Hamilton, NH
Bruce S. Hamilton, Hampstead, NH US
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20150352317 | REMOVABLE ANGLED GUIDEWIRE STORAGE DEVICE - An article comprising a guidewire having a distal end and terminating at a distal tip and a removable angled guidewire storage device located about the distal end, wherein the removable angled, guidewire storage device is generally tubular in shape and contains one or more internal structures for maintaining the distal end of the guidewire; and wherein during transport and storage of the article, the distal end is maintained at an angle by the removable angled guidewire storage device. | 12-10-2015 |
Daniel Hamilton, Mont Vernon, NH US
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20110275998 | SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT - Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir for containing a fluid and a fluid communicator in fluid communication with the reservoir. An electrochemical actuator is coupled to the reservoir and configured to exert a force on the reservoir upon actuation such that fluid within the reservoir is communicated through the fluid communicator. The actuator includes a first end that is constrained and a second end that is not constrained. The actuator is configured to bend at a location along a length of the actuator when actuated such that the second end of the actuator is displaced in a direction toward the fluid reservoir. The actuator can be an electrochemical actuator. The apparatus can further include a transfer structure disposed between the actuator and the reservoir configured to contact the reservoir upon actuation of the actuator. | 11-10-2011 |
20140350470 | SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT - Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir for containing a fluid and a fluid communicator in fluid communication with the reservoir. An electrochemical actuator is coupled to the reservoir and configured to exert a force on the reservoir upon actuation such that fluid within the reservoir is communicated through the fluid communicator. The actuator includes a first end that is constrained and a second end that is not constrained. The actuator is configured to bend at a location along a length of the actuator when actuated such that the second end of the actuator is displaced in a direction toward the fluid reservoir. The actuator can be an electrochemical actuator. The apparatus can further include a transfer structure disposed between the actuator and the reservoir configured to contact the reservoir upon actuation of the actuator. | 11-27-2014 |
Daniel E. Hamilton, Mont Vernon, NH US
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20160038133 | MEDICAL DEVICES AND RELATED METHODS OF USE - A tissue retractor for attachment to an elongate member of a medical device. The tissue retractor includes a cap having a central longitudinal axis. The cap includes an attachment section adapted to attach to a distal end of the elongate member. The cap further includes a moveable component pivotally attached to the attachment section at one or more pivot points, and an actuator connected to the moveable component to transition the moveable component across the central longitudinal axis from an insertion state to an actuated state. | 02-11-2016 |
Jared Hamilton, Manchester, NH US
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20160051757 | INFUSION SET FOR A FLUID PUMP - A medical device for delivery of a fluid to a patient from a line terminating in a tubing needle. The medical device includes a cannula assembly for coupling the fluid into a cannula that is inserted into the patient. The cannula assembly has a first locking element disposed in a fixed position with respect to the cannula. Coupling the line to the cannula assembly is an infusion flap. The infusion flap includes a second locking element for engaging the first locking element of the cannula assembly and a lift tab for disconnecting the infusion flap from the cannula assembly. Coupling of the first and second locking elements requires initial mating of the infusion flap and cannula assembly followed by locking through rotation of the infusion flap with respect to the cannula assembly. | 02-25-2016 |
Katherine Ann Hamilton, Auburn, NH US
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20140190911 | Device for securing chopsticks to dishwasher rack - In accordance with one embodiment, a device to be affixed to an automatic dishwasher rack in order to provide a means by which one can secure a number of chopsticks or similarly shaped items such that the items can be cleaned without risk of damaging either the dishwasher or aforementioned items. | 07-10-2014 |
Katherine Ann Hamilton, Manchester, NH US
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20160067075 | FOOT DROP DEVICE - This invention describes a multi-point soft flexible ankle foot brace support orthosis apparatus and method for compensating for weakness of the ankle and ankle/foot dorsiflexion resulting in steppage gait of foot drop comprising an ankle cuff that is securely connected to footwear by way of clips and elastic cords, allowing for natural walking motion. The connection of the ankle cuff to the shoe is secure, yet adjustable to accommodate each user's individual need and is easily fastened and unfastened for daily use. | 03-10-2016 |
Marissa Hamilton, Derry, NH US
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20080237288 | Safe sack - A backpack having increased security features is disclosed that helps prevent the theft of objects stored in the interior portion of the backpack and in the external pockets. In particular, the backpack includes a security cover flap that is disposed to prevent access to the closing mechanism of the interior portion of the backpack. The security cover includes a latch portion that is secured to the first surface of the backpack, proximate to the wearer to prevent a criminal from accessing the closing mechanism, opening the backpack and stealing items from the interior. External pockets are provided on the front surface of the backpack, proximate to the wearer's body making them and the objects contained therein inaccessible to other people. | 10-02-2008 |
Stephen Hamilton, Enfield, NH US
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20090130709 | Endomannosidases in the modification of glycoproteins in eukaryotes - The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and, hosts engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced. | 05-21-2009 |
20100028951 | PRODUCTION OF GLYCOPROTEINS WITH MODIFIED FUCOSYLATION - Methods are disclosed for genetically engineering host cells that lack an endogenous pathway for fucosylating N-glycans of glycoproteins to be able to produce glycoproteins with fucosylated N-glycans. | 02-04-2010 |
20100062516 | Expression of Class 2 Mannosidase and Class III Mannosidase in Lower Eukaryotic Cells - A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway. | 03-11-2010 |
20100062523 | Expression of Class 2 Mannosidase and Class III Mannosidase in Lower Eukaryotic Cells - A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway. | 03-11-2010 |
20120064568 | ENDOMANNOSIDASES IN THE MODIFICATION OF GLYCOPROTEINS IN EUKARYOTES - The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and, hosts engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced. | 03-15-2012 |
20120232007 | METHOD FOR PRODUCING PROTEINS IN PICHIA PASTORIS THAT LACK DETECTABLE CROSS BINDING ACTIVITY TO ANTIBODIES AGAINST HOST CELL ANTIGENS - Methods for producing proteins and glycoproteins in | 09-13-2012 |
20130266981 | EXPRESSION OF CLASS 2 MANNOSIDASE AND CLASS III MANNOSIDASE IN LOWER EUKARYOTIC CELLS - A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway. | 10-10-2013 |
20130295608 | YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATION - Lower eukaryotic host cells have been recombinantly engineered to produce glycoprotein having human-like O-glycosylation. The glycoproteins are useful for the production of glycoprotein compositions with advantages for the production of human therapeutics. | 11-07-2013 |
20140200180 | METHOD FOR PRODUCING PROTEINS IN PICHIA PASTORIS THAT LACK DETECTABLE CROSS BINDING ACTIVITY TO ANTIBODIES AGAINST HOST CELL ANTIGENS - Methods for producing proteins and glycoproteins in | 07-17-2014 |
Stephen R. Hamilton, Lebanon, NH US
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20130217067 | Combinatorial DNA Library for Producing Modified N-Glycans In Lower Eukaryotes - The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man | 08-22-2013 |
20150051381 | COMBINATORIAL DNA LIBRARY FOR PRODUCING MODIFIED N-GLYCANS IN LOWER EUKARYOTES - The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man | 02-19-2015 |
Stephen Robin Hamilton, Enfield, NH US
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20110053214 | PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES - The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein. | 03-03-2011 |
Ward Hamilton, Amherst, NH US
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20090326632 | Triangular or Crescent Shaped Defibrillation Electrode - A defibrillation electrode for application to the front of the chest of a patient, the electrode comprising a metallic layer, a conductive liquid-containing layer in contact with the metallic layer and configured to contact the skin of the patient, an adhesive layer surrounding the conductive liquid-containing layer and having a layer of adhesive configured to adhere the electrode to the patient, a release layer configured to be removed from the electrode prior to application to the patient, the release layer being in contact with the adhesive and the conductive liquid-containing layer prior to removal, wherein the electrode has a lateral perimeter at or laterally outside of the adhesive layer, and wherein the lateral perimeter is generally triangular. | 12-31-2009 |
20110015688 | Defibrillators - Defibrillators are provided that include a graphical user interface to assist a caregiver in administering resuscitation. | 01-20-2011 |
20110054553 | Memory Device Associated With Defibrillation Electrodes - An electrode package for use with a defibrillator, the electrode package comprising an outer shell providing a vapor barrier between an interior space inside the outer shell and an exterior environment, one or more defibrillation electrodes positioned in the interior space inside the outer shell, each of the defibrillation electrodes including a metallic layer in electrical contact with a conductive liquid-containing layer through which electrical current is delivered to a patient when the defibrillation electrodes have been applied to the patient, the conductive a liquid-containing layer being subject to drying out as liquid from the water-containing layer vaporizes and travels from the interior space to the external environment, and one or more electrical conductors extending from inside of the outer shell to a package electrical connector outside of the shell, the package electrical connector being configured to be connected to a mating defibrillator electrical connector connected to the defibrillator, and an electronic memory device positioned outside the outer shell and in electrical contact with some of the electrical conductors extending from the outer shell to the package electrical connector. | 03-03-2011 |
20150094625 | UNIVERSAL DEFIBRILLATION ELECTRODE PAD ASSEMBLY FOR ADULT AND PEDIATRIC SUBJECTS - A defibrillation electrode pad includes an electrode section and a CPR administration section. The electrode section and the CPR administration section are positioned in the defibrillation electrode pad relative to each other such that the CPR administration section is located above a sternum of an adult subject and the electrode section is located in a position appropriate for the administration of a defibrillation shock to the adult subject when the defibrillation electrode pad is oriented in a first orientation and such that the CPR administration section is located above a sternum of a pediatric subject and the electrode section is located in a position appropriate for the administration of a defibrillation shock to the pediatric subject when the defibrillation electrode pad is oriented in a second orientation different from the first orientation. | 04-02-2015 |