Laxman
Laxman Eltepu, Carlsbad, CA US
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20110311583 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(0)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ?-aminoalkyl, ?-(substituted)aminoalky, ?-phosphoalkyl or ?-thiophosphoalkyl. | 12-22-2011 |
Laxman Eltepu, Cambridge, MA US
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20110311582 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R | 12-22-2011 |
20120095075 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure: | 04-19-2012 |
Laxman Gangwani, Evans, GA US
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20120077753 | JNK INHIBITORS FOR USE IN TREATING SPINAL MUSCULAR ATROPHY - The brain specific isoform (JNK3) of c-Jun NH2-terminal kinase (JNK) has been found to mediate the degeneration of spinal motor neurons caused by SMN deficiency in spinal muscular atrophy (SMA). Moreover, the ability of JNK inhibitors to reduce degeneration of neurons lacking SMN is also disclosed. The JNK signaling pathway can therefore mediate neurode-generation in SMA and represents a therapeutic target for treatment of SMA. | 03-29-2012 |
Laxman Murugesh, San Ramon, CA US
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20130035022 | Two-Part Plastic Retaining Ring - A retaining ring includes a generally annular lower portion and a generally annular upper portion. The lower portion has a bottom surface for contacting a polishing pad during polishing and a top surface. The upper portion has a bottom surface secured to the top surface of the lower portion and a top surface configured to be mechanically affixed to and abut a rigid base of a carrier head. The lower portion is a first plastic, and the upper portion is a different second plastic that is about the same or more rigid than the first plastic. | 02-07-2013 |
20140167327 | SURFACE ANNEALING OF COMPONENTS FOR SUBSTRATE PROCESSING CHAMBERS - A method of fabricating a processing chamber component comprises forming a processing chamber component having a structural body with surface regions having microcracks, and directing a laser beam onto the microcracks of the surface regions of the structural body for a sufficient time to heal and close off the microcracks by themselves. | 06-19-2014 |
Laxman Nallan, Alhambra, CA US
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20120172361 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS - Compounds of the formula (I) and formula (II) and pharmaceutically acceptable salts thereof. | 07-05-2012 |
20120196860 | Triazine derivatives and their therapeutical applications - The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases. | 08-02-2012 |
20120202818 | UREIDOPHENYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS - The present invention provides Uredophenyl substituted triazine derivatives and provides methods of using these compounds to modulate protein kinases and methods of using these compounds to treat protein kinase mediated diseases and conditions. | 08-09-2012 |
20120238576 | Triazine Derivatives and their Therapeutical Applications - The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof. | 09-20-2012 |
20120264759 | BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS - The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases. | 10-18-2012 |
20130023497 | Triazine Derivatives and their Therapeutical Applications - The present invention comprises inter alia triazine compounds as shown in formula (I) and pharmaceutically acceptable salts thereof. | 01-24-2013 |
20150057285 | BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS - The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases. | 02-26-2015 |
Laxman Pasunoori, Warangal IN
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20130184284 | DIAMINOCYCLOHEXANE COMPOUNDS AND USES THEREOF - The present invention provides compounds of Formula (I): | 07-18-2013 |
Laxman Sahasrabuddhe, San Ramon, CA US
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20090276510 | System and Method for Network Design - A system and method for network design are disclosed. In one embodiment of a method incorporating teachings of the present disclosure, embedded network information describing at least one existing network element and a plurality of physical locations available for locating new network nodes may be received. A demand forecast for a coverage area of a proposed network may also be received. In an embodiment in which a proposed network has a core layer, a number of core layer nodes to be included in the proposed network may also be received. In an embodiment in which a proposed network has an aggregation layer, a number of aggregator layer nodes to include in the proposed network may be calculated by adding a positive integer to a lower bound number of aggregator layer nodes. Consideration may be given to these and other inputs in connection with generating a network design. | 11-05-2009 |
20120271929 | System and Method for Network Design - A method includes accessing network information stored at a remote device, the network information identifying one or more available physical locations to deploy one or more network nodes of a proposed network. The method further includes receiving data indicating a number of core layer nodes to be included in the proposed network. The method further includes determining a number of aggregator layer nodes to be included in the proposed network, the number of aggregator layer nodes determined based on incrementing a threshold number of aggregator layer nodes that supports a coverage area of the proposed network. The method further includes generating a network design of the proposed network. The network design identifies particular physical locations of the one or more available physical locations to deploy each of the core layer nodes and each of the aggregator layer nodes of the proposed network. | 10-25-2012 |