Patent application number | Description | Published |
20080213481 | Method for creating a reference region and a sample region on a biosensor - A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor. | 09-04-2008 |
20090186776 | Microcolumn-platform based array for high-throughput analysis - A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity. | 07-23-2009 |
20100152060 | ASSAY SOLUTION COMPOSITIONS AND METHODS FOR GPCR ARRAYS - Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5′-diphosphate (GDP) salt, and/or an anti-oxidant reagent. | 06-17-2010 |
20110008912 | Polymer-coated substrates for binding biomolecules and methods of making and using Thereof - Described herein are polymer-coated substrates for binding biomolecules and methods of making and using thereof. | 01-13-2011 |
20110043828 | OPTICAL READER SYSTEM AND METHOD FOR MONITORING AND CORRECTING LATERAL AND ANGULAR MISALIGNMENTS OF LABEL INDEPENDENT BIOSENSORS - An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate. | 02-24-2011 |
20110128546 | Variable Penetration Depth Biosensor - A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications. | 06-02-2011 |
20110171746 | Variable Penetration Depth Biosensor Methods - A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications. | 07-14-2011 |
20120133943 | Systems And Methods For Multi-Wavelength SPR Biosensing With Reduced Chromatic Aberration - Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed. | 05-31-2012 |
20120244568 | LABEL-FREE RIGID CELL ASSAY METHOD - A label-free cell assay method including:
| 09-27-2012 |
20140220581 | PCR REACTION CLEANUP BUFFERS - The present disclosure relates to buffers containing polyols for use with affinity-binding and/or magnetically susceptible thermoplastic particles and methods of making and use thereof. | 08-07-2014 |