Patent application number | Description | Published |
20080286237 | Systemic Treatment of Metastatic and/or Systemically-Disseminated Cancers using GM-CSF-Expressing Poxviruses - The present invention concerns methods and compositions for the treatment of cancer and cancer cells using intravascular administration of a vaccinia virus. In some embodiments, methods and compositions involve a replicative vaccinia virus that encodes GM-CSF. | 11-20-2008 |
20090004723 | Methods and Compositions Concerning Poxviruses and Cancer - The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer. | 01-01-2009 |
20100303714 | ONCOLYTIC VACCINIA VIRUS CANCER THERAPY - Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations. Further aspects of the invention include methods for inducing oncolysis or collapse of tumor vasculature in a subject having a tumor comprising administering to a subject administered at least 1×108 viral particles of a TK-deficient, GM-CSF-expressing, replication-competent vaccinia virus vector sufficient to induce oncolysis of cells in the tumor. | 12-02-2010 |
20130183271 | Methods and Compositions Concerning Poxviruses and Cancer - The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer. | 07-18-2013 |
20140322173 | Oncolytic Vaccinia Virus Combination Cancer Therapy - Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia virus and administering an anti-angiogenic agent if reperfusion is detected. | 10-30-2014 |
20150037355 | GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS - The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor. | 02-05-2015 |
20160038548 | Systemic Treatment of Metastatic and/or Systemically-Disseminated Cancers Using GM-CSF-Expressing Poxviruses - The present invention concerns methods and compositions for the treatment of cancer and cancer cells using intravascular administration of a vaccinia virus. In some embodiments, methods and compositions involve a replicative vaccinia virus that encodes GM-CSF. | 02-11-2016 |
Patent application number | Description | Published |
20130087152 | DEVICE FOR SECURING AN ORAL TUBE IN A PATIENT - A device for securing an oral tube, such as an endotracheal tube, positioned in a patient's trachea includes a support surface, such as an open channel, for supporting the tube. First and second arms extend outwardly from the open channel. The first and second arms form an arch having first and second ends. Bite blocks are provided adjacent the first and second arch ends for contacting the patient's teeth or gums, and a receiver for securing the tube against the support surface is likewise provided. A flexible member having first and second ends for looping around the patient's nasal septum is likewise provided. At least one of the ends of the flexible member is received in a retainer and assists in securing the device in position. | 04-11-2013 |
20130190701 | MEDICAL TUBE UNCLOGGING SYSTEM AND RELATED METHOD - A medical tube unclogging system includes a power supply, a reservoir of fluid, a tube for insertion into a lumen of a medical tube having a clog therein, a pump powered by the power supply and connected to the tube for generating a flow of fluid from the reservoir of fluid through the tube, a fitting through which the tube passes having a first opening coupled to the medical tube, a second opening for receiving the tube, and a third opening through which fluid pumped through the tube and into the medical tube, and fragments of the clog can be exhausted. The system may also include a sensor for monitoring a pressure of the fluid flowing through the tube and producing a signal indicative of the pressure, and a controller or processor for receiving the signal from the sensor and adjusting the pump. | 07-25-2013 |
20150150619 | DEVICE FOR EFFECTING CHANGE IN TISSUE AT A TREATMENT SITE - A device for effecting change in tissue at a treatment site includes a housing having an aperture for receiving a user's finger, a cold plate supported by said housing for cooling the tissue at the treatment site, and at least one thermoelectric cooling semiconductor thermally coupled to said cold plate and electrically coupled to a power source. In another embodiment, the cold plate may include a surface for contacting the treatment site, and at least a portion of said cold plate including said surface may extend from said housing. | 06-04-2015 |
20150246201 | BRIDLE SYSTEM FOR PLACING AND SECURING A NASAL TUBE IN A PATIENT - A bridle system for placing and securing a medical tube in a patient includes a flexible member having a magnet attached to a first end for insertion into a patient's nose, and a magnetic probe for insertion into a second nare of the nose. The magnetic probe attracts the flexible member magnet to assist in retrieving the first end of the flexible member through the second nare of the nose. The system further includes a receiver for securing the medical tube and the flexible member externally, adjacent the nose to prevent dislodgement by the patient or otherwise. The receiver includes a main body and a cantilever arm extending from the main body, forming an arcuate recess for receiving the tube. | 09-03-2015 |
Patent application number | Description | Published |
20130341055 | ELECTRICALLY OPERATED GAS VENT FOR FIRE PROTECTION SPRINKLER SYSTEMS - An automatic electrical gas vent, method and resulting fire protection sprinkler system, is useful with a water source and at least one sprinkler. The at least one sprinkler is connected with the water source by a piping network. An automatic electrical gas vent is adapted to be connected with the piping network to discharge gas from said piping network. The automatic electrical gas vent includes an electrically operated valve that is electrically actuatable to discharge from said piping network and a sensor. The sensor senses the presence of gas at a portion of the piping network and causes actuation of the valve to discharge from the piping network in the absence of a conductive liquid. | 12-26-2013 |
20140332240 | Corrosion Monitoring In A Fire Sprinkler System - A fire sprinkler system according to one aspect of the present disclosure includes a pipe having a first pipe portion and a second pipe portion. The first pipe portion includes a wall having a first wall thickness, and the second pipe portion includes a wall having a second wall thickness that is greater than the first wall thickness. The fire sprinkler system further includes structure coupled to the pipe and defining a sealed chamber between the structure and at least the first pipe portion, and a sensor for sensing a pressure in the sealed chamber. Example corrosion monitoring devices and methods for monitoring corrosion in pipe systems, including fire sprinkler systems, are also disclosed. | 11-13-2014 |
20150083441 | Electrically Operated Gas Vents For Fire Protection Sprinkler Systems And Related Methods - A fire protection sprinkler system includes a water source, a sprinkler, a piping network interconnecting the water source and the sprinkler, and an automatic gas vent coupled to the piping network and configured to discharge gas from the system. The automatic gas vent includes a sensor configured to sense a presence or absence of a liquid and an electrically operated valve. The automatic gas vent is configured to open the electrically operated valve in response to the sensor sensing the absence of a liquid and close the electrically operated valve in response to the sensor sensing the presence of a liquid. Automatic gas vent assemblies and methods of venting and discharging gas from fire protection sprinkler systems are also disclosed. | 03-26-2015 |
20150290483 | Corrosion Monitoring In A Fire Sprinkler System - A fire sprinkler system according to one aspect of the present disclosure includes a pipe having a first pipe portion and a second pipe portion. The first pipe portion includes a wall having a first wall thickness, and the second pipe portion includes a wall having a second wall thickness that is greater than the first wall thickness. The fire sprinkler system further includes structure coupled to the pipe and defining a sealed chamber between the structure and at least the first pipe portion, and a sensor for sensing a pressure in the sealed chamber. Example corrosion monitoring devices and methods for monitoring corrosion in pipe systems, including fire sprinkler systems, are also disclosed. | 10-15-2015 |
20160030786 | Pump Assemblies And Methods For Inhibiting Oxygen From Entering Water Supply Systems - A method of inhibiting oxygen in ambient air from entering a water supply system having at least one ingress point at which a fluid can enter the water supply system includes supplying an inert gas to the at least one ingress point of the water supply system. The inert gas enters the water supply system at the at least one ingress point and substantially inhibits ambient air including oxygen from entering the water supply system at the at least one ingress point to substantially inhibit oxygen corrosion in the water supply system. Example pump assemblies for coupling to water supply systems, piping networks, and water-based fire sprinkler systems for inhibiting ambient air, including oxygen it may contain, from entering the systems are also disclosed. | 02-04-2016 |
Patent application number | Description | Published |
20090068060 | Corrosion Monitor - An apparatus for monitoring corrosion in a pressurized system such as a water-based fire protection system comprising a corrosion monitor mounted within a section of the system containing fluid, wherein the corrosion monitor comprises a surface comprising at least one point of weakness wherein corrosion of a point of weakness causes a change in pressure in an interior chamber of the monitor, which change can be to provide a signal alerting monitoring personnel. | 03-12-2009 |
20110265880 | WATER-CONSERVING FIRE PROTECTION SYSTEMS - Water-based fire protection systems are provided that enable water conservation during testing and maintenance and manage water use by the system. Water reclamation aspects allow for cost savings in operation, testing, and maintenance of the system and reduce environmental impact. For example, the present systems and operating methods afford water collection aspects, water conservation through reuse, sustainability, and a reduction in energy necessary for testing. The water collection and reuse features can be part of a water conservation system that is integrated with a fire protection system during installation or can be coupled to a preexisting fire protection system. | 11-03-2011 |
20140290967 | WATER-CONSERVING FIRE PROTECTION SYSTEMS - Water-based fire protection systems are provided that enable water conservation during testing and maintenance and manage water use by the system. Water reclamation aspects allow for cost savings in operation, testing, and maintenance of the system and reduce environmental impact. For example, the present systems and operating methods afford water collection aspects, water conservation through reuse, sustainability, and a reduction in energy necessary for testing. The water collection and reuse features can be part of a water conservation system that is integrated with a fire protection system during installation or can be coupled to a preexisting fire protection system. | 10-02-2014 |