Patent application number | Description | Published |
20100016669 | FLUORESCENCE ENDOSCOPE SYSTEM - Provided is a fluorescence endoscope system for observing fluorescence from a fluorochrome attached to or absorbed in biological tissue, including an excitation light source that emits excitation light that excites the fluorochrome; an image-acquisition section that acquires fluorescence emitted from the biological tissue when irradiated with the excitation light from the excitation light source; an autofluorescence signal setting section that sets an autofluorescence signal intensity to be emitted from the biological tissue when irradiated with the excitation light; and an image compensation section that compensates fluorescence image information acquired by the image-acquisition section on the basis of the autofluorescence signal intensity set by the autofluorescence signal setting section. | 01-21-2010 |
20100036203 | ENDOSCOPE SYSTEM - It is possible to acquire a fluorescence distribution image for each fluorescent agent from a fluorescence image acquired in a mixed state, thus improving the diagnostic performance of cancer cells. There is provided an endoscope system ( | 02-11-2010 |
20100094136 | ENDOSCOPE SYSTEM - A fluorescence distribution image of each fluorescent agent can be acquired from a fluorescence image that has been captured in a mixed state so as to improve the diagnosability of cancer cells. An endoscope system comprises: a light source section for selectively irradiating two or more types of excitation lights having different spectral characteristics so as to excite two or more types of fluorescent agents having different optical characteristics; an imaging section provided on a part to be inserted into a body cavity, and having a light-receiving sensitivity in the wavelength bands of the two or more types of fluorescence radiated from the observation target by respective types of excitation lights; a storage section for storing relation information between the fluorescence intensity and the concentration of each of the fluorescent agents; a concentration information computing section for computing concentration information of each of the fluorescent agents on the basis of the fluorescence intensities of two or more images captured by the imaging section and the relation information stored in the storage section, and outputting the concentration information; and a mode switching section capable of switching between a first fluorescence observation mode in which at least one of the fluorescence intensity images acquired by the imaging section is presented, and a second fluorescence observation mode in which the concentration information of each of the fluorescent agents computed by the concentration information computing section is presented. | 04-15-2010 |
20100106013 | FLUORESCENCE OBSERVATION DEVICE FOR ORGANISM TISSUE - The concentration distribution of a fluorescence dye capable of selectively staining normal tissue and abnormal tissue is accurately observed by eliminating the unevenness due to irregular distance from the distal end of an endoscope to an organism surface or the surface roughness of the organism. There is provided a fluorescence observation device for organism tissue comprising: an excitation light optical system for irradiating an organism tissue adhered or infiltrated with a first fluorescence dye whose stainability is different between normal tissue and abnormal tissue in the organism tissue, and a second fluorescence dye whose fluorescence wavelength or absorption wavelength is different from that of the first fluorescence dye and whose stainability is nonselective between normal tissue and abnormal tissue in the organism tissue, with excitation light which excites the first fluorescence dye and the second fluorescence dye, either simultaneously or in a time sharing manner; a fluorescence detecting section for separately detecting fluorescence from the first fluorescence dye and fluorescence from the second fluorescence dye excited by the excitation light from the excitation light optical system; a compensation processing section for compensating the fluorescence information from the first fluorescence dye, based on the fluorescence information from the second fluorescence dye detected by the fluorescence detecting section; and a display section for displaying the fluorescence information compensated by the compensation processing section. | 04-29-2010 |
20110009702 | FLUORESCENCE OBSERVATION APPARATUS - The number of ACF can be readily counted without overlooking the existence of ACF to achieve reduced observation time. A fluorescence observation apparatus includes a light source unit inserted into a body cavity of a biological organism and emitting excitation light onto an inner wall of the body cavity; an image acquisition unit that acquires image information by acquiring an image of fluorescence generated when a fluorescent probe whose fluorescence characteristic changes by reacting with a molecule existing in an ACF formed in the inner wall of the body cavity is excited by the excitation light; a position control unit that moves the light source unit and the image acquisition unit relative to the inner wall of the body cavity; and a counting section that counts the number of fluorescence generation sites included in the image acquired by the image acquisition unit. | 01-13-2011 |
20110068278 | FLUORESCENCE OBSERVATION APPARATUS - To accurately obtain fluorescence intensity in a variable passband. Provided is a fluorescence observation apparatus including an excitation light source that emits excitation light; a Fabry-Perot resonator including a variable passband in which the wavelength of light that passes therethrough changes with changes in distance between the surfaces of optical members opposing each other with a distance therebetween, a fixed passband in which the wavelength of light that passes therethrough does not change irrespective of changes in the distance between the surfaces, and a transition band therebetween; an excitation-light cut filter that blocks passage of the excitation light; a band cut filter having a cut-off band including the transition band and not including the wavelength of the excitation light; and a photodetector that detects fluorescence that has passed through the Fabry-Perot resonator, the excitation-light cut filter, and the band cut filter. | 03-24-2011 |
20140092282 | SPECTRAL IMAGING APPARATUS - A spectral imaging apparatus includes a variable wavelength spectroscopic element changing a distance between surfaces of a pair of optical substrates opposite to each other to change a peak wavelength, a light splitting unit which splits light transmitted by the variable wavelength spectroscopic element into components in each of the predetermined wavelength ranges, and image-capturing units each of which captures only a spectral image formed by the components in each of the wavelength ranges into which the transmitted light is split by the light splitting unit, the wavelength ranges including the peak wavelengths respectively. | 04-03-2014 |
20140316279 | BIOLOGICAL OBSERVATION APPARATUS - Provided is a biological observation apparatus including irradiating portions that radiate illumination light onto biological tissue, an imaging portion that, of reflected light reflected at the biological tissue due to the illumination light radiated by the irradiating portions, captures reflected light in a wavelength band in which an absorption characteristic of β-carotene is greater than an absorption characteristic of hemoglobin, thus acquiring a reflected-light image, and a display portion that displays the reflected-light image acquired by the imaging portion. | 10-23-2014 |