Patent application number | Description | Published |
20090105461 | Calicheamicin conjugates - Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. | 04-23-2009 |
20100021483 | HUMANIZED ANTI-5T4 ANTIBODIES AND ANTI-5T4/CALICHEAMICIN CONJUGATES - Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same. | 01-28-2010 |
20100173382 | HUMANIZED ANTI-5T4 ANTIBODIES AND ANTI-5T4/CALICHEAMICIN CONJUGATES - Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same. | 07-08-2010 |
20120064600 | ANTI-5T4 ANTIBODIES AND USES THEREOF - Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same. | 03-15-2012 |
20120213804 | CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES - Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. | 08-23-2012 |
20140235835 | CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES - Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. | 08-21-2014 |
20140308302 | ANTI-5T4 ANTIBODIES AND USES THEREOF - Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same. | 10-16-2014 |
Patent application number | Description | Published |
20080230036 | Roller actuator for a mechanical fuel pump - A fuel pump actuator comprising a body portion and a contact end fitted to the body portion for actuating a mechanical fuel pump in response to a camshaft lobe. A roller mounted to the body portion is configured to ride on the lobe. The contact end of the actuator engages a plunger of the fuel pump. The body portion of the actuator is preferably a body portion of a conventional hydraulic valve lifter and preferably includes a lash adjuster and is reciprocally disposed in a bore on the engine block. Lubrication of the reciprocating actuator is also similar to the lubrication provided to conventional valve lifters and lash adjusters. The contact end of the actuator is configured to reduce the mass of the actuator. Several styles of the contact end and ways of attaching the contact end to the body portion are provided. | 09-25-2008 |
20080314340 | Two-step roller finger cam follower assembly having a follower travel limiter - A two-step roller finger follower assembly for use in conjunction with a camshaft of an internal combustion engine, wherein the camshaft has at least one first lobe and at least one second lobe. The roller finger follower assembly comprises a follower body for engaging the first cam lobe and having a central aperture, a follower pivotably disposed on the follower body in the central aperture for engaging the second cam lobe, and a limiting stop disposed on the follower body for engaging a feature on the follower to limit travel of the follower body with respect to the follower. The limiting stop prevents overtravel of the follower body during valve-deactivation mode of the assembly, thus preventing excessive leak down of an associated hydraulic lash adjuster. | 12-25-2008 |
20090048729 | METHOD FOR DIAGNOSING THE OPERATIONAL STATE OF A VARIABLE VALVE ACTUATION (VVA) DEVICE USING A KNOCK SIGNAL - A method for determining whether a variable valve actuation (VVA) device or subsystem is operating in an improper mode of operation is performed in real-time by an embedded engine or powertrain controller configured to monitor and evaluate an already-available knock sensor output signal. The knock sensor output is captured during a predefined sampling window, defined to include a valve closing event when the VVA device is operating in a proper mode. The captured knock sensor output signal is processed to detect the presence (or absence) of a valve closing event. The absence of a valve closing event when one is expected is indicative of a malfunctioning VVA device. | 02-19-2009 |
20090272365 | Cam lobe profile for driving a mechanical fuel pump - In a fuel-pumping system in an internal combustion engine, a mechanical fuel pump roller actuator is slidably disposed to ride on a dedicated tri-lobate camshaft lobe. In prior art camshaft lobes for this purpose, a portion of the lift profile over a certain angle of camshaft rotation imparts a constant velocity, and hence zero acceleration and zero jerk, to the roller actuator. It has been found that such areas of zero acceleration give rise to undesirably high contact stress between the lobe and the roller actuator. In a method in accordance with the present invention, a reference radius of curvature of a reference camshaft lobe lift profile is adjusted such that, between regions of minimum lift and maximum lift, there are no regions imparting zero acceleration to the actuator and maximum contact stress is reduced. | 11-05-2009 |
20100000476 | Anti-Rotation Feature for an Engine Tappet - An alignment feature for preventing in-bore rotation of an engine tappet. A first portion extends outwards from a tappet and a second portion extends into a hole in the tappet. The first portion extends longitudinally past the mounting hole such that when the feature and tappet are installed in an engine bore, the entire feature is prevented from rotation within the hole. The second portion extending orthogonally from the first portion into the mounting hole need not be close-fitting to the hole. The first portion may be substantially semi-cylindrical, having a convex cylindrical outer surface for fitting the walls of a semi-cylindrical channel in the engine bore and a concave cylindrical inner surface for fitting the outer wall of the tappet. The pin portion is preferably cylindrical. Other pin shapes are possible. The alignment feature may or may not be hardened. | 01-07-2010 |