Kraan
Heleen Kraan, Oudewater NL
Patent application number | Description | Published |
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20150030629 | METHODS AND COMPOSITIONS FOR STABILIZING DRIED BIOLOGICAL MATERIALS - The present invention relates to methods for producing dried formulations of biopharmaceutical agents that aim to minimize the loss of activity of the agents upon drying and to provide dried formulations with an extended shelf life. The method comprises the step of drying an aqueous solution comprising, in addition to the biopharmaceutical agent, at least an amino acid, a polyol and a metal salt. Preferably the amino acid is glutamate, the polyol is sorbitol and optionally also mannitol and the metal salt is a magnesium salt. The solution is dried by vacuum drying or by lyophilization. The methods are particularly useful for preparing dried formulations of viruses such as poliovirus or respiratory syncytial virus to be used for vaccination. The invention also relates to dried formulations prepared in accordance with the methods of the invention and to their use as medicaments, e.g. as vaccines. | 01-29-2015 |
Jaco Kraan, Rotterdam NL
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20120178645 | IDENTIFYING CIRCULATING TUMOR CELLS (CTCS) USING CD146 IN BREAST CANCER PATIENTS - The present invention relates to a method for diagnosing cancer in a subject said method comprising the steps of providing a biological sample from a subject, and determining the expression of the MCAM gene in a circulating tumor cell (CTC) in said biological sample. | 07-12-2012 |
Stefan Kraan, County Galway IE
Patent application number | Description | Published |
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20120177806 | NATURAL AND SUSTAINABLE SEAWEED FORMULA THAT REPLACES SYNTHETIC ADDITIVES IN FISH FEED - A seaweed-based commercial salmon feed additive which replaces the synthetic chemical additives that are currently used in salmon fish feed is provided. Synthetic additives are replaced with a combination of seaweed species thereby providing a natural product that improves the nutritional value of the farmed fish, qualifies the fish for marketing as organic, reduces the environmental impact of fish farming practices and may replace the chemical use of lice treatment. | 07-12-2012 |
Stefan Kraan, Headford, County Galway IE
Patent application number | Description | Published |
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20160000117 | NATURAL AND SUSTAINABLE SEAWEED FORMULA THAT REPLACES SYNTHETIC ADDITIVES IN SWINE FEED - A seaweed-based commercial swine feed additive which replaces the synthetic chemical additives that are currently used in swine feed is provided. Synthetic additives are replaced with a combination of seaweed species thereby providing a natural product that improves the nutritional value of the pork, and may replace the chemical use of antibiotics. | 01-07-2016 |