Patent application number | Description | Published |
20150045350 | METHOD FOR NORIBOGAINE TREATMENT IN PATIENTS ON METHADONE - A short treatment with noribogaine shows promise for treating drug dependency. Many opioid addicts are treated with methadone. Giving noribogaine to mammal concurrently being administered methadone surprisingly exacerbates methadone's negative side-effects, and increases the risk of death. Therefore, prior to noribogaine treatment, a patient on methadone therapy undergoes a period of methadone abstinence to wash out the methadone. Surprisingly, noribogaine does not react negatively to morphine. According to the invention, methadone regimen is replaced with morphine prior to noribogaine treatment. | 02-12-2015 |
20150231146 | METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION - This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine at a dosage that provides an average serum concentration of 50 ng/mL to 180 ng/mL (AUC/24 h) under conditions where the QT interval prolongation does not exceed about 50 milliseconds. | 08-20-2015 |
20150231147 | METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION - This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine at a dosage that provides an average serum concentration of about 50 ng/mL to about 180 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds. | 08-20-2015 |
20150238503 | LOW DOSE NORIBOGAINE FOR TREATING NICOTINE ADDICTION AND PREVENTING RELAPSE OF NICOTINE USE - This invention provides methods and compositions for treating nicotine addiction or treating or preventing nicotine cravings in a subject. The method comprises administering to the patient in need thereof a therapeutically effective amount of noribogaine, noribogaine derivative, or a pharmaceutically acceptable salt thereof. | 08-27-2015 |
20150257667 | METHODS AND COMPOSITIONS FOR PRE-SCREENING PATIENTS FOR TREATMENT WITH NORIBOGAINE - This invention is directed to a method for pre-screening an opioid-addicted patient to determine the patient's tolerance for a therapeutic dose of noribogaine. | 09-17-2015 |
20150258104 | USE OF NORIBOGAINE FOR THE TREATMENT OF PAIN - This invention is directed to methods of treating pain in patients comprising treating patients with noribogaine at a dosage that provides an average serum concentration of 50 ng/mL to 180 ng/mL, including under conditions where the QT interval prolongation does not exceed about 50 milliseconds. | 09-17-2015 |
20150258105 | METHODS FOR ACUTE AND LONG-TERM TREATMENT OF ALCOHOL DEPENDENCE - This invention is directed to a method of treating alcohol dependence, including acute and post-acute withdrawal symptoms, comprising treating an alcohol dependent patient with noribogaine, noribogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds. | 09-17-2015 |
20150258106 | METHODS FOR ACUTE AND LONG-TERM TREATMENT OF SUBSTANCE ABUSE - This invention is directed to a method of treating drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine or a pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides a therapeutic serum concentration. In one embodiment, the average serum concentration is 50 ng/mL to 180 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds, and preferably about 30 milliseconds. | 09-17-2015 |
20150258107 | METHODS AND COMPOSITIONS FOR TREATING DEPRESSION - This invention provides a method for treating depression and/or posttraumatic stress disorder in a patient, comprising administering to the patient in need thereof a therapeutically effective amount of noribogaine, noribogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof. | 09-17-2015 |
20150258109 | LOW DOSE ADMINISTRATION OF IBOGAINE FOR TREATING NICOTINE ADDICTION AND PREVENTING RELAPSE OF NICOTINE USE - This invention relates generally to methods and compositions for the treatment of nicotine addiction by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses. This invention further relates generally to methods and compositions for the treatment or prevention of relapse of nicotine use by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses. | 09-17-2015 |
20150258110 | METHODS FOR ACUTE AND LONG-TERM TREATMENT OF ALCOHOL DEPENDENCE USING IBOGAINE - This invention is directed to a method of treating alcohol dependence, including acute and post-acute withdrawal symptoms, comprising treating an alcohol dependent patient with ibogaine, ibogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds. | 09-17-2015 |