Patent application number | Description | Published |
20090075383 | COMPOSITION AND METHOD FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS TO CELLS USING CHITOSAN - There is disclosed a composition and a method for the efficient non-viral delivery of nucleic acids to cells using chitosan. In order to achieve high efficiency of transfection, the composition contains a nucleic acid and a chitosan that has the following physico-chemical properties: a combination of a number-average molecular weight between 8 kDa and 185 kDa and a degree of deacetylation between 72% and 92%. The chitosan molecule can also present additional physiochemical properties such as a block distribution of acetyl groups obtained by a heterogeneous treatment of chitin, and/or a polydispersity index between 1.4 and 7.0. By correctly controlling these parameters, efficient delivery systems may be produced that are effective when optimized for different conditions such as the pH of transfection media and amine-to-phosphate ratio. | 03-19-2009 |
20090149421 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 06-11-2009 |
20110313056 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 12-22-2011 |
20120321721 | NOVEL FORMULATION OF PHYSIOLOGICAL CHITOSAN-INORGANIC SALT SOLUTION/BLOOD MIXTURES FOR TISSUE REPAIR - The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, a polymer, such as chitosan, and at least one inorganic salt, such as NaCl, method of using the composition and method of preparing the composition. | 12-20-2012 |
Patent application number | Description | Published |
20120151895 | HOT GAS PATH COMPONENT COOLING FOR HYBRID PULSE DETONATION COMBUSTION SYSTEMS - The flow through the core of a hybrid pulse detonation combustion system is passed through a compressor and then separated into a primary flow, that passes directly to the combustor, and a bypass flow, which is routed to a portion of the system to be used to cool components of the system. The bypass includes a pump that raises the pressure of the bypass flow sufficient to deliver it to downstream stations of the engine that contain combustion products that are at a higher pressure than the compressor exit. | 06-21-2012 |
20120151896 | HOT GAS PATH COMPONENT COOLING FOR HYBRID PULSE DETONATION COMBUSTION SYSTEMS - The flow through the core of a hybrid pulse detonation combustion system is passed through a compressor and then separated into a primary flow, that passes directly to the combustor, and a bypass flow, which is routed to a portion of the system to be used to cool components of the system. The bypass flow is routed to a nozzle of the pulse detonation combustor. The flow is then passed back into the primary flow through the core downstream of where it was extracted. | 06-21-2012 |
20130283781 | TURBOCHARGED POWER UNIT AND METHOD OF OPERATING UNDER HIGH LOAD CONDITIONS - A first stage turbocharger configured to receive an ambient intake air stream. A compressor of the first stage turbocharger coupled to a first intercooler. The first intercooler coupled to a turboexpander stage. The turbine of the turboexpander discharging an expanded air stream to an intake manifold of an engine. The expanded airstream having a temperature of less than the ambient intake air stream, thereby reducing enabling operation of the engine under high load conditions while maintaining reduced emissions. | 10-31-2013 |
20140109571 | SYSTEM AND METHOD FOR CONTROLLING EXHAUST EMISSIONS AND SPECIFIC FUEL CONSUMPTION OF AN ENGIINE - A method includes combusting air within a plurality of cylinders of an internal combustion engine by injecting a fuel into the plurality of cylinders. The method further includes expanding a first portion of an exhaust gas generated from the plurality of combustion cylinders via a turbine. The method further includes controlling at least one of feeding a second portion of the exhaust gas via an exhaust channel bypassing the turbine; and recirculating a third portion of the exhaust gas to the plurality of combustion cylinders via a recirculation channel, as a function of an intake manifold air temperature and pressure at which the engine is operated. | 04-24-2014 |
20140358404 | SYSTEM AND METHOD OF OPERATING AN INTERNAL COMBUSTION ENGINE - A method of operating an internal combustion engine is provided. The method includes combusting a mixture of fresh air and fuel within multiple cylinders. The method also includes directing a first portion of exhaust gases into a first-stage turbine and a second-stage turbine of a turbocharger for expanding the exhaust gases, directing a second portion of exhaust gases from the exhaust manifold via an exhaust channel bypassing the first-stage turbine and recirculating a third portion of exhaust gases into an intake manifold after mixing with fresh air. The method includes controlling at least one of: reducing a normal engine speed at each engine power setting while maintaining constant engine power level by increasing a fuel injection per cycle; concurrently increasing a flow rate of the third portion of exhaust gas during recirculation; and advancing a fuel injection timing for reducing emission levels that meets Tier 4 requirements. | 12-04-2014 |