Patent application number | Description | Published |
20140180254 | Distal Catheter Tip Formation - The present disclosure provides various embodiments of methods of forming a tapering distal tip for a catheter. An exemplary method includes providing a mandrel and a holding hypotube, placing a tip first material with a first outer diameter over the mandrel and the hypotube, placing a tip second material with a second outer diameter over the mandrel and under the first material, placing a shrink tube of heat-shrink material around at least a junction of the first material and second material, heating the shrink tube, cooling the first material and second material, and removing the shrink tube and the hypotube. The first outer diameter is greater than the second outer diameter. | 06-26-2014 |
20140180255 | DISTAL CATHETER TIPS AND FORMATION THEREOF - The present disclosure provides various embodiments of products for a tapered catheter tip and methods of forming a tapered distal tip for a catheter. An exemplary tapered catheter tip of the invention includes a proximal segment, a distal segment, and a midsection there between. The midsection includes at least two tip materials in an overlapping configuration and the distal segment includes one of the at least two tip materials. | 06-26-2014 |
20150297807 | DEVICES AND METHODS FOR TREATING FISTULAS - The invention generally relates to treatment of fistulas and abscesses and specifically to an all-in-one treatment device. The invention provides an aspiration catheter with imaging capabilities that can also deploy a blocking device, thereby providing an all-in-one treatment device for treating a fistula or an abscess. The device is inserted into an abscess and its imaging capabilities can be used to guide the device to a treatment site. A clogging device can be deployed from the device to prevent draining into, or out of, the abscess. In certain aspects, the invention provides a device for aspirating an abscess or fistula that includes a catheter having an extended body with a lumen therein, an imaging device such as an ultrasonic transducer disposed at a distal portion of the catheter, and a clogging device deployable from the catheter. | 10-22-2015 |
Patent application number | Description | Published |
20090214560 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-27-2009 |
20100143368 | Human Antibodies That Bind Cd22 And Uses Thereof - The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure. | 06-10-2010 |
20110150892 | HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to LAG-3 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human LAG-3. In certain embodiments, the antibodies bind both human and monkey LAG-3 but do not bind mouse LAG-3. The invention provides anti-LAG-3 antibodies that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen- specific T cell responses. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. This disclosure also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which an anti- LAG-3 antibody is co-administered with at least one additional immuno stimulatory antibody, is also provided. | 06-23-2011 |
20110182904 | ANTIBODIES TO BONE MORPHOGENIC PROTEINS AND RECEPTORS THEREFOR AND METHODS FOR THEIR USE - The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPR1A, BMPR1B, ACTR1, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, BMP4, BMPR1A, BMPR1B, ACTR15 and/or BMPR2. | 07-28-2011 |
20110206681 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-25-2011 |
20120225086 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 09-06-2012 |
20130156788 | FULLY HUMAN ANTIBODIES SPECIFIC TO CADM1 - The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed. | 06-20-2013 |
20130230530 | HUMAN ANTIBODIES THAT BIND CD22 AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure. | 09-05-2013 |
20140017255 | FULLY HUMAN ANTIBODIES TO BTLA - The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders. | 01-16-2014 |
20140186892 | MONOCLONAL ANTIBODIES AGAINST GLYPICAN-3 - The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed. | 07-03-2014 |
20150218279 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-06-2015 |
Patent application number | Description | Published |
20080261708 | FDB MOTOR WITH TAPERED SHAFT FOR IMPROVED PUMPING EFFICIENCY - For motors having a journal with one or more groove regions and a shaft for relative rotation in the journal, aspects include providing a dual tapered shaft. The shaft may be tapered by the application of a wear resistant coating at least opposite the groove regions. The coating introduces a shaft taper from near a top end and from near a bottom end towards the shaft middle. The shaft taper may provide for improved pumping efficiency. The coating may be applied in various processes such as chemical vapor deposition or physical vapor deposition to establish a thickness gradient of coating material from near the top end and near the bottom end towards the shaft middle. In one example, the coating includes a DLC coating. Additionally, shaft portions may be shielded to prevent coatings thereon. | 10-23-2008 |
20080273263 | LUBRICATED LIMITER FOR FLUID DYNAMIC BEARING MOTOR - In one example, a FDB motor having a top-cover attached, EM biased bearing system is provided. The motor includes a shaft and rotor disposed for relative rotation, and an axial limiter for restricting axial movement of the rotor with respect to the shaft, wherein the axial limiter is wet or lubricated during contact. The limiter is spatially fixed with respect to one of the shaft or the rotor and disposed with an axial end surface opposing a surface portion spatially fixed with respect to the other of the shaft or the rotor to form a gap therebetween. The gap may be filled with a fluid such as bearing lubricant, thereby providing a lubricated or wet contact surface to restrict axial movement of the shaft and rotor. Additionally, one or both surfaces may include a groove or slot to provide circulation of fluid through the gap. | 11-06-2008 |
20090079283 | Fluid dynamic bearing motor with a lubricated contact surface - A fluid dynamic bearing motor is provided having relatively rotatable facing surfaces that are reliably lubricated. A radial gap is defined between the relatively rotatable facing surfaces, wherein a first axial end of a fluid dynamic bearing has a larger radial gap as compared to a central region of the fluid dynamic bearing. In an aspect, a fluid recirculation passageway is established between the first axial end and the central region of the fluid dynamic bearing. In an aspect, a fluid reservoir is formed axially above the first axial end of the fluid dynamic bearing. Robustness of the FDB motor is increased, and sensitivity to external loads or mechanical shock events is reduced. Dry surface-to-surface contact of bearing surfaces and reduced performance or failure of the motor or disc drive components is averted. The use of diamond-like coating on relatively rotatable fluid bearing surfaces may also be reduced or eliminated. | 03-26-2009 |
20100053807 | LUBRICATED LIMITER FOR FLUID DYNAMIC BEARING MOTOR - A component for restricting relative movement of a rotor and a shaft is disclosed. A motor may include a shaft and a rotor, where the rotor is disposed for relative rotation with respect to said shaft. A component is operable to restrict relative movement of the rotor and the shaft, where the component includes a first surface operable to receive a fluid. | 03-04-2010 |
20120319516 | Shield restricting axial movement - In one example, an FDB motor having a shield member is provided. In one example, the method includes disposing a first member and a second member for relative rotation about an axis of rotation. An annular shield member is attached to the first member, the shield member disposed adjacent a fluid reservoir for containing a bearing fluid. The reservoir is filled through an aperture (e.g., a fill hole) in the shield member. Thereafter, the aperture is at least partially sealed. The aperture may be hermetically sealed via one or more laser pulses. In other examples, a two piece shield is provided for shielding a reservoir without a fill hole. | 12-20-2012 |
Patent application number | Description | Published |
20090142009 | FLUID DYNAMIC BEARING SYSTEM - Fluid dynamic bearing systems produced by specified methods are provided. In one example, a method for designing a fluid dynamic bearing system includes determining a first stability ratio for a first journal bearing configuration. The method further includes determining a second stability ratio for a second journal bearing configuration. In a further example system, the first configuration has two sub-journal bearings and the second configuration has three sub-journal bearings. The method may comprise comparing the two stability ratios to determine whether adding a sub-journal increases the stability ratio of the bearing system. | 06-04-2009 |
20100141071 | MOTOR ASSEMBLY WITH MULTIFUNCTIONAL COMPONENTS - Multifunctional components enable the construction of economical motor assemblies. A first embodiment of the present invention provides a hub, cup, spindle, and base assembly for a motor assembly having at least one journal bearing, at least one thrust bearing, and at least one fluid seal. A second embodiment of the present invention provides a hub, spindle, and base with integrated cup assembly for a disc drive bearing having at least one journal bearing, at least one thrust bearing, and at least one fluid seal. In a third embodiment, a hub is rotatably assembled with a spindle coupled to a thrust bearing, prior to assembly with a base. In further embodiments, motor assemblies comprise the above embodiments combined with stator and rotor assemblies. | 06-10-2010 |
20130064484 | HUB AND SPINDLE ASSEMBLY - A rotating hub and fixed spindle assembly with first and second fluid dynamic journal bearings and first and second fluid dynamic thrust bearings for a disc drive memory system has a pump seal and a radial ring seal at a first axial terminus for lubricant containment, and a capillary seal and a labyrinth seal at a second axial terminus for lubricant containment and storage. Lubricant fluid pressure differences between first and second seals are minimized through one or more lubricant fluid communicating channels in the hub assembly, in order to minimize lubricant fluid loss through a seal. Lubricant fluid can also be purged of any air bubbles by lubricant fluid circulation through the channel. | 03-14-2013 |
20140286600 | APPARATUS INCLUDING CAPILLARY AND LABYRINTH SEALS - Provided herein is an apparatus including a stationary portion having a thrust cup; a rotating portion having a sleeve configured to be rotatable with respect to the stationary portion; a first axially extending space defined by the thrust cup and the sleeve, wherein the first axially extending space includes a second portion positioned above a first portion of the first axially extending space; a capillary seal in the first portion of the first axially extending space; and a labyrinth seal, in the second portion of the first axially extending space. | 09-25-2014 |
Patent application number | Description | Published |
20110206839 | METHOD AND APPARATUS FOR FORMING STRUCTURES OF POLYMER NANOBEADS - The disclosure relates to providing printed structures of polymer that have substantially flat printed surfaces. In one embodiment, the disclosure relates to a post-printing treatment apparatus for receiving a substrate supporting a polymer printing thereon. The polymer can be PMMA or other suitable polymer. In a related embodiment, the polymer defines a thermoplastic polymer having a glass transition temperature. The apparatus can comprise of a chamber, and input manifold, an exhaust manifold, a solvent reservoir and a gas reservoir. The solvent reservoir provides one or more solvent systems adapted to chemically bind, and potentially react, with the polymer. The gas reservoir provides one or more gases for drying the substrate and printed polymer after the solvent treatment step. In one application, a substrate having printed surface thereon is placed in the chamber and exposed to the solvent system for sufficient period of time to provide substantially flat print surfaces. | 08-25-2011 |
20110262624 | Method and Apparatus for Depositing LED Organic Film - In one embodiment the disclosure relates to an apparatus for depositing an organic material on a substrate, including a source heater for heating organic particles to form suspended organic particles; a transport stream for delivering the suspended organic particles to a discharge nozzle, the discharge nozzle having a plurality of micro-pores, the micro-pores providing a conduit for passage of the suspended organic particles; and a nozzle heater for pulsatingly heating the micro-pores nozzle to discharge the suspended organic particles from the discharge nozzle. | 10-27-2011 |
20120015104 | Method and Apparatus for Depositing LED Organic Film - In one embodiment the disclosure relates to an apparatus for depositing an organic material on a substrate, including a source heater for heating organic particles to form suspended organic particles; a transport stream for delivering the suspended organic particles to a discharge nozzle, the discharge nozzle having a plurality of micro-pores, the micro-pores providing a conduit for passage of the suspended organic particles; and a nozzle heater for pulsatingly heating the micro-pores nozzle to discharge the suspended organic particles from the discharge nozzle. | 01-19-2012 |