Patent application number | Description | Published |
20100216238 | COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING - Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. | 08-26-2010 |
20110159587 | Chimeric Molecules to Modulate Gene Expression - The present invention provides a chimeric molecule including a base-pairing segment that binds specifically to a single-stranded nucleic acid molecule; and a moiety that modulates splicing or translation. The invention also provides a chimeric molecule including a base-pairing segment that binds specifically to a double-stranded nucleic acid molecule; and a peptide that modulates transcription, wherein the peptide comprises up to about one hundred amino acid residues. | 06-30-2011 |
20120149757 | COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING - Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. | 06-14-2012 |
20130109091 | COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING | 05-02-2013 |
20130289092 | COMPOUNDS AND METHODS FOR MODULATING INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS - Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA. | 10-31-2013 |
20140011977 | CHIMERIC MOLECULES TO MODULATE GENE EXPRESSION - The present invention provides a chimeric molecule including a base-pairing segment that binds specifically to a single-stranded nucleic acid molecule; and a moiety that modulates splicing or translation. The invention also provides a chimeric molecule including a base-pairing segment that binds specifically to a double-stranded nucleic acid molecule; and a peptide that modulates transcription, wherein the peptide comprises up to about one hundred amino acid residues. | 01-09-2014 |
20140357558 | COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY - Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy. | 12-04-2014 |
20150025231 | COMPOSITIONS AND METHODS FOR MODULATION OF IKBKAP SPLICING - The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia. | 01-22-2015 |
20150275211 | ANTISENSE COMPOUNDS AND USES THEREOF - The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer. | 10-01-2015 |
20150353929 | COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING - Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. | 12-10-2015 |
Patent application number | Description | Published |
20140072429 | CIRCUITS, SYSTEMS AND METHODS FOR INTEGRATING SENSING AND HEATING FUNCTIONS - Embodiments relate to integrated circuits, systems and methods for combined sensing and heating functions in structures suitable for use in deicing, heating and other applications. In an embodiment, an integrated circuit is coupled to a heating element and configured to control operation of the heating element to provide heat as well as to utilize the heating element as at least part of a sensing structure to sense the presence of ice, water or air on or near the heating element. In embodiments, the heating element comprises a conductive polymer structure, and the presence of ice, water or air is sensed based on a capacitance, impedance or other spectroscopy of the structure sensed and analyzed by integrated circuitry coupled to the structure. | 03-13-2014 |
20150016163 | DETECTOR AND A VOLTAGE CONVERTER - A detector for detecting an occurrence of a current strength of interest of a current of a signal to be sensed includes a magnetoresistive structure and a detection unit. The magnetoresistive structure varies a resistance depending on a magnetic field caused by the current of the signal to be sensed. Further, the detection unit generates and provides a current detection signal indicating an occurrence of the current strength of interest based on a detected magnitude of the varying resistance of the magnetoresistive structure. | 01-15-2015 |
20160025403 | TEMPERATURE REGULATING SYSTEM AND METHOD OF DEICING THE TEMPERATURE REGULATING SYSTEM - In one example, a temperature regulating system, the system comprising temperature regulating device including a hot side and a cold side; and an icing sensor disposed on the cold side and which provides an output which changes based on a condition of the cold side; wherein the system is configured to detect, via the output of the icing sensor, icing of the cold side during a temperature regulating operation, and initiate deicing of the cold side based on the detection of the icing of the cold side. | 01-28-2016 |