Patent application number | Description | Published |
20130296561 | PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE - The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin. | 11-07-2013 |
20130303779 | PROCESS FOR THE PREPARATION OF DIOL SULFONES - The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds. | 11-14-2013 |
20140343292 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS - The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament. | 11-20-2014 |
20140357864 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR - The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament. | 12-04-2014 |
20150251998 | PROCESS TO PRODUCE ATORVASTATIN INTERMEDIATES - The invention provides a process for the production of a compound of formula (I), said process comprising reacting a compound of formula (II) with a compound of formula (III) wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out at reduced pressure. This may advantageously allow for lower reaction temperatures and/or may result in a higher yield. Also, a phase separation step may be omitted. | 09-10-2015 |
20150259285 | PROCESS TO PRODUCE ATORVASTATIN INTERMEDIATES - The invention provides a process for the production of 1 a compound of formula (I), said process comprising reacting a compound of formula (II), with a compound of formula (III), wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out in the presence of a base. Using a base may advantageously allow a lower temperature and/or may result in a higher yield. Also, a phase separation step may be omitted. | 09-17-2015 |
Patent application number | Description | Published |
20090310449 | System And Method For Embedding Optical Drive Compatibility Information In Optical Media - Compatibility information embedded in an optical medium modifies actions allowed by predetermined non-compatible optical disc drives on the optical medium, such as optical disc drives that may suffer damage if certain actions are performed on the optical medium. For instance, a compatibility engine of the optical disc drive applies compatibility information read from an optical medium to determine restrictions to impose on the use of the optical medium, such as restricting the optical disc drive from writing to the optical medium, reading from the optical medium or performing any operations until an update to the optical disc drive firmware is performed either automatically or by display of a compatibility user interface at an information handling system associated with the optical disc drive. In one embodiment, the compatibility information identifies incompatible optical disc drives and firmware versions by unique identifiers. | 12-17-2009 |
20110075533 | DETECTION OF DATA IN BURST CUTTING AREA OF OPTICAL DISK - An apparatus generates outgoing data (OD) to be provided on an optical disk ( | 03-31-2011 |
20110103213 | System and Method for Embedding Optical Drive Compatibility Information In Optical Media - Compatibility information embedded in an optical medium modifies actions allowed by predetermined non-compatible optical disc drives on the optical medium, such as optical disc drives that may suffer damage if certain actions are performed on the optical medium. For instance, a compatibility engine of the optical disc drive applies compatibility information read from an optical medium to determine restrictions to impose on the use of the optical medium, such as restricting the optical disc drive from writing to the optical medium, reading from the optical medium or performing any operations until an update to the optical disc drive firmware is performed either automatically or by display of a compatibility user interface at an information handling system associated with the optical disc drive. In one embodiment, the compatibility information identifies incompatible optical disc drives and firmware versions by unique identifiers. | 05-05-2011 |
20140064054 | DETECTION OF DATA IN BURST CUTTING AREA OF OPTICAL DISK - An apparatus generates outgoing data to be provided on an optical disk in a burst cutting area. The burst cutting area further comprises markings which cause a marking frequency spectrum when reading out the burst cutting area. The apparatus comprises a channel coder which receives processed data and supplies the outgoing data having an outgoing data frequency spectrum with suppressed DC-content. The apparatus further comprises a data processing device which generates the processed data to obtain an outgoing frequency spectrum wherein a frequency component causing interference with a low frequent component of the markings is suppressed or not present. | 03-06-2014 |
Patent application number | Description | Published |
20100184948 | MOLECULES FOR TARGETING COMPOUNDS TO VARIOUS SELECTED ORGANS OR TISSUES - The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells. | 07-22-2010 |
20120322724 | MOLECULES FOR TARGETING COMPOUNDS TO VARIOUS SELECTED ORGANS OR TISSUES - The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells. | 12-20-2012 |