Patent application number | Description | Published |
20110132562 | WAXLESS PRECISION CASTING PROCESS - Alloy products are produced with a waxless casting process. A model of a ceramic casting vessel ( | 06-09-2011 |
20110204205 | CASTING CORE FOR TURBINE ENGINE COMPONENTS AND METHOD OF MAKING THE SAME - A turbine engine component, such as a turbine blade or vane, with complex internal features can be cast using a core having a first region with normal resolution features and a second region with high resolution features. The core can be formed from a single structure. Alternatively, the first region can be defined by a first ceramic core piece, which can be formed by any conventional process, such as by injection molding or transfer molding. The second region can be defined by a second ceramic core piece formed separately by a method effective to produce high resolution features, such as tomo lithographic molding. The first core piece and the second core piece can be joined by interlocking engagement, such as by male and female dovetails. The high resolution features can be effective to produce high efficiency internal cooling features in the cast component. | 08-25-2011 |
20120177503 | COMPONENT COOLING CHANNEL - A cooling channel ( | 07-12-2012 |
20130139990 | Systems, Devices, and/or Methods for Producing Holes - Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, and/or composition of matter adapted for and/or resulting from, and/or a method for activities that can comprise and/or relate to, a first form comprising: a plurality of surface artifacts that substantially spatially replicate a surface geometry of a stacked foil mold; and a prong that is adapted to form a hole in a cast product. | 06-06-2013 |
20140241938 | PRECISION CASTING PROCESS - A ceramic casting vessel ( | 08-28-2014 |
20140286791 | Component Cooling Channel - A cooling channel ( | 09-25-2014 |
20140342176 | Systems, Devices, and/or Methods for Producing Holes - Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, and/or composition of matter adapted for and/or resulting from, and/or a method for activities that can comprise and/or relate to, a first form comprising: a plurality of surface artifacts that substantially spatially replicate a surface geometry of a stacked foil mold; and a prong that is adapted to form a hole in a cast product. | 11-20-2014 |
20150118034 | TRAILING EDGE COOLING USING ANGLED IMPINGEMENT ON SURFACE ENHANCED WITH CAST CHEVRON ARRANGEMENTS - A gas turbine engine component, including: a pressure side ( | 04-30-2015 |
Patent application number | Description | Published |
20130238170 | AUTONOMOUS VEHICLE AND METHOD FOR COORDINATING THE PATHS OF MULTIPLE AUTONOMOUS VEHICLES - A method for coordinating the paths of multiple autonomous vehicles and a vehicle configured to coordinate its path with the path(s) of other vehicles so as to enhance cooperation between the vehicles. The method also enables the vehicles to perform their respective missions more efficiently. The method is applicable to any system in which multiple autonomous vehicles may need to coordinate their paths with each other. | 09-12-2013 |
20140081505 | AUTONOMOUS VEHICLE AND METHOD FOR COORDINATING THE PATHS OF MULTIPLE AUTONOMOUS VEHICLES - A non-transitory processor-readable medium storing code causes a processor at a first vehicle (e.g., a first autonomous vehicle) to generate a first planned path based on a current position of the first vehicle and a mission requirement assigned to the first vehicle. A first planned path associated with a second vehicle (e.g., a second autonomous vehicle), which is based on a current position of the second vehicle and a mission requirement assigned to the second vehicle, is received at the first vehicle. After the first planned path associated with the second vehicle is received, a second planned path is generated based on the first planned path associated with the second vehicle and at least one of the mission requirement assigned to the first vehicle or the first planned path of the first vehicle. The second planned path of the first vehicle is transmitted to the second vehicle. | 03-20-2014 |
20150025713 | AUTONOMOUS VEHICLE AND METHOD FOR COORDINATING THE PATHS OF MULTIPLE AUTONOMOUS VEHICLES - A non-transitory processor-readable medium storing code causes a processor at a first vehicle (e.g., a first autonomous vehicle) to generate a first planned path based on a current position of the first vehicle and a mission requirement assigned to the first vehicle. A first planned path associated with a second vehicle (e.g., a second autonomous vehicle), which is based on a current position of the second vehicle and a mission requirement assigned to the second vehicle, is received at the first vehicle. After the first planned path associated with the second vehicle is received, a second planned path is generated based on the first planned path associated with the second vehicle and at least one of the mission requirement assigned to the first vehicle or the first planned path of the first vehicle. The second planned path of the first vehicle is transmitted to the second vehicle. | 01-22-2015 |
Patent application number | Description | Published |
20140342360 | METHOD OF MEASURING IMMUNE ACTIVATION - The invention is directed to methods for measuring immune activation by the level of clonotypes having the same unique regions and different isotype-determining regions. In one aspect, the method of the invention comprises forming a sequence-based clonotype profile from a sample containing B lymphocytes, wherein each clonotype of such profile comprises a unique region, such as a portion of a VDJ segment, and an isotype determining region, such as a portion of a C gene segment. Immune activation is indicated whenever the level of such clonotypes exceeds an upper bound of a reference range determined from multiple individual measurements or population measurements. | 11-20-2014 |
20150031043 | DETERMINING PAIRED IMMUNE RECEPTOR CHAINS FROM FREQUENCY MATCHED SUBUNITS - The invention is directed to methods for determining nucleic acids that encode immune receptor chains originating from the same cell, that is, paired immune receptor chains. Methods of the invention comprise high-throughput sequencing of rearranged nucleic acids encoding immune receptors from one or more samples of lymphocytes. In one aspect, from a plurality of subsets of a sample, nucleic acids encoding separate chains of a pair are separately sequenced, wherein the size of the sample and the number of subsets are selected so that the distribution of lymphocytes approximates a binomial model. Paired chains are determined by identifying pairs that appear together or that are entirely absent in the subsets. | 01-29-2015 |
20150031553 | METHOD OF MEASURING IMMUNE ACTIVATION - The invention is directed to a method of detecting immune activation in an individual by measuring frequencies and sizes of certain groups of related clonotypes, referred to herein as “clans,” in a clonotype profile of the individual. A clan may arise from a single lymphocyte progenitor that gives rise to many related lymphocyte progeny, each possessing and/or expressing a slightly different immunoglobulin receptor due to somatic mutation(s), such as base substitutions, inversions, related rearrangements resulting in common V(D)J gene segment usage, or the like. Immune activation is correlated to frequencies and sizes of clans in a clonotype profile exceeding reference values for those features. | 01-29-2015 |
20150038346 | MONITORING IMMUNE RESPONSIVENESS TO CANCER VACCINATION - The invention is direct to a method for determining a cancer patient's immune responsiveness to anti-cancer vaccination. In one aspect, for each of a plurality of vaccinations, pairs of clonotype profiles are obtained, one immediately prior to vaccination and one during the period of peak immune response, usually within two to twenty days after the vaccination. Responsiveness is correlated to successive increases in identical clonotypes within each pair of clonotype profiles in at least two successive vaccinations. | 02-05-2015 |
20150247198 | MONITORING CLONOTYPES OF PLASMA CELL PROLIFERATIVE DISORDERS IN PERIPHERAL BLOOD - The invention is directed to sequencing-based methods for monitoring a minimal residual disease of a plasma cell proliferative disorder, such as multiple myeloma and/or MGUS, by one or more clonotypes correlated with the disorder. In some embodiments, such methods comprise the following steps: (a) obtaining a sample of peripheral blood from the patient; (b) amplifying molecules of nucleic acid from the sample, the molecules of nucleic acid comprising recombined DNA sequences from immunoglobulin genes; (c) sequencing the amplified molecules of nucleic acid to form a clonotype profile; and (d) determining from the clonotype profile a presence, absence and/or level of one or more patient-specific clonotypes correlated with the plasma cell proliferative disorder and phylogenic clonotypes thereof. | 09-03-2015 |
Patent application number | Description | Published |
20130150252 | DETECTION AND MEASUREMENT OF TISSUE-INFILTRATING LYMPHOCYTES - The present invention is drawn to methods for measuring numbers, levels, and/or ratios of cells, such as lymphocytes, infiltrated into a solid tissue, such as a tumor or a tissue affected by an autoimmune disease, and to methods for making patient prognoses based on such measurements. In one aspect, methods of the invention comprise sorting lymphocytes from an accessible tissue, such as peripheral blood, into functional subsets, such as cytotoxic T cells and regulatory T cells, and generating clonotype profiles of each subset. An inaccessible disease-affected tissue is sampled and one or more clonotype profiles are generated. From the latter clonotype profiles, levels lymphocytes in each of the functional subsets are determined in the disease-affected tissue by their clonotypes, which are identified from lymphocytes sorted into subsets from the accessible tissue. | 06-13-2013 |
20130202718 | MONITORING IMMUNOGLOBULIN HEAVY CHAIN EVOLUTION IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA - The invention is directed to methods of monitoring B-cell lymphoid proliferative disorders, such as B-cell acute lymphoblastic leukemias, by measuring the presence, absence and/or levels of correlating, or index, clonotypes and related clonotypes that have evolved therefrom, for example, as part of the disease condition. In one aspect, such methods are implemented by generating sequencing-based clonotype profiles and determining frequencies of correlating, or index, clonotypes present, including new clonotypes that have evolved therefrom, particularly, in the case of B-cell ALL, by VH substitution. The invention also includes use of such monitoring information to modify treatment status of a patient. | 08-08-2013 |
20150275296 | DETERMINING ANTIGEN-SPECIFIC T-CELLS - The invention is directed to methods for determining antigen-specific T cells. In some embodiments, methods of the invention may be implemented by the steps of reacting under interaction conditions one or more antigens with T cells in a plurality of subsets of a tissue sample, such as peripheral blood; sorting antigen-interacting T cells from other T cells; separately sequencing for each subset recombined nucleic acid encoding a segment of a TCR chain from a sample of T cells prior to exposure to antigen and from a sample of T cells isolated based on their interaction with antigen, thereby forming a clonotype profile for the former sample and the latter sample for each subset; and identifying as antigen-specific T cells those T cells associated with a clonotype whose frequency increases in the latter sample relative to its frequency in the former sample. | 10-01-2015 |
Patent application number | Description | Published |
20080282669 | PARTICULATE FILTER HAVING EXPANSIBLE CAPTURE STRUCTURE FOR PARTICULATE REMOVAL - A combustion engine comprising an exhaust system containing a particulate filter ( | 11-20-2008 |
20090091113 | EXTENDABLE BUS CROSSING ARM - A crossing arm for a vehicle having a longitudinal axis includes a plurality of hollow telescoping members. The telescoping members are mounted onto the vehicle and configured for extension parallel to the longitudinal axis. The members define a variable volume chamber, where the chamber has a minimum volume when the members are nested, and the chamber has a maximum volume when the members are extended. An actuator is in fluid communication with the plurality of telescoping members and is configured for delivering fluid to the chamber to move at least one telescoping member with respect to a second telescoping member to extend the crossing arm. | 04-09-2009 |
20090139442 | PIVOTABLE BUS CROSSING ARM - A crossing arm for a vehicle having a longitudinal axis includes a body pivotably mounted onto the vehicle and configured for extension from a surface of the vehicle. The body has a free-standing, upwardly vertical position generally perpendicular to the longitudinal axis, and a horizontal position generally cantilevered from the vehicle and parallel to the longitudinal axis. An actuator is configured for pivoting the body from a vertical position to a horizontal position. | 06-04-2009 |
20100032222 | Auxiliary Power Units For Vehicles - Cooperative operation of an auxiliary power unit having a mechanical power output shaft with a transmission coupled power takeoff operation system of a vehicle is provided by allowing the vehicle's main engine to be cranked by the auxiliary power unit through the power takeoff operation system. | 02-11-2010 |
20100070153 | Engine Idle Control Using GPS Telematics - A vehicle reporting its position, typically derived from a global positioning or other navigation system, implements idle time limitation protocols based on its position. The particular protocol can be derived from a central, updated location using a telematics link. | 03-18-2010 |
20100108411 | AIR POWER ENERGY TRANSFORMATION TO ELECTRICAL ENERGY FOR HYBRID ELECTRIC VEHICLE APPLICATIONS - A vehicle having one or more small vehicle-mounted electricity generating wind turbines located within an area of wind recirculation. The electricity generated is used to recharge vehicle batteries, partially power an auxiliary electric propulsion motor, or supply vehicle parasitic loads. | 05-06-2010 |
20110011073 | INTERACTIVE PARASITIC DEVICES FOR ENGINE PERFORMANCE IMPROVEMENT - A motor vehicle power take off system for a motor vehicle engine includes a viscous coupling. The input rotor of the viscous coupling is provided with a variable geometry impeller section which allows direct control over the proportion of input torque on the input shaft transferred to the viscous fluid and thereby to an output shaft. Both passive and active control schemes are proposed. | 01-20-2011 |
Patent application number | Description | Published |
20100161371 | Governance Enactment - Software systems and methods for governance are presented supporting governance solution specification and enactment including assessing, defining, implementing deployment, and executing of the governance solution. For example, a software system for governance includes a governance solution model component operative to provide at least one definition and at least one semantic of at least one governance entity and a relationship of the at least one governance entity to an operational model of an organization, a governance solution editor operative to specifying a governance solution by forming a governance specification, a governance solution bundle operative to provide packaging of the governance specification into a package that can be deployed and enacted, a governance solution enactment component operative to deploy the governance solution into an organizational context, a process enactment tool operative to provide at least one configuration point, and a governance lifecycle component operative to provide a view into a state of the governance solution. | 06-24-2010 |
20130145285 | REVERSE METADATA VIEWING BY MULTIPLE PARTIES - Reverse metadata viewing by multiple parties, in one aspect, determines one or more second users that share one or more concerns of the first user, enable the first user to select said one or more second users. One or more concerns of said selected one or more second users are determined based on metadata information in electronic artifacts associated with said selected one or more second users. The first user is enabled to explore said one or more concerns of said selected one or more second users. | 06-06-2013 |
20130219358 | SYSTEM AND METHOD FOR AUTOMATICALLY DETERMINING RELATIONSHIPS BETWEEN SOFTWARE ARTIFACTS USING MULTIPLE EVIDENCE SOURCES - A method (which can be computer implemented) for inferring whether at least a first relationship exists between at least first and second entities includes the steps of applying a first assessor to obtain a first confidence level pertaining to putative existence of said at least first relationship between said at least first and second entities, applying a second assessor to obtain a second confidence level pertaining to putative existence of said at least first relationship between said at least first and second entities, and combining said first and second confidence levels to obtain an overall inference whether said at least first relationship exists between said at least first and second entities. | 08-22-2013 |
20130325763 | PREDICTING LIKELIHOOD OF ON-TIME PRODUCT DELIVERY, DIAGNOSING ISSUES THAT THREATEN DELIVERY, AND EXPLORATION OF LIKELY OUTCOME OF DIFFERENT SOLUTIONS - A task effort estimator may determine a probability distribution of an estimated effort needed to complete unfinished tasks in a project based on one or more of a set of completed tasks belonging to a project and attributes associated with the completed tasks belonging to the project, a set of completed tasks not belonging to the project and attributes associated with the completed tasks not belonging to the project, or the combination of both. A project completion predictor may determine a probability distribution of completion time for the project based on the probability distribution of an estimated effort needed to complete the unfinished tasks in the project, and one or more resource and scheduling constraints associated with the project. | 12-05-2013 |
20140222485 | EXPLORING THE IMPACT OF CHANGING PROJECT PARAMETERS ON THE LIKELY DELIVERY DATE OF A PROJECT - A user may be allowed to specify a change in one or more parameter data associated with the project, the one or more parameter data used previously to compute a probability distribution of completion time of the project. The probability distribution of completion time of the project may be recomputed based on the change. The recomputed probability distribution of the completion time of the project may be presented. An option to save the recomputed probability distribution may be provided. An option may be provided to specify another change in one or more parameter data associated with the project and repeat the recomputing and the presenting procedures based on another change in one or more parameter data associated with the project. | 08-07-2014 |
20140222497 | DETECTING PATTERNS THAT INCREASE THE RISK OF LATE DELIVERY OF A SOFTWARE PROJECT - Historic and current development data associated with the project may be gathered. A catalog of patterns, each pattern associated with a data measure and an analysis routine capable of detecting the pattern according to the data measure in a given data set may be obtained. A pattern describes a particular indication in the historical and development data, which arises one or more of, at a discrete point in time or over a period of time. The analysis routine may be applied to the historic and current development data. A notification may be issued responsive to identifying the pattern in the historic and current development data. The applying and the issuing may be performed for each pattern in the catalog of patterns. | 08-07-2014 |
20140236654 | INCORPORATING USER INSIGHTS INTO PREDICTING, DIAGNOSING AND REMEDIATING PROBLEMS THAT THREATEN ON-TIME DELIVERY OF SOFTWARE AND SYSTEMS - Incorporating user insights in predicting, diagnosing and remediating problems that threaten on-time delivery of a project may comprise gathering information. The information may be conveyed to one or more users. A user may be allowed to input a new value associated with the project, the new value assessed based on the information and representing an expert assessment of the information. The user may be allowed to also indicate a period of time the user considers the information to be applicable. The new value and the period of time may be incorporated into data used in a prediction algorithm that predicts probability distribution of completion time of the project as the project is progressing. | 08-21-2014 |
20140236660 | GUI SUPPORT FOR DIAGNOSING AND REMEDIATING PROBLEMS THAT THREATEN ON-TIME DELIVERY OF SOFTWARE AND SYSTEMS - A graphical interface module may provide a set of graphical presentations comprising at least: a Likelihood of Delivery chart showing a probability distribution of predicted delivery dates; a Delivery Date Risk Trend chart showing how the completion time for the project predicted according to the Likelihood of Delivery chart has changed over time; and a Burndown chart that shows at least work-items of planned work for the project. Each of the Likelihood of Delivery chart, the Delivery Date Risk Trend chart, and the Burndown chart has a timeline axis. | 08-21-2014 |
20140258966 | CONTINUOUS UPDATING OF TECHNICAL DEBT STATUS - A system and method to automatically and continuously update the urgency rating of a backlog item associated with a technical debt item in a software development project are described. The technical debt represents potential additional work or rework associated with current code. The method includes a user defining a plurality of components that comprise the software development project. The method also includes a processor associating the technical debt with one or more components of the plurality of components, and the processor updating the urgency of the backlog item associated with the technical debt according to a function based on a development event associated with at least one of the one or more components. | 09-11-2014 |
20140258967 | CONTINUOUS UPDATING OF TECHNICAL DEBT STATUS - A system and method to automatically and continuously update the urgency rating of a backlog item associated with a technical debt item in a software development project are described. The technical debt represents potential additional work or rework associated with current code. The method includes a user defining a plurality of components that comprise the software development project. The method also includes a processor associating the technical debt with one or more components of the plurality of components, and the processor updating the urgency of the backlog item associated with the technical debt according to a function based on a development event associated with at least one of the one or more components. | 09-11-2014 |
20150149983 | SYSTEM AND METHOD FOR AUTOMATICALLY DETERMINING RELATIONSHIPS BETWEEN SOFTWARE ARTIFACTS USING MULTIPLE EVIDENCE SOURCES - A method (which can be computer implemented) for inferring whether at least a first relationship exists between at least first and second entities includes the steps of applying a first assessor to obtain a first confidence level pertaining to putative existence of said at least first relationship between said at least first and second entities, applying a second assessor to obtain a second confidence level pertaining to putative existence of said at least first relationship between said at least first and second entities, and combining said first and second confidence levels to obtain an overall inference whether said at least first relationship exists between said at least first and second entities. | 05-28-2015 |