Helfrich
Barbara A. Helfrich, Lakewood, CO US
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20100196366 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 08-05-2010 |
20120177641 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 07-12-2012 |
Brian Helfrich, Seattle, WA US
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20140188534 | SYSTEM AND METHOD FOR MANAGING REQUESTS FOR POOLED RESOURCES DURING NON-CONTENTION - A computer system that provides pooled computing resources to clients may receive requests for resources, each of which includes a bid amount. While the supply of resources exceeds the demand, the system may adaptively determine a theoretical bid threshold for the resource pool that represents the predicted value of the lowest bid amount for which corresponding requests will be granted when demand for the resources exceeds supply. The determination may be dependent on a distribution of the bid amounts included in the requests for resources. The system may adaptively determine the lowest bid amount for which corresponding ones of the requests will be granted during non-contention dependent on changes in demand for the resources, the total capacity of the resource pool, and the theoretical bid threshold value, and may grant requests that include higher bid amounts. The use of some resources may be terminated in response to changes in demand. | 07-03-2014 |
20140297866 | USER-DEFINED POOLS - One or more resource slots are allocated to a customer according to a first set of pricing policies. The customer is allowed to identify at least one of the resource slots and identify other users allowed to access the identified resource slots according to a second pricing policy, the second pricing policy being designated by the customer. | 10-02-2014 |
20140297867 | CAPACITY MERGING FOR USER-DEFINED POOLS - One or more resource slots are allocated to at least two entities according to a first set of pricing policies. The entities are allowed to identify users allowed to access identified resource slots according to a second pricing policy, the second pricing policy being designated by one or both of the users. | 10-02-2014 |
20140297868 | BURST CAPACITY FOR USER-DEFINED POOLS - One or more resource slots are instantiated and allocated to a user according to a first set of pricing policies. The user is allowed to identify at least one of the resource slots and identify other users allowed to access the identified resource slots according to a second pricing policy, the second pricing policy being designated by the user. An indication is received that a request has been received that exceeds a computing capacity. In response, additional computing capacity to allow fulfillment of the request is allocated. | 10-02-2014 |
Casey John Helfrich, Pittsburgh, PA US
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20150234987 | System and Method for Processing Healthcare Information - A system for processing healthcare information includes: a patient clinical context module including a patient-user relationship model, a medical knowledge database, and an applied workflow execution model; the patient clinical context module being configured to retrieve information from a plurality of data sources and to use the patient-user relationship model, the medical knowledge database, and the applied workflow execution model to produce output information relevant to a patient; and a user display configured to display the output information in a longitudinal view of health data for the patient aggregated from the plurality of data sources. A method for processing healthcare information that can be implemented by the system is also disclosed. | 08-20-2015 |
Douglas R. Helfrich, New Philadelphia, OH US
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20150337875 | Hydraulic Actuator Gland - Various embodiments of a hydraulic actuator gland and a hydraulic actuator are provided. In one embodiment, a hydraulic actuator gland comprises: an outer bearing carrier; an intermediate bearing carrier; and an inner bearing carrier; wherein the outer bearing carrier is oriented axially closer to a distal end of the gland; wherein the inner bearing carrier is oriented axially closer to a proximal end of the gland; and wherein at least a portion of the intermediate bearing carrier is oriented axially between the outer bearing carrier and the inner bearing carrier. | 11-26-2015 |
Elizabeth C. Helfrich, Dallas, TX US
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20130341324 | Multi-Compartment Receptacle - A container for use as a waste receptacle that is stackable and may be made using a single continuous material. The container may lock together with an identical container to form a multi-compartment receptacle. Additionally, the container is stackable within identical containers. The container is easily separable from the locked position with another container. | 12-26-2013 |
Eric Helfrich, Baltimore, MD US
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20130346328 | METHOD AND SYSTEM FOR ASSESSING COMPLIANCE RISK OF REGULATED INSTITUTIONS - A method for distributing requests for artifacts to a regulated institution for risk assessment includes: storing a client profile including a risk rating value corresponding to a risk that the related regulated institution will not be compliant with a set of regulations; identifying a plurality of artifacts to be provided by the regulated institution, each artifact including a frequency, a weight, one of a plurality of waves, and one of a plurality of categories; assigning a priority value to each of the categories; grouping each artifact into a plurality of buckets, each bucket including artifacts that include a common wave and a common category, and wherein the artifacts are evenly distributed into the buckets; and generating a request schedule, wherein the request schedule is a schedule for the distribution of requests for artifacts included in each bucket over a predetermined period of time. | 12-26-2013 |
Evert Alle Helfrich, Seattle, WA US
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20120246858 | POSITION SENSING TOOTHBRUSH - The toothbrush includes a handle portion ( | 10-04-2012 |
20130330687 | INTERFACE STRUCTURE FOR LIQUID/AIR BURST DENTAL CLEANING APPLIANCE - The power dental appliance includes a handle/receiver assembly ( | 12-12-2013 |
20150230594 | POSITION SENSING TOOTHBRUSH - The toothbrush includes a handle portion ( | 08-20-2015 |
Evert Alle Helfrich, Seattle NL
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20140090197 | POSITION SENSING TOOTHBRUSH - The toothbrush includes a handle portion ( | 04-03-2014 |
Evert Alle Helfrich, Bellevue, WA US
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20110247159 | DENTAL CLEANING MOUTHPIECE WITH REPLACEABLE BRISTLE FIELDS - The dental mouthpiece includes an assembly ( | 10-13-2011 |
Evert Alle Helfrich, Groningen NL
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20110258792 | SYSTEM FOR AXIAL BRISTLE MOTION IN A TEETH CLEANING MOUTHPIECE - The mouthpiece includes a mouthpiece carrier member ( | 10-27-2011 |
Jeffrey W. Helfrich, Dallas, TX US
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20130341324 | Multi-Compartment Receptacle - A container for use as a waste receptacle that is stackable and may be made using a single continuous material. The container may lock together with an identical container to form a multi-compartment receptacle. Additionally, the container is stackable within identical containers. The container is easily separable from the locked position with another container. | 12-26-2013 |
Jens Helfrich, Speyer DE
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20090009232 | Power Switches - A switching device suitable for operation in temperatures over 150 C comprises first 1 and second 2 transistors, the source | 01-08-2009 |
Jim C. Helfrich, Sun River, MT US
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20080211232 | Water current powered motor - A water powered motor for extracting raw energy from a water current and converting it to kinetic energy. The water powered motor is generally rectangular in shape with a generally round water wheel consisting of foldable vanes. The vanes receive raw energy produced by water current transforming that raw energy into usable energy for powering a pump, electric generator or as a general power source to power other equipment such as desalinization machinery. | 09-04-2008 |
Joe Helfrich, Milwaukee, WI US
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20120086220 | ENERGY SYSTEM FOR HEAVY EQUIPMENT - An energy system for heavy equipment having an actuator for operating a tool includes a bus, an engine, a generator, an energy storage device, and a controller. The bus is for providing electricity to the actuator as a function of operation of the tool. The engine is for providing a power output and the generator is coupled to the engine and configured to provide electricity to the bus. The energy storage device is configured to receive electricity from the bus for storage of energy, and is further configured to provide electricity to the bus to supplement the electricity provided by the generator. The controller is configured to change the power output of the engine as a function of electrical demand on the bus. In response to a change in the electrical demand, the controller is configured to change the power output of the engine at a rate that is less than a maximum capability of the engine. | 04-12-2012 |
Joseph Helfrich, Milwaukee, WI US
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20110056192 | TECHNIQUE FOR CONTROLLING PUMPS IN A HYDRAULIC SYSTEM - A hydraulic system includes a plurality of pumps that provide pressurized fluid to a plurality of hydraulic actuators some of which work more that others. That system is controlled by producing a usage value for each of the plurality of pumps which indicates an amount that the respective pump has worked. One of the pumps is assigned to each hydraulic actuator in response to the usage values. The pumps with lower usage values are assigned to hydraulic actuators which work more, so as to equalize the use of each pump. The assignment of pumps to hydraulic actuators changes with changes in the usage values for the plurality of pumps. When a given one of the plurality of hydraulic actuators is to operate, hydraulic fluid is routed from the assigned pump to that given one of the plurality of hydraulic actuators. | 03-10-2011 |
20110056194 | HYDRAULIC SYSTEM FOR HEAVY EQUIPMENT - Heavy equipment includes first and second hydraulic pumps, and first and second hydraulic actuators, where the first hydraulic actuator facilitates a first work function of the heavy equipment and the second hydraulic actuator facilitates a second work function of the heavy equipment. The heavy equipment further includes valving and a computerized controller. The valving is configured to allow the first hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator, and to allow the second hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator. The computerized controller is coupled to the valving, and has a logic module. The logic module provides instructions to the computerized controller to operate the valving as a function of inputs from an operator command, a sensor input, and prioritization logic associated with the first and second work functions, so as to optimize performance of the work functions facilitated by the hydraulic actuators with respect to available output of the hydraulic pumps. | 03-10-2011 |
20110233931 | ENERGY MANAGEMENT SYSTEM FOR HEAVY EQUIPMENT - Equipment having an energy management system includes an articulated arm, a work implement, an energy management system, and a hydraulic circuit. The articulated arm includes hydraulic actuators designed to maneuver the articulated arm, and the work implement is fastened to the articulated arm. The energy management system is adjustable between a first configuration and a second configuration, and includes a hydraulic rotating machine and an electric rotating machine coupled to the hydraulic rotating machine. When the energy management system is in the first configuration, the hydraulic rotating machine and the electric rotating machine function as an electric motor powering a hydraulic pump. When the energy management system is in the second configuration, the hydraulic rotating machine and the electric rotating machine function as a hydraulic motor powering an electric generator. The hydraulic circuit is designed to supply a hydraulic fluid to drive the hydraulic actuators when the energy management system is in the first configuration, and is further designed to recover the hydraulic fluid from the hydraulic actuators and to generate electrical power when the energy management system is in the second configuration. | 09-29-2011 |
20120089280 | ENERGY MANAGEMENT SYSTEM FOR HEAVY EQUIPMENT - Heavy equipment includes a body, an electrical bus, and working components coupled to the body and powered by electricity conveyed via the electrical bus. The heavy equipment further includes a generator set providing an electrical output to the electrical bus, an energy storage element configured to be coupled to the electrical bus, and a computerized controller coupled to the energy storage element. The computerized controller includes a logic module for coupling the energy storage element to the electrical bus in advance of a predicted increase in demand upon the electrical bus, where the increase in demand is anticipated by the computerized controller as forthcoming based upon extrapolation, at least in part, from data related to a previous operation of the heavy equipment. | 04-12-2012 |
20140136042 | ENERGY MANAGEMENT SYSTEM FOR HEAVY EQUIPMENT - Power supply systems and methods for controlling such systems are provided. One power supply system includes a generator set configured to provide an electrical output to an electrical bus, over which power is supplied to heavy equipment. The power supply system further includes a computerized controller configured to be coupled to an energy storage element, wherein the computerized controller is configured to couple the energy storage element to the electrical bus in advance of a predicted increase in demand upon the electrical bus to maintain a substantially constant voltage on the electrical bus during the predicted increase in demand and prevent a drop in voltage on the electrical bus that would otherwise result from the predicted increase in demand. The predicted increase in demand is anticipated by the computerized controller as forthcoming based upon extrapolation, at least in part, from data related to a past operation of the heavy equipment. | 05-15-2014 |
Joseph Helfrich, Milwaikee, WI US
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20120089279 | ENERGY MANAGEMENT AND STORAGE SYSTEM - Heavy equipment is designed for operation in a substantially-repetitive work cycle that includes lifting, rotating, and lowering steps. The heavy equipment includes a generator, an electrical bus, an energy storage component, and working components. The generator provides a substantially constant electrical output to the electrical bus, which is communicated to the working components. As such, the working components of the heavy equipment are driven directly or indirectly by the electrical output of the generator. The controller selectively couples the energy storage component to the electrical bus, and the energy storage component is configured to store electricity provided by the generator, and to provide electricity to the working components by way of the electrical bus. The electrical output of the generator is less than the power used by the heavy equipment during a portion of the work cycle, and the controller couples the energy storage component to the electrical bus to supplement the electrical output of the generator during the portion of the work cycle in which the electrical output of the generator is less than the power used by the working components of the heavy equipment. | 04-12-2012 |
Juliana Helfrich, Glauchau DE
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20080220527 | MODULAR TRANSFECTION SYSTEMS - The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the transfection, the nucleic acid to be transfected is then loaded with the modified protein, whereby the nucleic acid and the protein form a filament-like complex, and this complex is finally added to the cells to be transfected. The invention further relates to a transfection agent consisting of nucleoprotein filaments (NPF), with at least one nucleoprotein filament-forming protein being modified with at least one functional component for the transfection. Furthermore, the present invention relates to the use of the transfection agent according to the invention for producing a drug for gene therapeutic treatment of humans and animals. The present inventions also includes corresponding pharmaceutical preparations, especially for use in gene therapy as well as the use of such transfection agents as component in kits. | 09-11-2008 |
20090023131 | CIRCUIT ARRANGEMENT FOR INJECTING NUCLEIC ACIDS AND OTHER BIOLOGICALLY ACTIVE MOLECULES INTO THE NUCLEUS OF HIGHER EUCARYONTIC CELLS USING ELECTRICAL CURRENT - The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality. | 01-22-2009 |
Juliana Helfrich, Cologne DE
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20110117654 | BUFFER SOLUTION FOR ELECTROPORATION AND A METHOD COMPRISING THE USE OF THE SAME - A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1 | 05-19-2011 |
Kenneth Helfrich, Duluth, GA US
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20110276734 | USB Dedicated Charger Identification Circuit - In an embodiment, set forth by way of example and not limitation, a USB dedicated charger identification circuit includes a USB D+ port, a USB D− port, a first circuit conforming to a first identification protocol, a second circuit conforming to a second identification protocol, and logic selectively coupling one of the first circuit and the second circuit to the USB D+ port and the USB D− port. In an alternate embodiment set forth by way of example and not limitation, a method to provide USB charger identification includes providing a first USB charger identification at a USB D+ port and a D− port. Next, it is detected if the first USB charger identification was inappropriate. Then, if the first USB charger identification was inappropriate, a second USB charger identification is provided at the USB D+ port and the D− port. | 11-10-2011 |
20130207595 | USB Dedicated Charger Identification Circuit - In an embodiment, set forth by way of example and not limitation, a USB dedicated charger identification circuit includes a USB D+ port, a USB D− port, a first circuit conforming to a first identification protocol, a second circuit conforming to a second identification protocol, and logic selectively coupling one of the first circuit and the second circuit to the USB D+ port and the USB D− port. In an alternate embodiment set forth by way of example and not limitation, a method to provide USB charger identification includes providing a first USB charger identification at a USB D+ port and a D− port, Next, it is detected if the first USB charger identification was inappropriate. Then, if the first USB charger identification was inappropriate, a second USB charger identification is provided at the USB D+ port and the D− port. | 08-15-2013 |
Kenneth J. Helfrich, Duluth, GA US
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20140245030 | Method and Apparatus for Providing Power to an Electronic Device - In an embodiment, set forth by way of example and not limitation a USB power converter for an electronic device includes a USB bus including VBUS power line, a D− data line and a D+ data line, a variable voltage converter, a processor clock, a USB transceiver coupled to the D− data line and the D+ data line, and a processor coupled to processor clock and to the USB transceiver. Preferably, the variable voltage converter has an alternating current (AC) input, a direct current (DC) output coupled to the VBUS power line, and a voltage control input responsive to a voltage control signal to provide a plurality of voltage levels at the DC output. The process is, in this example embodiment, operative to develop the control signal based upon communication from an electronic device connected to the USB bus. In a non-limiting embodiment, the USB power converter further includes a host ID controller having a host ID control input coupled to the processor, the host ID controller selectively coupled to the D− data line and the D+ data line in response to a host ID control signal developed by the processor. | 08-28-2014 |
Kenneth Jay Helfrich, Peachtree Corners, GA US
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20150261641 | ACCESSORY MANAGEMENT AND DATA COMMUNICATION USING AUDIO PORT - A method for accessory management and data communication between a portable electronic device and an accessory via audio port is disclosed. The method involves using a microphone line of the accessory in different communication modes including a MIC data mode and a power mode. In the MIC data mode, the MIC line disconnects from a microphone load to operate on a voltage above a predetermined threshold whenever the accessory needs to communicate with the host electronic device. In the MIC power mode, the MIC line connects with the microphone load for the normal operation of the microphone. | 09-17-2015 |
Kenneth Jay Helfrich, Duluth, GA US
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20120082166 | ANALOG FRONT END PROTOCOL CONVERTER/ADAPTER FOR SLPI PROTOCOL - In an embodiment, an analog front end (AFE) bridge for a SLPI PHY includes: an AFE LINK-side circuit having at least one pair of differential LINK-side nodes which does not conform to SLPI PHY specifications; an AFE PHY-side circuit having a pair of differential PHY-side nodes conforming to SLPI PHY specifications, wherein the AFE PHY-side circuit is coupled to the AFE LINK-side circuit; and a termination control circuit coupled to the AFE PHY-side circuit. A method of bridging a legacy LINK circuit to a SLPI PHY circuit includes: communicating with a legacy LINK circuit with a legacy LINK protocol; communicating with a SLPI PHY circuit with a SLPY PHY protocol over a differential pair; converting outputs of the legacy LINK circuit into inputs of the SLPI PHY circuit; converting outputs of the SLPI PHY circuit into inputs of the legacy LINK circuit; controlling a termination of the differential pair. | 04-05-2012 |
20140089552 | USB HUBS WITH GALVANIC ISOLATION - A universal serial bus (USB) hub includes a USB AFE circuit module, a hub core and an isolator circuit module interposed between the USB AFE circuit module and the hub core. Data communications between the hub core and the first USB AFE circuit module pass through the isolator circuit module. A method for communicating through a universal serial bus hub includes providing a USB AFE circuit module, providing a hub core, providing an isolator circuit module interposed between the USB AFE circuit module and the hub core, and directing communication from the USB AFE circuit module to the hub core through the isolator circuit module. | 03-27-2014 |
20150293875 | USB HUBS WITH GALVANIC ISOLATION - A universal serial bus (USB) hub includes a USB AFE circuit module, a hub core and an isolator circuit module interposed between the USB AFE circuit module and the hub core. Data communications between the hub core and the first USB AFE circuit module pass through the isolator circuit module. A method for communicating through a universal serial bus hub includes providing a USB AFE circuit module, providing a hub core, providing an isolator circuit module interposed between the USB AFE circuit module and the hub core, and directing communication from the USB AFE circuit module to the hub core through the isolator circuit module. | 10-15-2015 |
Michael Helfrich, München DE
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20090162420 | Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids - The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of producing the transdermal therapeutic system. | 06-25-2009 |
Michael Helfrich, Salem, MA US
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20120149353 | DECISION SUPPORT - Decision support information is exchanged over a secure wireless network among mobile computing devices, and also optionally a central command computer. Each of the mobile computing devices has one or more sensors connected and interfaced to it. Output data from the sensor(s) can be sent over the network to one or more other devices on the network. A command for a sensor also can be sent over the network to cause the sensor to take some action such as turning on or turning off. The mobile computing devices on the network automatically share plug-in software components needed by any of the devices to view transmitted sensor output data and/or act on sensor commands. | 06-14-2012 |
20130252586 | DECISION SUPPORT - Decision support information is exchanged over a secure wireless network among mobile computing devices, and also optionally a central command computer. Each of the mobile computing devices has one or more sensors connected and interfaced to it. Output data from the sensor(s) can be sent over the network to one or more other devices on the network. A command for a sensor also can be sent over the network to cause the sensor to take some action such as turning on or turning off. The mobile computing devices on the network automatically share plug-in software components needed by any of the devices to view transmitted sensor output data and/or act on sensor commands. | 09-26-2013 |
20140155087 | DECISION SUPPORT - Decision support information is exchanged over a secure wireless network among mobile computing devices, and also optionally a central command computer. Each of the mobile computing devices has one or more sensors connected and interfaced to it. Output data from the sensor(s) can be sent over the network to one or more other devices on the network. A command for a sensor also can be sent over the network to cause the sensor to take some action such as turning on or turning off. The mobile computing devices on the network automatically share plug-in software components needed by any of the devices to view transmitted sensor output data and/or act on sensor commands. | 06-05-2014 |
Michael Helfrich, Leutenbach DE
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20100248888 | TANDEM AXLE HAVING TWO DRIVABLE AXLES AND A DRIVETRAIN WHICH CAN BE PARTIALLY DISCONNECTED - A tandem axle having two drivable axles, each axle including a differential gearing with a drive input gearwheel, drivable by a shaft, as a differential gearing input and with two drive input semi-axles driving the wheels of the axle using axle shaft wheels. The wheels of the first axle are permanently positively coupled to the drive input gearwheel of the axle. An activatable distributor wheel is seated on a drive input shaft of the drive input gearwheel of the first axle. The distributor wheel meshes with a through drive shaft wheel which is arranged in a rotationally rigid fashion on a through drive shaft. The output of the through drive shaft is coupled to the input-side drive input gearwheel of the second axle by means of intermediate members. Switchable clutches are arranged in the second axle between the axle shaft wheels and their adjacent wheels. | 09-30-2010 |
Michael Helfrich, Swampscott, MA US
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20140207486 | HEALTH MANAGEMENT SYSTEM - A decentralized system with at least a server ( | 07-24-2014 |
Michael Helfrich, München DE
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20090162420 | Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids - The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of producing the transdermal therapeutic system. | 06-25-2009 |
Patrick Helfrich, Monroe, CT US
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20100298775 | ACCESS SHEATH WITH CENTRAL SEAL - An access apparatus for use during a surgical procedure to provide access to the interior of the body includes an access member defining a longitudinal axis and having a proximal end for being disposed at an exterior side of the body and a distal end for extending into the interior of the body. The access member has a bore therethrough dimensioned to permit passage of an object. A seal is disposed within the longitudinal bore substantially at the rotational center of the access member. The seal has inner seal portions adapted to establish a substantial seal about a surgical instrument introduced within the longitudinal bore of the access member. An access housing may be mounted to the proximal end of the access member. A zero closure valve may be mounted to the access housing. The zero-closure valve may be adapted to close in the absence of the instrument. The seal may be generally disc shaped. The seal may define an aperture for reception of the surgical instrument. The seal may comprise a fabric material, an elastomeric material or a gel material. | 11-25-2010 |
20120238827 | ACCESS SHEATH WITH CENTRAL SEAL - A surgical access apparatus includes an access member defining a longitudinal axis and proximal and distal ends, and having a longitudinal opening. A central seal member is mounted to the access member at an approximate rotational center thereof. The central seal member has inner seal portions defining a seal passage dimensioned for sealed reception of a surgical object. | 09-20-2012 |
Randall Helfrich, Chandler, AZ US
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20140330731 | SYSTEM AND METHOD FOR MANAGING BACKFLOW PREVENTION ASSEMBLY TEST DATA - The present disclosure includes a system, method and computer program product for managing Backflow Prevention Assembly (“BPA”) test result data. A Compliance Management System (“CMS”) may generate a keycode indicating a necessary BPA teat which is sent to a purveyor. The purveyor may transmit the keycode to a BPA owner, and the BPA owner may transmit the keycode to a tester. The tester may enter the keycode into a Backflow Test Application (“BTA”) which identifies the BPA. The tester may test the BPA and enter test results into the BTA on a portable device. The BTA may transmit the test results to the CMS. CMS may integrate the test results into a to of BPA test results. A purveyor may approve the test results, and the CMS may generate a new keycode for the next annual test for the BPA. | 11-06-2014 |
Steffen Helfrich, Saalstadt DE
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20120160796 | CRANE AND METHOD FOR OPERATING A CRANE USING RECOVERY OF ENERGY FROM CRANE OPERATIONS AS A SECONDARY ENERGY SOURCE - A crane, in particular a large crane, including a power consumer system for providing energy, a primary energy source for feeding primary energy into the power consumer system, at least one secondary energy source, independent of the primary energy source, for feeding secondary energy into the power consumer system, at least one energy storage unit arranged locally on the crane and is, in particular, associated with the at least one crane component and connected to the power consumer system for storing primary energy and/or secondary energy, at least one drive motor connected to the power consumer system for operating at least one crane component and a secondary energy source configured such that energy returned from the crane operation is at least partially fed as secondary energy into the power consumer system. The at least one crane component is configured as a secondary energy source for energy recovery. | 06-28-2012 |
Wijnand Helfrich, Groningen NL
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20080234177 | Targeting-enhanced activation of galectins - Lectin-binding proteins and their therapeutic use. In particular, described are the targeting and targeting-enhanced multimerization and activation of galectins. Provided is a galectin-conjugate including at least one galectin molecule conjugated to a non-galectin cell targeting means. Exemplary targeting means include targeting means able to bind EGP2, a pancarcinoma-associated cell surface target antigen, CD antigen, such as CD7 or CD38, or a TNF family member, such as TRAIL-R. The targeting means may comprise an antibody or a functional fragment thereof, such as a single chain variable antibody fragment (scFv). Also provided is the use of a galectin-conjugate for treating a disease, like cancer or an immune disorder, such as auto-immune disease, allergic disorder, auto-immune encephalomyelitis, arthritis, colitis, hepatitis, asthma, multiple sclerosis, transplant rejection, Graft-versus-host disease (GVHD) and/or inflammatory bowel disease. | 09-25-2008 |