Kriger
Inna V. Kriger, College Station, TX US
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20100113477 | Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof - The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl-naphthyl-, or thienyl-substituted diketo acids and carboxylate derivatives thereof. Also provided are methods of treating tuberculosis or other pathophysiological conditions associated with a malate synthase enzyme with the inhibitory compounds and methods of in silico design of the inhibitory compounds. In addition, the present invention provides the inhibitory compounds designed by this method. Furthermore, three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds are provided. Further still a method for stabilizing an aromatic or heteroaromatic diketo acid or its prodrug or close analog in solution by derivatizing at least the ortho position on the aromatic ring is provided. | 05-06-2010 |
20140171444 | Inhibitors of Mycobacterium Tuberculosis Malate Synthase, Methods of Making and Uses Thereof - The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl- naphthyl-, or thienyl-substituted diketo acids and carboxylate derivatives thereof. Also provided are methods of treating tuberculosis or other pathophysiological conditions associated with a malate synthase enzyme with the inhibitory compounds and methods of in silico design of the inhibitory compounds. In addition, the present invention provides the inhibitory compounds designed by this method. Furthermore, three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds are provided. Further still a method for stabilizing an aromatic or heteroaromatic diketo acid or its prodrug or close analog in solution by derivatizing at least the ortho position on the aromatic ring is provided. | 06-19-2014 |
Joshua F. Kriger, Cambridge, MA US
Patent application number | Description | Published |
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20090066722 | System, Device, and Method for Conveying Information Using Enhanced Rapid Serial Presentation - A method for rendering a rapid serial presentation on a consumer device having at least a display screen involves rendering a portion of the rapid serial presentation on the display screen of the consumer device, automatically pausing rendering of the rapid serial presentation, displaying a message on the display screen for a quantum of time during such pausing, and thereafter resuming rendering of the rapid serial presentation on the display screen. The message may include an advertisement, a suggested action, or a question presented to a consumer. RSP content and non-RSP content may be rendered at different locations of the display screen. | 03-12-2009 |
Marc Kriger, Mercer Island, WA US
Yefim Kriger, Ansonia, CT US
Patent application number | Description | Published |
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20090132099 | Vehicle with on-board overweight and obesity preventing system and method - A motor vehicle and a method of operating same, including an on-board vehicle microcomputer having a memory, and a display connected to the microcomputer. An on-board weighing apparatus located in the vehicle is adapted to weigh a person in the vehicle and provide an input to the on-board vehicle microcomputer of the weight of the person from time to time, whereby a weight trend can be analyzed for the person and overweight or obesity condition of the person that may develop in a short period of time, if any, will be forecasted and information of such weight trends provided to a health care professional to prevent it. | 05-21-2009 |
Yefim G. Kriger, Ansonia, CT US
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20080294370 | GLOBAL OVERWEIGHT AND OBESITY PREVENTING AND TRACKING SYSTEM AND METHOD - An obesity preventing and tracking system, the system comprising: at least one in-building overweight and obesity preventing module for collecting anthropometry information from a person at a fixed location in order to forecast and prevent development of an obesity condition; and/or at least one on-board vehicle overweight and obesity preventing module for collecting the anthropometry information from the person in a vehicle operable by the person in order to forecast and prevent development of an obesity condition and/or at least one entertainment overweight and obesity preventing module for collecting anthropometry information from said person while said person is a guest at an entertainment facility in order to forecast and prevent development of an obesity condition; and a communications network for linking at least one in-building overweight and obesity preventing module and at least one on-board vehicle overweight and obesity preventing module and at least one entertainment overweight and obesity preventing module to a trend obesity preventing service for predicting the development of an obesity condition of the person. | 11-27-2008 |
20110096558 | MULTI-ENERGY VEHICLE ILLUMINATING SYSTEM AND METHOD - A vehicle multi-energy illuminating system is disclosed. The system having at least one multi-energy source module configured to collect waste energy from a vehicle headlamp, the at least one a multi-energy source module having at least one photovoltaic device configured to collect infrared energy and at least one photovoltaic device configured to collect visible light energy from the vehicle headlamp: at least one solar energy source module configured to collect visible light energy not generated from the vehicle headlamp bulb; a rechargeable battery coupled to the least one multi-energy source module and the at least one solar energy source module, the rechargeable battery being configured to collect and store the waste energy from the headlamp bulb and the visible light energy not generated from the vehicle headlamp bulb; a safety light; a light sensor; and a microcontroller coupled to the rechargeable battery, the safety light and the light sensor, wherein the microcontroller illuminates the safety light by coupling the safety light to the rechargeable battery when the light sensor provides a signal to the microcontroller indicating that detected light is below a predetermined value. | 04-28-2011 |
20140353048 | TECHNOLOGY AND METHODS OF ON-BOARD VEHICLE OCCUPANT ACCURATE WEIGHING BY A SIMPLIFIED WEIGHING APPARATUS BASED ON WEIGHING MODERATOR AND ITS APPLICATIONS IN ON-BOARD OCCUPANT WEIGHING SYSTEMS - An on-board vehicle occupant weighing technology includes a simplified vehicle occupant weighing apparatus based on the discovered horwest effect and weighing moderator. The simplified weighing apparatus utilizes a weighing unit connected to the car seat of the vehicle occupant and a further weighing moderator, which provides convenient weighing of the foot part of the occupant's body by the same weighing unit that is connected to the car seat. The technology employs several methods of the weight measurements provided by different moderator approaches. The technology, methods, and simplified weighing apparatus are employed in on-board vehicle overweight and obesity preventing system wherein a weight trend analyzer provides predicting possibility of the occupant's overweight or obesity in a short predetermined period of time and automatically warning a vehicle occupant and a health care provider of the condition. The technology may also provide an accurate and convenient occupant's weight measurement in the vehicle safety devices such as seat belt and air bag Supplemental Restraint System (SRS system) to improve the Occupant Classification System to prevent possible extra force applied to the occupant's body in case of collision. | 12-04-2014 |