Hamilton, MA
Al Hamilton, Southborough, MA US
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20110205087 | Gen II meter system - Apparatus for controlling and monitoring vehicle parking meter systems wherein a plurality of programmable single space parking meters enable the resetting of time upon a vehicle departure and the occurrence of any other operational parameter; multiple low power microprocessors for monitoring and initiating changes in the logic for all the devices monitoring the parking meter spaces; a plurality of specialized microprocessors for monitoring the system to assure reliable operation thereof; a master operational microprocessor connected to each of the additional low power microprocessors for monitoring of and control of any changes in the logic to establish new operating parameters for the low power microprocessors; a centralized operational controller accessible to parking personnel to monitor and control the space monitoring units from a remote location; a pass-through radio frequency communication device for passing messages from the centralized operational controller to and from each space monitoring unit by way of the internet; and a power supply comprising a rechargeable battery receiving a charge from any combination of high energy density-low current battery and/or a solar panel mounted onto the power supply. | 08-25-2011 |
Alfred Hamilton, Southborough, MA US
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20080224617 | Remotely Monitored And Controlled Distributed Emergency Power System - An emergency lighting system includes a plurality of emergency lights and a plurality of emergency power systems. Each of the plurality of emergency power systems is electrically connected to a respective one of the plurality of emergency lights through a respective one of a plurality of power switches. The emergency lighting system also includes a plurality of processors. Each of the plurality of processors is electrically connected to a respective one of the plurality of emergency power systems and executes software that monitors a status of a respective one of the emergency power systems and controls a state of the plurality of power switches. The emergency lighting system also includes a plurality of radio transceivers. Each of the plurality of radio transceivers is electrically connected to a respective one of the plurality of processors and communicates with other radio transceivers in the plurality of radio transceivers that are in radio wave proximity. In addition, a gateway node radio transceiver routes signals to and from the plurality of radio transceivers. | 09-18-2008 |
20110148302 | Remotely Monitored And Controlled Distributed Emergency Power System - An emergency lighting system includes a plurality of emergency lights and a plurality of emergency power systems. Each of the plurality of emergency power systems is electrically connected to a respective one of the plurality of emergency lights through a respective one of a plurality of power switches. The emergency lighting system also includes a plurality of processors. Each of the plurality of processors is electrically connected to a respective one of the plurality of emergency power systems and executes software that monitors a status of a respective one of the emergency power systems and controls a state of the plurality of power switches. The emergency lighting system also includes a plurality of radio transceivers. Each of the plurality of radio transceivers is electrically connected to a respective one of the plurality of processors and communicates with other radio transceivers in the plurality of radio transceivers that are in radio wave proximity. In addition, a gateway node radio transceiver routes signals to and from the plurality of radio transceivers. | 06-23-2011 |
Brian L. Hamilton, Newton, MA US
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20100234277 | COADMINISTRATION OF ALPHA-FETOPROTEIN AND A DISEASE MODIFYING ANTI-RHEUMATIC DRUG FOR TREATING INFLAMMATORY ARTHRITIC DISEASE - The present invention relates to methods for treating an anti-inflammatory arthritic disease by coadministering therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a disease modifying anti-rheumatic drug (DMARD) to a patient in need thereof. Also disclosed are compositions and kits that include therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a DMARD. | 09-16-2010 |
Bruce Hamilton, Lowell, MA US
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20100318113 | Medical Device Balloons Containing Thermoplastic Elastomers - A dilatation balloon and catheter for insertion into a bodily conduit. The catheter ( | 12-16-2010 |
20120016405 | Medical Device Balloons Containing Thermoplastic Elastomers - A dilatation balloon, the dilatation balloon having a multilayer structure wherein the multilayer structure comprises a thermoplastic elastomer coextruded with a non-compliant structural polymer, the thermoplastic elastomer as an outer layer and the non-compliant structural material is an inner layer. | 01-19-2012 |
Charles W. Hamilton, Watertown, MA US
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20090274613 | Hydrogen Production Using Ammonia Borane - Hydrogen (“H | 11-05-2009 |
Douglas George Hamilton, Dalton, MA US
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20100137500 | NEUTRAL STATIC POLYCARBONATES, METHODS OF MAKING, AND ARTICLES FORMED THEREFROM - Disclosed herein is a method of preparing a polycarbonate composition comprising melt blending a first polycarbonate prepared by interfacial polymerization and having hydroxy end groups that are capped with endcapping groups, with a second polycarbonate prepared by melt polymerization and having hydroxy end groups that are capped with endcapping groups, wherein the second polycarbonate has a lower mole percent of endcapping groups than that of the first polycarbonate; wherein an article having a thickness of 3.2 mm and molded from the polycarbonate composition has a haze of less than 3 according to ASTM D1003-00; and wherein a flat article molded from the polycarbonate composition has a surface charge of −2 to +2 kV. A polycarbonate composition and complex article prepared according to the method are also disclosed. | 06-03-2010 |
Geraldine Hamilton, Cambridge, MA US
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20140186414 | METHODS AND USES FOR EX VIVO TISSUE CULTURE SYSTEMS - The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival. | 07-03-2014 |
Geraldine A. Hamilton, Cambridge, MA US
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20140158233 | AEROSOL DELIVERY TO A MICROFLUIDIC DEVICE - The present invention is directed to systems and methods for delivering aerosolized micro-droplets into microfluidic devices. In some embodiments, the microfluidic devices are designed for the culture of living cells at an air interface. In some embodiments, the systems and methods described herein can be used to deliver aerosolized micro-droplet into detection systems and small animals, tissues, organs and organisms. | 06-12-2014 |
20140199764 | MICROFLUIDIC MODULE AND USES THEREOF - Described herein are microfluidic modules and methods for making the same, wherein the microfluidic modules include a substrate comprising at least one ether-based, aliphatic polyurethane, and at least one fluidic element disposed therein. The ether-based aliphatic polyurethane can be either the substrate of the microfluidic modules or a coating of another substrate material, such that at least a portion of the ether-based, aliphatic polyurethane is in fluid communication. In one embodiment, the ether-based, aliphatic polyurethane includes dicyclohexylmethane-4,4′-diisocyanate. As the ether-based aliphatic polyurethane can decrease absorption of molecules, e.g., hydrophobic molecules, in such microfluidic modules, the microfluidic modules described herein can be used in various applications such as drug screening and fluorescent microscopy. | 07-17-2014 |
20140342445 | ORGAN CHIPS AND USES THEREOF - Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies. | 11-20-2014 |
20150209783 | REMOVING BUBBLES IN MICROFLUIDIC SYSTEMS - A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane. | 07-30-2015 |
James Hamilton, Boston, MA US
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20130202173 | CLASSIFICATION OF BIOLOGICAL TISSUE BY MULTI-MODE DATA REGISTRATION, SEGMENTATION AND CHARACTERIZATION - A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable. | 08-08-2013 |
James A. Hamilton, Newton, MA US
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20100137711 | Apparatus and Method of Analyzing Arterial Plaque - A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. The one or more tests do, in fact, test the plaque for the plurality of the hallmarks. The method then formulates a vulnerability quantity as a function of the determined hallmarks. The vulnerability quantity identifies whether the plaque is vulnerable to disruption. | 06-03-2010 |
Jason Hamilton, Dartmouth, MA US
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20090204081 | COMPRESSION EXPANDED CANNULA - Various methods and devices are provided for accessing an interior surgical site using an access portal which can be inserted and removed with minimal tissue damage and which can form a seal with tissue while inserted. Generally, a device is provided having a rigid elongate surgical access member with a lumen extending therethrough that is configured to receive a surgical tool. The device can also include a flexible sleeve having a lumen extending therethrough that is configured to receive the elongate surgical access member. A substantially rigid collar is provided disposed adjacent to a proximal end of the flexible sleeve and having a lumen extending therethrough that is configured to receive the elongate surgical access member. In an exemplary embodiment, the collar is movable relative to the elongate surgical access member to selectively configure the flexible sleeve in a relaxed condition in which the flexible sleeve has a relatively smooth outer tissue-contacting surface and a compressed condition in which the flexible sleeve has a plurality of protrusions formed on the outer tissue-contacting surface that are configured to create a seal between the outer tissue-contacting surface and tissue. | 08-13-2009 |
20120065679 | WIRED SUTURES - Methods and devices are provided for anchoring suture to bone. In one exemplary embodiment, a cannulated suture anchor is provided and it includes a suture-engaging member formed therein and configured to receive a suture therearound such that trailing ends of the suture can extend through the suture anchor. The present invention also provides exemplary sutures and drivers that can be used with the various methods and devices disclosed herein, or with other methods and devices known in the art. | 03-15-2012 |
20130303858 | COMPRESSION EXPANDED CANNULA - Various methods and devices are provided for accessing an interior surgical site using an access portal which can be inserted and removed with minimal tissue damage and which can form a seal with tissue while inserted. Generally, a device is provided having a rigid elongate surgical access member with a lumen extending therethrough that is configured to receive a surgical tool. The device can also include a flexible sleeve having a lumen extending therethrough that is configured to receive the elongate surgical access member. A substantially rigid collar is provided disposed adjacent to a proximal end of the flexible sleeve and having a lumen extending therethrough that is configured to receive the elongate surgical access member. In an exemplary embodiment, the collar is movable relative to the elongate surgical access member to selectively configure the flexible sleeve in a relaxed condition in which the flexible sleeve has a relatively smooth outer tissue-contacting surface and a compressed condition in which the flexible sleeve has a plurality of protrusions formed on the outer tissue-contacting surface that are configured to create a seal between the outer tissue-contacting surface and tissue. | 11-14-2013 |
20150374407 | COMPRESSION EXPANDED CANNULA - Various methods and devices are provided for accessing an interior surgical site using an access portal which can be inserted and removed with minimal tissue damage and which can form a seal with tissue while inserted. Generally, a device is provided having a rigid elongate surgical access member with a lumen extending therethrough that is configured to receive a surgical tool. The device can also include a flexible sleeve having a lumen extending therethrough that is configured to receive the elongate surgical access member. A substantially rigid collar is provided disposed adjacent to a proximal end of the flexible sleeve and having a lumen extending therethrough that is configured to receive the elongate surgical access member. In an exemplary embodiment, the collar is movable relative to the elongate surgical access member to selectively configure the flexible sleeve in a relaxed condition in which the flexible sleeve has a relatively smooth outer tissue-contacting surface and a compressed condition in which the flexible sleeve has a plurality of protrusions formed on the outer tissue-contacting surface that are configured to create a seal between the outer tissue-contacting surface and tissue. | 12-31-2015 |
Jason L. Hamilton, Dartmouth, MA US
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20130085325 | HAND-MOUNTED, VIDEO-GUIDED SYSTEM FOR TREATING PERITONITIS AND OTHER MEDICAL CONDITIONS - A hand-mounted, video-guided system comprising: | 04-04-2013 |
Jeffrey Hamilton, Agawam, MA US
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20150323315 | BICYCLE ALIGNMENT TOOL - A bicycle alignment device can be used to align the nose of the bicycle seat with the top tube of the bicycle frame. In addition, the same device can be used to align the handlebar stem with the front tire of the bicycle. The device can use a pointing device, such as a pin or a laser pointer, to align the seat to the top tube. The device can be easily broken down into its components for easy and convenient storage when not in use. | 11-12-2015 |
John V. Hamilton, Foxborough, MA US
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20100094229 | SPINAL FLUID INTRODUCTION - A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer. | 04-15-2010 |
20120065594 | SPINAL FLUID INTRODUCTION - A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer. | 03-15-2012 |
John V. Hamilton, Foxboro, MA US
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20080208320 | Delivery Apparatus and Methods for Vertebrostenting - The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent. | 08-28-2008 |
20100114111 | DELIVERY APPARATUS AND METHODS FOR VERTEBROSTENTING - The invention relates to a method of delivering and deploying a stent into a curvilinear cavity within a vertebral body or other bony or body structure. The invention also relates to devices that may be used to perform the steps to deliver and deploy a stent. | 05-06-2010 |
20140121667 | Delivery of Apparatus and Methods for Vertebrostenting - The present invention generally is directed toward a spinal fixation system whereby a coupling element allows the physician to selectively lock or unlock either the connection between the coupling element and a fastener, such as to allow for repositioning of the coupling element, or the connection between the coupling element and an elongate rod. The locking or unlocking of these connections may be made independently and as desired by the physician. | 05-01-2014 |
Jonathon Bradley Hamilton, Littleton, MA US
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20150232810 | METHODS OF PREPARING PLURIPOTENT STEM CELLS - The invention relates to pluripotent stems cells and their methods of use. The invention also relates to methods of producing pluripotent stem cells. | 08-20-2015 |
Lei Hamilton, Lexington, MA US
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20160055124 | SYSTEMS AND METHODS FOR LOW-RANK MATRIX APPROXIMATION - Systems and methods for generating a low-rank approximation of a matrix are provided. The various systems and methods may identify at least a first set of right singular vectors and a first set of singular values of a subset of the matrix, reduce the subset by an amount of energy of a selected data entry of the subset based on the first set of right singular vectors and the first set of singular values, incorporate a new data entry from the matrix into the subset, update the first set of right singular vectors and the first set of singular values of the subset based on the new data entry by a singular value decomposition (SVD) update, and generate the low-rank approximation of the matrix based on the updated first set of right singular vectors and the updated first set of singular values. | 02-25-2016 |
Mark Hamilton, Upton, MA US
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20080212074 | Hand-Held, Self-Contained Optical Emission Spectroscopy (OES) Analyzer - A hand-held, self-contained, battery-powered test instrument for analyzing composition of a sample includes an exciter for exciting at least a portion of the sample, a compact cross-dispersed spectrometer for receiving an optical signal from the excited portion of the sample and a processor for processing spectral data about the optical signal from the spectrometer. The exciter may include a spark generator and a counter electrode, a laser or other device for generating the optical signal from the sample portion. The spectrometer has a wavelength range broad enough to enable the test instrument to detect and determine relative quantities of carbon, phosphorous, sulfur, manganese, silicon, iron and other elements necessary to identify common alloys. The spectrometer includes a structural member made of a light-weight material having a small coefficient of thermal expansion (CTE). The spectrometer is dimensionally stable over a range of expected ambient temperatures, without controlling the temperature of the spectrometer. | 09-04-2008 |
20090050786 | Fast and Precise Time-Resolved Spectroscopy with Linear Sensor Array - Time-resolved analysis of a spectrum is performed by illuminating a one-dimensional array of charge-transfer device light-sensitive pixel cells and periodically non-destructively copying charges in the light-sensitive cells to respective storage cells (“row storage registers”) co-located with the light-sensitive cells in an integrated circuit. Information about the charges stored in at least some of the storage cells is provided to a component external to the integrated circuit. | 02-26-2009 |
20090057422 | Contactless Memory Information Storage for Sample Analysis and Hand-Holdable Analyzer for Use Therewith - An analytical instrument stores and/or reads information related to a sample in a contactless memory, such as a passive or active radio-frequency identification (RF-ID) tag. The information may include information about: composition of the sample, one or more analytical instruments that were used to analyze the sample, operator(s) who used the instrument(s) to analyze the sample, user-entered data about the sample (such as an origin of the sample) or a combination thereof or the like. The memory may be attached to the sample or to a container, in which the sample is stored or transported. One or more copies of such a memory may be loosely stored with the sample, such as with soil in a plastic bag or a rail car. When the memory is attached to, or stored with, the sample, the sample becomes essentially self-documenting. Information about the sample, such as its composition or origin, may be read by a contactless memory reader, such as an RF-ID reader. | 03-05-2009 |
20090057582 | DOCKING STAND FOR ANALYTICAL INSTRUMENT - An analytical instrument may be docked in a stand. The stand provides electrical power, cooling, gas to purge air from an analytical gap within the instrument and/or other supplies or services to the instrument. The stand contains a contactless memory, such as an RF-ID tag, which stores information about the supplies and/or services the stand is capable of providing to the instrument. The instrument reads the stand's contactless memory and automatically sets operational parameters of the instrument in accordance with the supplies and/or services the stand is capable of providing. Thus, the instrument may automatically operate in an enhanced mode, such as at a higher x-ray beam power, as a result of being mounted in the stand. | 03-05-2009 |
20090064276 | Analytical Instrument with Automatic Lockout against Unauthorized Use - An analytical instrument includes a contactless memory reader, such as an RF-ID reader. Each person authorized to use the instrument carries a contactless memory, such as an RF-ID tag in an identification (ID) badge. The instrument scans for a contactless memory containing information identifying an authorized user prior to performing an analysis or prior to operating in a predetermined mode, thus preventing unauthorized persons from operating the instrument or from operating the instrument in an unauthorized mode. | 03-05-2009 |
20090079980 | Compact Cross-Dispersed Spectrometer for Extended Spectral Range - A spectrometer includes a structural member made of a light-weight material having a small coefficient of thermal expansion (CTE). The spectrometer is dimensionally stable over a range of expected ambient temperatures, without controlling the temperature of the spectrometer. | 03-26-2009 |
20090251007 | Hot-Swappable Battery Retrofit Module - A retrofit module electrically connects to a device's battery terminals, where an original main battery would otherwise connect to the device, and a hot-swappable battery electrically connects to the retrofit module, thereby retrofitting the device for operation with hot-swappable batteries, without shutting down the device to swap the batteries. When a charged hot-swappable battery is connected to the retrofit module, the retrofit module powers the device from the hot-swappable battery. The retrofit module includes a bridge battery and a circuit that charges the bridge battery from the hot-swappable battery and that provides power to the device from the bridge battery while the hot-swappable battery is replaced. The retrofit module may include a releasable structure that maintains the module in contact with the device's battery terminals, even after the hot-swappable battery has been removed. The retrofit module may have a form factor and power supplying terminals similar to those of the main battery that the device is configured to accept. | 10-08-2009 |
20110142200 | Small Spot X-Ray Fluorescence (XRF) Analyzer - A hand-held, self-contained x-ray fluorescence (XRF) analyzer produces a small x-ray spot on a sample to interrogate the elemental composition of a sample region of millimeter-size characteristic dimension. The analyzer includes a collimator for aiming an x-ray beam toward a desired location on the sample and for determining the size of the spot produced on the sample. The analyzer may include a digital camera oriented toward the portion of the sample that is, or would be, interrogated by the x-ray spot to facilitate aiming the analyzer. The analyzer may generate a reticule in a displayed image to indicate the portion of the sample that is, or would be, illuminated by the x-ray beam. The analyzer may automatically annotate the image of the sample with text or graphics that contain information about the analyzed sample. The image may be stored in the hand-held analyzer or provided for external storage or display. | 06-16-2011 |
Mark A. Hamilton, Upton, MA US
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20100284003 | Optical Emission Spectroscopic (OES) Instrument with Automatic Top and Bottom Slit Curtains - An optical emission spectroscopic (OES) instrument includes a spectrometer, a processor and an adjustable mask controlled by the processor. The adjustable mask defines a portion of an analytical gap imaged by the spectrometer. The instrument automatically adjusts the size and position of an opening in the mask, so the spectrometer images an optimal portion of plasma formed in the analytical gap, thereby improving signal and noise characteristics of the instrument, without requiring tedious and time-consuming manual adjustment of the mask during manufacture or use. | 11-11-2010 |
20110051135 | Multiple-Light-Path Front End for OES Instrument - An optical emission spectroscopic system contains multiple distinct light paths that provide increased light to a spectrometer, thereby increasing sensitivity and signal-to-noise of the system. | 03-03-2011 |
20130321793 | SAMPLE ANALYSIS - An analyzer for analyzing a composition of a sample, and methods of operating an analyzer. The analyzer may include an optical illuminator and a Raman spectrometer to produce Raman spectral data representative of Raman radiation emitted from the sample in response to the illuminating light. Features to reduce background fluorescence are optionally provided. An x-ray illuminator may be provided to illuminate the sample with x-rays, and also an x-ray spectrometer may be present to produce x-ray spectral data representative of fluorescence radiation emitted from the sample in response to the illuminating x-rays. A processor receives the Raman spectral data and any x-ray spectral data and provides an analysis of a compound in the sample. | 12-05-2013 |
20140104609 | OPTICAL EMISSION SPECTROSCOPIC (OES) INSTRUMENT WITH AUTOMATIC TOP AND BOTTOM SLIT CURTAINS - An optical emission spectroscopic (OES) instrument includes a spectrometer, a processor and an adjustable mask controlled by the processor. The adjustable mask defines a portion of an analytical gap imaged by the spectrometer. The instrument automatically adjusts the size and position of an opening in the mask, so the spectrometer images an optimal portion of plasma formed in the analytical gap, thereby improving signal and noise characteristics of the instrument, without requiring tedious and time-consuming manual adjustment of the mask during manufacture or use. | 04-17-2014 |
20140268132 | OPTICAL EMISSION SPECTROSCOPIC (OES) INSTRUMENT WITH AUTOMATIC TOP AND BOTTOM SLIT CURTAINS - An optical emission spectroscopic (OES) instrument includes a spectrometer, a processor and an adjustable mask controlled by the processor. The adjustable mask defines a portion of an analytical gap imaged by the spectrometer. The instrument automatically adjusts the size and position of an opening in the mask, so the spectrometer images an optimal portion of plasma formed in the analytical gap, thereby improving signal and noise characteristics of the instrument, without requiring tedious and time-consuming manual adjustment of the mask during manufacture or use. | 09-18-2014 |
Maureen A. Hamilton, Littleton, MA US
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20140051089 | METHOD FOR DETECTING MICROORGANISMS - Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample. | 02-20-2014 |
Meg D. Hamilton, Beverly, MA US
Michael Hamilton, Beverly, MA US
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20090070734 | SYSTEMS AND METHODS FOR MONITORING SOFTWARE APPLICATION QUALITY - Computer-based systems, methods and software products for monitoring software application quality comprise enabling a computer to generate a developer-identifying output identifying which software application developer ( | 03-12-2009 |
Peter Hamilton, East Bridgewater, MA US
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20100145353 | Flexible Vacuum Grabber for Holding Lesions - A grabbing device includes a transparent flexible cup that can be placed adjacent to a selected region of an inner surface of a body cavity. The flexible cup is visually put in place by the surgeon, and a vacuum is applied to draw a selected amount of tissue into the flexible cup, so that it may, e.g., be excised. The device may also retrieve the tissue excised from the body cavity. | 06-10-2010 |
20130116702 | Flexible Vacuum Grabber for Holding Lesions - A grabbing device includes a transparent flexible cup that can be placed adjacent to a selected region of an inner surface of a body cavity. The flexible cup is visually put in place by the surgeon, and a vacuum is applied to draw a selected amount of tissue into the flexible cup, so that it may, e.g., be excised. The device may also retrieve the tissue excised from the body cavity. | 05-09-2013 |
Peter A. Hamilton, East Bridgewater, MA US
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20090192462 | APPARATUS AND METHOD FOR STEERING A GUIDEWIRE AND CONNECTING TO AN EXTENSION GUIDEWIRE - An apparatus for steering a guidewire and for connecting the guidewire to an extension guidewire. The apparatus includes a steering device for gripping an exterior of the guidewire, the steering device defining a passageway therein through which the guidewire may pass; and a connecting device for connecting the guidewire to the extension guidewire. The connecting device is configured for mating with the steering device to form an integral unit. The invention further includes a method of inserting a guidewire in a body and connecting the guidewire to an extension guidewire. The method includes the steps of: providing an integral guidewire holder and tool for connecting a guidewire to an extension guidewire; gripping the guidewire with the integral guidewire holder; inserting the guidewire into a body lumen; displacing the integral guidewire holder and tool relative to the guidewire so that the proximal end of the guidewire is located in a slot of the integral guidewire holder and tool; inserting an extension guidewire into the slot of the integral guidewire holder and tool; and connecting the guidewire to the extension guidewire. The method further includes the step of aligning the guidewire and extension guidewire in the slot prior to the connecting step. | 07-30-2009 |
20120271408 | Low Profile Medical Stent - A medical prosthesis having a low profile for delivery into a body lumen is disclosed. The stent includes a plurality of wire strands woven to form a plurality of joints at the intersections, some of which are helically wrapped. The helically wrapped joints may be offset form the joints of a second plurality of wire strands concentric to the first. Alternatively, the helically wrapped joints can doubled forming box nodes. | 10-25-2012 |
Scott A. Hamilton, Lexington, MA US
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20100104277 | MODULATOR FOR FREQUENCY-SHIFT KEYING OF OPTICAL SIGNALS - Described are an FSK modulator and a method for large-alphabet FSK modulation. The FSK modulator and the method are based on filtering of a multi-tone optical source such as a mode-locked laser which provides a comb distribution of tones. A frequency-selective component selects for transmission a subset of the tones. In various embodiments the frequency-selective component is a Mach-Zehnder interferometer filter or a microring resonator filter. A second frequency-selective component selects a subset of the tones from the comb distribution provided by the first frequency-selective component. Still more frequency-selective components can be used according to the number of tones supplied by the multi-tone optical source to the FSK modulator. The optical signal exiting the last frequency-selective component includes only a single tone which corresponds to the symbol to be transmitted. | 04-29-2010 |
20110274429 | METHOD AND APPARATUS FOR PHASE SHIFT KEYED OPTICAL COMMUNICATIONS - A burst-mode differential phase shift keying (DPSK) communications system according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical transmitter and receiver. An embodiment of the system utilizes a single interferometer in the receiver with a relative path delay that is matched to the DPSK symbol rate of the link. DPSK symbols are transmitted in bursts, and the data rate may be varied by changing the ratio of the burst-on time to the burst-off time. This approach offers a number of advantages over conventional DPSK implementations, including near-optimum photon efficiency over a wide range of data rates, simplified multi-rate transceiver implementation, and relaxed transmit laser line-width requirements at low data rates. | 11-10-2011 |
20130148983 | MODULATOR FOR FREQUENCY-SHIFT KEYING OF OPTICAL SIGNALS - Described are an FSK modulator and a method for large-alphabet FSK modulation. The FSK modulator and the method are based on filtering of a multi-tone optical source such as a mode-locked laser which provides a comb distribution of tones. A frequency-selective component selects for transmission a subset of the tones. In various embodiments the frequency-selective component is a Mach-Zehnder interferometer filter or a microring resonator filter. A second frequency-selective component selects a subset of the tones from the comb distribution provided by the first frequency-selective component. Still more frequency-selective components can be used according to the number of tones supplied by the multi-tone optical source to the FSK modulator. The optical signal exiting the last frequency-selective component includes only a single tone which corresponds to the symbol to be transmitted. | 06-13-2013 |