Isabel
Elise Isabel, Point-Claire CA
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20100305056 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE - Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, strongyloidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases: | 12-02-2010 |
20130244962 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES - Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, stronglyoidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. | 09-19-2013 |
Elise Isabel, Pointe-Claire CA
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20090170828 | Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase - Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I) | 07-02-2009 |
20100048551 | Tricyclic Compounds Useful as Inhibitors of Kinases - The present invention provides inhibitors of kinases, specifically IκB kinases, JAK1, JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-κB-mediated diseases. | 02-25-2010 |
20100152208 | BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I). | 06-17-2010 |
20110301143 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE - Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R | 12-08-2011 |
Matthew Isabel, Seattle, WA US
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20140344662 | INK TO TEXT REPRESENTATION CONVERSION - Technologies are generally provided for converting handwritten ink input to text annotations. A user may provide handwritten ink input to content displayed on a computing device to edit and mark up the content. The ink input may be provided employing touch or an electronic stylus on a user interface of the computing device to edit the content. The ink input may be processed to identify insertion of comments, deletion of text, and to identify insertion of markup symbols and shapes. The ink input may be converted to a text annotation based on a context of the ink input and a grammar and proofreading analysis. The text annotation may be displayed in an annotation view. The ink input may be converted periodically after predefined periods of time and upon detection of selection of a conversion button to activate conversion of the ink input. | 11-20-2014 |
Sandra Isabel, Quebec CA
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20160053242 | THERMOSTABLE NUCLEASE - A heat-stable nuclease found in | 02-25-2016 |
Scott Isabel, Sunnyvale, CA US
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20140112496 | MICROPHONE PLACEMENT FOR NOISE CANCELLATION IN VEHICLES - Systems and methods for processing acoustic signals in vehicles are provided. An example system comprises one or more microphones and a voice monitoring device. The voice monitoring device can receive, via the one or more microphones, an acoustic signal and suppress noise in the acoustic signal to obtain a clean speech component. The obtained clean speech component can be provided to one or more vehicle systems. In some embodiments, two microphones selected from the one or more microphones can be positioned on an inner side of a roof of the vehicle, above a windshield, in front of a driver's seat, and directed towards a driver. The two microphones can be equidistant with respect to a symmetry plane of the driver's seat. | 04-24-2014 |
Yves Isabel, Montreal-Nord CA
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20090014609 | PRELOADING BRACE FOR GAS TURBINE ENGINE TRANSPORTATION - An assembly for preventing damage to bearings of a gas turbine engine during transportation is provided. The assembly comprises a turbofan gas turbine engine having an engine casing and at least one turbine shaft supported by a plurality of bearings, and, a brace secured relative to the engine casing and biasing the shaft along an axial direction of the shaft. | 01-15-2009 |