Heron, GB
Andrew Heron, Oxford Oxfordshire GB
Patent application number | Description | Published |
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20140356289 | Multisomes: Encapsulated Droplet Networks - The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins. | 12-04-2014 |
Andrew Heron, Oxford GB
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20150068904 | MUTANT LYSENIN PORES - The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin. | 03-12-2015 |
20150191709 | MODIFIED HELICASES - The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides. | 07-09-2015 |
20150218629 | ENZYME CONSTRUCT - The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides. | 08-06-2015 |
Andrew John Heron, Oxford GB
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20100032627 | FORMATION OF BILAYERS OF AMPHIPATHIC MOLECULES - A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems. | 02-11-2010 |
20120107802 | METHOD FOR SEQUENCING A HETEROPOLYMERIC TARGET NUCLEIC ACID SEQUENCE - The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore. | 05-03-2012 |
20130129910 | BILAYERS - A method for producing a bilayer of amphipathic molecules comprising providing a hydrated support and providing a hydrophilic body, and bringing the hydrated support and hydrophilic body into contact to form a bilayer of amphipathic molecules. A bilayer produced by the method of the invention, and uses of the bilayer. | 05-23-2013 |
20130146815 | FORMATION OF BILAYERS OF AMPHIPATHIC MOLECULES - A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems. | 06-13-2013 |
20140186823 | MUTANT PORES - The invention relates to mutant forms of Msp. The invention also relates to nucleic acid characterisation using Msp. | 07-03-2014 |
20140255921 | ENZYME METHOD - The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore. | 09-11-2014 |
20140335512 | ENZYME METHOD - The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a RecD helicase. The helicase controls the movement of the target polynucleotide through the pore. | 11-13-2014 |
20150065354 | METHOD FOR CHARACTERISING A POLYNUCELOTIDE BY USING A XPD HELICASE - The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and an XPD helicase. The helicase controls the movement of the target polynucleotide through the pore. | 03-05-2015 |
20150152492 | HAIRPIN LOOP METHOD FOR DOUBLE STRAND POLYNUCLEOTIDE SEQUENCING USING TRANSMEMBRANE PORES - The invention relates to a new method of sequencing a double stranded target polynucleotide. The two strands of the double stranded target polynucleotide are linked by a bridging moiety. The two strands of the target polynucleotide are separated using a polynucleotide binding protein and the target polynucleotide is sequenced using a transmembrane pore. | 06-04-2015 |
20150265994 | FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR - An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate. | 09-24-2015 |
20150285781 | DROPLET INTERFACES - The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium, which method comprises: (a) providing a first volume comprising polar medium and a second volume comprising polar medium which are separated from one another by an apolar medium, wherein at least one of said first and second volumes comprises a layer comprising amphipathic molecules, at the interface between the polar medium and the apolar medium, wherein each of the amphipathic molecules comprises a first outer hydrophilic group, a hydrophobic core group, and a second outer hydrophilic group, wherein each of the first and second outer hydrophilic groups is linked to the hydrophobic core group; and (b) causing the first and second volumes to come into contact with one another to form a membrane comprising said amphipathic molecules between the first and second volumes. The invention also provides a system comprising a membrane between a first volume of a polar medium; and a second volume of a polar medium, which membrane comprises the amphipathic molecules, and wherein the first volume of polar medium is within an apolar medium. | 10-08-2015 |
Bernard Mark Heron, Yorkshire GB
Patent application number | Description | Published |
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20100039688 | 6-(BIPHENYL-ESTER)-3H-NAPHTHO[2,1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM - A naphthopyran compound represented by the formula (I) wherein: n | 02-18-2010 |
20110122475 | PHOTOCHROMIC DICHROIC NAPHTHO-PYRANS AND OPTICAL ARTICLES CONTAINING THEM - A naphthopyran compound represented by the formulae (I) to (II) wherein:—mi, Hi2, p, q are each an integer comprised from O to 4 or 5 inclusive;—Ri, R2 and R4, represent a group selected from halogen, H, —Ra, aryl, —OH, —ORa, —SH, —SRa, —NH2, —NR8RaI, —NRbRc, —NRaI-CORa, —NRaiCO(aryl), —NRai aryl, —N-aryfe, —N(aryl)CO(aryl), —CO—R3, —CO2R3I, —OC(O)—Rd, and —X—(Re)—Y, and linear or branched (Ci-Ci8) perfluoroalkyl group, wherein R3, RaI, Rb, Rc, X, Y, Re, Rd are as defined into the description;—Zi re resent a group selected from: (formules) | 05-26-2011 |
Bernard Mark Heron, Brough GB
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20100202033 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM - A naphthopyran compound represented by the formula (I): | 08-12-2010 |
Dale R. Heron, Crawley GB
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20080235198 | Translation Service for a System with a Content Directory Service - A system includes a device (MS-a) which stores media content information using a form of Content Directory Service (CDS) and querying devices (CP-a) which make queries for media content information. An entity ( | 09-25-2008 |
Dale Robert Heron, Crawley GB
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20090106193 | REAL TIME RESPONSES IN DECENTRALIZED NETWORKS - A method of enabling a user to obtain a query result in a data network is provided taken latency problems of decentralised networks comprising a number of entities into account. The method comprises the steps of sending a query from a requesting entity to a number of further entities in the data network, receiving responses from at least some of the further entities and determining an initial relative response time for an initial group of said responses, determining a current relative response time for further incoming responses, comparing the initial relative response time with the current relative response time, and presenting the responses to a user of the requesting entity when the difference between the initial relative response time and the current relative response time exceeds a relative response-time parameter Further, a computer readable medium and a device provided with or for carrying out such methods are provided. | 04-23-2009 |
Giles Douglas Yorke Heron, Hampstead GB
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20160127192 | LOOP-FREE CONVERGENCE IN COMMUNICATION NETWORKS - In one embodiment, a method includes identifying a change in network topology at a network device, transmitting a test packet from the network device to determine if an adjacent network device located in a backup path has converged following the network topology change, and updating a forwarding information base at the network device in response to the network topology change if a response to the test packet indicates that the adjacent network device has converged. An apparatus and logic are also disclosed herein. | 05-05-2016 |
Giles D.y. Heron, Hampstead GB
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20150049631 | TOPOLOGY AWARE PROVISIONING IN A SOFTWARE-DEFINED NETWORKING ENVIRONMENT - An example method for topology aware provisioning in a software-defined network environment is provided and includes receiving, at a provider edge device (PE), access network topology information associated with a customer edge device in a network environment, synthesizing the access network topology information and a local router information associated with the PE into a topology message, and publishing the topology message to a central controller in the network environment. The synthesizing can include aggregating the access network topology information and the local router information, modeling the aggregated information in a representation-independent format and encoding the representation-independent formatted aggregated information in standardized machine-parsable format. | 02-19-2015 |
Jean-Paul Heron, Belfast GB
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20120011539 | METHOD, SYSTEM AND APPARATUS FOR PROCESSING A BROADCAST TELEVISION SIGNAL - The present invention relates generally to a method, system and/or apparatus for processing a broadcast television signal transmitted over a broadcast medium. A method of processing a digital television ‘TV’ signal at a customer premises system comprises the steps of: receiving a digital TV signal over a digital TV broadcast medium; converting packet data comprising said received digital TV signal to internet protocol ‘IP’ data packets; and transmitting said IP data packets to a customer premises; IP device or IP network. A customer premises apparatus for processing a digital television ‘TV’ signal comprises: means for receiving a digital TV signal over a digital TV broadcast medium; processing means for converting packet data comprising said received digital TV signal to internet protocol ‘IP’ data packets; and means for transmitting said IP data packets to a customer IP device or IP network. | 01-12-2012 |
Nicola Heron, Sheffield GB
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20160074202 | NECK ORTHOSIS - A neck orthosis, head support system and method of use for supporting a head of a patient having a medical condition are described. The neck orthosis can comprise a body made of a material which is flexible and stretchy and a releasable fastener. The neck orthosis is shaped to cause the neck orthosis snuggly to conform to the anatomy of the patient adjacent the neck of the patient when the neck support is secured in use about the neck of the patient by the releasable fastener to support the head of the patient. A head support system can include a plurality of different support members which can be releasably attached to the neck orthosis to provide different types of support to the head of the patient. | 03-17-2016 |
Nicola Heron, Macclesfield GB
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20090275570 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS - The invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer. | 11-05-2009 |
Nicola Murdoch Heron, Macclesfield GB
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20090012077 | Novel Compound - 827 - The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K. | 01-08-2009 |
20100069412 | PHOSPHONOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE - Quinazoline derivatives of formula (I): | 03-18-2010 |
20140162984 | PHOSPHONOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE - Quinazoline derivatives of formula (I): | 06-12-2014 |
20150307534 | CHEMICAL COMPOUNDS - Quinazoline derivatives of formula (I): | 10-29-2015 |
Roger Heron, Bedford GB
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20100126601 | Pilot Valve For A Pressure Reducing Valve - A pilot valve ( | 05-27-2010 |
Scott R. Heron, East Kilbride GB
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20120145890 | Methods And Systems For Mass Spectrometry - The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI. | 06-14-2012 |
20130252246 | Methods And Systems For Mass Spectrometry - The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI. | 09-26-2013 |
Steven Heron, Brighton GB
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20110184905 | METHOD OF STORING AND ANALYSING DATA PRODUCED FROM INTERACTIONS BETWEEN EXTERNAL AGENTS AND A SYSTEM - The present invention relates to a method of storing data records produced from monitoring interactions between external agents and a system. The method comprises defining specific interactions that can occur between the external agents and the system as potential events of interest. A chain of interactions occurring during respective interaction sessions between a respective external agent and the system are monitored and potential events of interest occurring in the said chain are determined. Data records from the monitored chain of interactions are produced, the respective data record including data identifying determined potential events of interest and data associated therewith. A profile identity, representative of the external agent, is assigned to each data record produced during a said interaction session. Data records of individual potential events of interest are stored in a way that is ordered according to the type of potential event of interest and data records of potential events of interest occurring during an interaction session are stored in a way that is ordered according to assigned profile identity. | 07-28-2011 |