Patent application number | Description | Published |
20100092957 | COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING - The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group. | 04-15-2010 |
20110020853 | COMPOSITIONS AND METHODS FOR DETECTING PHOSPHOMONOESTER - The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of the first carbodiimide compound to the electrophilic moiety over the phosphomonoester moiety, thereby forming an electrophile-protected target compound; and (c) contacting the electrophile-protected target compound with a second carbodiimide compound and a nucleophilic compound under conditions for addition of the nucleophilic compound to the phosphomonoester. | 01-27-2011 |
20130244888 | COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING - The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group. | 09-19-2013 |
20140370498 | COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING - The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group. | 12-18-2014 |
Patent application number | Description | Published |
20110245101 | CO-LOCALIZATION AFFINITY ASSAYS - The invention provides a new assay format for high throughput molecular binding studies at a single molecule level. The invention enables creation of binding event identifiers in a highly parallel way. Individual binding events occur between two agents of a binding pair, e.g., a protein-based binding pair or a binding pair comprising a protein and a chemical moiety. The binding event identifier created through the binding of the two binding agents is unique to that pair, and identification of the binding event identifier is indicative of the binding of these specific may be assessed through a readout that is digital in nature. The invention enables very large sets of thousands or more of different binding agents or potential binding agents to be assayed simultaneously, resolving millions or more of potential interactions, and distinguishing specific interactions from those that are less specific. | 10-06-2011 |
20120129248 | ASSAY TOOLS AND METHODS OF USE - The present invention provides assay tools for the detection of biological or chemical activity in a sample. The assay tools of the invention provide direct detection using a positive signal generated on a surface of the assay tool. These assay tools provide improved methods for detection and/or identification of multiple agents (e.g., enzymes) in a sample, analysis of substrate specificity of such agents, and binding affinities and specificities of such agents. Upon activity a component is released from a first immobilised construct and then captured by a capture surface. At least two different immobilised constructs are used. | 05-24-2012 |
20120258871 | PEPTIDE CONSTRUCTS AND ASSAY SYSTEMS - The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome. | 10-11-2012 |
20140051589 | PEPTIDE CONSTRUCTS AND ASSAY SYSTEMS - The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome. | 02-20-2014 |
Patent application number | Description | Published |
20090164641 | Media Toolbar and Aggregated/Distributed Media Ecosystem - A method and network architecture through which user-specific media profile data can be made available to third parties. A browser is optionally enhanced to facilitate playback and control of one or more media players, thereby allowing the user to play content via the browser. As the user plays content in the browser or any of the media players, information is collected about the content and stored in a database. By monitoring all media-related interactions made by the user within the browser, the collected content information can encompass information from a wide range of sources. User-specific profile data is then determined based on the collected data and such user-specific profile data is made available to third parties. The user-specific profile data can be used, for example, for social networking purposes, and may also be used to drive advertisements or other content to the user. | 06-25-2009 |
20130185422 | MEDIA TOOLBAR AND AGGREGATED/DISTRIBUTED MEDIA ECOSYSTEM - A method and network architecture through which user-specific media profile data can be made available to third parties. A browser is optionally enhanced to facilitate playback and control of one or more media players, thereby allowing the user to play content via the browser. As the user plays content in the browser or any of the media players, information is collected about the content and stored in a database. By monitoring all media-related interactions made by the user within the browser, the collected content information can encompass information from a wide range of sources. User-specific profile data is then determined based on the collected data and such user-specific profile data is made available to third parties. The user-specific profile data can be used, for example, for social networking purposes, and may also be used to drive advertisements or other content to the user. | 07-18-2013 |
Patent application number | Description | Published |
20130187914 | Method and Apparatus for Rendering and Modifying Terrain in a Virtual World - A system for rendering virtual terrain includes an Internet-connected server and software executing on the server from a non-transitory physical medium, the software providing a first function for building a basic terrain from geometric blocks, a second function for analyzing surrounding terrain properties, a third function for adding or subtracting blocks from the terrain, and a fourth function for smoothing the final terrain surfaces. | 07-25-2013 |
20140213369 | Player-Side Cache - A method includes steps of opening a link between a player's appliance and a network-connected server providing games, selecting a game to play by the player through an interface provided to the player's appliance by the server, transmitting virtual world data by the server to the player's appliance, along with a version identification, storing the virtual world data and associated version identification in a cache at the player's appliance, playing the game by the player using the player's appliance, and suspending play of the game by the player. | 07-31-2014 |
20140342823 | Lighting Management in Virtual Worlds - A system has a server with a processor, a storage medium and coded instructions executable on the processor causing the server to display a video game to a player operating a computer, the video game comprising a virtual world having objects with surfaces, movable in the space of the virtual world by the player, and one or more light sources, create and manage a voxel grid associated with the player, compute an occupancy value for individual ones of the cells of the grid, compute an illumination value for cells of the grid by consideration of position and direction of the light sources, the occupancy value of the cell, and illumination values of immediately adjacent cells in the voxel grid, and determine brightness for pixels in display of surfaces of objects in frames of the video game based on the illumination values of cells proximate to the surfaces of the objects. | 11-20-2014 |