Patent application number | Description | Published |
20090088562 | Oligonucleotide analogs having cationic intersubunit linkages - Morpholino oligomers containing both uncharged and cationic intersubunit linkages are provided. The oligomers are oligonucleotide analogs containing predetermined sequences of base-pairing moieties. The presence of the cationic intersubunit linkages in the oligomers, typically at a level of about 10-50% of total linkages, provides enhanced antisense activity, in various antisense applications, relative to the corresponding uncharged oligomers. Also provided are such oligomers conjugated to peptide transporter moieties, where the transporters are preferably composed of arginine subunits, or arginine dimers, alternating with neutral amino acid subunits. | 04-02-2009 |
20100234281 | ANTIBACTERIAL ANTISENSE OLIGONUCLEOTIDE AND METHOD - A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications. | 09-16-2010 |
20140213737 | ANTIBACTERIAL ANTISENSE OLIGONUCLEOTIDE AND METHOD - A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications. | 07-31-2014 |
Patent application number | Description | Published |
20100205102 | Method and System for Manipulation of Scheduling Information in a Distributed Virtual Enterprise - A method, system, apparatus, and computer program product for processing e-commerce information are presented. A business entity may transfer e-commerce agreements through an electronic marketplace. The business entity retrieves dependency information about a commercial transaction from an e-commerce agreement. The business entity incorporates the dependency information, e.g., dates, costs, deliveries, etc., as dependency relationships within a project model that represents a project for a product or service for sale by the first business entity. User input is received for manipulating a scheduling dependency relationship within the project model while constraining the user input to ensure that another type of dependency relationship is not incompatible with modifications to the scheduling dependency relationship. | 08-12-2010 |
20140195309 | METHOD AND SYSTEM FOR MANIPULATION OF COST INFORMATION IN A DISTRIBUTED VIRTUAL ENTERPRISE - A method, system, apparatus, and computer program product for processing e-commerce information are presented. A business entity may transfer e-commerce agreements through an electronic marketplace. The business entity retrieves dependency information about a commercial transaction from an e-commerce agreement. The business entity incorporates the dependency information, e.g., dates, costs, deliveries, etc., as dependency relationships within a project model that represents a project for a product or service for sale by the first business entity. User input is received for manipulating a cost dependency relationship within the project model while constraining the user input to ensure that another type of dependency relationship is not incompatible with modifications to the cost dependency relationship. | 07-10-2014 |