Patent application number | Description | Published |
20090197311 | METHOD FOR THE PRODUCTION OF SIMVASTATIN - The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process. | 08-06-2009 |
20100009404 | PRODUCTION OF BETA-LACTAM ANTIBIOTICS - The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains. | 01-14-2010 |
20100217032 | PROCESS FOR PREPARING PRAVASTATIN - The present invention provides a polypeptide having an amino acid sequence according to SEQ ID NO 3, SEQ ID NO 6 or SEQ ID NO 43-59. The present invention also provides a polynucleotide comprising a DNA sequence encoding these polypeptides and a method for isolating polynucleotides encoding polypeptides capable of improving the compactin into pravastatin conversion. Furthermore, the present invention provides a method for producing pravastatin and a pharmaceutical composition comprising pravastatin. | 08-26-2010 |
20110054193 | STATIN PRODUCTION - The present invention relates to a polypeptide with HMG-CoA reductase activity, to its polynucleotide congener and to a method for the production of a statin comprising over expression of said polypeptide. | 03-03-2011 |
20110223640 | IMPROVED STATIN PRODUCTION - The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising the polynucleotide of the lovE transcription regulator gene from | 09-15-2011 |
20130144034 | METHOD FOR THE PRODUCTION OF A COMPOUND OF INTEREST - The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest. | 06-06-2013 |
Patent application number | Description | Published |
20120310904 | DATA VALIDATION AND SERVICE - A data validation service includes providing a user interface to a subscriber of the service via a computer device of the subscriber, receiving a data validation rule specified by the subscriber and an address of a database subject to the data validation, and generating a configuration file that includes the address of the database. The service also includes transmitting the configuration file and a thin client application to the computer device over a network, the thin client application configured to read the configuration file and pull data from the database. The service further includes receiving the data from the computer device via the network, performing the data validation by executing the data validation rule with respect to the data, and compiling results of the data validation and providing the results to the computer device. | 12-06-2012 |
20120310905 | DATA VALIDATION AND SERVICE - A data validation service includes providing a user interface to a subscriber of the service via a computer device of the subscriber, receiving, via the user interface, a data validation rule specified by the subscriber and an address of a database subject to the data validation, and generating a configuration file that includes the address of the database and an address of a location of executable code corresponding to the data validation rule. The data validation service also includes transmitting the configuration file and remote methods to the computer device over the network. The remote methods are configured to execute the data validation rule with respect to the data and compile results of the execution. | 12-06-2012 |
20130006692 | SYSTEMS AND METHODS FOR REAL TIME TRANSFORMATION OF RETAIL BANK BRANCH OPERATIONS - Methods and arrangements for generating process recommendations. Customer information is assimilated, the customer information including a number of present customers. An efficiency matrix is assimilated, which indicates efficiency for each of a plurality of actual resources with respect to each of a plurality of services. At least one hypothetical resource is created, which incorporates a best efficiency from among the actual resources with respect to each of the plurality of services, and a scheduling policy is assimilated. A customer queue is generated with respect to each hypothetical resource and in accordance with the at least one scheduling policy. Each hypothetical resource is mapped to each actual resource and a minimum parameter increase from among pairs comprising a hypothetical resource and an actual resource is determined. | 01-03-2013 |