Laure
Laure Aurelian, Baltimore, MD US
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20110059134 | PREVENTION OF RECURRENT VIRAL DISEASE - The present invention discloses compositions and methods for ameliorating or reducing recurrent viral disease, which compositions and methods result in an increase in virus specific immunoglobulin subclasses reflective of a preferential Th1 response. | 03-10-2011 |
Laure Aurellan, Baltimore, MD US
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20110033419 | Methods and Compositions for Treating Cancer - The invention relates to a method of treating cancer, comprising administering to a subject in need thereof an effective amount of a HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10. The invention further relates to pharmaceutical compositions comprising HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10. | 02-10-2011 |
Laure Bachelet, Paris Cedex FR
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20120093725 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 04-19-2012 |
20120183475 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 07-19-2012 |
20140134102 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 05-15-2014 |
Laure Bajard, Toulouse FR
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20150279018 | METHOD FOR DETERMINING A STATE OF OBSTRUCTION OF AT LEAST ONE CAMERA INSTALLED IN A STEREOSCOPIC SYSTEM - To improve the performance for determining obstruction of a stereoscopic system using two cameras or more, a hybrid of local and semi-global methods is provided. For each stereoscopic image formed from simultaneous left and right images, a breakdown of each left and right image into corresponding sectors is applied. Obstruction level is determined by a disparity map by sector, based on left or right images, and in which a disparity is assigned to each pixel corresponding to the best matching score. A determination of density by sector of the disparity map is carried out by reference to a fraction of pixels with a disparity considered to be valid. A state of obstruction of at least one camera is determined based on a weighted average of the probabilities of obscuring of the sectors of the disparity map obtained by comparison between the density of the sectors and a predefined density level. | 10-01-2015 |
Laure Berdin, Bernay FR
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20160083573 | TRANSPARENT AND ANTISTATIC PMMA COMPOSITION - A transparent antistatic composition based on polymethyl methacrylate (PMMA), including: 55% to 99.9% by weight of PMMA, and 0.1% to 45% by weight of at least one polyamide (PA) block-containing and polyether (PE) block-containing copolymer (PEBA) including polyethylene glycol (PEG), with respect to the total composition weight, said copolymer including in the range 50% to 80% by weight of PEG with respect to the total weight of copolymer. Also, the use of a composition of this type for the manufacture of at least a portion of the following items: an industrial part, an automobile part, a safety accessory, sign, luminous strip, signalling and advertizing panel, display, etching, furniture, shop fitting, decoration, contact ball, dental prosthesis, ophthalmological implant, membrane for hemodialysis, optic fibers, artwork, sculpture, camera lenses, disposable camera lenses, printing support, in particular a support for direct printing with UV inks for pictures, photographs, window glass, panoramic roof. | 03-24-2016 |
Laure Berruet, Chaville FR
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20080292612 | COMPOSITION CONTAINING SEVERAL BOTULIC TOXINS - The invention concerns a composition including at least one botulinum neurotoxin type A1, and one botulinum neurotoxin type A the amino acid sequence of which as at least 5% difference with the amino acid sequence of botulinum neurotoxin type A1. | 11-27-2008 |
Laure Berti-Equille, Springfield, NJ US
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20100293129 | DEPENDENCY BETWEEN SOURCES IN TRUTH DISCOVERY - A method and system for truth discovery may implement a methodology that accounts for accuracy of sources and dependency between sources. The methodology may be based on Bayesian probability calculus for determining which data object values published by sources are likely to be true. The method may be recursive with respect to dependency, accuracy, and actual truth discovery for a plurality of sources. | 11-18-2010 |
Laure Berti-Equille, La Duranne FR
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20120303555 | Scalable Automatic Data Repair - A computer implemented method for generating a set of updates for a database comprising multiple records including erroneous, missing and inconsistent values, the method comprising using a set of partitioning functions for subdividing the records of the database into multiple subsets of records, allocating respective ones of the records to at least one subset according to a predetermined criteria for mapping records to subsets, applying multiple machine learning models to each of the subsets to determine respective candidate replacement values representing a tuple repair for a record including a probability of candidate and current values for the record, computing probabilities to select replacement values for the record from among the candidate replacement values which maximise the probability for values of the record for an updated database. | 11-29-2012 |
Laure Bissey-Beugras, Levallois-Perret FR
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20080226756 | COMPOSITIONS COMPRISING A C-GLYCOSIDE COMPOUND - The present invention relates, in particular, to: | 09-18-2008 |
Laure Cala US
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20150030882 | STEEL PLATE FOR PRODUCING LIGHT STRUCTURES AND METHOD FOR PRODUCING SAID PLATE - The invention relates to a steel plate, the chemical composition of which comprises, the contents being expressed by weight: 0.010%≦C≦0.20%, 0.06%≦Mn≦3%, Si≦1.5%, 0.005%≦Al≦1.5%, S≦0.030%, P≦0.040%, 2.5%≦Ti≦7.2%, (0.45×Ti)−0.35%≦B≦(0.45×Ti)+0.70%, and optionally one or more elements chosen from: Ni≦1%, Mo≦1%, Cr≦3%, Nb≦0.1%, V≦0.1%, the balance of the composition consisting of iron and inevitable impurities resulting from the smelting. | 01-29-2015 |
Laure Cala, Montigny-Les-Metz FR
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20130174942 | STEEL PLATE FOR PRODUCING LIGHT STRUCTURES AND METHOD FOR PRODUCING SAID PLATE - The invention relates to a steel plate, the chemical composition of which comprises, the contents being expressed by weight: 0.010%≦C≦0.20%, 0.06%≦Mn≦3%, Si≦1.5%, 0.005%≦Al≦1.5%, S≦0.030%, P≦0.040%, 2.5%≦Ti≦7.2%, (0.45×Ti)−0.35%≦B≦(0.45×Ti)+0.70%, and optionally one or more elements chosen from: Ni≦1%, Mo≦1%, Cr≦3%, Nb≦0.1%, V≦0.1%, the balance of the composition consisting of iron and inevitable impurities resulting from the smelting. | 07-11-2013 |
Laure Chevalley, Paris FR
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20150149000 | Unkown - The drone comprises: a vertical-view camera ( | 05-28-2015 |
20150161456 | METHOD FOR ANGLE CALIBRATION OF THE POSITION OF A VIDEO CAMERA ON BOARD AN AUTOMOTIVE VEHICLE - The method consists in taking, when the vehicle is running, images of the road markings delimiting the circulation lanes of the road, and in fully estimating, through an iterative process, the orientation of the camera with respect to the vehicle, based on the position of two lanes located side-by-side on the image. The calibration essentially comprises: correcting the position of the lane edges in the image ( | 06-11-2015 |
Laure Chivot, Antibes FR
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20160125069 | DYNAMIC DATABASE OBJECT MANAGEMENT - Systems, methods, and computer program products for dynamically managing a travel object database that maintains one or more travel objects. A time limit request is received at a processing system for a record associated with one or more travel objects of the travel object database. A base time limit for a geographical identifier associated with the record is determined based at least in part on the geographical identifier by querying a time limit rules database based at least in part on the geographical identifier. The base time limit is adjusted based at least in part on the geographical identifier and at least one time adjustment rule to determine a geographical identifier time limit. A time limit for the record is determined based at least in part on the geographical identifier time limit to thereby transform the record and information thereof into a time limit for the travel objects associated with the record and maintained by the travel object database. | 05-05-2016 |
Laure Cloarec-Blanchard, Paris FR
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20100056564 | Association of an anti-atherothrombotic agent and an anti-platelet-aggregation agent - The present invention relates to a new association of an anti-atherothrombotic agent and an anti-platelet-aggregation agent. | 03-04-2010 |
Laure Cornilleau, Joue Les Tours FR
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20080268325 | Sealed Fuel Cell Stack - The invention relates to a fuel cell consisting of a stack of elementary cells and interconnectors ( | 10-30-2008 |
Laure Dehuyser, Saint Andre De Corcy FR
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20140349952 | MANNOSYLATED COMPOUNDS USEFUL FOR THE PREVENTION AND THE TREATMENT OF INFECTIOUS DISEASES - The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms of length. Pharmaceutical compositions and therapeutic uses thereof are also provided. | 11-27-2014 |
Laure Deremble, Mountrouge FR
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20120109611 | System and Method for Performing Wellsite Containment Operations - A system and method for performing an adaptive wellsite operation about a wellsite having a sub-surface system with a wellbore formed through at least one subterranean formation, wherein the subterranean formations are configured to store fluid. The system has a containment unit. The containment unit has a static model unit for generating a static model of a subsurface system. The static model unit further has a defect model unit for generating a defect model. The containment unit has a dynamic leak model unit for generating a dynamic leak model. The containment unit has a leak mitigation unit for providing at least one containment plan. The leak mitigation unit and the dynamic leak model unit are integrated for passing data therebetween and whereby the containment plan may be adapted as the static model, the defect model, and/or the dynamic model is generated. | 05-03-2012 |
Laure Devun, Saint-Jerome FR
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20130261622 | IMPLANT FOR PROXIMAL FRACTURES OF LONG BONES - Surgical implant for treating fractures of long bones, notably of the femur, having an intramedullary section ( | 10-03-2013 |
Laure Duchemin Laporte, Morangis FR
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20150224017 | DEVICE FOR DISCRIMINATION OF STAGES OF A PATIENT'S SLEEP - A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response. | 08-13-2015 |
20150224018 | DEVICE FOR THE TREATMENT OF SLEEP APNEA SYNDROME IN A PATIENT BY KINESTHETIC STIMULATION - A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient | 08-13-2015 |
Laure Dumont Di Leone, Dijon FR
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20150276762 | Collagen-Derived Recombinant Proteins with Von Willebrand Factor-Binding Activity - A method for diagnosing von Willebrand disease and novel polypeptides which bind to von Willebrand factor. | 10-01-2015 |
Laure Dumoutier, Brussels BE
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20080213881 | Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof - The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors. | 09-04-2008 |
20090311802 | Isolated Soluble IL-TIF/IL-22 Receptor or Binding Protein Which Binds to IL-TIF/IL-22 and Uses Thereof - The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described. | 12-17-2009 |
Laure Fageon, Paris FR
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20100330018 | COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT - A composition in the form of an emulsion containing an aqueous phase, a fatty phase, a superabsorbent polymer, and an organic UV screening agent. Method for the treatment of a keratinous substance whereby the composition described is applied to the keratinous substance. | 12-30-2010 |
20130039963 | COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND A GEMINI SURFACTANT - A cosmetic composition in the form of an emulsion comprising at least one aqueous phase and at least one fatty phase, at least one superabsorbent polymer and at least one surfactant of formula (I): | 02-14-2013 |
20140294975 | SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA - The present invention thus relates to a solid composition, in particular in the form of a loose or compact powder, comprising, in a cosmetically acceptable medium: a) at least one pulverulent phase; b) at least one lipophilic organic UV screening agent characterized in that the pulverulent phase comprises at least aerogel particles of hydrophobic silica exhibiting a specific surface per unit of weight (S | 10-02-2014 |
20140302159 | Cosmetic composition comprising a superabsorbent polymer and a lamellar or platelet-shaped matting mineral filler - The present invention relates to a composition for topical application, comprising at least one aqueous phase, at least one superabsorbent polymer and at least one lamellar or platelet-shaped matting mineral filler. A subject of the invention is also a cosmetic treatment process for keratin materials, which consists in applying to the keratin materials a composition as defined above, and also the use of this composition in the cosmetic or dermatological field, and in particular for caring for, protecting and/or making up bodily or facial skin, or for haircare. The composition according to the invention has both a matt appearance throughout all the steps of its use, from the appearance of the product up to the finished skin, and a comfortable sensation throughout its use, from the application to the total penetration of the product. | 10-09-2014 |
20140370062 | COMPOSITION WITH A CONTINUOUS OIL PHASE CONTAINING AT LEAST ONE LIPOPHILIC ORGANIC UV-SCREENING AGENT AND HYDROPHOBIC SILICA AEROGEL PARTICLES - The present invention relates to a composition comprising, in a cosmetically acceptable medium, at least one continuous oil phase, characterized in that the oil phase comprises a) at least one non-volatile non-cyclic silicone oil with a viscosity at 25° C. ranging from 4 to 5000 mm | 12-18-2014 |
20150224046 | COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT - A composition in the form of an emulsion containing an aqueous phase, a fatty phase, a superabsorbent polymer, and an organic UV screening agent. Method for the treatment of a keratinous substance whereby the composition described is applied to the keratinous substance. | 08-13-2015 |
Laure Flavigny, Paris FR
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20110189144 | Compositions Comprising Lactobacillus Casei for Improving Resistance to Common Infectious Diseases - The use of a | 08-04-2011 |
Laure Gigout, New York, NY US
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20120220492 | Viral Vectors with Improved Properties - Methods to improve the tropism or other features of a virus are disclosed. Such methods can be used to prepare, e.g., DNA or plasmid libraries of variants of a gene encoding a viral capsid or envelope protein having a randomly inserted restriction site, libraries of viral clones with such variant genes with a randomly inserted restriction site or polypeptide sequence targeting a receptor expressed by a specific type of mammalian cells. Described are also methods to prepare mosaic viruses, i.e., viral particles wherein copies of one or more capsid or envelope proteins originate from different sources. These methods can be used to prepare mosaic viruses of a specific mixture of wild-type and mutant proteins, or of different types of mutant proteins. | 08-30-2012 |
Laure Graveleau, Fresnes FR
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20100200496 | METHOD AND INSTALLATION FOR BIOLOGICALLY TREATING WASTE WATER - The invention relates to a method for biologically treating waste water, using a set of micro-organisms having different metabolic spectra, in order to eliminate carbon and nitrogen, even phosphorus. Some of the micro-organisms are fixed to mobile solid carriers ( | 08-12-2010 |
20150360981 | PROCESS FOR TREATING EFFLUENTS CONTAINING NITROGEN IN AMMONIUM FORM, AND EQUIPMENT FOR IMPLEMENTING THIS PROCESS - Process for treating effluents containing nitrogen in ammonium form, using a sequential biological reactor ( | 12-17-2015 |
Laure Guenin-Mace, Paris FR
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20140329771 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN - The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y—O—W (I), wherein Y and W are as defined in claim | 11-06-2014 |
Laure Guetaz, Grenoble FR
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20140099565 | FUEL CELL COMPRISING A PROTON-EXCHANGE MEMBRANE, HAVING AN INCREASED SERVICE LIFE - A fuel cell having a proton-exchange membrane, an anode, and a cathode. The anode and cathode are fixed on opposing sides of the proton-exchange membrane. The anode demarcates a flow conduit between a molecular-hydrogen inlet area and a molecular-hydrogen outlet area. A quantity of catalyst at the molecular-hydrogen outlet area is smaller than a quantity of catalyst at the molecular-hydrogen inlet area. The anode also has a thickness that decreases continuously between the molecular-hydrogen inlet and outlet areas. | 04-10-2014 |
20140193740 | FUEL CELL COMPRISING A PROTON-EXCHANGE MEMBRANE, HAVING AN INCREASED SERVICE LIFE - A fuel cell includes a proton-exchange membrane, and a cathode and anode fixed on its opposite sides. The anode delimits a flow conduit between a molecular-oxygen inlet area and a water outlet area. The cathode includes a support for catalyst material. The support has first and second materials to which catalyst is fixed, the first material being a graphitized material. The second material has a resistance to corrosion by oxygen that is greater than that of the first material. A quantity of the second material at the inlet area is greater than a quantity of the second material at the water outlet. The cathode comprises a first layer including the first material and a second layer including the second material. A thickness of the second layer decreases between the molecular-oxygen inlet area and the water outlet area. | 07-10-2014 |
Laure Jamot, Marseille FR
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20090203747 | NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE - The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. | 08-13-2009 |
Laure Jamot, Paris FR
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20150190465 | HIP/PAP PROTEIN AND DERIVATIVES THEREOF FOR USE IN TREATING CANCER - This invention concerns a HIP/PAP protein or derivative thereof, for its use in treating or managing cancer and preferentially solid tumors. | 07-09-2015 |
20160058833 | Composition Including the HIP/PAP Protein or One of the Derivatives Thereof for Treating Insulin Resistance - The invention relates to a HIP/PAP protein or to one of the derivatives thereof for use thereof for treating or preventing insulin resistance in non-insulin dependent subjects. | 03-03-2016 |
Laure Johann, Bitche FR
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20140121238 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS - Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents. | 05-01-2014 |
Laure Jouffroy-Wendlinger, Saint-Arnoult-En-Yvelines FR
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20130266529 | PROCESS FOR STRIPPING KERATIN FIBRES USING A COMPOSITION COMPRISING A SULFINIC ACID DERIVATIVE AND AN ACIDIC AQUEOUS COMPOSITION - The present invention relates to a process for stripping keratin fibres, and in particular human keratin fibres such as the hair, dyed with oxidation dyes and/or direct dyes, using a composition obtained by extemporaneous mixing of an anhydrous or aqueous composition (A) comprising at least one suitably selected sulfinic acid derivative and an aqueous composition (B) with a pH of less than (5), comprising at least one organic acid other than the compounds of formula (I), with a pKa of less than or equal to (4) when the composition (A) is aqueous, the pH of the mixture of the two compositions (A) and (B) being less than or equal to (5). The invention also relates to a composition for stripping the artificial colour from keratin fibres, comprising at least one suitably selected sulfinic acid derivative and at least one thickener chosen from anionic polymers and nonionic polymers. The compositions used in the context of the invention afford efficient stripping, especially in terms of power, of the artificial colour of keratin fibres dyed with a wide range of oxidation dyes and/or direct dyes. They do not induce lightening of the natural base of the keratin fibres and limit the sensitization of the keratin fibres. They apply well to the hair, uniformly, which makes it possible to obtain regular stripping of the colour along the entire fibre. | 10-10-2013 |
Laure Jourdin, Paris FR
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20150031901 | METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES - The invention relates to a method for preparing 5-amino-benzoyl-benzofuran derivatives having the general formula in which R | 01-29-2015 |
Laure Landric-Burtin, Athis Mons FR
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20100311112 | METHOD FOR AMIDATING POLYPEPTIDES WITH BASIC AMINO ACID C-TERMINALS BY MEANS OF SPECIFIC ENDOPROTEASES - The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry. | 12-09-2010 |
Laure Landric-Burtin, Paris FR
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20140323698 | PROTEIN PURIFICATION USING BIS-TRIS BUFFER - The invention provides a two-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution. | 10-30-2014 |
20160083454 | CONTINUOUS MULTISTEP PROCESS FOR PURIFYING ANTIBODIES - The invention provides a three-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution. | 03-24-2016 |
Laure Lapasset, Montpellier FR
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20140056860 | METHOD FOR REJUVENATING CELLS - The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog. | 02-27-2014 |
Laure Laporte-Duchemin, Morangis FR
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20150328464 | ACTIVE IMPLANTABLE MEDICAL DEVICE WITH AUTOMATIC OPTIMIZATION OF THE CONFIGURATION OF A MULTI-ELECTRODE STIMULATION LEAD - A device includes a pulse generator coupled to a neurostimulation lead placed around the nerve and a set of electrodes individually connected to the generator by a splitter circuit controlled to preferentially stimulate certain regions of the nerve relative to other regions. The device performing an iterative search of an optimal configuration operating by selection of a plurality of different stimulation configurations, storing of a cardiac physiological parameter measured for each selected stimulation configuration, and designation as optimal stimulation configuration of the one of said selected different stimulation configurations, depending on at least the stored values of the physiological parameter measured for different electrode configurations. | 11-19-2015 |
Laure Le Guenne, Bruges FR
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20100055571 | CURRENT COLLECTOR FOR THE ANODE OF A PRIMARY LITHIUM ELECTROCHEMICAL GENERATOR - An electrode comprising a metallic lithium strip ( | 03-04-2010 |
Laure Mandrou, Bellaire, TX US
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20130192844 | PASSIVE OFFSHORE TENSION COMPENSATOR ASSEMBLY - A tensions compensator assembly for a slip type joint in an offshore work string. The assembly includes a chamber at the joint which is constructed in a manner to offset or minimize a pressure differential in a production channel that runs through the work string. Thus, potentially very high pressures running through the string are less apt to prematurely force actuation and expansiveness of the slip joint. Rather, the expansive movement of the joint is more properly responsive to heave, changes in offshore platform elevation and other outside forces of structural concern. | 08-01-2013 |
20140054044 | ORIENTING A SUBSEA TUBING HANGER ASSEMBLY - An apparatus includes an engagement device to be disposed on a landing string. The engagement device includes a retracted state to allow the apparatus to be run inside a riser and an expanded state to engage the riser to secure the apparatus to the riser. The apparatus further includes an actuator assembly to be disposed on the landing string. The actuator assembly is remotely actuatable from a sea surface to rotate a tubing of the landing string relative to the engagement device to rotate the landing string to orient a tubing hanger assembly. | 02-27-2014 |
Laure Mandrou, Pearland, TX US
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20090050335 | DOWNHOLE VALVE HAVING INCREMENTALLY ADJUSTABLE OPEN POSITIONS AND A QUICK CLOSE FEATURE - A valve that is usable with a well includes an indexer and a closing mechanism. The indexer includes a profile to establish a sequence of open settings for the valve, and the indexer is adapted to respond to first control stimuli to transition the valve through the settings according to the sequence. The closing mechanism is adapted to operate independently of the sequence in response to a second control stimulus to close the valve. | 02-26-2009 |
20090133880 | VOLUMETRIC COMPENSATING ANNULAR BELLOWS - Embodiments of the present invention relate to a volumetric compensating annular bellows used to compensate two fluid volumes by an annular displacement. This is achieved using a bellows welded on to a tube with a varying shape radius. A bellows is arranged within the annulus and is deformable in an annular direction in response to fluid volume expansion. The bellows can be used in several oilfield applications for fluid compensation. | 05-28-2009 |
20090243875 | SYSTEM AND METHOD FOR CONTROLLING MULTIPLE WELL TOOLS - A technique facilitates control over multiple well tools. Multiple well tools can be actuated between operational positions. The well tools are coupled to a plurality of multidrop modules with each multidrop module typically being coupled to one or two well tools. Control lines are connected the multidrop modules, and the multidrop modules have the capability of controlling a number of well tools greater than the number of control lines. Each well tool can be actuated individually by providing pressure inputs through one or more of the control lines. | 10-01-2009 |
20090283276 | OVERRIDING A PRIMARY CONTROL SUBSYSTEM OF A DOWNHOLE TOOL - A system that is usable with a well may include a piston, a primary control subsystem and an override subsystem. The piston actuates the downhole tool, and the primary control subsystem may be connected to at least one hydraulic line in order to move the piston in response to pressure that is communicated to the tool via the hydraulic line(s). The override subsystem may be connected to the hydraulic line(s) to override the primary control subsystem and move the piston in response to pressure communicated to the tool via the hydraulic line(s). | 11-19-2009 |
20100038092 | SYSTEM AND METHOD FOR CONTROLLING A DOWNHOLE ACTUATOR - A technique is provided for utilizing a hydraulic fluid metering control module in cooperation with a downhole component. The downhole component is shifted via hydraulic fluid delivered through first and/or second control lines to an actuator of the downhole component. The hydraulic fluid metering control module works in cooperation with the actuator and the control lines to enable shifting of the actuator according to a controlled, incremental process. | 02-18-2010 |
20110284241 | Overriding a Primary Control Subsystem Of A Downhole Tool - A system that is usable with a well may include a piston, a primary control subsystem and an override subsystem. The piston actuates the downhole tool, and the primary control subsystem may be connected to at least one hydraulic line in order to move the piston in response to pressure that is communicated to the tool via the hydraulic line(s). The override subsystem may be connected to the hydraulic line(s) to override the primary control subsystem and move the piston in response to pressure communicated to the tool via the hydraulic line(s). | 11-24-2011 |
Laure Marillet, Lyon FR
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20160116463 | METHOD FOR MEASURING THE PLASMA CONCENTRATION OF AN ANALYTE DIRECTLY ON A WHOLE BLOOD SAMPLE - A method of measuring an analyte amount in a whole blood sample, including: | 04-28-2016 |
Laure Martin, Sens FR
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20090219731 | OPTICAL SYSTEM WITH MAIN FUNCTION FOR MOTOR VEHICLE - An optical system for a motor vehicle, the optical system performing at least one main optical function and including in particular a diffusion screen, at least one light source of the LED type, each LED of the optical system producing a set of rays of light to be propagated in the diffusion screen wherein the screen is in the form of a curved sheet, with an upper lateral flange and a lower lateral flange which meet at a periphery which has in particular a rear face and a front edge and the principal function is performed essentially via an output face constituted by the front edge of the diffusion screen. | 09-03-2009 |
20130163264 | OPTICAL SYSTEM WITH MAIN FUNCTION FOR MOTOR VEHICLE - An optical system for a motor vehicle, the optical system performing at least one main optical function and including in particular | 06-27-2013 |
Laure Martin-Al-Khatib, Paris FR
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20130146286 | Self-Repairing Cements - A self-adaptive cement formulation includes cement, water and thermoplastic block-polymer particles. The set cement demonstrates self-healing properties when exposed to methane, and is particularly suited for well-cementing applications. After placement and curing, the self healing properties help maintain zonal isolation should bonding be disrupted between the set cement and the formation or a casing string, should cracks or defects appear in the set-cement matrix, or both. | 06-13-2013 |
Laure Mauboules, Billere FR
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20090306246 | CROSSLINKED COMPOSITION COMPRISING A CORE/SHELL COPOLYMER, METHOD OF OBTAINING SAME AND USES THEREOF - The invention relates to is a crosslinked composition containing in parts by weight: 20 to 100 parts of at least one elastomer (I), 2 to 50 parts of at least one core/shell copolymer (II), and 0 to 100 parts of at least one thermoplastic polymer (III). The invention also relates to a method of producing one such crosslinked composition, which is characterized in that it consists in: mixing an elastomer and a core/shell copolymer optionally in the presence of: a grafted polyolefin, a plasticizer, fillers and/or additives, and a suitably-selected crosslinking system, and subsequently crosslinking said mixture at a suitable temperature. In a preferred embodiment of the invention, the mixture is crosslinked at a temperature of between 150 and 320° C. The invention method be carried out in an internal mixer, or, alternately, in a twin-screw extruder or a Buss®-type co-kneader. Depending on the case, the resulting mass is calendared or extruded, cooled and subsequently granulated. The granules thus obtained are then ready to be transformed, by means of heating, into sheets, plates, extrusions, tubes or other desired products. The invention further relates to the use of one such composition in the production of ducts, pipes, tubing, couplers or similar for conveying fluids, such as the fluid transfer conduits, pipes and other elements which are used in the automobile industry in braking, cooling, steering and air-conditioning systems. The inventive crosslinked composition can also be used in the production of belts, tires, electrical cable sheaths, and shoe soles.” | 12-10-2009 |
Laure Meynie, Paris FR
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20110034585 | METHOD OF PREPARING A TRANSPARENT POLYMER MATERIAL COMPRISING A THERMOPLASTIC POLYCARBONATE AND SURFACE-MODIFIED MINERAL NANOPARTICLES - A method of preparing a transparent polymer material includes i) obtaining composite nanoparticles having mineral nanoparticles at least partially coated with at least one monomer and/or at least one polymer suitable for promoting physicochemical interactions at the interface between the mineral nanoparticles and a thermoplastic polycarbonate matrix, the mineral nanoparticles being surface-modified by the monomer and/or the polymer, either directly by grafting or directly by adsorption of the monomer and/or polymer onto the surface of the mineral nanoparticles; or via a coupling agent selected from a chlorosilane or an organosilane including a functional group that is capable of reacting by a radical pathway. The composite nanoparticles obtained in step i) are mixed with the thermoplastic polycarbonate matrix in the molten state to obtain the transparent polymer material. | 02-10-2011 |
20110034588 | METHOD OF PREPARING A TRANSPARENT POLUMER MATERIAL COMPRISING A THERMOPLASTIC POLYCARBONATE AND MINDERAL NANOPARTICLES - A method of preparing a transparent polymer material includes mixing mineral nanoparticles selected from nanoparticles of alkaline-earth metal carbonates, alkaline-earth metal sulfates, metallic oxides, oxides of metalloids, and siloxanes, and a composition A including at least one thermoplastic polymer in the molten state selected from polycarbonate (PC), polystyrene (PS) and polymethyl methacrylate (PMMA) in order to obtain a master-batch, the mixture of step i) including at least 25% and at most 75% by weight of the mineral nanoparticles. The master-batch obtained in step i) is mixed with a composition B of a thermoplastic polycarbonate matrix (PCm) in the molten state, to obtain a transparent polymer material including at most 10% by weight of the mineral nanoparticles, preferably at most 5% by weight of the mineral nanoparticles. | 02-10-2011 |
20110281989 | METHOD FOR PREPARING A TRANSPARENT POLYMER MATERIAL INCLUDING MINDERAL NANOPARTICLES WITH A SHAPE FACTOR STRICTLY HIGHER THAN 1.0 - The present invention provides a method of preparing a transparent polymer material, the method comprising steps i) and ii) in any order, the steps consisting in: | 11-17-2011 |
Laure Monconduit, Jacou FR
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20090286156 | Method for production of an anode for a lithium-ion battery - The invention relates to a method for producing an anode for a lithium-ion battery, said anode comprising a current collector formed from a transition metal M in the form of a foam and an active material comprising a binary phosphide of said metal M, said active material corresponding to the formula MP | 11-19-2009 |
20110042628 | Negative Electrode Material for Li-Ion Batteries - The present invention relates to lithium cells, accumulators and batteries, and more particularly an active material for the negative electrode of rechargeable batteries. | 02-24-2011 |
20120097890 | High Voltage Negative Active Material for a Rechargeable Lithium Battery - The invention relates to active material for the negative electrode of secondary rechargeable lithium batteries, wherein the active material is based on doped or undoped carbon-bearing lithium titanium ramsdellite oxide with general formula Li | 04-26-2012 |
Laure Moutouh-De Parseval, Basel CH
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20150265616 | Pharmaceutical Combinations Comprising a B-RAF Inhibitor, and EGFR Inhibitor and Optionally a PI3K-Alpha Inhibitor - A pharmaceutical combination comprising (a) a B-Raf inhibitor, (b) a EGFR inhibitor and, optionally, (c) a PI3K inhibitor; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination. | 09-24-2015 |
Laure Patricia Ouadji-Njiki, Laval CA
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20090047345 | Sustained-release tramadol formulations with 24-hour efficacy - A sustained-release tramadol formulation oral administration is provided which, upon initial administration of one dose, provides an analgesic effect within 2 hours, which analgesic effect continues for at least 24 hours after administration | 02-19-2009 |
20100151022 | Controlled-release compositions - A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is relatively fast. The first matrix can be a cross-linked high amylose starch and the second matrix can be a mixture of polyvinyl acetate and polyvinylpyrrolidone. | 06-17-2010 |
Laure Poigt, La Talaudiere FR
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20100116643 | DEVICE FOR GENERATING COLD PLASMA IN A VACUUM CHAMBER AND USE OF SAID DEVICE FOR THERMO-CHEMICAL PROCESSING - A device for generating a cold plasma in a vacuum enclosure includes a cathode body having hollow chambers for confining the plasma. Magnets are placed around each hollow chamber for creating a magnetic field forcing electrons to rotate about the field lines. The cathode body cooperates with an element for circulating a coolant to extract the heat generated by an intense ion bombardment at each of the hollow chambers. | 05-13-2010 |
Laure Poquet, Servion CH
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20140329904 | INCREASING THE BIOAVAILABILITY OF HYDROXYCINNAMIC ACIDS - The present invention generally relates to the field of nutrition, health and wellness. For example, the present invention relates to hydroxycinnamic acids and their health benefits. The present invention discloses compositions that allow increasing the bioavailability and/or bioefficacy of hydroxycinnamic acids. According to the invention, this can be achieved by co-administering at least one glycoside conjugate of a flavonoid with hydroxycinnamic acids. | 11-06-2014 |
Laure Quiquerez, Michelbach FR
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20160096343 | DOUBLE SHEET ALUMINUM PANEL AND METHOD FOR MANUFACTURE THEREOF - A double sheet aluminum panel has a first layer of a first aluminum material attached to a second layer of a second aluminum material by an adhesive, such as a thermosetting polymer disposed there between, producing a non-flammable panel. In a method for making the panel, the adhesive is applied to one or both sheets of aluminum, heated, then pressure rolled to distribute the adhesive into a thin film that bonds the two layers of aluminum together. The layers may be of the same or different composition and thickness and may be subjected to anodization and conversion coating. | 04-07-2016 |
Laure Ramos-Stanbury, Sceaux FR
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20100202998 | USE OF AT LEAST ONE LYSINE-DERIVED COMPOUND FOR THE CONDITIONING OF KERATINOUS FIBERS, COSMETIC COMPOSITION COMPRISING IT AND METHOD FOR CONDITIONING THE FIBERS - The present disclosure relates to a method for the conditioning of keratinous fibers comprising applying to dry or wet fibers, a cosmetic composition comprising at least one entity chosen from lysine-derived compounds of formula (I), and the salts and/or solvates thereof. The disclosure also relates to a cosmetic composition for conditioning keratinous fibers comprising, in a cosmetically acceptable medium, at least one entity chosen from lysine-derived compounds of formula (I) and the salts and/or solvates thereof and at least one cosmetic adjuvant. The disclosure also relates to a mixture of at least one entity chosen from lysine-derived compounds of formula (I) and the salts and/or solvents thereof. | 08-12-2010 |
20110052513 | CATIONIC SURFACTANT COMPOUNDS, USE THEREOF AS CONDITIONER, COSMETIC TREATMENT METHOD, AND COSMETIC OR PHARMACEUTICAL COMPOSITIONS COMPRISING SAME - The present patent application relates to novel surface-active cationic compounds, to their use, in particular as hair conditioning agent, to a cosmetic treatment method, in particular for the hair, employing the said compounds, and to the cosmetic or pharmaceutical compositions, in particular hair compositions, comprising the said surfactants. | 03-03-2011 |
20110097287 | COSMETIC COMPOSITION COMPRISING A CATIONIC SURFACTANT COMPOUND, NOVEL COMPOUNDS, USE AS CONDITIONER AND COSMETIC TREATMENT METHOD - The present patent application relates to cosmetic compositions comprising cationic compounds of quaternary ammonium esters derived from 2-[2-(diethylamino)ethoxy]ethanol type, to the use of these cationic compounds, in particular as conditioning agent, to a cosmetic treatment method, in particular a hair treatment method, employing them and to the novel cationic compounds. | 04-28-2011 |
20150250698 | ANTI-DANDRUFF SUGARS - The invention relates to the cosmetic use of at least one compounds according to the following formula (I), as an anti-dandruff agent or for preventing and/or treating scalp dandruff: where “sugar” denotes a monosaccharide residue chosen from rhamnose, xylose, fucose, mannose, lyxose, and arabinose; where R, substituting the anomeric oxygen in the sugar (represented by “O” in formula (I)), denotes a radical comprising 6 to 38 carbon atoms chosen from: —a linear or branched, saturated alkyl radical; —a linear or branched, alkenyl radical; said linear or branched saturated alkyl radical being optionally substituted by at least one OH and/or NH2 function; —if “sugar” denotes a mannose residue, R denotes a linear C6-C38 alkyl radical, substituted by at least one OH function or an NH2 function; and the salts and solvates and/or optical isomers thereof, alone or in a mixture, particularly racemic forms. The invention also relates to compounds according to formula (I), and cosmetic compositions containing same. | 09-10-2015 |
20160081889 | AQUEOUS COMPOSITION COMPRISING HYDROPHOBIC SILICA AEROGEL PARTICLES, A DEODORANT AGENT AND/OR AN ANTIPERSPIRANT ACTIVE AGENT AND A SPECIFIC ALCOHOL - A subject of the present invention is therefore a composition comprising, in a cosmetically acceptable medium: a) an aqueous phase and b) at least hydrophobic silica aerogel particles and; c) at least one alcohol of formula (I) below and also optical isomers thereof: | 03-24-2016 |
Laure Saias, Paris FR
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20110212440 | CELL SORTING DEVICE - An integrated microsystem, comprising: a microchannel, a field generator to create a magnetic field in at least one first portion of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area in fluid connection with the microchannel, | 09-01-2011 |
20110306041 | DEVICE FOR CELL CULTURE - A device for cell culture, in particular of neuronal cells, including: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second microfluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons, to extend from one chamber to the other, wherein the interconnection system of the device is made so as to promote the progression of at least one first type of cellular extension, the first and second types of extension being different either due to the microfluidic chamber from which they originate, or due to the type of cell of which they constitute an extension. | 12-15-2011 |
Laure Sonnier, Paris FR
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20090131320 | PEPTIDES MODULATING THE ACTIVITY OF THE ENGRAILED TRANSCRIPTION FACTOR - The invention relates to peptides which can become fixed to the engrailed transcription factor and which can modulate the activity thereof. | 05-21-2009 |
Laure Timperman, Tours FR
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20140168855 | NOVEL IONIC LIQUIDS THAT CAN BE USED AS PART OF THE ELECTROLYTE COMPOSITION FOR ENERGY STORAGE DEVICES - The present invention relates to ionic liquids comprising, as cation, a specific phosphonium cation, as anion, a formiate anion, which can be used, alone or as a mixture, to constitute electrolytes for energy storage devices. | 06-19-2014 |
20150187514 | COMPOSITION COMPRISING A SPECIFIC IONIC LIQUID - The invention relates to a composition comprising an ionic liquid consisting in the combination of a pyrrolidinium cation and a nitrate anion and comprising a solvent selected from lactone solvents, carbonate solvents, nitrile solvents and mixtures thereof. The composition may be used as an electrolyte, for example, for such applications as energy storage devices. | 07-02-2015 |
Laure Waegemans, Neder-Over-Heembeek BE
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20120102668 | THICKENED LIQUID HARD SURFACE CLEANING COMPOSITION - The present invention relates to a thickened alkaline liquid hard surface cleaning composition comprising a surfactant system and chelant to provide cleaning and shine. | 05-03-2012 |
Laure Waegemans, Bruxelles BE
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20110220680 | FABRIC ADDITIVE ARTICLES AND PACKAGE THEREFOR - The present invention provides an article of manufacture or package for containing and dispensing unitized doses of a laundry additive in article form. The package comprises a plurality of laundry additive articles, means for preventing exposure of the laundry articles to moisture prior to dispensing or use, and a container having a compartment and closure for enclosing the plurality of articles in the container. The container can be a tub, tray, jar, bottle, pouch, bag, box or some combination thereof and will preferably be made from polymeric materials. Optionally, the container may have dividing means for subdividing the container compartment into subcompartments so that the container can accommodate a variety of different additives in separate compartments. Optionally, but preferably, the container closure will have child resistant features as well as a window or other means for viewing the contents of the package when the closure is in a closed position. The means for preventing exposure of the articles to moisture may simply be a seal about the container closure or it may comprise separate a seal for each laundry additive article. Seals for the individual articles will preferably be a tray with a recess formed therein for receiving the laundry additive article and a polymeric film adhered to the tray over the recess to seal the article within. | 09-15-2011 |