unique identification information additionally implicating connectivity in some embodiments. The identification device may include a plurality of clips configured to engage corresponding posts on a latch of the optoelectronic device. | 10-22-2009 |
20120057821 | ACTIVE OPTICAL CABLE - Integrated cables are disclosed that can include a first optical fiber for optical communication over the length of the integrated cables from a first connector at a first end to a second connector at a second end. The integrated cable can further include a second electrical connector configured to connect with a second electrical port external to the integrated cable. The integrated cable can further include an electrical conductor extending from the first electrical connector to the second electrical connector and configured to supply operating power to an electronic device connected to the second electrical connector but external to the integrated cable. | 03-08-2012 |
20140205298 | INTELLIGENT BAIL - An identification device is configured to be coupled externally to an optoelectronic device to provide connectivity and/or identification information in an optical network in which the optoelectronic device is implemented. The identification device may include an integrated circuit with unique identification information and a plurality of contacts coupled to the integrated circuit and configured to be coupled to an outside identification system. The outside identification system communicates with the identification device via the plurality of contacts to collect unique identification information, the ability to retrieve the unique identification information additionally implicating connectivity in some embodiments. The identification device may include a plurality of clips configured to engage corresponding posts on a latch of the optoelectronic device. | 07-24-2014 |
Patent application number | Description | Published |
20090246596 | Fuel cell system for charging an electric vehicle - A method for charging electric vehicles includes receiving information regarding an electric vehicle. At least a portion of the information is received through a vehicle interface configured to place a battery of the electric vehicle into electrical communication with a fuel cell system. A charge is delivered from the fuel cell system to the battery of the electric vehicle through the vehicle interface without use of a direct current to alternating current (DC/AC) converter. The charge is delivered based at least in part on the information. | 10-01-2009 |
20100013317 | Integrated fuel cell system with auxiliary power delivery - A method of providing electrical power using a split bus configuration includes receiving a first direct current at a positive bus of a split bus, where the first direct current originates from a first fuel cell segment. A second direct current is received at a negative bus of the split bus, where the second direct current originates from a second fuel cell segment. A third direct current is also received at the split bus such that a combined direct current is formed including the first direct current, the second direct current, and the third direct current. The third direct current originates from an alternative direct current (DC) source. The combined direct current is provided to an inverter such that an alternating current is generated for a load. | 01-21-2010 |
20130009481 | Integrated Fuel Cell System with Auxiliary Power Delivery - A method of providing electrical power using a split bus configuration includes receiving a first direct current at a positive bus of a split bus, where the first direct current originates from a first fuel cell segment. A second direct current is received at a negative bus of the split bus, where the second direct current originates from a second fuel cell segment. A third direct current is also received at the split bus such that a combined direct current is formed including the first direct current, the second direct current, and the third direct current. The third direct current originates from an alternative direct current (DC) source. The combined direct current is provided to an inverter such that an alternating current is generated for a load. | 01-10-2013 |
20130163192 | Energy Center - Systems are provided for creating and operating data centers. A data center may include an information technology (IT) load and a fuel cell generator configured to provide power to the IT load. | 06-27-2013 |
20130163193 | Method of Operating an Energy Center - Methods are provided for creating and operating data centers. A data center may include an information technology (IT) load and a fuel cell generator configured to provide power to the IT load. | 06-27-2013 |
20140049206 | Fuel Cell System for Charging an Electric Vehicle - A method for charging electric vehicles includes receiving information regarding an electric vehicle. At least a portion of the information is received through a vehicle interface configured to place a battery of the electric vehicle into electrical communication with a fuel cell system. A charge is delivered from the fuel cell system to the battery of the electric vehicle through the vehicle interface without use of a direct current to alternating current (DC/AC) converter. The charge is delivered based at least in part on the information. | 02-20-2014 |
Patent application number | Description | Published |
20100221104 | AIRCRAFT FLUID DIVERSION INLET LOUVER - An inlet system, including for an auxiliary power unit includes an inlet louver mounted to an inlet duct, the inlet louver defines a multiple of vanes positioned to shield the inlet duct from fluids which fall in direction generally transverse to a free stream airflow. | 09-02-2010 |
20130001369 | AUXILIARY POWER UNIT INLET - An aircraft auxiliary power unit assembly includes an aircraft skin providing a cavity. The aircraft skin is secured to a structure in an assembled condition and provides an opening. An auxiliary power unit is arranged within the cavity and secured to the structure. The aircraft skin substantially covers the auxiliary power unit in the assembled condition. An inlet duct is removably secured within the opening and is selectively connected to the auxiliary power unit between installed and service positions. The installed and service positions are with the aircraft skin in the assembled condition. A method of servicing the auxiliary power unit includes removing the auxiliary power unit inlet duct from the opening in the aircraft skin. The auxiliary power unit that is arranged within the cavity of the aircraft skin is exposed. A portion of the auxiliary power unit is serviced through the opening. | 01-03-2013 |
20130031911 | APU SELECTIVE COOL DOWN CYCLE - An APU has a control for controlling a load on the APU from an associated aircraft. The control further receives information with regard to a temperature challenge around the APU. If the temperature challenge exceeds a predetermined threshold, then the control operates the APU with a reduced load in a cool down cycle to reduce the heat load from the APU on an associated tail cone. A method is also disclosed. | 02-07-2013 |
20130174567 | Automatic Engine Noise Reduction - A method of reducing engine noise for an engine under little or low load conditions includes the steps of: establishing an engine idle speed for the engine when the engine has less than a predetermined minimum level of load; measuring the level of load on the engine; measuring the speed of the engine; and reducing the speed of the engine to the engine idle speed if the measured level of load on the engine is less than the predetermined minimum level of load and the measured speed of the engine is greater than the engine idle speed. | 07-11-2013 |
20130228648 | AUXILIARY POWER UNIT INLET - An aircraft auxiliary power unit assembly includes an aircraft skin that provides a cavity. It is secured to a structure in an assembled condition and it provides an opening. An auxiliary power unit is arranged within the cavity and is secured to the structure. The aircraft skin substantially covers the auxiliary power unit in the assembled condition. An inlet duct that is removable is secured within the opening and is selectively connected to the auxiliary power unit between the installed and service positions. The installed and service positions are with the aircraft skin in the assembled condition. | 09-05-2013 |