Patent application number | Description | Published |
20100036502 | MEDICAL DEVICE FOR BONE IMPLANT AND METHOD FOR PRODUCING SUCH DEVICE - A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration. | 02-11-2010 |
20100226897 | METHOD FOR MODIFYING THE WETTABILITY AND/OR OTHER BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS MADE THEREBY - The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient. | 09-09-2010 |
20100226958 | METHOD FOR MODIFYING THE WETTABILITY AND/OR OTHER BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS MADE THEREBY - The invention provides a method for preparing a biological material for implanting. The invention also provides a biological material for surgical implantation. The invention further provides a biological composition for surgical implantation. | 09-09-2010 |
20100227523 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provide for a method of improving bioactivity of a surface of an object. The invention further provides for a method of preparing an object for medical implantation. The invention even further provide for an article made by a method comprising the steps of forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the article into the reduced-pressure chamber, and irradiating at least a portion of the surface of the object with the gas-cluster ion-beam. The invention still further provides for an article for medical or surgical implantation made by a method comprising selecting at least a portion of a surface of the object for increased bioactivity, forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the object into the reduced-pressure chamber, and irradiating the selected at least a portion with the gas-cluster ion-beam to increase the bioactivity of the at least a portion. | 09-09-2010 |
20100234948 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provide a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cells, and for an article for medical implantation. | 09-16-2010 |
20130138212 | MEDICAL DEVICE FOR BONE IMPLANT AND METHOD FOR PRODUCING SUCH A DEVICE - A bone implantable medical device made from a biocompatible material, preferably comprising titanic or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration. | 05-30-2013 |
20130138213 | MEDICAL DEVICE FOR BONE IMPLANT AND METHOD FOR PRODUCING SUCH A DEVICE - A method of modifying a surface of implantable medical device provides coating at least a first portion of the surface of the medical device with a therapeutic agent to form a coated surface region; and irradiating at least a portion of the coated surface region with a gas cluster ion beam infusing the therapeutic agent into the at least a portion of the coated surface region. | 05-30-2013 |
20140074159 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity of a surface of a surgical suture and sutures prepared thereby provides forming a gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing a surgical suture into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said surgical suture with a GLIB derived beam. | 03-13-2014 |