Patent application number | Description | Published |
20080214407 | METHOD AND SYSTEM FOR QUANTIFICATION OF A TARGET COMPOUND OBTAINED FROM A BIOLOGICAL SAMPLE UPON CHIPS - A method quantifies a target compound selected from the group consisting of a polynucleotide or a protein present in a sample solution. The method includes putting into contact a target compound with a capture probe and detecting signals resulting from the binding between the target compound and its corresponding capture probe and resulting from the printed detection molecule in the different discrete regions. The method obtains a detection curve of the detected signals of the detection molecule and converts the signal obtained from the target compound bound to a specific capture probe into a concentration value and quantifies the target compound by converting the concentration value into a target amount using a target concentration curve. | 09-04-2008 |
20080227658 | Cdna Microarrays With Random Spacers - The present invention discloses an improved cDNA microarray, which employs spacers of random sequence and a length of the spacers of at least 50 to 80 nucleotides. The inventive cDNA microarray may be employed for example in fields like the determination of gene expression, DNA sequencing, fingerprinting or mapping. In addition, a method for the preparation of the cDNA microarray, the use of spacer molecules with random sequence and a kit are specified. | 09-18-2008 |
20080293057 | DETECTION OF UNSPECIFIED GENETICALLY MODIFIED ORGANISM (GMO) ON MICRO-ARRAYS - The present invention is related to a method, kit and computer program for detecting the presence in a sample of an unspecified Genetically Modified Organism (GMO). | 11-27-2008 |
20090082223 | METHOD AND KIT FOR THE DETERMINATION OF CELLULAR ACTIVATION PROFILES - A method for obtaining an activation profile of a biological sample by disposing onto a solid support in a pre-determined spatial arrangement a subset of capture molecules able to interact with one or more activated transcription factor(s) present in the biological sample, contacting the biological sample upon the solid support under conditions allowing their interaction, monitoring signals resulting from their interaction, and providing a cellular activation profile from the detected signals. | 03-26-2009 |
20090156415 | REAL-TIME PCR OF TARGETS ON A MICRO-ARRAY - The present invention relates to a method and apparatus for monitoring on a micro-array a PCR amplification of a nucleotide molecule being present in a solution. The method includes the steps of: providing a support having fixed upon its surface a microarray having at least a capture molecule being immobilized in specifically localized areas of the support and a reaction chamber; introducing a solution containing the nucleotide molecule into the reaction chamber and reagents for nucleotide molecule amplification and labelling; submitting the solution to at least 2 thermal cycles having at least 2 and preferably 3 different temperature steps in order to obtain labelled target nucleotide molecule by PCR amplification; performing at least a measurement of the labelled target nucleotide molecule in at least one thermal cycle by incubating the labelled target nucleotide molecule under conditions allowing a specific binding between the target nucleotide molecule and its corresponding capture molecule and measuring the light emission from the bound labelled target nucleotide molecule in response to excitation light with the solution being present in the chamber and containing the labelled target nucleotide molecule. The surface of emission for a localized area is between about 0.1 μm | 06-18-2009 |
20090186401 | LID FOR PCR VESSEL COMPRISING PROBES PERMITTING PCR AMPLIFICATION AND DETECTION OF THE PCR PRODUCT BY HYBRIDISATION WITHOUT OPENING THE PCR VESSEL - The present invention proposes a simple and effective lid being part of a device having multiwells for performing simultaneous amplifications by PCR and detections of multiple target molecules on unlabeled capture molecules immobilized on the lid. | 07-23-2009 |
20090191618 | REACTION CHAMBER FOR REAL TIME PCR COMPRISING CAPTURE PROBES AND PERMITTING DETECTION OF THE PCR PRODUCT BY HYBRIDISATION WITHOUT OPENING THE PCR VESSEL - A reaction chamber ( | 07-30-2009 |
20090239234 | IDENTIFICATION AND/OR QUANTIFICATION METHOD OF NUCLEOTIDE SEQUENCE(S) ELEMENTS SPECIFIC OF GENETICALLY MODIFIED PLANTS ON ARRAYS - A method for identifying a genetically modified plant by identification and/or quantification of different, multiple nucleotide sequence elements corresponding to at least a portion of an exogenous nucleotide sequence integrated into the genome of the genetically modified plant. The method involves amplifying a nucleic acid sequence element into target nucleic acid sequences, contacting the target nucleic acid sequences with single stranded capture nucleotide sequences, detecting binding of the target nucleotide sequences, constructing a genetic map, and identifying the genetically modified plant. | 09-24-2009 |
20090273356 | INSULATED SUBSTRATE IMPEDANCE TRANSDUCERS - The present invention provides an electronic transducer ( | 11-05-2009 |
20100099860 | CAPTURE MOLECULES FOR THE DETECTION OF AMPLICONS WITH HIGH SENSITIVITY - The invention relates to a method for the design and/or the preparation of a polynucleotide capture molecule for detecting an amplicon having one strand serving as target to be detected and/or quantified after hybridization on said capture molecule, comprising the steps of: (a) selecting a primer pair defining the amplicon; (b) selecting a specific sequence of 10 to 100 nucleotides within the amplicon, such that said specific sequence defines two non-complementary ends of the amplicon; (c) defining the capture molecule having a capture portion that is complementary to the specific sequence selected in step b), and a spacer portion comprising at least 20 nucleotides; and (d) identifying among the two non-complementary ends of the amplicon a spacer end and a non-spacer end, respectively, such that the spacer end is non-complementary to the spacer portion of the capture molecule, and said spacer end exceeds said non-spacer end by at least 50 bases. | 04-22-2010 |
20100137144 | METHOD AND MEANS FOR DETECTING AND/OR QUANTIFYING HIERARCHICAL MOLECULAR CHANGE OF A CELL IN RESPONSE TO AN EXTERNAL STIMULUS - The present invention is related to a method for detecting and/or quantifying hierarchical (regulated) molecular changes of a cell in response to any external stimulus. | 06-03-2010 |
20100196358 | METHOD AND KIT TO PROFILE TUMORS BY BIOMARKER ANALYSES INCLUDING TRANSCRIPTIONAL FACTOR ASSAYS - The present invention is related to a method and kit (or device) for the detection and/or the quantification of biomarkers related to tumorigenesis. Said method is advantageously used to propose or adapt an anti-tumoral therapeutic protocol to be administered to a subject. Furthermore, said method and kit (or device) are a technical platform for the identification of new compounds, which are preferably used at (a) specific step(s) of an anti-tumoral therapeutic protocol. | 08-05-2010 |
20120231962 | REAL-TIME PCR OF TARGETS ON A MICRO-ARRAY - The present invention relates to a method and apparatus for monitoring on a micro-array a PCR amplification of a nucleotide molecule being present in a solution. The method includes the steps of: providing a support having fixed upon its surface a microarray having at least a capture molecule being immobilized in specifically localized areas of the support and a reaction chamber; introducing a solution containing the nucleotide molecule into the reaction chamber and reagents for nucleotide molecule amplification and labelling; submitting the solution to at least 2 thermal cycles having at least 2 and preferably 3 different temperature steps in order to obtain labelled target nucleotide molecule by PCR amplification; performing at least a measurement of the labelled target nucleotide molecule in at least one thermal cycle by incubating the labelled target nucleotide molecule under conditions allowing a specific binding between the target nucleotide molecule and its corresponding capture molecule and measuring the light emission from the bound labelled target nucleotide molecule in response to excitation light with the solution being present in the chamber and containing the labelled target nucleotide molecule. The surface of emission for a localized area is between about 0.1 μm | 09-13-2012 |