Harmer, GB
Andrea Harmer, Sheffield GB
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20140178857 | Method - The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies. | 06-26-2014 |
20140273267 | Methods of depleting antibodies directed towards major histocompatibility complex - The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample. | 09-18-2014 |
20150260622 | METHODS OF DEPLETING ANTIBODIES DIRECTED TOWARDS MAJOR HISTOCOMPATIBILITY COMPLEX - The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample. | 09-17-2015 |
20160103135 | METHOD - The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies. | 04-14-2016 |
Mark Andrew Harmer, Landenberg GB
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20140093719 | CLOSED-CELL TANNIN-BASED FOAMS WITHOUT FORMALDEHYDE - Disclosed are foam compositions and processes to form closed-cell tannin-based foams. The foams comprises a continuous polymeric phase defining a plurality of cells, wherein the continuous polymeric phase comprises a tannin-based resin derived from a tannin and a monomer, wherein the monomer comprises furfural, glyoxal, acetaldehyde, 5-hydroxymethylfurfural, acrolein, levulinate esters, sugars, 2,5-furandicarboxylic acid, 2,5-furandicarboxylic aldehyde, urea, difurfural (DFF), furfuryl alcohol, glycerol, sorbitol, lignin, or mixtures thereof, and wherein the plurality of cells comprises a plurality of open-cells and a plurality of closed-cells with an open-cell content measured according to ASTM D6226-5, of less than 50%. The foam composition also comprises a discontinuous phase disposed in at least a portion of the plurality of closed-cells, the discontinuous phase comprising one or more blowing agents. | 04-03-2014 |
Nick Harmer, Wiltshire GB
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20150095102 | COMPUTER IMPLEMENTED SYSTEM AND METHOD FOR ENSURING COMPUTER INFORMATION TECHNOLOGY INFRASTRUCTURE CONTINUITY - The present invention relates to a system computer implemented information technology (“IT”) management solution that bridges the gap between deployed computer information technology infrastructure and business services to determine what information technology a business entity or other organization currently has, what is at risk and what is needed to assure IT infrastructure continuity. | 04-02-2015 |
Paul Harmer, Comberton GB
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20090043282 | Drug Delivery Devices and Related Components, Systems and Methods - This description relates to drug delivery devices ( | 02-12-2009 |
Quentin Harmer, Wiltshire GB
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20120321717 | DEVICES AND PHARMACEUTICAL COMPOSITIONS FOR ENHANCING DOSING EFFICIENCY - The present invention relates to enhancing the dosing efficiency of pharmaceutical dry powder formulations administered by pulmonary inhalation. In particular, the present invention relates to the provision of dry powder inhalers and dry powder compositions which reproducibly achieve a much higher delivered dose of the pharmaceutically active agent than currently achieved. | 12-20-2012 |
Quentin Harmer, Cambridge GB
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20100313886 | INHALER - In an inhaler for administering a powdery medicament in the form of an inhalable substance, substance formulation or mixture, a blister cavity to be opened by piercing elements ( | 12-16-2010 |
20110056488 | INHALER - An inhaler for producing an inhalable aerosol of powdered medicament is disclosed. The inhaler includes an aerosolising device having a chamber of substantially circular cross-section, inlet and outlet ports at opposite ends of the chamber for the flow of drug laden air through the chamber between said ports and, a bypass air inlet for the flow of clean air into the chamber. The bypass air inlet is configured so that air entering the chamber through said inlet forms a cyclone in the chamber that interacts with the drug laden air flowing between the inlet and outlet ports. | 03-10-2011 |
Quentin Harmer, Waterbeach GB
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20110073106 | DRY POWDER INHALER - An Inhaler for delivering an aerosolised dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entreinment device to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed. | 03-31-2011 |
20110132358 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 06-09-2011 |
20130220321 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 08-29-2013 |
20130312747 | INHALER - An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway. | 11-28-2013 |
Quentin John Harmer, Chippenham GB
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20140373839 | INHALER - A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler comprises an impaction element onto which the air stream can impact together with entrained inhalation formulation for better deagglomeration. Alternatively, the inhaler comprises an oscillating and/or vibrating device for better de-agglomeration of the inhalation formulation. Alternatively or additionally, the inhaler comprises one or two mixing means for generating swirls, preferably with opposite rotation directions. | 12-25-2014 |
Quentin John Harmer, Cambridge GB
Patent application number | Description | Published |
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20090090362 | Blister piercing element for dry powder inhaler - A blister piercing element for puncturing the Hd of a blister containing a dose of medicament for inhalation by a user is disclosed. The piercing element comprising an outlet opening for the passage of medicament entrained in an airflow out of the blister and, a piercing head extending beyond and overhanging the opening that cuts a flap in a lid of a blister and pushes it away from the opening during insertion. | 04-09-2009 |
20110041841 | Inhaler - A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa | 02-24-2011 |
20110094507 | INHALER - A passive inhaler ( | 04-28-2011 |
20140018663 | Magnetic Marker for Surgical Localization - A method and apparatus for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the method comprises the steps of: removing a biopsy sample from the tissue of interest; placing a magnetic marker at the biopsy site; performing a pathology analysis of the biopsy sample; and if the pathology analysis indicates that the tissue of interest should be removed, locating the tissue for surgery using a magnetic detection probe. In one embodiment, the marker comprises magnetic nanoparticles in a bioabsorbable matrix. A system for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the system includes a magnetic marker and magnetic detection probe system. | 01-16-2014 |
Richard Harmer, Cheam GB
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20090294174 | DOWNHOLE SENSOR SYSTEM - A method includes sensing a parameter in a well using a sensor disposed on a drillstring, determining a position of the sensor in a wellbore based on a position of the sensor in the drillstring and a position of the drillstring in the wellbore. | 12-03-2009 |
Richard Harmer, Surrey GB
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20090065262 | DRILL BIT - A drill bit | 03-12-2009 |
20100163306 | Modeling Vibration Effects Introduced By Mud Motor - Torsional, axial and lateral vibrations introduced when a mud motor is used with a drilling tool to drill a borehole are calculated using a model. The model includes different computational modules for each of three distinct motor sections: power, transmission and bearing. The resulting calculated vibration effects are used to enhance the drilling tool and drilling operation. | 07-01-2010 |
20140129148 | DOWNHOLE DETERMINATION OF DRILLING STATE - A method for determining a drilling state of a bottom hole assembly in a wellbore includes acquiring one or more downhole sensor measurements and processing the sensor measurements using a downhole processor to determine a drilling state of the bottom hole assembly. An operating state of the bottom hole assembly may be automatically changed in response to the determined drilling state. A method for computing a dynamic drilling energy of a bottom hole assembly includes acquiring at least one sensor measurement and processing the sensor measurements to obtain at least one of (i) an energy of axial motion of the bottom hole assembly, (ii) an energy of rotational motion of the bottom hole assembly, and (iii) an energy of lateral motion of the bottom hole assembly. | 05-08-2014 |
20140309978 | METHODS FOR ANALYZING AND DESIGNING BOTTOM HOLE ASSEMBLIES - A method for selecting a bottomhole assembly, including performing a first dynamic simulation of a first bottomhole assembly, performing at least a second dynamic simulation of the first bottomhole assembly, in which the at least a second dynamic simulation includes a different constraint than the first dynamic simulation, and outputting results for both the first dynamic simulation and the second dynamic simulation, in which the results include at least one output showing performance as a function of position along the bottomhole assembly. | 10-16-2014 |
Stuart Harmer, Herefordshire GB
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20160097852 | Remote Detection And Measurement Of Objects - Provided are methods of using electromagnetic waves for detecting metal and/or dielectric objects. Methods include directing microwave and/or mm wave radiation in a predetermined direction using a transmission apparatus, including a transmission element; receiving radiation from an entity resulting from the transmitted radiation using a detection apparatus; and generating one or more detection signals in the frequency domain using the detection apparatus. Methods may include operating a controller, wherein operating the controller includes causing the transmitted radiation to be swept over a predetermined range of frequencies, performing a transform operation on the detection signal(s) to generate one or more transformed signals in the time domain, and determining, from one or more features of the transformed signal, one or more dimensions of a metallic or dielectric object upon which the transmitted radiation is incident. A system and method for remote detection and/or identification of a metallic threat object using late time response (LTR) signals is also disclosed. | 04-07-2016 |
Stuart Harmer, London GB
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20100005044 | Remote Detection and Measurement of Objects - Provided are methods of using electromagnetic waves for detecting metal and/or dielectric objects. Methods include directing microwave and/or mm wave radiation in a predetermined direction using a transmission apparatus, including a transmission element; receiving radiation from an entity resulting from the transmitted radiation using a detection apparatus; and generating one or more detection signals in the frequency domain using the detection apparatus. Methods may include operating a controller, wherein operating the controller includes causing the transmitted radiation to be swept over a predetermined range of frequencies, performing a transform operation on the detection signal(s) to generate one or more transformed signals in the time domain, and determining, from one or more features of the transformed signal, one or more dimensions of a metallic or dielectric object upon which the transmitted radiation is incident. | 01-07-2010 |
Stuart Harmer, Manchester GB
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20110181300 | Remote Detection and Measurement of Objects - Provided are methods of using electromagnetic waves for detecting metal and/or dielectric objects. Methods include directing microwave and/or mm wave radiation in a predetermined direction using a transmission apparatus, including a transmission element; receiving radiation from an entity resulting from the transmitted radiation using a detection apparatus; and generating one or more detection signals in the frequency domain using the detection apparatus. Methods may include operating a controller, wherein operating the controller includes causing the transmitted radiation to be swept over a predetermined range of frequencies, performing a transform operation on the detection signal(s) to generate one or more transformed signals in the time domain, and determining, from one or more features of the transformed signal, one or more dimensions of a metallic or dielectric object upon which the transmitted radiation is incident. A system and method for remote detection and/or identification of a metallic threat object using late time response (LTR) signals is also disclosed. | 07-28-2011 |
20120256786 | Detection of Objects - A detection method comprising directing radiation such that it is incident upon a target, the radiation containing a component having a first polarisation and a component having a second orthogonal polarisation, detecting radiation which is scattered from the target, and analysing the polarisation state of the detected scattered radiation to determine whether the target includes an object. | 10-11-2012 |
20150369756 | SCANNING APPARATUS - A method of scanning a shoe. The method comprises directing from a source at least one first signal at the shoe, the at least one first signal comprising substantially millimetre and/or microwave radiation, receiving at one or more receivers a plurality of second signals, the plurality of second signals comprising reflections of the at least one first signal from different positions with the shoe. The method further comprises processing each of the second signals to determine a plurality of reflection positions within the shoe and processing the plurality of second signals and reflection positions to generate second data, the second data indicating a composition of the shoe. | 12-24-2015 |