Patent application number | Description | Published |
20110017798 | Automatic Quick Clear Nose for Nailer - A fastener driving apparatus includes a motor with an output shaft. The motor is shiftable between a de-energized condition in which it can not be actuated to move the output shaft, and an energized condition in which it can be actuated to move the output shaft. The apparatus further includes a nose and a control device. The nose is shiftable between differently configured conditions, including a first condition for guiding a fastener driven by the output shaft, and a second condition for releasing a fastener that jams when the nose is in the first condition. The control device maintains the nose in the first condition while the motor remains in the energized condition. | 01-27-2011 |
20110148437 | Nailer With Integrated Stud Finder - A nailer incorporates an integrated stud finder for sensing when a stud is present. The nailer has a work contact element and a magazine for storing nails. The stud finder includes a sensor plate coupled to the work contact element of a nailer and a stud sensing circuit coupled to the sensor plate. The stud sensing circuit is provided for reading a capacitance level and for determining whether the sensor plate is positioned adjacent a stud based upon the capacitance level that is read. The stud finder also includes at least one signaling device coupled to the sensor plate for signaling to a user when a stud is present. The sensor plate is coupled to a no mar tip that is tethered to the nailer. A storage post for storing the no mar tip is positioned on the magazine for storing the no mar tip when not in use. | 06-23-2011 |
20130153683 | Paint Sprayer with Paint Container Attachment Apparatus - A paint sprayer is configured for use with a paint container. The sprayer includes a housing having an air inlet and a nozzle located on the housing. Movable grip members are supported on the housing. The grip members are located in a circular array with an inner diameter that is greater than the outer diameter of the paint container. A ring extends circumferentially about the circular array of grip members, and is supported on the housing for rotation relative to the housing. When the ring rotates relative to the housing, it moves the grip members to a condition in which the inner diameter of the circular array is not greater than the outer diameter of the paint container. | 06-20-2013 |
20140339329 | PAINT SPRAYER - According to one embodiment, an apparatus comprises a paint container, a paint sprayer assembly, movable grip members, and a ring. The paint container has an outer diameter. The paint sprayer assembly includes a housing having an air inlet and a nozzle located on the housing. The movable grip members are supported on the housing in a circular array having an inner diameter greater than the outer diameter of the paint container. The ring extends circumferentially about the circular array of grip members. The ring is supported on the housing for rotation relative to the housing, and is configured to move the grip members to a condition in which the inner diameter of the circular array is not greater than the outer diameter of the paint container upon rotation of the ring relative to the housing. | 11-20-2014 |
20140360744 | HANDHELD PNEUMATIC TOOLS HAVING PRESSURE REGULATOR - A handheld pneumatic tool includes an air supply port and a pressure regulator. The pressure regulator is configured to regulate the pressurized air and discharge regulated, pressurized air at a substantially constant pressure. | 12-11-2014 |
Patent application number | Description | Published |
20100180937 | HOLOGRAPHIC ENERGY-COLLECTING MEDIUM AND ASSOCIATED DEVICE - An energy-collecting medium including an optically transparent holographic layer is presented. The energy-collecting medium includes a photochemically active dye and an optically transparent polymer material. Also provided is a method for making an optically transparent holographic layer. An energy conversion device including the energy-collecting medium is also provided. | 07-22-2010 |
20110051586 | OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE SAME - There are provided optical data storage media and methods of optical data storage using the same. The optical data storage media comprises a non-linear sensitizer capable of absorbing actinic radiation to cause upper triplet energy transfer to a reactant that undergoes change upon triplet excitation. The refractive index change (Δn) of the medium is at least about 0.005, or even at least about 0.05. | 03-03-2011 |
20110053054 | COMPOSITIONS, OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE OPTICAL DATA STORAGE MEDIA - There are provided compositions, optical data storage media and methods of using the optical data storage. The compositions comprise a non-linear sensitizer comprising one or more platinum ethynyl complexes capable of absorbing actinic radiation to cause upper triplet energy transfer to a reactant that undergoes a photochemical change upon triplet excitation. | 03-03-2011 |
20110053055 | COMPOSITIONS, OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE OPTICAL DATA STORAGE MEDIA - There are provided compositions, optical data storage media and methods of using the optical data storage media. The compositions comprise a non-linear sensitizer comprising one or more subphthalocyanine reverse saturable absorbers capable of absorbing actinic radiation to cause upper triplet energy transfer to a reactant that undergoes a photochemical change upon triplet excitation. | 03-03-2011 |
20110242958 | SYSTEM AND METHOD FOR TRANSFER OF DATA STORED IN HOLOGRAPHIC STORAGE MEDIUM - A system for processing information is provided. The system includes multiple micro-holograms contained in multiple volumes arranged along multiple tracks in one or more storage mediums. Each of the micro-hologram includes a data. The system also includes one or more pick-up head devices with optical lenses for directing laser beams on the multiple tracks. Further, the system includes a subsystem for arranging the one or more pick-up head devices for recording and retrieving of the data from the one or more storage mediums. | 10-06-2011 |
20110261667 | SYSTEM AND METHOD FOR PROTECTING PIRACY IN OPTICAL STORAGE - A method for encoding in a holographic disk storage medium is provided. The method includes recording multiple micro-holograms such that the micro-holograms are aligned across a respective plurality of tracks and across a respective plurality of layers at a pre-determined location of an original holographic disk. The method also includes detecting a characteristic waveform signal of a reflected beam from the original holographic disk. The method further includes detecting a second waveform signal from a second holographic disk. The method also includes comparing the second waveform signal with the characteristic waveform signal. The method further includes determining authenticity of the second holographic disk based upon comparison. | 10-27-2011 |
20110273973 | SYSTEM AND METHOD FOR IMPROVED DATA STORAGE - A method for storing data on a storage medium is provided. The method includes receiving a modulated bitstream, wherein the modulated bitstream comprises a plurality of bits comprising a bitstate of 1 and 0. The method also includes secondary modulating each of the pluality of bits comprising the bitstate of 1 to output a plurality of secondary modulated bits. The method further includes forming a plurality of marks in the storage medium, the marks indicative of each of the plurality of secondary modulated bits and the plurality of bits comprising the bitstate of 0 in the modulated bitstream. | 11-10-2011 |
Patent application number | Description | Published |
20090114068 | Zero Hysteresis Electric Ratchet Socket Driver - The invention is an improved ratchet to drive sockets for the purpose of tightening or loosening threaded fastener. The invention contains an electric motor, battery and worm gear system to drive the sockets. The battery and motor are contained within the handle of the invention and are thus limited in size and power. A switch is also located on the handle and is used to activate the motor in the desired direction. The motor is powerful enough to drive most fasteners when the fasteners are somewhat loose, and as such the invention can drive the loose fasteners rapidly. At such times when the fasteners are snug or tight the invention will perform as a conventional ratchet. As the handle is pulled the worm and pion gears will lock and transmit the torque to the socket. As the handle is released the motor will drive the worm and spin the pion gear/socket and take up all of the slack. The invention operates as a zero hysteresis ratcheting socket driver when the fastener is snug and as an electrically powered ratchet when the fastener is loose. The invention is of superior advantage when used in confined spaces with limited access to the socket end and limited room to swing the handle end. | 05-07-2009 |
20140130700 | SUSPENDED COACH DRIVE BOGIE - A suspended coach drive bogie advantageously provides several enhancements to existing systems, including junction switching, higher speeds, reserved energy storage for emergency operations and for assistance with meeting peak grid electrical load demand, cooperative computing with multiple bogies, and self-diagnostics of the bogies which serves to make systems employing the same more reliable, faster, safer, and more energy efficient than other automated people movers. | 05-15-2014 |
20140130704 | SUSPENDED COACH TRANSIT SYSTEM - A suspended coach transit system comprising suspended coaches incorporating self-contained emergency evacuation means, dynamically balanced sway control for passenger comfort, system-wide communications for autonomous movement, radiant passenger heating and cooling and aerodynamic drag reduction for maximization of energy efficiency which serve to make the related products more comfortable, faster, safer and more energy efficient. | 05-15-2014 |
Patent application number | Description | Published |
20090166175 | SOLVENT EXTRACTION AND RECOVERY - Systems and methods for improving dense gas solvent extraction of a solute and recovery of the solvent are provided. A pressure of the solvent/solute mixture obtained from an extraction chamber is increased, e.g. with a pump, thereby providing the mixture above saturation conditions. The increased pressure provides greater solubility of the solute and less solvent being vaporized in a heat exchanger. A buildup of solute in the system is reduced, thus improving system longevity. Also, process conditions of the separation process are isolated from those of the extraction process. Accordingly, the process conditions for the separating process are maintained while the process conditions of the extraction chamber vary with ambient temperature, thus saving cost and energy. This isolation also provides an ability to use, in the gas recovery cycle, a heat pump that can be used for many applications and environmental conditions while still using a conventional refrigerant. | 07-02-2009 |
20100228000 | NYLON EXTRACTION FROM COMMINGLED MATERIALS - The present invention provides energetically and economically efficient methods for separating polyamide polymer(s) from commingled materials. The methods generally involve precipitating a polyamide polymer dissolved in a solvent (e.g., formic acid) using dimethyl ether (DME) as an antisolvent. The methods comprise dissolving the polyamide polymer in a solvent that (i) selectively dissolves the polyamide polymer relative to the other materials and (ii) has a higher solubility for DME relative to the polyamide polymer; and then contacting the mixture of the solvent with the dissolved polyamide polymer with DME, thereby precipitating the polyamide polymer. | 09-09-2010 |
20110112329 | ENERGY EFFICIENT ACETONE DRYING METHOD - The present invention provides energy and economically efficient and environmentally responsible processes for using acetone to dry, dehydrate and/or dewater various hydrated feedstocks. | 05-12-2011 |
20130296525 | METHOD FOR THE PREPARATION OF HIGHLY PURIFIED RECYCLED NYLON - The present invention relates to the recovery of nylon from co-mingled materials (e.g., carpet) with reduced or eliminated ash (e.g., calcium carbonate) contamination. | 11-07-2013 |
Patent application number | Description | Published |
20090069420 | Small molecule inhibitors of STAT3 with anti-tumor activity - The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents. | 03-12-2009 |
20110201576 | Small molecule inhibitors of stat3 with anti-tumor activity - The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents. | 08-18-2011 |
20110201609 | PROTEASOME INHIBITORS FOR SELECTIVELY INDUCING APOPTOSIS IN CANCER CELLS - The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical structure shown in formula I: | 08-18-2011 |
20120142917 | PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY - Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols was regioselective with TiCl | 06-07-2012 |
Patent application number | Description | Published |
20110109640 | System and Method for Sprite Capture and Creation - A sprite capture and reproduction system for a gaming machine is disclosed. A sprite is a graphic image that can move within a larger graphic image. The system includes a sprite capture component and a sprite reproduction component. The sprite capture component enables capture of a sprite in video memory for use as another sprite. The sprite reproduction component enables reproduction of independent animated images that are combinable in a larger animation. The system does not require a discreet texture for each and every image that is loaded. Additionally, the system dramatically increases likelihood that desired images are resident and available for use in video memory, thereby saving texture memory. Further, the system minimizes shadow RAM usage. | 05-12-2011 |
20110110416 | Video Codec System and Method - Various embodiments disclosed herein are directed to a video codec engine system for a gaming machine. The system includes: an encoder and decoder system for encoding and decoding video and still images, wherein the encoder and decoder system includes a library to encode to blob and decode from blob, wherein blob is a binary large object comprising a large image or sound file, and a partial decoding component, wherein the partial decoding component supports decoding a sub-rectangle of a given frame. The encoder and decoder system breaks up an image into spatial blocks, choosing an encoding type for each block from a list of possible encoding schemas. The schemas are individually designed such that decoding procedures are a series of repetitive operations on byte-aligned symbols in a fixed length data stream. The video codec engine system enables a seek function that advances in stream without decoding all frames in-between a beginning seek frame and an ending seek frame. The video codec engine system enables alpha blending of its output buffer with an output from another buffer. The system supports both still frames and video. | 05-12-2011 |
20110111861 | GAMING DEVICE ARCHITECTURE AND RELATED COMPONENTS - A gaming platform for a gaming machine includes a game application having non-shared, executable game objects and game specific information. The game application comprises at least one game manager interface, at least one library routine for receiving commands from the game manager and sending commands to gaming machine drivers, and at least one I/O server comprising a plurality of gaming machine hardware drivers. The gaming platform also includes an operating system having an operating system application and data that are used to provide a plurality of general gaming features, wherein the operating system runs the game application and executes general gaming features in response to requests from the game application. The gaming platform further includes a testing manager in communication with the game manager, wherein the testing manager communicates with an external test client to determine operability of one or more components within the gaming machine. In this embodiment, the game manager interface receives an I/O stream to the game application and communicates with at least one of the library routine, the I/O server, and the operating system to facilitate game application functions. | 05-12-2011 |
20110112667 | Gaming Audio Codec System and Method - Various embodiments disclosed herein are directed to a method for playing an audio file using an audio codec engine system in a gaming environment. The method comprising: reading an audio file into a memory buffer only once; receiving a request from a game application to play the audio file; inputting the memory buffer into the audio codec engine to obtain a decompressed audio sample in response to the request; and decoding only a one second maximum of an audio sample at time, wherein the audio codec does not decode the entire audio file at once; and wherein an audio file's samples are decoded only when the audio file is requested for active playback by the game application. | 05-12-2011 |
20110115810 | GAMING DEVICE HAVING A COLOR REDUCTION FILTER AND RELATED METHODS - Various embodiments are directed to gaming devices utilizing a color reduction filter. In one embodiment, the color reduction filter reduces the number of unique colors in a digital image presented on a gaming device from N to M where N>M. The color reduction filter maintains the color palette and clarity of the image with fewer colors while enhancing the effectiveness of file compression. As a result, the processing unit of the gaming device has more time to run various applications and has more available memory for computational processes. | 05-19-2011 |
20110115824 | Multimedia Codec System and Method Providing Bink Support - Various embodiments disclosed herein are directed to an audio/video codec engine system and method for a gaming machine. The method displays content using a multimedia codec engine system with BINK support. The method includes: loading a multimedia file into memory from a disk; decoding a frame from memory to the off-screen buffer when requested by the video engine, wherein decoding a frame from the off-screen buffer requires a seek operation to a proper position in the multimedia file; and performing a draw operation on decoded data from the off-screen buffer that was requested by the video engine, wherein the draw operation may request only a target region of the source resolution to be updated by specifying an update region that is smaller than the source resolution. | 05-19-2011 |
20110118016 | Video Extension Library System and Method - Various embodiments disclosed herein are directed to a game platform and video extension system for a gaming machine, in which game videos interact with the game platform and video extension system. The system includes a game operating system that provides services to render graphics for the gaming machine. Further, the operating system includes an OS video engine and a window server. The system also includes a game, wherein the game comprises a game library and game application. The game library includes one or more library video engines, in which each video engine may be used in conjunction with the window server of the operating system. The game application includes one or more game modules, in which each game module is associated with, and supported by, a corresponding library video engine in the game library or OS video engine in the game operating system. The game application uses an application program interface of the operating system to display video content. Additionally, the system enables game modules within the gaming application that have new features which are not supported by the video engine of the game operating system to be instead supported by corresponding library video engines within the game library. In this manner, the system does not require game operating system enhancements to play game modules that have new features which are unsupported by the game operating system. | 05-19-2011 |
20140106880 | VIDEO EXTENSION LIBRARY SYSTEM AND METHOD - Various embodiments disclosed herein are directed to a game platform and video extension system for a gaming device. The system includes an operating system that provides services to render graphics for the gaming device. Further, the operating system includes an OS video engine and a server. The system also includes a game that includes a game library and game application. The game library includes one or more library video engines. The game application includes one or more game modules, in which each game module is associated with a corresponding library video engine in the game library or OS video engine in the operating system. Additionally, the system enables game modules within the gaming application that have new features which are not supported by the video engine of the game operating system to be instead supported by corresponding library video engines within the game library. | 04-17-2014 |
20150035845 | System and Method for Sprite Capture and Reproduction - A sprite capture and reproduction system for a gaming machine is disclosed. The system includes a sprite capture component and a sprite reproduction component. The sprite capture component enables capture of a sprite in video memory for use as another sprite. The sprite reproduction component enables reproduction of independent animated images that are combinable in a larger animation. The system does not require a discrete texture for each and every image that is loaded. In some cases, images may be compresses, further reducing video memory requirements. Additionally, the system dramatically increases likelihood that desired images are resident and available for use in video memory, thereby saving texture memory. Further, the system minimizes shadow RAM usage. | 02-05-2015 |
Patent application number | Description | Published |
20100160417 | Chromosome Therapy - The present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromosomal regions where they subsequently reduce the expression of deleterious genes, or cause the death of deleterious cells. Where the nucleic acid sequence is a silencing sequence, it may encode an Xist RNA or other non-coding, silencing RNA. Accordingly, the present invention features, inter alia, nucleic acid constructs that include a transgene (e.g., a silencing sequence encoding an Xist RNA or other non-coding RNA that silences a segment of a chromosome); first and second sequences that direct insertion of the silencing sequence into a targeted chromosome; and, optionally, a selectable marker. | 06-24-2010 |
20120252123 | NUCLEIC ACID SILENCING SEQUENCES - The present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromosomal regions where they subsequently reduce the expression of deleterious genes, or cause the death of deleterious cells. Where the nucleic acid sequence is a silencing sequence, it may encode an Xist RNA or other non-coding, silencing RNA. Accordingly, the present invention features, inter alia, nucleic acid constructs that include a transgene (e.g., a silencing sequence encoding an Xist RNA or other non-coding RNA that silences a segment of a chromosome); first and second sequences that direct insertion of the silencing sequence into a targeted chromosome; and, optionally, a selectable marker. | 10-04-2012 |
20140127810 | NUCLEIC ACID SILENCING SEQUENCES - The present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromosomal regions where they subsequently reduce the expression of deleterious genes, or cause the death of deleterious cells. Where the nucleic acid sequence is a silencing sequence, it may encode an Xist RNA or other non-coding, silencing RNA. Accordingly, the present invention features, inter alia, nucleic acid constructs that include a transgene (e.g., a silencing sequence encoding an Xist RNA or other non-coding RNA that silences a segment of a chromosome); first and second sequences that direct insertion of the silencing sequence into a targeted chromosome; and, optionally, a selectable marker. | 05-08-2014 |
20140213475 | METHODS OF DIAGNOSING CANCER USING EPIGENETIC BIOMARKERS - The invention features methods of diagnosing cancer in a mammal (e.g., a human) by detecting a biomarker selected from a satellite II ribonucleic acid (RNA) molecule, a cancer-associated polycomb group (CAP) body, a cancer-associated satellite transcript (CAST) body, and UbH2A. Also featured is a method for identifying an agent for treating cancer in a mammal by contacting a cancer cell having a biomarker selected from a CAP body, a CAST body, and a satellite II RNA molecule with a test agent and determining whether the test agent reduces the level of the biomarker in the cancer cell. Other inventions featured are a method for determining whether a chemotherapeutic agent increases epigenetic imbalance of a cell and a method for detecting epigenetic imbalance by determining a copy number of a satellite II DNA locus at chromosome 1q12 in a cell. | 07-31-2014 |
20140294785 | DOSAGE COMPENSATING TRANSGENES AND CELLS - Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16. | 10-02-2014 |
Patent application number | Description | Published |
20090141632 | SYSTEMS AND METHODS FOR NETWORK ROUTING IN A MULTIPLE BACKBONE NETWORK ARCHITECTURE - Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address. | 06-04-2009 |
20120198075 | CONTENT DELIVERY NETWORK WITH DEEP CACHING INFRASTRUCTURE - Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices. | 08-02-2012 |
20120327946 | SYSTEMS AND METHODS FOR NETWORK ROUTING IN A MULTIPLE BACKBONE NETWORK ARCHITECTURE - Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address. | 12-27-2012 |
20130018978 | CONTENT DELIVERY NETWORK WITH DEEP CACHING INFRASTRUCTURE - Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices. | 01-17-2013 |
20150039755 | ANALYSIS OF NETWORK TRAFFIC - Embodiments generally disclosed herein include a computer-implemented method for monitoring and correlating network traffic data associated with a primary network that is in communication with a plurality of secondary networks. The method generates a network traffic data set by monitoring network traffic between the primary network and the plurality of secondary networks. The method also determines a mapping of network connectivity by monitoring inter-network routing information between the primary network and the plurality of secondary networks. In addition, the method generates a traffic measurement data set by monitoring network utilization statistics between the primary network and the plurality of secondary networks. With the collected data sets, the method then calculates a relational network mapping between the primary network and the plurality of secondary networks by correlating the network traffic data set, the mapping of network connectivity, and the traffic measurement data set. | 02-05-2015 |
20150067092 | CONTENT DELIVERY NETWORK WITH DEEP CACHING INFRASTRUCTURE - Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices. | 03-05-2015 |
20150067174 | CONTENT DELIVERY NETWORK WITH DEEP CACHING INFRASTRUCTURE - Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices. | 03-05-2015 |
Patent application number | Description | Published |
20100195516 | NETWORK COST ANALYSIS - Embodiments generally disclosed herein include methods and systems for calculating incremental network costs between logical city pairs in a network (each city pair being in communication across the network via one or more physical links). For example, the method includes a cost analyzer that, for each physical link in the network, determines a steady state capacity allocation associated with each city pair in the network and, in the same vein, determines a restoration capacity allocation associated with each city pair in the network. The cost analyzer is capable of calculating an incremental cost per unit of traffic for a given city pair based on: i) the steady state capacity allocation and a restoration capacity allocation associated with a given city pair, as compared to, ii) the aggregate steady state capacity allocations and restoration capacity allocations associated with each city pair in the network. | 08-05-2010 |
20140344331 | SELECTING A CONTENT PROVIDING SERVER IN A CONTENT DELIVERY NETWORK - Aspects of the present disclosure involve systems, methods, computer program products, and the like, for managing the distribution of content from a content distribution network (CDN). In general, the system receives a request for content from the CDN from a user of the network and determines a server within the CDN to provide the content to the user. In addition, the system of the present disclosure may determine a preferred server or group of servers from which the content is provided to the user. This preference may be based on information received from a Border Gateway Protocol feed or Interior Gateway Protocol feed and one or more business determinations, such as the cost of providing the content through the CDN and particular egress port associated with the CDN. | 11-20-2014 |
Patent application number | Description | Published |
20100307542 | Method of Reducing Surface Oil on Encapsulated Material - A method is provided for removing surface oil form a surface of an encapsulated material without using any type of solvent. The method includes contacting an encapsulated material having a moisture content of about 1 to about 60 weight percent with at least about 5 weight percent of an oil removing material for an amount of time effective for reducing surface oil on the encapsulated material by at least about 80%. | 12-09-2010 |
20100310666 | Delivery of Functional Compounds - Functional ingredients including an esterified component and microencapsulated in an enteric matrix to increase the microencapsulation efficiency and reduce undesired organoleptic properties of the microencapsulated material while providing a desired release rate and ester hydrolysis rate, the process including forming an emulsion in water and titrating the emulsion with a precipitating agent to produce a particulate precipitate. | 12-09-2010 |
20100310726 | Novel Preparation of an Enteric Release System - Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix. | 12-09-2010 |
20120273982 | Novel Preparation Of An Enteric Release System - Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix. | 11-01-2012 |
Patent application number | Description | Published |
20100209994 | Protein Surface Remodeling - Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest. | 08-19-2010 |
20120129759 | PROTEIN SURFACE REMODELING - Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest. | 05-24-2012 |
Patent application number | Description | Published |
20090069420 | Small molecule inhibitors of STAT3 with anti-tumor activity - The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents. | 03-12-2009 |
20110190315 | INDOLINE SCAFFOLD SHP-2 INHIBITORS AND CANCER TREATMENT METHOD - The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: | 08-04-2011 |
20110201576 | Small molecule inhibitors of stat3 with anti-tumor activity - The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents. | 08-18-2011 |
20130059839 | PYRIDYLTHIAZOLE-BASED UREAS AS INHIBITORS OF RHO ASSOCIATED PROTEIN KINASE (ROCK) AND METHODS OF USE - Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed. | 03-07-2013 |
20140057913 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF - Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed. | 02-27-2014 |
20140179689 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE - The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table 5. | 06-26-2014 |
20140303134 | PLATINUM COMPOUNDS THAT INHIBIT CONSTITUTIVE STAT3 SIGNALING AND INDUCE CELL CYCLE ARREST AND APOPTOSIS OF MALIGNANT CELLS - The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention. | 10-09-2014 |
Patent application number | Description | Published |
20110201099 | Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge. | 08-18-2011 |
20120190589 | Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge. | 07-26-2012 |
Patent application number | Description | Published |
20080206391 | Injection Molding Nozzle Assembly with Composite Nozzle Tip - A nozzle assembly for an injection molding assembly has a nozzle housing having a melt channel extending therethrough, a nozzle tip, and a retainer that retains the nozzle tip against the nozzle housing. The nozzle tip is formed of a precipitation hardened, high thermal conductivity material and a precipitation hardened, high strength material, which are integrally joined together to form the body. The thermal conductivity of the high thermal conductivity material is greater than the thermal conductivity of the high strength material, and the strength of the high strength material is greater than the strength of the high thermal conductivity material. The high thermal conductivity material and the high strength material can be precipitation hardened together under the same precipitation hardening conditions to achieve increases in the value of at least one strength aspect of the high thermal conductivity material and the value of at least one strength aspect of the high strength material. | 08-28-2008 |
20080206396 | Hot Runner System with Composite Nozzle Tip - A hot runner assembly for an injection molding assembly includes an injection unit adapted to contain a flowable material, a manifold having a first segment of a melt channel formed therein, a nozzle assembly connected to the manifold including a nozzle housing and a nozzle tip, a retainer that retains the nozzle tip against the nozzle housing, and a mold cavity. The nozzle tip is formed of a precipitation hardened, high thermal conductivity material and a precipitation hardened, high strength material, which are integrally joined together to form the body. The thermal conductivity of the high thermal conductivity material is greater than the thermal conductivity of the high strength material, and the strength of the high strength material is greater than the strength of the high thermal conductivity material. The high thermal conductivity material and the high strength material can be precipitation hardened together under the same precipitation hardening conditions. | 08-28-2008 |
20090100962 | CAM APPARATUS FOR VALVE STEM ACTUATION - A cam and cam follower apparatus translates linear cam bar movement to perpendicular valve stem actuation in an injection molding system. The cam bars reciprocate up and down on linear bearing rails such that an actuation plate, fitted with a plurality of valve stems, is cycled normal to the direction of the cam bar movement via cam followers traveling within cam slots in the cam bars. The cam slots in the cam bars are profiled such that the cam followers affect the speed and force at which the valve stems travel while at the same time reducing frictional effects and their associated power requirement. The cam followers of the valve stem actuation plate travel in cam slots in the cam bars from a valve stem forward position, to a valve stem retracted position and ultimately, the entire actuation plate may be removed from the cam bars for maintenance via open ended slots in the cam bars. | 04-23-2009 |
20110018172 | SAFETY CONNECTOR FOR HOT RUNNER, HAVING LATCH DESTRUCTIVELY INTERLOCKING VALVE STEM WITH ACTUATION PLATE - Disclosed is a safety connector ( | 01-27-2011 |
20110086121 | Safety Connector for Hot Runner, having Latch Releasably Interlocking Valve Stem with Actuation Plate - Disclosed is a safety connector for a hot runner having a valve stem and an actuation plate, the safety connector including: (i) a latch releasably interlocking the valve stem with the actuation plate so that in response to movement of the actuation plate, the valve stem becomes movable; and (ii) a latch mover being cooperative with the latch, and the latch mover being configured to move the latch responsive to a predetermined force acting on the valve stem so that so that the valve stem is released from the actuation plate. | 04-14-2011 |
20140076982 | Selective Adjustment of Position of Nozzle Assembly - A mold-tool system ( | 03-20-2014 |
Patent application number | Description | Published |
20110218076 | SPRINT TRAINER AID - Disclosed is a sprinter training aid which pulls the sprinter forward in an over speed condition, for the purpose of exercise the muscles which pull the leg forward when running, such the hip flexor muscles. Two devices can be used, one pulling the sprinter forward and one pulling the sprinter backward at the start of a run. The backward pulling at the start of the run exercises the sprinter's muscles which are used when going from a stationary position, to a full speed sprint. The device which pulls the sprinter forward would take over when the rearward pulling device shut off, and pull the sprinter to an over speed condition. Include in the device is a cable and cable winder, and a motor, computer, and a wireless connection to a data compilation computer. | 09-08-2011 |
20140221159 | FORCE FEEDBACK STARTING BLOCKS - A force feedback starting block and system for using it. The technology includes starting blocks with sensors for pressure, a step sensor for determining where the runner's first step out of the starting blocks occurs, a laser ruler, and a beam break for determining when a runner crosses a finish line. Timing and pressure information is displayed on a computer display. | 08-07-2014 |
20140323270 | SPRINT TRAINER AID - Disclosed is a sprinter training aid which pulls the sprinter forward in an over speed condition, for the purpose of exercise the muscles which pull the leg forward when running, such the hip flexor muscles. Two devices can be used, one pulling the sprinter forward and one pulling the sprinter backward at the start of a run. The backward pulling at the start of the run exercises the sprinter's muscles which are used when going from a stationary position, to a full speed sprint. The device which pulls the sprinter forward would take over when the rearward pulling device shut off, and pull the sprinter to an over speed condition. Include in the device is a cable and cable winder, and a motor, computer, and a wireless connection to a data compilation computer. | 10-30-2014 |