Patent application number | Description | Published |
20100222338 | BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 09-02-2010 |
20110118250 | BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 05-19-2011 |
20110251190 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I | 10-13-2011 |
20120329830 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B | 12-27-2012 |
20130018064 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of UseAANM Paras; Nick A.AACI San FranciscoAAST CAAACO USAAGP Paras; Nick A. San Francisco CA USAANM Cheng; YuanAACI Newbury ParkAAST CAAACO USAAGP Cheng; Yuan Newbury Park CA USAANM Powers; TimothyAACI MalibuAAST CAAACO USAAGP Powers; Timothy Malibu CA USAANM Brown; JamesAACI MoorparkAAST CAAACO USAAGP Brown; James Moorpark CA USAANM Hitchcock; Stephen A.AACI JupiterAAST FLAACO USAAGP Hitchcock; Stephen A. Jupiter FL USAANM Judd; TedAACI Simi ValleyAAST CAAACO USAAGP Judd; Ted Simi Valley CA USAANM Lopez; PatriciaAACI West HillsAAST CAAACO USAAGP Lopez; Patricia West Hills CA USAANM Xue; QiufenAACI Newbury ParkAAST CAAACO USAAGP Xue; Qiufen Newbury Park CA USAANM Yang; BryantAACI Simi ValleyAAST CAAACO USAAGP Yang; Bryant Simi Valley CA US - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B | 01-17-2013 |
20130040931 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein ring A, B | 02-14-2013 |
20130157996 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS - Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 06-20-2013 |
20130158034 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS - Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 06-20-2013 |
20130225552 | HETEROBICYCLIC COMPOUNDS - Heterobicyclic compounds of Formula (I): | 08-29-2013 |
20140171406 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS - Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 06-19-2014 |
20140171639 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS - Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 06-19-2014 |
20140235642 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS - Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 08-21-2014 |
20140275058 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-18-2014 |
20150031668 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS - Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 01-29-2015 |
20150038497 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 02-05-2015 |
20150252011 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-10-2015 |
20150252059 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-10-2015 |
Patent application number | Description | Published |
20100040402 | DISPENSING APPLICATOR FOR FLUIDS - The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 02-18-2010 |
20110142527 | DISPENSING APPLICATOR FOR FLUIDS - The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. In one embodiment, the dispensing applicator comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Optionally, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. Also optionally, the applicator tip comprises a semi-permeable or non-permeable partial shield member disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 06-16-2011 |
20110262207 | DISPENSING APPLICATOR FOR FLUIDS - The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 10-27-2011 |
20120163898 | DISPENSING APPLICATOR FOR FLUIDS - Disclosed is a hand-held dispensing applicator comprising a fluid source, frangible applicator tip attached to the fluid source, and absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs reinforcing the tongue element to resist unintentional breaking of the frangible region. Also, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 06-28-2012 |
20120230753 | DISPENSING APPLICATOR FOR FLUIDS - Disclosed is a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 09-13-2012 |
20120251219 | DISPENSING APPLICATOR FOR FLUIDS - A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 10-04-2012 |
20130028651 | DISPENSING APPLICATOR FOR FLUIDS - A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. The applicator may be applicable for a medical purpose. When the frangible applicator tip is broken, the fluid flows from the source to the absorbent member, spread on a surface. The frangible applicator tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region there between. The tongue element may comprise ribs for reinforcing the tongue element. The applicator tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. | 01-31-2013 |
20130336705 | DISPENSING APPLICATOR FOR FLUIDS - A hand-held dispensing applicator comprising a fluid source, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip is provided. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. | 12-19-2013 |
20140126949 | Dispensing Applicator for Fluids - A single-piece, injection molded, hand-held liquid dispensing applicator. The single-piece applicator comprising a source of fluid and a frangible applicator tip attached to the fluid source. When the frangible applicator tip is broken, the fluid flows from the source to an absorbent member attached to the applicator tip to spread the liquid on a surface. The frangible tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region therebetween. The tongue element may comprise ribs for reinforcement. The frangible tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. The dispensing applicator may be used in various medical applications. | 05-08-2014 |
20140308059 | DISPENSING APPLICATOR FOR FLUIDS - A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip is provided. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region, and the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose. | 10-16-2014 |
20150273196 | DISPENSING APPLICATOR FOR FLUIDS - A dispensing applicator may include a tubular container configured to contain a fluid. The container may include an inlet end and an outlet end, the container including a head member at the outlet end, the head member including a frangible region. A substantially rigid tongue may extend longitudinally through the frangible region. A fracture anvil may be engaged with the rigid tongue element and configured to fracture the frangible region without entirely separating the tongue from the head member. A cap may be secured to the inlet end of the container. A gasket placed between the inlet end and the cap, and the cap may be configured to deform the gasket such that the gasket fills any void remaining within the container after the container is filled with a predetermined volume of the fluid. | 10-01-2015 |
20150290443 | DISPENSING APPLICATOR FOR FLUIDS - A liquid dispensing applicator may include a liquid source for housing a liquid. An absorbent member may be adjacent to a proximal end of the liquid source, and may be configured to deliver the liquid to an external surface. An attachment member may secure the absorbent member to the liquid source, and may include a through passage to allow the liquid to flow from the liquid source into the absorbent member. A rigid member may extend outwardly from the attachment member into the absorbent member. A shield member may be positioned adjacent to the attachment member and may extend from the attachment member so as to be positioned within the absorbent member. A capillary tube may be configured to provide fluid communication between the liquid source and the liquid dispenser upon application of pressure to the liquid source. | 10-15-2015 |
Patent application number | Description | Published |
20090290492 | METHOD AND APPARATUS TO INDEX NETWORK TRAFFIC META-DATA - A method, system, and apparatus for indexing network traffic meta-data is disclosed. In one embodiment, a method includes identifying a packet having a header and a payload in a flow of a data through a network, classifying the header of the packet in a type of the header, determining an algorithm to extract a meta-data (e.g., which may be stored in a database of the storage device, and the storage device may be limited in a storage capacity) having information relevant to network traffic visibility based on the type of the header, extracting the meta-data from the header, and streaming the meta-data to a storage device. The method may include applying a last recently used algorithm to discard information from the storage device when storage device is limited in the storage capacity. The method may also include determining that the type of the header is an Ethernet header. | 11-26-2009 |
20090290501 | CAPTURE AND REGENERATION OF A NETWORK DATA USING A VIRTUAL SOFTWARE SWITCH - Methods and a system of capture and regeneration of a network data using a virtual software switch are disclosed. In an embodiment, a method includes capturing a network data using a virtual software switch, a processor, and a memory. The network data is captured to perform a network visibility analysis and the network data is communicated to at least one port of the virtual software switch. The method includes forming a stored network data in a memory. The method also includes regenerating the stored network data to form a reconstructed data. | 11-26-2009 |
20090290580 | METHOD AND APPARATUS OF NETWORK ARTIFACT INDENTIFICATION AND EXTRACTION - A method, system, and apparatus of network artifact identification and extraction are disclosed. In one embodiment, a method includes aggregating a payload data (e.g., may be a component of the extracted artifact) from different network packets to form an aggregated payload data, matching the payload data with an entry of a library of known artifacts, determining a type of the payload data based on a match with the entry of the library of known artifacts, separating the payload data from a header data in a network packet, and communicating the aggregated payload data as an extracted artifact to a user. The method may include using the extracted artifact to perform network visibility analysis of users on packets flowing across the network. The method may validate that the entry is accurate by performing a deeper analysis of the payload data with the entry of the library of known artifacts. | 11-26-2009 |
20090292681 | PRESENTATION OF AN EXTRACTED ARTIFACT BASED ON AN INDEXING TECHNIQUE - A system and method of presentation of an extracted artifact based on an indexing technique are disclosed. In an embodiment, the method includes indexing a database of a captured network characteristic data using a processor and a memory to form an indexed capture data. The method includes enhancing a query response time with the indexed capture data. The method further includes searching the indexed capture data to generate a capture query result. The capture query result includes an extracted artifact. The method also includes graphically presenting the capture query result as at least one of an artifact list and an artifact image. | 11-26-2009 |
Patent application number | Description | Published |
20110117119 | NOVEL COMPOSITIONS AND METHODS - The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c protein sequence for use in the treatment or prevention of latent TB. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of latent tuberculosis. | 05-19-2011 |
20110206712 | TUBERCULOSIS RV2386C PROTEIN, COMPOSITIONS AND USES THEREOF - The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis. | 08-25-2011 |
20110223200 | NOVEL COMPOSITIONS AND METHODS - The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis | 09-15-2011 |
20120294882 | MODIFIED TUBERCULOSIS ANTIGENS - Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis. | 11-22-2012 |
20140086948 | TUBERCULOSIS RV2386C PROTEIN, COMPOSITIONS AND USES THEREOF - The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis. | 03-27-2014 |
20140178423 | NOVEL COMPOSITIONS AND METHODS - The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis. | 06-26-2014 |
20140314802 | NOVEL COMPOSITIONS AND METHODS - The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis. | 10-23-2014 |
20150093414 | MODIFIED ANTIGENS - Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis. | 04-02-2015 |