Liang Guo
Liang Guo, St. Louis, MO US
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20080229456 | Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 09-18-2008 |
20090013434 | Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 01-08-2009 |
20090070898 | Plant microRNAs and methods of use thereof - This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention. | 03-12-2009 |
20090188005 | METHODS FOR GENETIC CONTROL OF PLANT PEST INFESTATION AND COMPOSITIONS THEREOF - The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples. | 07-23-2009 |
20100223694 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 09-02-2010 |
20110035838 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 02-10-2011 |
20110035839 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 02-10-2011 |
20110214205 | Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 09-01-2011 |
20120246748 | ISOLATED NOVEL ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENE PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 09-27-2012 |
20130232644 | PHASED SMALL RNAS - This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed by this invention are transgenic plant cells, plants, and seeds containing a recombinant DNA construct of this invention | 09-05-2013 |
20140165234 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM FOXTAIL MILLET AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 06-12-2014 |
20140325702 | Methods for genetic control of plant pest infestation and compositions thereof - The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples. | 10-30-2014 |
20150197765 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOYBEANS AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 07-16-2015 |
20150307890 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 10-29-2015 |
Liang Guo, Waltham, MA US
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20100250922 | METHOD AND SYSTEM FOR PROPAGATING TRUST IN AN AD HOC WIRELESS COMMUNICATION NETWORK - A method and system enable robust and scalable propagation of trust between a first organization and a second organization, both operating in an ad hoc wireless communication network. The method includes establishing at a first member node of the first organization pair-wise trust with a first member node of the second organization using a predetermined inter-organizational trust establishment device (step | 09-30-2010 |
Liang Guo, Brighton, MA US
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20090276841 | METHOD AND DEVICE FOR DYNAMIC DEPLOYMENT OF TRUST BRIDGES IN AN AD HOC WIRELESS NETWORK - A method for deploying a trust bridge in an ad hoc wireless network can provide interoperability for multi-organizational authentication. The method includes processing at a delegate certification authority (DCA) node device authorizations received from of a plurality of certification authorities (CAs) of different organizations, where the authorizations authorize the DCA node device to serve as a DCA representing the CAs (step | 11-05-2009 |
20100115266 | METHOD AND DEVICE FOR ENABLING A TRUST RELATIONSHIP USING AN UNEXPIRED PUBLIC KEY INFRASTRUCTURE (PKI) CERTIFICATE - A method and device are useful for enabling a trust relationship using an unexpired public key infrastructure (PKI) certificate, where a current status of the PKI certificate is unavailable. The method includes determining at a relying party that a certificate status update for the PKI certificate is unavailable (step | 05-06-2010 |
20100115267 | METHOD AND DEVICE FOR ENABLING A TRUST RELATIONSHIP USING AN EXPIRED PUBLIC KEY INFRASTRUCTURE (PKI) CERTIFICATE - A method and device are useful for enabling a trust relationship using an expired public key infrastructure (PKI) certificate. The method includes determining at a relying party a maximum permissible grace period during which the PKI certificate can be conditionally granted a valid status (step | 05-06-2010 |
Liang Guo, Shenzhen City CN
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20110253437 | PRINTED CIRCUIT BOARD AND PRINTED CIRCUIT BOARD ASSEMBLY - A printed circuit board includes signal holes, at least one first securing hole, and at least one second securing hole. The signal holes and the first securing hole is able to secure a first electronic element or the signal holes and the second securing hole is able to secure a second electronic element. | 10-20-2011 |
20110290534 | PRINTED CIRCUIT BOARD - A printed circuit board includes a mounting area. The mounting area includes a first mounting portion and a second mounting portion. The first and second mounting portions partially overlap. The first mounting portion includes a number of first holes, a number of second holes, and a third hole. The first holes, the second holes, and the third hole are configured for the mounting of signal pins of a universal serial bus (USB) pin. The second mounting portion includes the first holes and a number of fixing holes. The first holes are configured for the mounting of signal pins of a USB connector. The fixing holes are configured for the mounting of fixing pins of the USB connector. | 12-01-2011 |
Liang Guo, Cambridge, MA US
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20110254171 | Integrated Method for High-Density Interconnection of Electronic Components through Stretchable Interconnects - Stretchable multi-chip modules (SMCMs) are capable of withstanding large mechanical deformations and conforming to curved surfaces. These SMCMs may find their utilities in elastic consumer electronics such as elastic displays, skin-like electronic sensors, etc. In particular, stretchable neural implants provide improved performances as to cause less mechanical stress and thus fewer traumas to surrounding soft tissues. Such SMCMs usually comprise of various electronic components attached to or embedded in a polydimethylsiloxane (PDMS) substrate and wired through stretchable interconnects. However, reliably and compactly connecting the electronic components to PDMS-based stretchable interconnects is very challenging. This invention describes an integrated method for high-density interconnection of electronic components through stretchable interconnects in an SMCM. This invention has applications in high-density SMCMs, as well as high-density stretchable/conformable neural interfaces. | 10-20-2011 |
20130338746 | 3D MICROELECTRODE DEVICE FOR LIVE TISSUE APPLICATIONS - A 3D microelectrode device includes a flexible substrate containing poly-dimethyl siloxane (PDMS). The device may be fabricated in a miniature form factor suitable for attachment to a small organ such as a lateral gastrocnemius muscle of a live rat. In addition to providing a miniaturized, conformable attachment, the device provides an anchoring action via one or more microelectrodes, each having an insertable tip particularly shaped to provide the anchoring action. Furthermore, a base portion of each of the microelectrodes is embedded inside conductive poly-dimethyl siloxane (cPDMS). The cPDMS is contained in a pad that is coupled to a conductive track embedded in the flexible substrate. Embedding of the base portion inside the cPDMS material not only allows the microelectrode to bend in various directions, but also provides good electrical conductivity while eliminating the need for attachment processes using solder or epoxy adhesives. | 12-19-2013 |
Liang Guo, New Hyde Park, NY US
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20120107861 | METHOD OF DETERMINING RISK OF ARRHYTHMIA - The present invention relates to a method of determining the risk of drug induced arrhythmia using stem cell derived cardiomyocytes in a high-throughput impedance or multi-electrode array assay. | 05-03-2012 |
Liang Guo, Anhui CN
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20120150391 | IN-VEHICLE PROTECTION SYSTEM USING MULTIPLE PROCESSING UNITS AND/OR USING MOBILE PHONE MODULE TO SEND POSITIONING INFORMATION - An in-vehicle protection system includes a signal input interface and a vehicle protection circuit. The signal input interface is arranged to receive at least an indication signal indicative of a status of a vehicle. The vehicle protection circuit includes a first processing unit, a second processing unit, and a controller. Each of the first processing unit and the second processing unit is capable of performing vehicle protection upon the vehicle, where computing power of the first processing unit is different from computing power of the second processing unit. The controller is used for receiving the indication signal, outputting the received indication signal to the first processing unit for further processing when the in-vehicle protection system operates under a first operational state, and outputting the received indication signal to the second processing unit for further processing when the in-vehicle protection system operates under a second operational state. | 06-14-2012 |
Liang Guo, Shanghai CN
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20120162977 | LED light bar - A LED light bar includes several LED light sources and a bar light source mounting base. The light source mounting base is made of an insulating and heat-conducting material. An electrical layer having several metal electricity-conducting plates is embedded in an inner part of the light source mounting base. The LED light sources are welded on the metal electricity-conducting plates to form an electrical electricity-conducting circuit. lighting sides of the LED light sources are exposed on a surface of the light source mounting base. The light source mounting base and the metal electricity-conducting plates are formed into a whole. Each LED light source is covered by lenses. | 06-28-2012 |
Liang Guo, Beijing CN
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20120198473 | COLLABORATIVE WORK OF APPLICATIONS - A method for collaborative work of applications can include reading a rule for defining a data transmission among collaborative working applications; initiating applications related to the rule; acquiring progress identifiers of the applications; and registering the progress identifiers of the applications. | 08-02-2012 |
20130007588 | SYSTEMS AND METHODS FOR GLOBALIZING WEB APPLICATIONS - Described are a system and method for testing a software application. Elements of a web document under test loaded in a web browser are identified. The elements are output to a plurality of string processors. The string processors determine one or more accessible strings of text and locale-sensitive information from the elements. The accessible strings are validated to determine whether the strings are at least one of correctly pseudo-translated and properly formatted. | 01-03-2013 |
20150237156 | LPC2468-BASED MVB-WTB GATEWAY AND WORKING METHOD THEREOF - The present invention discloses a LPC2468-based MVB-WTB gateway and associated operating methods in the field of train communications. The disclosed network gateway includes a MVB network card and a WTB network card. The WTB network card includes WTB-ARM and a WTB-FPGA module. The MVB network card includes MVB-ARM and MVB-FPGA module. The WTB-ARM module uses a LPC2468 processor to analyze data in the network layer and the data link layer based on gateway protocol. The WTB-FPGA module allows WTB to exchange data with other networks gateways, as well as between the WTB and MVB. The MVB-ARM module is responsible for executing protocols on the network cards. Via data communications on MVB, the MVB-FPGA module collects the process and message data of the MVB equipment, and exchange communication data between WTB within a network gateway. The present invention can increase speed and enhance reliability for communications between gateways. | 08-20-2015 |
20150261703 | PICOBLAZE-BASED MVB CONTROLLER - The present invention relates to the field of communications on rail trains. A PicoBlaze-based MVB controller includes a pMVB controller, a traffic memory, an ARM adapter, and a bus arbiter. The pMVB controller, the traffic memory, ARM adapter, and the bus arbiter are connected to an external bus BUS1. The pMVB controller is connected to the traffic memory. The ARM adapter is connected to an external ARM processor and the bus arbiter. The traffic memory can store network communication data and input control information, and send them to the pMVB controller. The pMVB controller responds to the control information, and sends the communication data, and after it is encoded, to the MVB bus via the external bus BUS1. The pMVB controller also decodes data received from the pMVB bus and triggers an interrupt. The bus arbiter is responsible for bus arbitration in accordance with the instructions from the pMVB controller. | 09-17-2015 |
Liang Guo, Cary, NC US
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20130031672 | PLANT REGULATORY ELEMENTS AND USES THEREOF - The invention provides DNA molecules and constructs, and their nucleotide sequences, useful for modulating gene expression in plants, and for specifying intracellular or extracellular localization of a gene product of interest. Transgenic plants, plant cells, plant parts, and seeds, comprising the DNA molecules operably linked to heterologous transcribable polynucleotides are also provided. | 01-31-2013 |
20140004088 | IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES | 01-02-2014 |
20150252366 | IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES - The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby. | 09-10-2015 |
Liang Guo, Frederick, MD US
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20130196238 | METHODS FOR CONTINUOUS DIRECT CARBON FUEL CELL OPERATION WITH A CIRCULATING ELECTROLYTE SLURRY - The present invention relates to methods and systems related to fuel cells, and in particular, to direct carbon fuel cells. The methods and systems relate to cleaning and removal of components utilized and produced during operation of the fuel cell, regeneration of components utilized during operation of the fuel cell, and generating power using the fuel cell. | 08-01-2013 |
Liang Guo, Saint Louis, MO US
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20130333061 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 12-12-2013 |
Liang Guo, San Jose, CA US
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20140095442 | TECHNIQUES FOR LIFECYCLE STATE MANAGEMENT AND IN-DATABASE ARCHIVING - Techniques for lifecycle state management and in-database archiving are described. Activity tracking refers to techniques that collect statistics related to user access patterns, such as the frequency or recency with which users access particular database elements. The statistics gathered through activity tracking can be supplied to data classification techniques to automatically classify the database elements or to assist users with manually classifying the database elements. Then, once the database elements have been classified, in-database archiving techniques can be employed to move database elements to different storage tiers based on the classifications. However, although the techniques related to activity tracking, data classification, and in-database archiving may be used together as described above; each technique may also be practiced separately. | 04-03-2014 |
20140095547 | TECHNIQUES FOR ACTIVITY TRACKING, DATA CLASSIFICATION, AND IN DATABASE ARCHIVING - Techniques for activity tracking, data classification, and in-database archiving are described. Activity tracking refers to techniques that collect statistics related to user access patterns, such as the frequency or recency with which users access particular database elements. The statistics gathered through activity tracking can be supplied to data classification techniques to automatically classify the database elements or to assist users with manually classifying the database elements. Then, once the database elements have been classified, in-database archiving techniques can be employed to move database elements to different storage tiers based on the classifications. However, although the techniques related to activity tracking, data classification, and in-database archiving may be used together as described above; each technique may also be practiced separately. | 04-03-2014 |
Liang Guo, Qingyang CN
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20140214818 | METHOD AND APPARATUS FOR HYBRID SOCIAL SEARCH MODEL - An approach is provided for determining the intent of a question and determining an appropriate audience to answer the question based on the intent of the question. The approach comprises processing and/or facilitating a processing of a query to cause, at least in part, a determination of one or more topics of the query based, at least in part, on one or more user preferences. The approach also comprises processing and/or facilitating a processing of the query to cause, at least in part, a determination of a classification of the query, The approach further comprises determining an audience comprising one or more candidate audience members for the query based, at least in part, on the classification of the query and the one or more topics of the query. | 07-31-2014 |
Liang Guo, Columbus, OH US
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20140125196 | Polymer Composite Actuator and Generator Driven by Water Gradients - Water-responsive composite materials are provided containing a polymeric matrix and a water-responsive gel integrated into the polymeric matrix. The water-responsive gel can include a polyol or an alkoxylated polyol crosslinked by reversibly hydrolysable bonds, such as borate ester bonds. The polymeric matrix can include conjugated polymers such as poly(pyrrole) containing polymers. The composite material is capable of rapid actuation in the presence of a water gradient and can exhibit power densities greater than 1 W/kg. Methods of making water-responsive composite materials are provided, including by electropolymerization. Devices containing water-responsive composite materials are provided for sensing, locomotion, and power generation. | 05-08-2014 |
Liang Guo, Nottingham GB
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20140255200 | FILM COOLING OF TURBINE BLADES OR VANES - The present invention relates to a turbine assembly having an aerofoil and/or an end wall each having an outer surface with a structure for directing a flow of a cooling medium at the outer surface. The structure at the outer surface has at least a first groove and a second groove extending in the outer surface from a leading to a trailing edge and being oriented in at least two different directions with a deflection angle (α) towards each other, with the deflection angle (α) having a component in a span wise direction of the aerofoil. The structure at the outer surface of the end wall has at least a first groove and a second groove extending in an axial direction of the turbine assembly, matching an outer profile of the aerofoil and oriented in at least two different directions with a deflection angle (α) towards each other. | 09-11-2014 |
Liang Guo, Vienna, VA US
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20140288314 | PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS - A process provides for producing chiral prostacyclin derivatives of Formula (I) | 09-25-2014 |
Liang Guo, Hefei CN
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20150329078 | IN-VEHICLE PROTECTION SYSTEM USING MULTIPLE PROCESSING UNITS AND/OR USING COMMUNICATION MODULE TO SEND POSITIONING INFORMATION - An in-vehicle protection system includes a signal input interface, a vehicle protection circuit, and a global navigation satellite system (GNSS) module. The signal input interface receives an indication signal indicative of a status of a vehicle. The vehicle protection circuit includes a first processing unit, a second processing unit, and a controller. The first and second processing units perform predetermined action in response to abnormality of a vehicle, and have different computing power. The controller outputs the indication signal to one of the first and second processing units according to an operational state of the in-vehicle protection system. The GNSS module obtains positioning information of the vehicle. After the second processing unit detects an abnormal status of the vehicle, the first processing unit sends at least one of the positioning information and vehicle alarm information indicative of the abnormal status through a communication network. | 11-19-2015 |
Liang Guo, Urumqi CN
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20160039845 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF - Disclosed in the present invention are a bis-β-carboline compound and a preparation method, a pharmaceutical composition and the use thereof. In particular, the bis-β-carboline compound and a pharmaceutical salt thereof are described as general formula I, and the bis-β-carboline compound is prepared through the condensation of β-carboline intermediate and dihaloalkane. Also disclosed in the present invention are a pharmaceutical composition comprising an effective dose of the bis-β-carboline compound as shown in formula I and a pharmaceutically acceptable carrier, and the use of the bis-β-carboline compound in preparing drugs resistant to tumours such as melanoma, stomach cancer, lung cancer, breast cancer, kidney cancer, liver cancer, oral epidermoid carcinoma, cervical cancer, ovarian cancer, pancreatic cancer, prostate cancer, and colon cancer. | 02-11-2016 |