Patent application number | Description | Published |
20110013869 | MICROMECHANICALLY ALIGNED OPTICAL ASSEMBLY - An optical assembly includes a combination of laser sources emitting radiation, focused by a combination of lenses into optical waveguides. The optical waveguide and the laser source are permanently attached to a common carrier, while at least one of the lenses is attached to a holder that is an integral part of the carrier, but is free to move initially. Micromechanical techniques are used to adjust the position of the lens and holder, and then fix the holder it into place permanently using integrated heaters with solder. | 01-20-2011 |
20120057607 | BROAD AREA LASER PUMP COMBINER - Multiple broad area lasers are coupled to a planar lightwave circuit, where the waveguides come together to form a single wide emitting aperture. A tapered lens is used at the output of the planar lightwave circuit to transform the highly asymmetric mode into a conventional round mode. This configuration allows much higher “brightness”, allowing 10 or more 100 um wide broad area lasers to be coupled into a single 100 um core multimode fiber. This is considerably more efficient than the standard method of combining a single 100 um wide broad area laser to a 100 um core multimode fiber. | 03-08-2012 |
20120195332 | EXTERNAL CAVITY WIDELY TUNABLE LASER USING A SILICON RESONATOR AND MICROMECHANICALLY ADJUSTABLE COUPLING - A widely tunable laser is described where a compound semiconductor gain chip is coupled to a waveguide filter fabricated on silicon. The filter has two resonators with different free-spectral-ranges, such that Vernier tuning between the filters can be used to provide a single wavelength of light feedback into the gain chip, where the wavelength is adjustable over a wide range. The coupling between the gain chip and the filter is realized through a microlens whose position can be adjusted using micromechanics and locked in place. | 08-02-2012 |
20130160266 | MICROMECHANICALLY ALIGNED OPTICAL ASSEMBLY - An optical assembly includes a combination of laser sources emitting radiation, focused by a combination of lenses into optical waveguides. The optical waveguide and the laser source are permanently attached to a common carrier, while at least one of the lenses is attached to a holder that is an integral part of the carrier, but is free to move initially. Micromechanical techniques are used to adjust the position of the lens and holder, and then fix the holder it into place permanently using integrated heaters with solder. | 06-27-2013 |
20130163252 | MICROMECHANICALLY ALIGNED OPTICAL ASSEMBLY - An optical assembly includes a combination of laser sources emitting radiation. focused by a combination of lenses into optical waveguides. The optical waveguide and the laser source are permanently attached to a common carrier. while at least one of the lenses is attached to a holder that is an integral part of the carrier, but is free to move initially. Micromechanical techniques are used to adjust the position of the lens and holder, and then fix the holder it into place permanently using integrated heaters with solder. | 06-27-2013 |
20140308007 | MICROMECHANICALLY ALIGNED OPTICAL ASSEMBLY - An optical assembly includes a combination of laser sources emitting radiation, focused by a combination of lenses into optical waveguides. The optical waveguide and the laser source are permanently attached to a common carrier, while at least one of the lenses is attached to a holder that is an integral part of the carrier, but is free to move initially. Micromechanical techniques are used to adjust the position of the lens and holder, and then fix the holder it into place permanently using integrated heaters with solder. | 10-16-2014 |
Patent application number | Description | Published |
20120033220 | QCL Spectroscopy System and Applications Therefor - A spectroscopy system comprising at least two laser modules, each of the laser modules including a laser cavity, a quantum cascade gain chip for amplifying light within the laser cavity, and a tuning element for controlling a wavelength of light generated by the modules. Combining optics are used to combine the light generated by the at least two laser modules into a single beam and a sample detector detects the single beam returning from a sample. | 02-09-2012 |
20120122084 | SYSTEM FOR IDENTIFYING AND SORTING LIVING CELLS - In embodiments of the present invention, a system and method of cytometry may include presenting a single sperm cell to at least one laser source configured to deliver light to the sperm cell in order to induce bond vibrations in the sperm cell DNA, and detecting the signature of the bond vibrations. The bond vibration signature is used to calculate a DNA content carried by the sperm cell which is used to identify the sperm cell as carrying an X-chromosome or Y-chromosome. Another system and method may include flowing cells past at least one QCL source one-by-one using a fluid handling system, delivering QCL light to a single cell to induce resonant mid-IR absorption by one or more analytes of the cell, and detecting, using a mid-infrared detection facility, the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a cell characteristic. | 05-17-2012 |
20120196356 | COMBINED INSPECTION SYSTEM INCLUDING MID-IR VIBRATIONAL SPECTROSCOPY AND A FLUORESCENT CYTOMETRY FACILITY - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source configured to deliver light to a cell within the cells in order to induce resonant mid-infrared absorption by one or more analytes of the cell. The system includes a laser source that excites at least one fluorophore present in the cell or on the surface of the cell and a fluorescence detector that measures the fluorescence intensity of the fluorophore. A mid-infrared detection facility detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light and the fluorescence intensity are used to identify at least one cell characteristic. | 08-02-2012 |
20120199741 | MINIMALLY INVASIVE CYTOMETRY SYSTEM USING QCL VIBRATIONAL SPECTROSCOPY FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS FROM FUNCTIONALLY DIFFERENTIATED CELLS BASED ON INSPECTION OF SINGLE CELLS - This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The cytometry system also includes a detection facility that detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify the differentiation status of the cell as either pluripotent or functionally differentiated. | 08-09-2012 |
20120199742 | SINGLE PARTICLE QCL-BASED MID-IR SPECTROSCOPY SYSTEM WITH ANALYSIS OF SCATTERING - This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information. | 08-09-2012 |
20120202277 | MINIMALLY INVASIVE CYTOMETRY SYSTEM WITH QCL INSPECTION OF SINGLE CELLS FOR CANCER DETECTION - This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The cytometry system also includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either cancerous or non-cancerous. | 08-09-2012 |
20120202278 | SYSTEM AND METHOD FOR REPEAT MEASUREMENT OF SINGLE CELLS USING VIBRATIONAL SPECTROSCOPY - This disclosure concerns a high-throughput cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light successively to single cells over a time period in order to make successive measurements of induced resonant mid-infrared absorption by one or more analytes of the cells. The cytometry system also includes a mid-infrared detection facility that detects the successively transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a changing cell characteristic over the time period. | 08-09-2012 |
20120204628 | USE OF VIBRATIONAL SPECTROSCOPY FOR DNA CONTENT INSPECTION - This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to calculate a DNA content carried by the cell. | 08-16-2012 |
20120225474 | SYSTEM AND METHOD FOR PATHOGEN DETECTION AND IDENTIFICATION - This disclosure concerns a pathogen inspection system that includes a handling system that presents single cells from a sample to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The system includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either a pathogen or not a pathogen. | 09-06-2012 |
20120225475 | CYTOMETRY SYSTEM WITH QUANTUM CASCADE LASER SOURCE, ACOUSTIC DETECTOR, AND MICRO-FLUIDIC CELL HANDLING SYSTEM CONFIGURED FOR INSPECTION OF INDIVIDUAL CELLS - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce resonant mid-IR vibrational absorption by one or more analytes, leading to local heating that results in thermal expansion and an associated shockwave. An acoustic detection facility that detects the shockwave emitted by the single cell. | 09-06-2012 |
20140091014 | SINGLE PARTICLE QCL-BASED MID-IR SPECTROSCOPY SYSTEM WITH ANALYSIS OF SCATTERING - This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information. | 04-03-2014 |