Patent application number | Description | Published |
20080249600 | STENTS WITH DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME - A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface. | 10-09-2008 |
20080249615 | STENTS WITH CERAMIC DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME - A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate. | 10-09-2008 |
20080262412 | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 10-23-2008 |
20080287984 | Medical balloons and methods of making the same - Medical balloons are provided that have enhanced properties, such as thinner walls, enhanced tensile strength, and/or electrical conductivity. Methods are also disclosed. | 11-20-2008 |
20080288041 | Cutting Member for Bifurcation Catheter Assembly - A catheter assembly for deployment in a vessel includes a catheter shaft extending from a proximal end portion to a distal end portion. A balloon is operatively coupled to the distal end portion of the catheter shaft. At least one cutting member is coupled to the catheter assembly. As the balloon is inflated, the cutting member is moved to a position to cut a portion of the vessel. | 11-20-2008 |
20080312639 | Hardened polymeric lumen surfaces - Apparatuses, systems, and methods for surface modification of catheters. The surface modification can be localized to a lumen surface of the catheter. The surface modification to the lumen surface extends radially into the catheter body a predetermined distance to provide a hardened zone having a hardness that is greater than a hardness of an exterior surface of the catheter body. | 12-18-2008 |
20090018644 | Boron-Enhanced Shape Memory Endoprostheses - An endoprosthesis comprises a member capable of supporting a body passageway. The member has a surface region overlying a bulk region, and comprises a shape memory alloy and boron. The concentration of boron in the surface region is greater than the concentration of boron in the bulk region. | 01-15-2009 |
20090029077 | Drug eluting medical devices having porous layers - In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent. | 01-29-2009 |
20090030500 | Iron Ion Releasing Endoprostheses - An endoprosthesis that includes a base portion and a source of Fe(II) ions that is compositionally distinct from the base portion and releasable from the endoprosthesis under physiological conditions. | 01-29-2009 |
20090030504 | Medical devices comprising porous inorganic fibers for the release of therapeutic agents - In accordance with an aspect of the invention, implantable or insertable medical devices are provided which comprise a substrate and a therapeutic-agent-loaded porous inorganic fiber. | 01-29-2009 |
20090043276 | DRUG DELIVERY DEVICE, COMPOSITIONS AND METHODS RELATING THERETO - An implantable drug delivery device including at least one flexible elongate element, the flexible elongate element including a polymeric carrier for a drug and anchors for attachment to a vessel wall of the patient. | 02-12-2009 |
20090048659 | Medical devices having sol-gel derived ceramic regions with molded submicron surface features - According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features. | 02-19-2009 |
20090062910 | STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT - The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medical device. More particularly, the invention is directed to a stent having a tubular sidewall with a first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer. | 03-05-2009 |
20090068244 | Polymeric/carbon composite materials for use in medical devices - The invention provides implantable or insertable medical devices, which contain one or more composite regions. These composite regions, in turn, contain polymer and carbon particles. Also, the invention provides composite materials for use in a medical device containing styrene-isobutylene copolymer and carbon nanotubes. | 03-12-2009 |
20090069878 | BIFURCATION POST-DILATATION BALLOON AND METHODS - A catheter assembly includes a balloon member and a balloon restricting arrangement. The balloon member includes a proximal portion, a distal portion and a circumferential bulge portion. The circumferential bulge portion extends around a circumference of the balloon member and is positioned at a location between the proximal and distal portions of the balloon member. The balloon restricting arrangement includes a proximal portion extending around the proximal portion of the balloon member and a distal portion extending around the distal portion of the balloon member to restrict an inflated size of the proximal and distal portions of the balloon member. The proximal and distal portions of the balloon restricting arrangement are spaced apart axially, and the circumferential bulge portion extends radially outward therebetween. The circumferential bulge portion inflates to a maximum inflated dimension that is greater than an inflated dimension of the proximal and distal portions of the balloon restricting arrangement. | 03-12-2009 |
20090076588 | Endoprosthesis - In embodiments, a stent includes a stent body and a wire-form carrying a drug located along the stent body. | 03-19-2009 |
20090076591 | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface - The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields. | 03-19-2009 |
20090081272 | MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject. | 03-26-2009 |
20090118809 | ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER - An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g. directly in the body of the stent, and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir | 05-07-2009 |
20090118821 | ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER - An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir. | 05-07-2009 |
20090123517 | MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted. | 05-14-2009 |
20090123521 | Medical devices having coatings for controlled therapeutic agent delivery - According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device. | 05-14-2009 |
20090125099 | STENT DESIGNS WHICH ENABLE THE VISIBILITY OF THE INSIDE OF THE STENT DURING MRI - A medical device that inhibits distortion of medical resonance images taken of the device. In particular, various structures are utilized to allow visibility proximate, and inside of, a tubular member, such as a stent. In one embodiment, the stent is constructed such that any closed path encircling at least a circumference of the stent will pass through at least two materials to reduce or eliminate electrical loops formed in the stent. | 05-14-2009 |
20090138077 | Articles having ceramic coated surfaces - According to an aspect of the invention, articles are provided which comprise a substrate and a ceramic coating which covers at least a portion of the substrate surface. The ceramic coating includes raised ceramic shells connected by a ceramic layer that is conformal with the substrate. According to another aspect of the present invention, carbon nanotubes are provided, which comprise a ceramic coating covering at least a portion of the carbon nanotubes. | 05-28-2009 |
20090143815 | Apparatus and Method for Sealing a Vessel Puncture Opening - A device for sealing a puncture opening in a wall of a blood vessel may include a base frame including a first bi-stable material having a first stable state corresponding to a delivery configuration of the base frame, in which the base frame is retracted to have a relatively smaller overall profile, and a second stable state corresponding to a deployed configuration of the base frame, in which the base frame is extended to have a relatively larger overall profile. The base frame is sized to engage an interior surface of the blood vessel wall when in the deployed configuration. A sealing section is coupled to the base frame and includes a second bi-stable material having a first stable state corresponding to an initial configuration of the sealing section, in which the sealing section permits fluid flow, and a second stable state corresponding to a barrier configuration of the sealing section, in which the sealing section prevents fluid flow. The sealing section in the barrier configuration is sized to block fluid flow through the puncture opening when the base frame is in the deployed configuration. | 06-04-2009 |
20090143855 | Medical Device Including Drug-Loaded Fibers - An endovascular or intraluminal stent comprising an expandable framework including a plurality of interconnected undulating or otherwise connected segments, and a plurality of fibers disposed on the expandable framework. At least a portion of the plurality of fibers is loaded with a therapeutic agent. | 06-04-2009 |
20090149948 | MEDICAL DEVICES CONTAINING SILICATE AND CARBON PARTICLES - According to one aspect of the present invention, implantable and insertable medical devices are provided which contain one or more particle-containing regions that comprise silicate particles and carbon particles. | 06-11-2009 |
20090157165 | Degradable Endoprosthesis - An endoprosthesis includes a body that has a first bioerodible metal and a surface, and a capsule formed of a second bioerodible metal disposed on the surface. The capsule includes a porous peripheral region and a drug-containing core. A method of making such an endoprosthesis is also disclosed. | 06-18-2009 |
20090157172 | STENTS WITH POLYMER-FREE COATINGS FOR DELIVERING A THERAPEUTIC AGENT - Described herein are implantable medical devices, such as intravascular stents, for delivering therapeutic agents to a patient, and methods for making such medical devices. The medical devices comprise a substrate having at least a cavity therein and a pellet disposed in the cavity. The pellet comprises a non-polymeric material having a plurality of pores therein. A therapeutic agent is disposed in at least some of the pores. | 06-18-2009 |
20090171336 | CATHETERS AND MANUFACTURING THEREOF - A catheter includes a longitudinally extending body having proximal and distal ends and defining at least one lumen that extends longitudinally from the proximal end through the body to the distal end and looping back to the proximal end. A liquid metal, e.g. an alloy of gallium and indium, such as galistan, is disposed in the lumen. In another aspect, a catheter includes a longitudinally extending body defining first and second lumens. An electrically driven device is coupled to a distal end of the body and is in electrical communication with the first and second lumens. A power source is in electrical communication with the first and second lumens and a liquid metal is disposed in the first and second lumens to provide an electrical conduit between the power source and electrically driven device. Each lumen may loop from a proximal end of the body to the distal end back to the proximal end. | 07-02-2009 |
20090187238 | SYSTEM AND METHOD FOR DEPLOYING SELF-EXPANDABLE MEDICAL DEVICE WITH COATING - A system and method for providing a coating on a self-expandable medical device such as a stent are disclosed. The system comprises a coating applicator at the distal end of a sheath which delivers coating material onto the stent as the stent is deployed from the sheath. Thus, the stent may be loaded into the sheath without a coating on the stent, thereby avoiding shearing off or damaging the coating during loading. Also, the coating is applied only as the stent exits the sheath, thereby avoiding shearing off or damaging the coating during deployment. | 07-23-2009 |
20090204196 | SELF-EXPANDABLE STENT WITH A CONSTRICTIVE COATING AND METHOD OF USE - The present invention provides a system and method for providing a coating on a self-expandable medical device, such as a stent, while avoiding the issues relating to coating damage from the delivery sheath during loading and deployment. In one embodiment, the present invention comprises a constrictive coating that acts as a constrictive sheath for the stent. A cutting mechanism is mounted on the end of the delivery tube such that when the stent with the constrictive coating exits the delivery tube, the constrictive coating is cut. This releases the constriction retaining the sheath, and the stent self-expands, pressing the cut portions of the coating against the lumen wall. | 08-13-2009 |
20090259300 | Medical Devices With an Interlocking Coating and Methods of Making the Same - Disclosed herein are medical devices, such as intravascular stents, for delivering a therapeutic agent to the body tissue of a patient, and a method for making such medical devices. More particularly, the medical devices have a coating that includes a polymer that adheres to the surface of the medical device so that the coating is able to resist damage during loading, deployment and implantation. | 10-15-2009 |
20090264975 | MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL - In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed. | 10-22-2009 |
20090269383 | MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS - An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles. | 10-29-2009 |
20090287301 | Coating for medical implants - A medical implant can include a body including a bioerodible metal and a coating overlying a surface of the bioerodible metal. The coating can include a matrix that includes a fatty acid salt and nano-particles within the matrix. | 11-19-2009 |
20090299468 | ENDOPROSTHESIS COATING - An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), includes a surface, a first layer having a polyelectrolyte deposited on the surface, a plurality of polymeric particles deposited on the first layer, and a coating of a porous material deposited on the plurality of polymeric particles. At least one particle of the plurality of polymeric particles includes a polymer matrix and a drug distributed in the polymer matrix. A method of making the endoprosthesis is also disclosed. | 12-03-2009 |
20090306765 | Bioerodible Endoprosthesis - An endoprosthesis can include a body including an underlying portion and a surface portion overlying the underlying portion. The underlying portion can include a bioerodible metal in the form of a matrix and corrosion enhancing deposits within the matrix. The surface portion including the bioerodible metal of the matrix. The surface portion having a first erosion rate when exposed to a physiological environment and the underlying portion having a second erosion rate when exposed to a physiological environment that is greater than the first erosion rate. | 12-10-2009 |
20090318848 | MEDICAL DEVICES EMPLOYING CONDUCTIVE POLYMERS FOR DELIVERY OF THERAPEUTIC AGENTS - In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer. | 12-24-2009 |
20090318862 | BALLOON CATHETERS AND METHODS FOR MANUFACTURING BALLOONS FOR BALLOON CATHETERS - Catheters, balloons, and methods of manufacturing balloons for balloon catheters using lasers are disclosed. A catheter with a shaft sized for use with a 0.014 inch guide wire includes a polymeric balloon having a body portion with an inflated outer diameter of more than 6 millimeters. An inflatable balloon includes an inflated outer diameter to inner waist diameter ratio of 12.5 to 1. An inflatable polymeric balloon that has a body portion with two regions that have different molecular orientations is also provided. A method of processing an elongate polymeric material includes heating a portion of the polymeric material with a laser while longitudinally stretching the portion of the polymeric material. A method of manufacturing a balloon includes heating and longitudinally stretching a first and second portion of an elongate polymeric tube to form first and second end portion. The remaining body portion is radially expanded to form the balloon. | 12-24-2009 |
20090319025 | RESONATOR FOR MEDICAL DEVICE - A device resonator for medical device is provided. The resonator device includes a helical structure and a capacitor structure. The resonator device can be used in conjunction with a medical device, including a stent. | 12-24-2009 |
20090319032 | ENDOPROSTHESIS COATING - An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed. | 12-24-2009 |
20090326638 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION - According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both. | 12-31-2009 |
20100008970 | Drug-Eluting Endoprosthesis - A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent. | 01-14-2010 |
20100010620 | Stent - A stent has a circumference and a plurality of members that define a lumen. The stent has three stable states, which include an unexpanded state, a partially deployed state, and a deployed state The lumen has a first cross-sectional shape in the unexpanded state, a second cross-sectional shape in the partially deployed state and a third cross-sectional shape in the deployed state The first cross-sectional shape of the lumen is different from the second and third cross-sectional shapes of the lumen, and the first cross-sectional shape of the lumen is a non-round shaped cross-sectional shape | 01-14-2010 |
20100016885 | Device to close openings in body tissue - Embodiments of the invention include a device for closing an opening in body tissue. The device may include a first end section and a second end section both including one or more anchoring members. Both end sections may be configured to transform in shape from a constrained configuration to an unconstrained configuration. The device may also include a midsection coupled between the end sections. The midsection may have at least one configuration that substantially prevents the flow of fluid therethrough. | 01-21-2010 |
20100021523 | Medical Devices Having Inorganic Barrier Coatings - Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask. | 01-28-2010 |
20100030143 | FOLDING APPARATUS AND METHODS FOR BIFURCATION POST-DILATATION BALLOON - A post dilatation balloon catheter includes a balloon member having a proximal portion, a distal portion and a circumferential bulge portion. The circumferential bulge portion extends around a circumference of the balloon member and is positioned at a location between the proximal and distal portions of the balloon member. The circumferential bulge portion inflates to a maximum inflated dimension that is greater than a maximum dimension of the proximal and distal portions of the balloon member. The balloon member is arranged into a folded state by folding at least one of the distal and proximal portions of the balloon member in a separate step from folding the circumferential bulge portion. | 02-04-2010 |
20100030319 | COILS FOR VASCULAR IMPLANTS OR OTHER USES - Medical devices comprising implants for use in blood vessels or other body lumens. The implant comprises an elongate member that, in its native configuration, follows a generally helical path. The elongate member is formed of one or more strands that are wound into a coil of minor windings, wherein the coil of minor windings is itself wound into the generally helical path. The one or more strands are formed of materials that provide the elongate member with the desired flexibility. In some cases, the elongate member may be capable of delivering a therapeutic agent. This can be accomplished by, for example, using capsules, swellable materials, corrodable elements, magnetically-sensitive particles, coatings, and/or core wires. Also provided are a method of treating a superficial femoral artery and a method of making an implant. | 02-04-2010 |
20100042205 | MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS - According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer. | 02-18-2010 |
20100047317 | USING BUCKY PAPER AS A THERAPEUTIC AID IN MEDICAL APPLICATIONS - Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site. | 02-25-2010 |
20100056985 | ELECTROACTIVE POLYMER ACTIVATION SYSTEM FOR A MEDICAL DEVICE - An activation circuit for selectively providing an electrical current to one or more electroactive polymers (EAPs) in a medical device is disclosed. The activation circuit may include a sensor for sensing a measure related to a parameter of an elongated member and/or a balloon of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter. | 03-04-2010 |
20100057188 | ENDOPROSTHESES WITH POROUS REGIONS AND NON-POLYMERIC COATING - Endoprostheses include an endoprosthesis wall that includes a surface layer that includes a metallic material and that defines a plurality of pores. A therapeutic agent fills one or more pores of the surface layer and a non-polymeric coating, covers the therapeutic agent in the one or more pores. The endoprostheses can, for example, deliver a therapeutic agent, such as a drug, in a controlled manner over an extended period of time. | 03-04-2010 |
20100057197 | MEDICAL DEVICES HAVING INORGANIC COATINGS FOR THERAPEUTIC AGENT DELIVERY - According to an aspect of the invention, medical devices are provided that comprise a substrate, at least one therapeutic agent disposed over or in the substrate, and at least one inorganic layer disposed over the therapeutic agent and the substrate, wherein the inorganic layer is either a porous inorganic layer or is a non-porous layer that becomes a porous inorganic layer in vivo. Other aspects of the invention comprise methods for forming medical devices. | 03-04-2010 |
20100063584 | ENDOPROSTHESES - Endoprosthesis assemblies and methods of making endoprosthesis assemblies are disclosed. For example, endoprosthesis assemblies are described that include an endoprosthesis body and a polymeric coating about the endoprosthesis body. The polymeric coatings are engaged tightly to the endoprosthesis wall through engageable features created on the surface of the polymeric coatings and the surface of the endoprosthesis wall prior to engaging the surfaces. | 03-11-2010 |
20100069838 | DEVICES AND SYSTEMS FOR DELIVERY OF THERAPEUTIC AGENTS TO BODY LUMENS - In accordance with one aspect, the invention provides medical devices that comprise an elongated drug delivery member, which is adapted to take on a radially expanded configuration upon actuation in vivo. | 03-18-2010 |
20100082093 | Medical Devices - Expandable stents and methods of using expandable stent within a body are described. | 04-01-2010 |
20100087783 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS TO BODY LUMENS - In accordance with one aspect, the invention provides a drug delivery device for delivery of a drug to the body. The device is provided with at least one layer that comprises drug-containing particles. | 04-08-2010 |
20100087910 | MEDICAL IMPLANT - A endoprosthesis includes a body comprising a plurality of interconnected struts. The body includes a bioerodible metal. At least a first strut of the plurality of interconnected struts includes a stripe on the surface of the first strut. The stripe including a nitride of the bioerodible metal, a fluoride of the bioerodible metal, or a combination thereof. The stripe runs along the length of the first strut. The stripe is part of a continuous network of stripes on struts adjacent to the first strut. | 04-08-2010 |
20100145437 | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface - The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields. | 06-10-2010 |
20100152830 | Single Wire Stent Delivery System - A stent delivery system for deployment at a bifurcated vessel includes a catheter and a balloon. The length of the balloon is defined by a proximal balloon region and a distal balloon region. The proximal balloon region is disposed about a first longitudinal axis and the distal balloon region is disposed about a second longitudinal axis. The balloon has an unexpanded state and an expanded state, and a bend along its length. The proximal balloon region intersects the distal balloon region at the bend. In both the unexpanded state and the expanded state, at least one of the first longitudinal axis and the second longitudinal axis define an oblique angle relative to the main vessel longitudinal axis. | 06-17-2010 |
20100198336 | MEDICAL DEVICES AND METHODS OF MAKING THE SAME - Medical devices, such as stents, and methods of the devices are described. In some embodiments, the invention features a method of making a medical device including providing a body having an electrically insulating first member defining an elongated lumen, and an electrically conducting second member on a first surface of the first member, removing a portion of the second member, and forming the body into the medical device, e.g., a stent. | 08-05-2010 |
20100209471 | MEDICAL DEVICES HAVING POLYMERIC NANOPOROUS COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY AND A NONPOLYMERIC MACROPOROUS PROTECTIVE LAYER - An implantable or insertable medical device is provided which contains the following: (a) a substrate, (b) a therapeutic agent-containable region disposed over the substrate, (c) a nanoporous polymeric layer disposed over the therapeutic agent-containable region and (d) a macroporous non-polymeric layer disposed over the nanoporous polymeric layer. The nanoporous polymeric layer largely regulates transport of species between the therapeutic agent-containable region and the exterior of the device. The macroporous non-polymeric layer has a larger pore size than the nanoporous polymeric layer and largely serves to isolate the polymeric material from surrounding tissue during in-situ delivery of the therapeutic agents. | 08-19-2010 |
20100217370 | Bioerodible Endoprosthesis - A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics. | 08-26-2010 |
20100222873 | Self-Buffering Medical Implants - A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body. | 09-02-2010 |
20100228341 | ENDOPROSTHESES - A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles. | 09-09-2010 |
20100233227 | MEDICAL DEVICES HAVING CARBON DRUG RELEASING LAYERS - According to various aspects of the invention, medical devices are provided, which comprise (a) a substrate, (b) a drug-containing layer disposed over the substrate, which contains one or more drugs and, optionally, one or more additional materials, and (c) a carbon layer disposed over the drug-containing layer. | 09-16-2010 |
20100241071 | Polymeric/Inorganic Composite Materials for Use in Medical Devices - In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block. | 09-23-2010 |
20100262222 | BIOERODIBLE, IMPLANTABLE MEDICAL DEVICES INCORPORATING SUPERSATURATED MAGNESIUM ALLOYS - A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C]. | 10-14-2010 |
20100274352 | Endoprosthesis with Selective Drug Coatings - An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided. | 10-28-2010 |
20100292776 | Bioerodible Endoprosthesis - A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodible metal compositions are different. | 11-18-2010 |
20110008260 | Use of Nanocrystals for Drug Delivery from a Balloon - A drug delivery balloon ( | 01-13-2011 |
20110022158 | Bioerodible Medical Implants - A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix. | 01-27-2011 |
20110022160 | Medical Devices Having an Inorganic Coating Layer Formed by Atomic Layer Deposition - Medical devices having a coating that comprises one or more inorganic coating layers. The inorganic coating layer may be formed by a self-limiting deposition process, such as atomic layer deposition. The inorganic coating layer may have a thickness of less than 30 nm. The inorganic coating layer may also be used in combination with a therapeutic agent as a control release barrier. The inorganic coating layer may have various desirable properties, including, for example, resistance to cracking or delamination, high degree of uniformity, high degree of conformality, and/or compatibility with low deposition temperatures. | 01-27-2011 |
20110045055 | MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS - According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after implantation in a subject. In various embodiments, a therapeutic agent delivery profile of this type is provided by employing a temporary barrier layer which initially permits little to no release of the therapeutic agent, but which layer permits much greater release levels after a predetermined period of time. Other aspects of the invention relate to methods of forming such devices and to methods of using such devices. | 02-24-2011 |
20110046539 | INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 02-24-2011 |
20110054443 | BALLOON CATHETER DEVICES WITH DRUG DELIVERY EXTENSIONS - A medical device is provided for dilatation of a vessel and delivery of therapeutic agent to a wall of the vessel. The medical device comprises a catheter, a balloon located at a distal end of the catheter, and a drug delivery extension. The drug delivery extension is configured to extend beyond the outer surface of the balloon when the balloon is in its expanded configuration in order to deliver the therapeutic agent to an area beyond the outer surface of the balloon. The drug delivery extension may be one or more tubes, elongate members and/or expandable structures. The drug delivery extension may include a sheath for drug delivery. | 03-03-2011 |
20110071559 | Cutting Member for Bifurcation Catheter Assembly - A catheter assembly for deployment in a vessel includes a catheter shaft extending from a proximal end portion to a distal end portion. A balloon is operatively coupled to the distal end portion of the catheter shaft. At least one cutting member is coupled to the catheter assembly. As the balloon is inflated, the cutting member is moved to a position to cut a portion of the vessel. | 03-24-2011 |
20110130829 | Medical Devices Containing Therapeutic Agents - The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices. | 06-02-2011 |
20110137155 | DELIVERY DEVICE FOR LOCALIZED DELIVERY OF A THERAPEUTIC AGENT - Therapeutic agent delivery devices and methods for delivering a therapeutic agent to a target location as well as methods for determining the location of a lesion on a vessel wall are disclosed. Various embodiments disclose an expandable member comprising a drug delivery matrix for selectively delivering a therapeutic agent to a lesion on a vessel wall. The drug delivery matrix may comprise one or more sensors and an electroactive polymer for releasing the therapeutic agent. Other embodiments disclose an expandable member comprising a plurality of radially-expanding flexible walls forming a plurality of channels for selectively delivering therapeutic agent to a target area adjacent one or more of the channels. Detecting a lesion may comprise using a plurality of Hall effect sensors disposed on a distal end of a catheter. | 06-09-2011 |
20110148003 | HARDENED POLYMERIC LUMEN SURFACES - Apparatuses, systems, and methods for surface modification of catheters. The surface modification can be localized to a lumen surface of the catheter. The surface modification to the lumen surface extends radially into the catheter body a predetermined distance to provide a hardened zone having a hardness that is greater than a hardness of an exterior surface of the catheter body. | 06-23-2011 |
20110152747 | MEDICAL DEVICE WITH ELECTROACTIVE POLYMER POWERED BY PHOTOVOLTAIC CELL - Medical devices comprising an electroactive polymer powered by a photovoltaic cell. In one embodiment, the medical device has an electroactive component comprising an electroactive polymer. The medical device further comprises a photovoltaic cell as a source of electrical power for electrically stimulating the electroactive polymer. The medical device further comprises a first electrode and a second electrode, both of which are electrically connected to the photovoltaic cell. The electroactive component covers over at least a portion of the first electrode. Also disclosed is a method of treating a patient using a medical device having an electroactive polymer powered by a photovoltaic cell. | 06-23-2011 |
20110152765 | MEDICAL DEVICE WITH EXPANDABLE BODY FOR DRUG DELIVERY BY CAPSULES - Medical devices using an expandable body to deliver a therapeutic agent. In one particular embodiment, the medical device comprises a tubular catheter and an inner expandable body (e.g., a scaffolding) contained within the catheter. The inner expandable body is connected to a core wire for advancing or retracting the inner body. The inner body may be advanced to exit out of the catheter or retracted to withdraw the inner body back into the catheter. This particular embodiment further comprises a sheath on the outside of the interior of the catheter. The sheath is connected to the inner body and/or the core wire. The sheath carries a plurality of capsules that contain a therapeutic agent. The therapeutic agent is delivered by pushing the core wire to advance the inner body, which expands against the sheath, causing the capsules on the sheath to be compressed against body tissue such that the therapeutic agent is released. Also described herein is a method of treating a patient. | 06-23-2011 |
20110160659 | Drug-Delivery Balloons - Drug-delivery balloons, as well as related medical devices and methods, are disclosed. | 06-30-2011 |
20110160839 | Endoprosthesis - An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits. | 06-30-2011 |
20110189377 | Coating for Medical Devices Comprising An Inorganic or Ceramic Oxide and a Therapeutic Agent - The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stem, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent. | 08-04-2011 |
20110238151 | SURFACE TREATED BIOERODIBLE METAL ENDOPROSTHESES - An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide. | 09-29-2011 |
20110245905 | ENDOPROSTHESIS - Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation. | 10-06-2011 |
20110251590 | BALLOON CATHETERS WITH FIBERS FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer. | 10-13-2011 |
20110251653 | IMPLANTABLE ELECTRODES CONTAINING POLYOXOMETALATE ANIONS AND METHODS OF MANUFACTURE AND USE - An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode. | 10-13-2011 |
20110275980 | MEDICAL DEVICES EMPLOYING ELECTROACTIVE POLYMERS FOR DELIVERY OF PARTICULATE THERAPEUTIC AGENTS - In accordance with one aspect, medical devices are provided which comprise an electroactive polymer material and therapeutic-agent containing particles. The device is configured such that the particles are delivered from the device upon actuation of the electroactive polymer material. | 11-10-2011 |
20110282433 | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface - The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields. | 11-17-2011 |
20110301565 | MEDICAL BALLOONS HAVING A SHEATH DESIGNED TO FACILITATE RELEASE OF THERAPEUTIC AGENT - Medical devices that comprise an elongate balloon and a sheath positioned around the balloon. The sheath is designed to facilitate the delivery of therapeutic agent. In one embodiment, the sheath has a non-circular shape (e.g., a square shape or polygonal shape). In some cases, the sheath has reservoirs at the corners with a therapeutic agent contained in the reservoirs. In another embodiment, the sheath has an area that undergoes shear strain when the balloon is expanded. The shear strain in the sheath facilitates the release of therapeutic agent. In another embodiment, the sheath has a chamber for containing a therapeutic agent. When the balloon expands, the chamber becomes compressed and causes the therapeutic agent to flow out of the chamber. | 12-08-2011 |
20120013043 | MEDICAL DEVICES AND PROCESSES FOR PREPARING SAME - Medical balloons comprising a predetermined pattern of conductive materials and methods of making the same. | 01-19-2012 |
20120022585 | VASCULAR CLOSURE DEVICE WITH BIODEGRADABLE ANCHOR - This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof. | 01-26-2012 |
20120059455 | Bioerodible Magnesium Alloy Containing Endoprostheses - A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy includes magnesium, between 7 and 8 weight percent aluminum, between 0.4 and 0.8 weight percent zinc, and between 0.05 and 0.8 weight percent manganese. | 03-08-2012 |
20120065726 | BIOERODIBLE ENDOPROSTHESES AND METHODS OF MAKING THE SAME - A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects. | 03-15-2012 |
20120150142 | Drug Eluting Balloons with Ability for Double Treatment - In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents. | 06-14-2012 |
20120150286 | BIOERODIBLE ENDOPROSTHESIS WITH BIOSTABLE INORGANIC LAYERS - Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed. | 06-14-2012 |
20120172928 | APPARATUS AND METHOD FOR SEALING A VESSEL PUNCTURE OPENING - A device for sealing a puncture opening may include a base frame having a delivery configuration, wherein the base frame is retracted to have a relatively smaller overall profile, and a deployed configuration, wherein the base frame is extended to have a relatively larger overall profile. The base frame is sized to engage an interior surface of the blood vessel wall in the deployed configuration. A sealing section is coupled to the base frame, the sealing section having an initial configuration, wherein the sealing section permits fluid flow, and a barrier configuration, wherein the sealing section prevents fluid flow. The sealing section in the barrier configuration is sized to block fluid flow through the puncture opening when the base frame is in the deployed configuration. | 07-05-2012 |
20120177910 | Coated Medical Devices - The present invention relates to medical devices, and in particular, medical devices that have an inorganic coating, e.g., a coating capable of releasing inorganic nanoparticles into a passageway to be treated with the medical device. | 07-12-2012 |
20120239128 | STENT AND DELIVERY SYSTEM - Techniques are disclosed that allow a stent to be folded within a balloon of a stent delivery system. In one example, a stent has first and second columns that extend from a proximal end to a distal end along a longitudinal axis. Each of the first columns extend substantially parallel to the longitudinal axis and comprise a plurality of elements that each have a substantially polygonal shape. Each of the second columns extend substantially parallel to the longitudinal axis and are between adjacent first columns. Each of the respective second columns include a plurality of first connectors that have a curvilinear shape and that extend in a substantially circumferential direction to connect adjacent first columns. The stent also has a plurality of second connectors, wherein at least one of the second connectors extends between a first element and a second element. | 09-20-2012 |
20120239138 | IMPLANTABLE MEDICAL DEVICES INCORPORATING X-RAY MIRRORS - An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers. | 09-20-2012 |
20120259405 | Radial Radiopaque Markers - A deployable medical device having at least one radiopaque marker is herein disclosed. In particular, the deployable medical device comprises a bio-absorbable stent or expandable medical balloon. Upon insertion of the deployable medical device, the at least one radiopaque marker is inserted into adjacent tissue, where it will remain even after the deployable medical device has been removed. | 10-11-2012 |
20120277843 | PROTECTIVE SURFACES FOR DRUG-COATED MEDICAL DEVICES - Medical balloons having one or more folds, on which are disposed protective surfaces e.g., protective lines or strips, and at least one therapeutic agent between the lines. The protective surfaces prevent, inhibit, or reduce the contact between therapeutic agent on one area, e.g., a surface area, and an opposing area or therapeutic agent on the opposing area when the balloon is folded. The protective surfaces also prevent, inhibit, or reduce loss of therapeutic agent from the balloon surface as a result of, for example, contact with a medical device during expansion or removal of a protective sheath. Also a medical device delivery system comprising a medical device surrounded by a retractable sheath, wherein protective surfaces are disposed on the sheath. | 11-01-2012 |
20120283636 | DRUG DELIVERY DEVICE WITH SHEATH FOR IMPROVED DRUG DELIVERY - A drug eluting balloon device is disclosed, comprising a balloon and a sheath disposed around the balloon, the sheath comprising a plurality of drug delivery areas. When the sheath is in a first position, the drug delivery areas are in the form of pockets adapted to contain a therapeutic agent. When the sheath is expanded, the pockets invert into protrusions in order to deliver the therapeutic agent. In an alternative embodiment, the pockets are adapted to be pushed outwardly upon inflation of the balloon. The device may further comprise a fluid or shape memory material to force the pockets outwardly. | 11-08-2012 |
20120316495 | DRUG DELIVERY DEVICE WITH INSTABLE SHEATH AND/OR PUSH ELEMENT - A balloon carries a drug in drug-carrying regions, wherein the drug-carrying regions protect the drug during delivery through a patient's vasculature. Once at a target site, the balloon expands, causing the drug-carrying regions to expose the drug to the target site. One drug eluting balloon device includes a longitudinal sheath that defines an interior space having a balloon disposed therein. When the balloon expands, at least one push element at least partially inverts at least one pocket formed on an outer surface of the sheath. This inversion causes a drug contained within the at least one pocket to be released to the target site. In another embodiment, a plurality of bands is provided, each band made of material having a different resistance to elongation. Upon expansion, the bands invert to expose a drug provided on a surface of the bands. | 12-13-2012 |
20120316633 | Durable Stent Drug Eluting Coating - In embodiments, medical devices, such stents, can deliver a therapeutic agent to body tissue of a patient. The medical device includes a porous therapeutic layer that is substantially free of a polymer matrix which can withstand expansion or contraction of the medical device, with minimal delamination. | 12-13-2012 |
20130090563 | INTRAVASCULAR TEMPERATURE MONITORING SYSTEM - A system for monitoring one or more temperatures at a vessel wall of a vessel of a patient includes an optical fiber, an optical read-out mechanism, and a therapeutic device. The optical fiber may be deployed along an extent of the vessel and may include one or more fiber Bragg grating (FBG) temperature sensors disposed at one or more corresponding sensor locations along a length of the optical fiber. The optical read-out mechanism may be optically coupled to the optical fiber, and it may be configured to transmit light into the optical fiber and detect light reflected from the one or more FBG temperature sensors. The detected light reflected from the one or more FBG temperature sensors may encode local temperatures at each of the one or more corresponding sensor locations. The therapeutic device may be configured for performing a therapeutic procedure to or through the vessel wall. | 04-11-2013 |
20130096588 | ATHERECTOMY POSITIONING DEVICE - Techniques are described for treating an occlusion in a patient. In one example, a system comprises an atherectomy device configured to remove an occlusion from a body lumen and a positioning device that positions the atherectomy device adjacent to the occlusion. The positioning device comprises a tubular body having first and second ends and defining a lumen therebetween, at least two fins engaged to the tubular body, wherein in a deployed state, the fins extend radially outward from the tubular body, and wherein in an undeployed state, the at least two fins wrap about one another and about the tubular body, a guide wire extending through the lumen, and first and second stopper members, each of the first and second stopper members engaged to the guide wire, wherein the first stopper member and the second stopper member substantially prevent movement of the tubular body along the guide wire. | 04-18-2013 |
20130116715 | MEDICAL CUTTING DEVICES AND METHODS OF USE - A cutting device for repairing a heart valve may include a delivery catheter, a cutting unit including an elongate shaft and a plurality of cutting wires, and a plurality of centralizing wires configured to center the cutting unit within a treatment site. A method of repairing a heart valve may include withdrawing a cutting unit through a treatment site while maintaining a plurality centralizing wires in an expanded centering configuration. | 05-09-2013 |
20130122060 | USING BUCKY PAPER AS A THERAPEUTIC AID IN MEDICAL APPLICATIONS - Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site. | 05-16-2013 |
20130123714 | VESSEL PROTECTION MEMBRANE - A medical device assembly may include an elongated guidewire, an elongated flexible tubular membrane disposed about the guidewire, and a percutaneous medical device, wherein the membrane is configured to permit the percutaneous medical device to pass through the lumen. A method of advancing a medical device through a vessel may include advancing an elongated flexible tubular membrane through the vessel to a treatment site, inserting the medical device into the membrane, and advancing the medical device through the membrane while maintaining the membrane in an axially stationary position relative to the vessel. | 05-16-2013 |
20130123832 | MEDICAL DEVICES - Medical systems and methods including balloons having nanotubes are disclosed. In some embodiments, a medical system includes an elongated shaft, and an expandable balloon carried by the shaft and including nanotubes. The medical system is capable of cooling the balloon to less than about 37° C. In some embodiments, a method includes providing a medical device having an elongated shaft, and an expandable balloon carried by the elongated shaft and including nanotubes; and cooling the balloon to less than about 37° C. | 05-16-2013 |
20130144328 | EXPANDING DISTAL SHEATH WITH COMBINED EMBOLIC PROTECTION - A medical device may include an elongate shaft having a distal end portion and a balloon disposed at least partially within the distal end portion. The distal end portion may be configured to selectively expand from a collapsed delivery configuration to a distally-opening expanded filtering configuration. A method of deploying a medical device may include obtaining an elongate shaft having a distal end portion and a balloon disposed at least partially within the distal end portion, advancing the elongate shaft through a vessel to a treatment site, disposing at least a portion of the balloon within the treatment site with the distal end of the elongate shaft positioned adjacent the treatment site, at least partially inflating the balloon, thereby expanding the distal end portion, and deflating the balloon and subsequently performing a procedure with the distal end of the elongate shaft positioned within the vessel adjacent to the treatment site. | 06-06-2013 |
20130150881 | VALVULOPLASTY DEVICE - A medical device may include an elongate shaft having a plurality of elongated balloons disposed at a distal end including a first balloon, a second balloon, and a third balloon, a manifold disposed at a proximal end of the elongate shaft in fluid communication with the plurality of balloons, and a distal tip disposed distal of the plurality of balloons, the distal end of each balloon being joined together by the distal tip. A medical device may include an elongate shaft having a plurality of elongated balloons disposed at a distal end including a first opposing pair and a second opposing pair, a manifold disposed at a proximal end of the elongate shaft in fluid communication with the plurality of balloons, and a distal tip disposed distal of the plurality of balloons, the distal end of each balloon being joined together by the distal tip. | 06-13-2013 |
20130150957 | DECALCIFYING HEART VALVE - Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. Methods of making the vascular valve systems are also described. | 06-13-2013 |
20130165920 | NERVE MODULATION SYSTEM HAVING HELICAL GUIDE - Systems for nerve modulation and methods for making and using the same are disclosed. An example system for nerve modulation may include a first elongate element having a distal end and a proximal end and having a helical guide having a proximal end and a distal end. The system may also include a second elongate element having a distal end and a proximal end and having a nerve modulation element proximate the distal end. A sheath may be disposed about both the first and second elongate elements. Pulling proximally on the proximal end of the first elongate element may cause simultaneous radial and longitudinal displacement of the nerve modulation element. | 06-27-2013 |
20130204184 | KERSTPIEK TIP FOR MEDICAL DEVICES - An apparatus may include a medical device including an elongate shaft disposed about a guidewire, and a distal tip including a plurality of rounded protrusions, wherein adjacent protrusions are fixed directly to each other by a discrete, relatively flexible connector. The plurality of protrusions may each decrease in size from a proximalmost protrusion distally to distalmost protrusion. | 08-08-2013 |
20130226287 | VALVULOPLASTY DEVICE - The disclosure pertains to valvuloplasty devices which include a first outer shaft, a second inner shaft, a plurality of elongate members disposed therebetween and adapted to be expanded radially by relative motion between the first outer shaft and second inner shaft and a circumferential member disposed about the central portions of the plurality of elongate members, wherein the circumferential member is urged by radial expansion of the plurality of elongate members to contact the valve to be treated thereby effecting a valvuloplasty and methods of use therefor. | 08-29-2013 |
20130245603 | Drug Eluting Balloons with Ability for Double Treatment - In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents. | 09-19-2013 |
20130245668 | MAGNETIC DEVICE TO CONTROL OBESITY AND RELATED METHOD OF USE - A medical device includes an outer shell defining a cavity, wherein the shell is movable between a deformed and unstressed state, a magnet disposed within the cavity, and a filler material carried within the cavity conforming to the interior shape of the shell in the unstressed state and being capable of holding its shape in the deformed state. The filler material converts from the deformed state to the unstressed state at a temperature not greater than human body temperature. | 09-19-2013 |
20130296988 | PACING LEADS WITH ULTRATHIN ISOLATION LAYER BY ATOMIC LAYER DEPOSITION - A medical implant includes a polymer material and a ceramic material. In one embodiment, the medical implant includes a nanolaminate comprising at least one ceramic layer and at least one polymer layer. Each ceramic layer is less than or equal to about 30 nanometers thick. | 11-07-2013 |
20130323306 | INJECTABLE BIODEGRADABLE PARTICLES FOR CONTROLLED THERAPEUTIC AGENT RELEASE - In accordance with one aspect, embolic particles are provided that comprise a biodegradable polymer and a therapeutic agent, wherein the particles are configured such that, upon administration to a body lumen of a subject, the therapeutic agent is released from the time of administration up until a first point in time that ranges anywhere from about 1 week after administration to about 4 weeks after administration, at which point in time the therapeutic agent release ceases. The particles are also configured such that particles remain present in the body lumen from the first point in time at which therapeutic agent release ceases up to a second point in time that ranges anywhere from about 2 weeks to about 12 months after the first point in time, at which point the particles are completely degraded. Other aspects pertain to methods of making such particles. Still other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. | 12-05-2013 |
20140073903 | METHOD AND APPARATUS FOR MONITORING AND ABLATING NERVES - Described herein is an apparatus for locally monitoring nerve activity that may be incorporated into a nerve ablation catheter. Such a catheter is equipped with magnetic sensing for both identifying nerves and assessing the success of the ablation. The catheter is also equipped with an ablation instrument for both stimulating and destroying nerve tissue. | 03-13-2014 |
20140100585 | MEDICAL DEVICE HAVING AN ELECTRO-MAGNETIC DEVICE TIP AND RELATED METHOD OF USE - A medical device may include an elongate shaft having a longitudinal axis and a distal end. The medical device may include a distal tip having at least one electromagnetic coil disposed adjacent the distal end and a plurality of bulbous elements disposed about the longitudinal axis. The plurality of bulbous elements may be operatively associated with the at least one electromagnetic coil such that the plurality of bulbous elements may translate relative to the longitudinal axis in response to activation of the at least one electromagnetic coil. A method of crossing an obstruction may include approaching the obstruction with a medical device, supplying alternating current to at least one electromagnetic coil, and advancing the medical device into engagement with the obstruction. | 04-10-2014 |
20140100596 | CENTERED BALLOON FOR THE LEFT ATRIAL APPENDAGE - A medical device for reducing the volume of a left atrial appendage (LAA) may include an elongate shaft having a distal portion, and a volume-reducing means expandable from a collapsed to an expanded state, the volume-reducing means being releasably attached to the distal portion. The volume-reducing means may include an actuatable frame and an impermeable covering disposed over the frame. The volume-reducing means may be sized to fit within the LAA in the expanded state while maintaining an open fluid flow path from a distal region through the ostium of the LAA. A medical device may include a second volume-reducing means to be placed within and substantially occlude a distalmost region of the LAA. A method may include inserting a volume-reducing means into the LAA, expanding the volume-reducing means, and positioning the volume-reducing means such that an open fluid flow path is maintained through an entire cycle of the heart. | 04-10-2014 |
20140114340 | ANTI-THROMBUS FEATURE FOR IMPLANTED MEDICAL DEVICES - A medical device for permanent implantation in a circulatory system of a patient may include an implant configured for percutaneous or minimally-invasive insertion into the patient, at least one connector fixedly attached to the implant and configured to releasably attach to a delivery device, the at least one connector being exposed to blood flow within the circulatory system following implantation, and an anti-thrombus feature configured to transition from an undeployed state to a deployed state. | 04-24-2014 |
20140128991 | BIOERODIBLE NANO-FIBROUS AND NANO-POROUS CONDUCTIVE COMPOSITES - A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth. | 05-08-2014 |
20140242141 | Polymeric/Inorganic Composite Materials for Use in Medical Devices - In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block. | 08-28-2014 |
20140257180 | KERSTPIEK TIP FOR MEDICAL DEVICES - An apparatus may include a medical device including an elongate shaft disposed about a guidewire, and a distal tip including a plurality of rounded protrusions, wherein adjacent protrusions are fixed directly to each other by a relatively flexible connector. The plurality of protrusions may decrease in size from a proximalmost protrusion distally to distalmost protrusion. | 09-11-2014 |
20140257352 | VESSEL OCCLUDING MATERIAL EXTRACTOR - Methods, devices, and systems for extracting vessel occluding material are provided. An embodiment of a vessel occluding material extractor includes a host structure, a plurality of expandable members, a slide mechanism, and a circumferential member. The host structure has an elongate axis. The expandable members are connected to the host structure arrayed radially around the elongate axis. The slide mechanism is connected to the expandable members and adjacent the host structure, and is slidable in the direction of the elongate axis. The circumferential member is connected to the expandable members between the connection of the slide mechanism and the host structure to the expandable members. | 09-11-2014 |
20140257445 | PACING LEADS WITH A STRUCTURED COATING - An implantable medical device includes a lead body having a distal end and a proximal end, a lumen and at least one lead wire extending through the lumen. The lead wire has an outer surface and a polymeric coating on at least a portion of the outer surface of the lead wire. The coating includes a first structure having a first end proximate the outer surface of the lead wire and a second end opposite the first end. The second end is movable relative to the first end and relative to the lead wire. | 09-11-2014 |
20140277010 | VIBRATION AND INERTIA ENHANCED ATHERECTOMY - An atherectomy device is disclosed herein. The atherectomy device includes a first drive shaft, a second drive shaft, a handle assembly, and a cutting member. The first drive shaft extends distally from the handle assembly and includes the cutting member mounted on a distal end region of the first drive shaft. The second drive shaft extends distally from the handle assembly to a distal end of the second drive shaft such that both the first and the second drive shafts are rotatable relative to the handle assembly, and the first drive shaft is rotatable independent of the second drive shaft. | 09-18-2014 |
20140323887 | THERMODILUTION CATHETER SYSTEMS AND METHODS FOR DETERMINING BLOOD FLOW RATES - Catheter systems and methods for determining blood flow rates based on temperature measurements by thermodilution. The catheter may include a fluid lumen defined between inner and outer tubular members for delivering an indicator fluid, and a guidewire lumen defined by the inner tubular member. The catheter may include fluid infusion openings at the distal end region of the outer tubular member configured to permit the indicator fluid to exit the catheter from the fluid lumen, and a fluid hole located at the distal end region of the inner tubular member configured to permit the indicator fluid to pass from the fluid lumen into the guidewire lumen. A temperature sensor positioned on a guidewire may be positioned within the guidewire lumen to measure the temperature of the indicator fluid entering the guidewire lumen through the fluid hole. A blood flow rate may be calculated based on the measured temperature. | 10-30-2014 |
20140324094 | DEVICES FOR OBSTRUCTING PASSAGE OF AIR OR OTHER CONTAMINANTS INTO A PORTION OF A LUNG AND METHODS OF USE - Provided are devices, systems and methods of selectively controlling air flow into one or more section of a patient's lungs. In particular, the devices may be valve devices having an inner lumen configured to transition between a first diameter and a second diameter smaller than the first diameter to control the airflow through the valve. | 10-30-2014 |
20150025532 | MEDICAL DEVICES FOR RENAL NERVE ABLATION - Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for tissue ablation. The medical device may include an elongated shaft having a distal region. An inflatable balloon may be mounted to the distal region. The inflatable balloon may include a body region, a proximal waist, a distal waist, a proximal cone region, and a distal cone region. A skirt may be attached to the inflatable balloon and may extend proximally from the body region. An electrode assembly may be applied directly to an outer surface of the body region of the inflatable balloon. The electrode assembly may include a first conductive member applied directly to the outer surface of the body region of the inflatable balloon and extending proximally therefrom along an outer surface of the skirt. | 01-22-2015 |
20150025629 | MEDICAL DEVICE, SYSTEM, AND METHOD FOR REGULATING FLUID FLOW IN BRONCHIAL PASSAGEWAYS - A medical device for regulating fluid flow within one or more lungs of a patient is disclosed. The medical device includes an elongate tubular member, a first extension, a second extension, and a valve member. The elongate tubular member includes a first plurality of channels extending between a proximal and distal ends. The first and second extensions defines a second and third plurality of channels, respectively, each extending from the distal end of the elongate tubular member and configured for placement in a first and second passageway of a lung. The valve member operably couples to the elongate tubular member and is configured to transition between a first position and a second position. The valve member prevents fluid flow to first set of the first plurality of channels in the first position and prevents fluid flow to second set of the first plurality of channels in the second position. | 01-22-2015 |
20150039065 | PACING LEADS WITH ULTRATHIN ISOLATION LAYER BY ATOMIC LAYER DEPOSITION - An implantable medical lead includes a substrate extending from a distal end to a proximal end of the medical lead. The substrate includes at least one polymer material and particles dispersed throughout the polymer material. In one embodiment, the particles are of at least one of nanoclay material and nanodiamond material. | 02-05-2015 |
20150066135 | Bioerodible Composites for Endoprostheses - A bioerodible endoprosthesis includes a composite including a matrix comprising a bioerodible magnesium alloy and a plurality of ceramic nanoparticles within the matrix. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns. The microstructure can be produced by one or more equal-channel high-strain processes. | 03-05-2015 |
20150073522 | ENDOPROSTHESIS DEVICES INCLUDING BIOSTABLE AND BIOABSORABLE REGIONS - Some embodiments are directed to medical devices, and methods for making and using the medical devices. An exemplary endoprosthesis includes an expandable tubular framework having a proximal end, a distal end, and a lumen extending therethrough. The tubular framework includes a number of interconnected biostable struts. The tubular framework has a proximal region extending distally from the proximal end to an intermediate location, and a distal region extending proximally from the distal end to the intermediate location. The distal region of the tubular framework is more flexible than the proximal region. | 03-12-2015 |