Patent application number | Description | Published |
20100203081 | VIRAL INHIBITORY NUCLEOTIDE SEQUENCES AND VACCINES - The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes. | 08-12-2010 |
20130345164 | TREATMENTS FOR CELLULAR PROLIFERATIVE DISORDERS AND IDENTIFICATION THEREOF - This invention concerns methods of identifying treatments for treating various disorders and related computer products and systems. Also disclosed are methods for treating cellular proliferative disorders and use of compounds identified for such treatment. | 12-26-2013 |
20140370544 | METHODS FOR IDENTIFYING SEQUENCE MOTIFS, AND APPLICATIONS THEREOF - The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented as compared to the frequency of those sequences that occur in other nucleotide sequences, and to methods of scoring sequences based on the occurrence of these sequence motifs. Such sequence motifs may be biologically significant, for example they may constitute transcription factor binding sites, mRNA stability/instability signals, epigenetic signals, and the like. The methods of the invention can also be used, inter alia, to classify sequences or organisms in terms of their phylogenetic relationships, or to identify the likely host of a pathogenic organism. The methods of the present invention can also be used to optimize expression of proteins. | 12-18-2014 |
Patent application number | Description | Published |
20120227004 | Form-based user-configurable processing plant management system and method - A computer-implemented system and method for defining the processes in a processing plant are disclosed. In one embodiment, the system uses input forms to allow a user to define the processes, chemicals, process streams, and sampling points in the plant in a way that requires no programming code to be written by the person defining the plant. In one embodiment, the electronic form-based user-configurable system can be used to configure and manage multiple plants belonging to one organization. The plant definition can be used to log information about the plant. The logged information can be used to generate reports or charts. Logging, reporting, and charting can be managed using input forms and without the user needing to write any computer code. | 09-06-2012 |
20140325331 | Form-based user-configurable process information system and method - A machine-implemented system and method for defining process information is disclosed. In one embodiment, the system or method allows a user to list processes, define processes using an input form, list process parameters, list sampling points, define sampling points using an input form, and list sampling point parameters for a chemical process or processes. Enhancements can include functionality that allows a user to list process streams, define process streams using an input form, list process stream parameters, list process stream chemicals, and list process chemicals. Other enhancements can include functionality that allows a user to list reports, render reports using an input form, and list sampling point logs. The objective is to allow users to log, report, and chart process data using electronic input forms that do not require the writing of programming code by the person defining the process or processes. | 10-30-2014 |
Patent application number | Description | Published |
20080255654 | SYSTEM FOR DELIVERING A STENT - A stent delivery system including an elongate member having a proximal segment and a distal segment, the distal segment having a first coil section, a second coil section, an intermediate coil section located between the first and second coil sections and a plastic material overlying one or more of the coil sections. | 10-16-2008 |
20080300667 | SYSTEM FOR DELIVERING A STENT - A stent delivery system comprising a guide having a retention member configured to exert either an internal force or an external force on the stent to assist in retaining the stent on the guide. | 12-04-2008 |
20090024205 | Radially Expandable Stent - A highly compressible stent is described. The stent includes a plurality of circumferentially offset and interconnected undulating rings having intermediate struts disposed between at least some of the undulating ring struts. | 01-22-2009 |
20090306760 | PROSTHESIS AND DELIVERY SYSTEM - A prosthesis delivery system including a prosthesis mounted on an elongate member. The prosthesis has longitudinally offset first and second locking members positioned on the prosthesis. The first and second locking members are configured to engage opposing proximal and distal sides of a radially extending member on the elongate member to lock or limit the longitudinal position of the prosthesis on the elongate member during delivery of the prosthesis to a treatment site. | 12-10-2009 |
20090306761 | PROSTHESIS AND DELIVERY SYSTEM - A prosthesis delivery system including a prosthesis mounted on an elongate member. The prosthesis has a locking member positioned on the prosthesis. The locking member includes a reduced diameter portion with two opposing surfaces that are configured to engage opposing proximal and distal sides of a radially extending member on the elongate member to lock or limit the longitudinal position of the prosthesis on the elongate member during delivery of the prosthesis to a treatment site. | 12-10-2009 |
20090326484 | LONG NOSE MANIPULATABLE CATHETER - A long nose manipulatable catheter is described herein. The catheter generally comprises a flexible joint region defining a main lumen and an adjacent wire lumen. The wire lumen has an opening near or at a distal end of the flexible joint region and a push/pull wire can be pushed or pulled through the wire lumen. The catheter assembly may also comprise at least one radio-opaque marker band for securing the push/pull wire. The joint region has a predetermined length sized to affect a flexure of the joint and is generally located at the distal end of the catheter. The joint region itself may be varied to extend distally from where the braid terminates, or it may extend to encompass a portion of the braid. By varying a length of the joint region, the amount of curvature and flexure of the joint region can be controlled. | 12-31-2009 |
20110276121 | Method And Apparatus For Caged Stent Delivery - In combination a device for delivering a stent within an intraluminal cavity and a stent including an elongated member configured to receive a stent thereon, a stent mounted on the elongated member and movable between a smaller diameter delivery position and an expanded placement position and a tubular portion attached to the elongated member. First and second stent engaging arms and a pusher arm extend distally of the tubular portion. The first and second engaging arms configured to constrain the stent in an area between the arms and the pusher arm configured to contact the proximal portion of the stent. The engaging arms are movable between a closed stent constraining position and an open stent release position. The delivery system can also be used to deliver other vascular implants. | 11-10-2011 |
20110282370 | ROTATIONAL THROMBECTOMY WIRE - A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor. | 11-17-2011 |
20120116429 | ROTATIONAL THROMBECTOMY WIRE - A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal region and a distal region and being rotatable by a motor. The distal region has a smaller diameter than the proximal region. A cable is coupled to the distal region of the core and extends distally thereof. A torque tube is positioned over the cable and a coil is positioned over a distal portion of the cable. A distal portion of the cable has a non-linear configuration. A first covering material is positioned over the coil. | 05-10-2012 |
20120239066 | ROTATIONAL THROMBECTOMY WIRE COUPLER - An assembly for breaking up vascular thrombus or other obstructive material including a motor housing having a motor, a motor shaft extending from the motor, a first housing positioned at a distal end of the motor shaft, a rotational thrombectomy wire and a second housing positioned at a proximal end of the wire. The first housing has a first magnet positioned therein and recessed from the distal edge of the first housing which has a first plurality of teeth. The second housing has a second magnet positioned therein and recessed from a proximal edge of the second housing which has a second plurality of teeth intermeshing with the first plurality of teeth when the wire is coupled to the motor shaft. The first and second plurality of teeth slip when a torque of the motor shaft exceeds a predetermined value. | 09-20-2012 |
20130006296 | DISTAL PROTECTION DEVICE - A distal protection device comprising a catheter having a first strut movable from a collapsed configuration to an expanded configuration having a first dimension and a second strut movable from a collapsed configuration to an expanded configuration having a second dimension larger than the first dimension. Movement of the first strut deploys filter material to a first position having a first deployed dimension and movement of the second strut to a first position deploys filter material to a second deployed dimension larger than the first expanded dimension. | 01-03-2013 |
20130030322 | TISSUE COLLECTION SYSTEM - The present invention relates to a tissue collection system. The system includes an outer housing, a first cylindrical fenestrated member within and immovable relative to the outer housing, a second cylindrical fenestrated member defining an inner tissue collection chamber and being positioned within and rotatable relative to the first cylindrical fenestrated member, a plunger axially movable within the second fenestrated member, an elongate rod being connected to the plunger, and one or more stop units attached to the outer housing. The present invention also relates to methods for separating components of a tissue sample using a system according to the present invention. | 01-31-2013 |
20130197564 | LONG NOSE MANIPULATABLE CATHETER - A long nose manipulatable catheter is described herein. The catheter generally comprises a flexible joint region defining a main lumen and an adjacent wire lumen. The wire lumen has an opening near or at a distal end of the flexible joint region and a push/pull wire can be pushed or pulled through the wire lumen. The catheter assembly may also comprise at least one radio-opaque marker band for securing the push/pull wire. The joint region has a predetermined length sized to affect a flexure of the joint and is generally located at the distal end of the catheter. The joint region itself may be varied to extend distally from where the braid terminates, or it may extend to encompass a portion of the braid. By varying a length of the joint region, the amount of curvature and flexure of the joint region can be controlled. | 08-01-2013 |
20140114144 | SYSTEMS AND METHODS FOR ASSESSING VASCULATURE HEALTH AND BLOOD CLOTS - A system and method for determining a pH level of blood in a vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator. The sensor measures the pH level of blood downstream of the blood clot. A system and method are also provided for determining a density of a blood clot in a vessel of a patient for subsequent selection of a treatment method. The system includes a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator, wherein the sensor determines the density of the blood clot and the indicator provides an indication of the density of the clot. | 04-24-2014 |
20140148831 | ROTATIONAL THROMBECTOMY WIRE - A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor. | 05-29-2014 |
20140324081 | ROTATIONAL THROMBECTOMY WIRE - A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal region and a distal region and being rotatable by a motor. The distal region has a smaller diameter than the proximal region. A cable is coupled to the distal region of the core and extends distally thereof. A torque tube is positioned over the cable and a coil is positioned over a distal portion of the cable. A distal portion of the cable has a non-linear configuration. A first covering material is positioned over the coil. | 10-30-2014 |
20140330358 | GUIDEWIRE LOADED STENT FOR DELIVERY THROUGH A CATHETER - A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities. | 11-06-2014 |
20140364766 | SYSTEMS AND METHODS FOR PHLEBOTOMY THROUGH A PERIPHERAL IV CATHETER - An apparatus includes a catheter, an introducer having a first member and a second member, a locking mechanism coupled to a distal end of the first member and configured to couple the introducer to a peripheral intravenous line, and an actuator coupled to the catheter. The actuator is configured to move from a first configuration, in which the catheter is disposed within the introducer, toward a second configuration to move the second member to a distal position relative to the first member. A portion of a guide of the second member being distal to the first member when the second member is in the distal position. The actuator is configured to move relative to the second member to be placed in the second configuration when the second member is in its distal position such that the catheter is disposed within and extending past an end of the peripheral intravenous line. | 12-11-2014 |
Patent application number | Description | Published |
20090216251 | Surgical suturing device, method and tools used therewith - A suture insertion device is provided for positioning a suture inside a layer of subcutaneous tissue from a remote access point. A tether insertion device is provided for positioning a tether within subcutaneous tissue for operating on the suture from a remote access point. The suture insertion device and the tether insertion device cooperate to form the suture into a tissue-supporting sling useful for performing various surgical procedures, including but not limited to plastic surgery such as mid face lifts, neck lifts, brow lifts, under eye lifts, breast lifts, and organ repositioning. | 08-27-2009 |
20100130991 | SURGICAL SUTURING DEVICE, METHOD AND TOOLS USED THEREWITH - An apparatus useful for performing various surgical procedures, including but not limited to plastic surgery such as mid face lifts, neck lifts, brow lifts, under eye lifts, breast lifts, and organ repositioning, includes a body | 05-27-2010 |
20140275750 | Structural support incorporating multiple strands - A fabricated component for providing desired structural support has plural strands of material extending between opposing gathering points, and free ends extending from the gathering points. The component is preferably fabricated from a single strand of material using an appropriate folding procedure which includes the formation of plural loops of the strand, one upon the other, and development of the gathering points in opposing regions of the looped strand by passing opposing ends of the strand around the loops of the strand, and then through the resulting throws, or using a separate knotting arrangement. The fabricated component can be used in medical procedures, such as the support of subcutaneous tissue, muscle and organs, and other non-medical applications. | 09-18-2014 |