Patent application number | Description | Published |
20110000472 | IGNITION COIL - An ignition apparatus includes a core, primary and secondary windings and a loop-shaped magnetic return path structure. The structure includes layers of wound strip steel or wound ferritic wire stacked in an outward fashion. The core is placed in an interior of the loop forming at least one air gap between a core end surfaces and the structure. A combined core and magnetic return path structure includes a continuous loop formed by winding ferritic wire either on a spool or on a mandrel and is then bonded. The bonded winding is cut to form two C-shaped portions. Each C-shaped portion has a central yoke that extends into a pair of parallel legs. The C-shaped portions are re-assembled over primary and second windings so that the legs form a pair of parallel branches. One branch acts as the core and the other branch acts as the magnetic return path. | 01-06-2011 |
20130033145 | ELECTRIC MACHINE MODULE INSULATION SYSTEM AND METHOD - Embodiments of the invention provide an electric machine module including a housing which can include a machine cavity. In some embodiments, an electric machine can be at least partially positioned within the machine cavity and can include a stator assembly. The stator assembly includes a stator core with slots. In some embodiments, conductors can be positioned in the slots and can include a first insulation. At least one insulation member can be disposed over at least a portion of the conductors. The insulation member can include a first element and a second element that can each comprise different constituent materials that include different properties. | 02-07-2013 |
20130069478 | ELECTRICAL MACHINE WITH WINDING CONDUCTOR HAVING CERAMIC INSULATION - An electrical machine is described that has a ceramic material as insulation around the winding wire. In some embodiments, the ceramic material is hexagonal boron nitride (HVR), aluminum oxide, aluminum nitride, or beryllium oxide. The ceramic material may be rolled, brush, sprayed, or dipped onto the wire using a binder-less or binder-containing solution. The whole wire may be coated, or just parts that are particularly subject to abrasion of the conductor and/or electrical contact with other conductive materials. | 03-21-2013 |
20130106231 | CONDUCTOR WELD-END LENGTH CONTROL FORMING | 05-02-2013 |
20130125396 | WRAPPED WIRE FOR ELECTRIC MACHINE - A method of insulating a conductor wire comprises the steps of providing an electrically conductive core having a longitudinal axis and applying an electrical insulation material to an outer surface of the core. The method further comprises the steps of elevating the temperature of the electrical insulation material and applying external pressure to the electrical insulation material to facilitate adhesion with the core. | 05-23-2013 |
20130127288 | ELECTRIC MACHINE WITH INSULATOR SPACER - A stator assembly for an electric machine including a stator core supporting a plurality of electrical conductors. A plurality of elongated insulator spacers is interwoven between the conductors proximate connection ends thereof in axially spaced relation to the stator core. | 05-23-2013 |
20130130571 | LOW-PROFILE CONNECTION SYSTEM - A high-voltage electric machine has one or more terminals at which wires are to be electrically connected to the machine. The machine's housing includes a cable entrance leading to the terminal(s) through which the wire is inserted. Access holes through the housing enable a technician to reach the terminals (for example, with a tool, such as a screwdriver) to connect each wire to a terminal. In some embodiments, the direction of the access through the hole to the terminal is substantially perpendicular to the direction from which the wire reaches the terminal. A plug may be inserted into each access hole to prevent accidental contact with the terminal(s), such as screw-type or friction-fit plugs. | 05-23-2013 |
20130140081 | COMPOSITE SLEEVE FOR A CONDUCTOR AND METHOD - A composite sleeve for a conductor including a conductor having an outer surface, a first sleeve positioned about the outer surface of the conductor, and a second sleeve positioned about the first sleeve. One of the first and second sleeves is formed from a compressed amide synthetic fiber. The first and second sleeves cooperate to provide protection for the conductor from external elements. | 06-06-2013 |
20130140925 | STATOR INCLUDING CONDUCTORS PROVIDED WITH A COMPOSITE SLEEVE - A stator includes a stator core having a plurality of slot segments, a plurality of stator winding conductors arranged in select ones of the plurality of slot segments, a jumper conductor interconnecting select ones of the plurality of stator winding conductors to form one or more stator windings, a common conductor connected to at least one of the stator winding conductors, a phase conductor connected to corresponding ones of the one or more stator windings, and a composite sleeve provided on at least one of the jumper conductor, the common conductor, and the phase conductor. The composite sleeve includes a first sleeve, and a second sleeve positioned about the first sleeve. One of the first and second sleeves is formed from a compressed amide synthetic fiber. The first and second sleeves cooperate to provide protection for the conductor from external elements. | 06-06-2013 |
20130156071 | Electric Machine Including Insulated Slot Liner With Temperature Sensor - A slot liner is configured for insertion into a slot of a core of an electric machine having a winding arrangement comprised of a plurality of conductors. The slot liner comprises a first insulation layer forming a cavity configured to receive at least one of the plurality of conductors of the winding arrangement. The slot liner also comprises a second insulation layer coupled to the first insulation layer. In addition, the slot liner includes a length of conductive material positioned between the first insulation layer and the second insulation layer. The length of conductive material has a resistance that varies with temperature. A first lead extends from a first end of the length of conductive material and a second lead extends from the second end of the length of conductive material. | 06-20-2013 |
20130162071 | ELECTRIC MACHINE WITH ENCAPSULATED END TURNS - An electric machine having a rotor and a stator. The stator includes an electrically conductive wire forming a stator winding. The stator winding forms a first plurality of end turns projecting axially beyond an axial end of the stator core. Each of the wire segments forming the first plurality of end turns has a discrete electrically insulative outer layer. A heat transmissive material having a thermal conductivity of at least about 50 W•m | 06-27-2013 |
20130169098 | MULTI-GRADE MAGNET FOR AN ELECTRIC MACHINE - Apparatus and methods for improved performance of electric machines, including internal permanent magnet electric machines. In some embodiments there are multiple pairs of permanent magnets. Each magnet is fabricated from a pair of materials, one of the materials being selected to have improved high temperature magnetic characteristics, and the second material, in some embodiments, being selected for having improved magnet characteristics at lower temperatures even if with lesser magnetic characteristics at the higher temperatures than the other material. | 07-04-2013 |
20130169103 | CONDUCTOR WELD-END FORMING PROCESS - A method of joining a plurality of electrical conductors in an electric machine comprises the steps of providing a core with a plurality of circumferentially spaced openings, and positioning a plurality of conductors within the openings of the core in a plurality of concentric layers. Each conductor includes an end that extends from the core. The ends of the conductors have a first shape. The method also includes the step of shaping the ends of the conductors with a set of forming dies to form a second shape. Additionally, the method includes the step of joining a pair of adjacent ends with a joining tool to form a joint with a third shape after shaping the ends to form the second shape. The method further includes the step of removing the set of forming dies and the joining tool from the joint after the joining step. | 07-04-2013 |
20130175853 | HOUSING ASSEMBLY WITH REED SWITCH AND MAGNET - An electric machine and vehicular subsystem, apparatus includes a connection disposed within a housing and connecting a high voltage line with the electric machine. A controller controls the coupling of a power source to the high voltage line. A reed switch is positioned within the housing proximate the high voltage line connection. A member is removably mounted on the housing and structured so that removal of the member is necessary to gain access to the high voltage line connection, the member having a magnet. At least one low voltage communication line extends from the reed switch to the controller. Removal of the member from the housing opens the reed switch. Mounting of the member to the housing closes the reed switch. The controller terminates the providing of electric power to the high voltage line when the member is removed from the housing. | 07-11-2013 |
20130175854 | SAFETY COVER WITH INTEGRATED MAGNET FOR REED SWITCH - An electric power source supplies electrical power to an electric machine of a vehicle via a plurality of high voltage lines. A plurality of connections are disposed within a housing for connecting the high voltage lines. A cover member encloses a hidden magnet and is removably secured to the housing so that removal is necessary to obtain access to the high voltage lines. A reed switch is mounted proximate the cover member, when secured, within a magnetic field of the magnet, whereby the reed switch is closed when the cover member is secured and is open when the cover member is removed. A controller is controllably coupled to the power source via a control connector and circuit of the electric machine. Such circuit extends from the reed switch to the controller, where the controller causes the electric power source to stop supplying electrical power when the cover member is removed. | 07-11-2013 |
20130187494 | STATOR ASSEMBLY FOR AN ELECTRIC MACHINE - A stator assembly includes a first conductor having a first leg portion, and second leg portion. Each of the first and second leg portions includes corresponding first and second free end portions. The first free end portion includes first and second surface portions and the second free end portion includes first and second surface segments. A second conductor includes a first leg section, and a second leg section including corresponding first and second free end sections. The first free end section includes first and second surface zones and the second free end section including first and second surface sectors. The second free end portion and the first free end section are twisted creating a cross-over region causing the first surface portion to abut the second surface zone. The second free end portion is joined to the first free end section through a bond that exists at the cross-over region. | 07-25-2013 |
20130252479 | TERMINAL BLOCK HOLDER - A terminal block holder is provided for securing a terminal block assembly having at least three conductive bus bars enclosed within corresponding individual insulating columns passing through a housing of an electric machine, the terminal block holder including a plate defining at least three openings therein, and including first and second dividers extending from the plate and respectively separating different adjacent ones of the openings, where the plate is adapted to abut the terminal block assembly in a first direction, where the plate is adapted to abut the housing in a second direction, where the dividers are adapted to abut the terminal block assembly in a third direction, and where the first, second and third directions are substantially perpendicular to one another. | 09-26-2013 |
20130257190 | IPM MACHINE WITH THERMALLY CONDUCTIVE COMPOUND - A synchronous electric machine includes a rotor having a substantially cylindrical core with axially extending slots, a plurality of permanent magnets configured as sets defining alternating poles in a circumferential direction, the permanent magnets being located in respective ones of the slots, and a thermally conductive material contiguous with the permanent magnets and the core for transferring heat of the permanent magnets, the material having a thermal conductivity of greater than 0.3 watts per (meter * Kelvin). | 10-03-2013 |
20130313923 | THERMALLY CONDUCTIVE COATING FOR PERMANENT MAGNETS IN ELECTRIC MACHINE - A method of manufacturing an electric machine that includes providing a core defining a slot, coating a magnet body prior to installation of the magnet body into the slot and installing the magnet body into the slot wherein the coating on the magnet body has a thermal conductivity of at least about 0.3 W·m | 11-28-2013 |
20130342030 | HIGH VOLTAGE PROTECTION INTERLOCK SYSTEM FOR SERVICEABILITY - An interlock system and method are provided for protecting high voltage electrical couplings. The interlock system may control access to the electrical couplings based on the voltage of the electrical couplings. The interlock system may also selectively energize and de-energize the electrical couplings based on the position of a lid. | 12-26-2013 |
20140014390 | BUSS BAR ASSEMBLY HAVING AXIALLY STACKED BUSS BAR PLATES - A buss bar assembly for a multiphase electrical machine, including a substantially annular dielectric housing having a central axis, a plurality of dielectric phase bar mounting members located within the housing, and a plurality of electrically conductive phase bars. The phase bars are disposed in the housing and substantially surround the central axis. Each phase bar has opposing, substantially planar axial sides and is in engagement with at least one phase bar mounting member. An axial side of each phase bar is in superposition with an axial side of another phase bar whereby the plurality of phase bars are axially stacked along the central axis. The phase bars have mutually spaced positions relative to each other in directions along the central axis, these positions defined by the phase bar mounting members whereby the phase bars are electrically isolated from each other within the housing. | 01-16-2014 |
20140015359 | BUSS BAR ASSEMBLY HAVING PRINTED BUSS BAR PLATES - A buss bar assembly for a multiphase electric machine. The buss bar assembly includes a substantially annular dielectric housing having a central axis. A plurality of dielectric mounting members is located within the housing. A buss bar plate assembly is disposed in the housing, and in engagement with the mounting members. The buss bar plate assembly includes a substantially planar dielectric substrate that has opposing, substantially planar axial sides, and substantially surrounds the central axis. The buss bar plate assembly also includes a plurality of electrically conductive phase bars applied to at least one of the opposing substrate sides. Each phase bar is for electrical connection to a different one of multiple electrical phases and substantially surrounds the central axis, with the phase bars being electrically isolated from each other within the housing. | 01-16-2014 |
20140021811 | PERMANENT MAGNET (PM) ELECTRIC MACHINE INCLUDING PERMANENT MAGNETS PROVIDED WITH A SACRIFICAL COATING HAVING A THERMAL INTERFACE MATERIAL (TIM) - A permanent magnet electric machine including a housing, a stator mounted within the housing, and a rotor assembly rotatably mounted within the housing relative to the stator. The rotor assembly includes a plurality of laminations. Each of the plurality of laminations includes a plurality of slots and one or more permanent magnets mounted within respective ones of the plurality of slots. Each of the plurality of permanent magnets includes a sacrificial coating formed from a thermal interface material (TIM). | 01-23-2014 |
20140028139 | PERMANENT MAGNET ROTOR WITH RESIN-COVERED MAGNET AND LAMINATION FOR THERMAL CONTROL - A method of forming a rotor includes placing a plurality of laminations into a stack having a plurality of longitudinally extending magnet slots, placing a plurality of permanent magnets into ones of the magnet slots, and injecting a low viscosity epoxy resin into the lamination stack, thereby substantially filling the magnet slots with a portion of the epoxy resin having a thermal conductivity greater than 0.3 Watts/(meter*degree Kelvin) and substantially filling axial spaces between adjacent ones of the laminations with a portion of the epoxy resin having a thermal conductivity less than that of the epoxy resin in the magnet spaces. | 01-30-2014 |
20140035404 | ANGLED WELD END TURNS FOR COOLANT ACCESS - An electric machine includes a stator core having a plurality of circumferentially-oriented slot positions, each slot position having a plurality of radially-oriented slots, each slot extending longitudinally through the core. The stator core has a plurality of conductor segments each extending through at least one of the slots. When a slot position is populated with at least two conductor segments, at least two exterior conductor portions exiting the slot position are angled radially apart from one another by more than one degree. A method of cooling an electric machine includes providing coolant access to embedded conductor end turn portions of a stator having circumferentially spaced slot positions by radially spreading exterior conductor portions exiting populated ones of the slot positions. | 02-06-2014 |
20140035426 | STATOR INCLUDING CONDUCTORS PROVIDED WITH A CERAMIC COVERING - A stator core includes a plurality of slot segments, a plurality of stator winding conductors arranged in select ones of the plurality of slot segments, and a ceramic covering provided on one or more of the plurality of stator winding conductors. The ceramic covering includes an adhesive bonded to the one of the plurality of stator winding conductors to provide insulation for the one or more stator winding conductors. | 02-06-2014 |
20140042840 | PERMANENT MAGNET (PM) ELECTRIC MACHINE INCLUDING PERMANENT MAGNETS PROVIDED WITH A THERMAL INTERFACE MATERIAL (TIM) BETWEEN ADJACENT PERMANENT MAGNETS - A permanent magnet electric machine includes a housing, a stator mounted within the housing, and a rotor assembly rotatably mounted within the housing relative to the stator. The rotor assembly includes a rotor body having a plurality of rotor laminations. A plurality of permanent magnets having axial end portions is mounted to the rotor body. An amount of thermal interface material (TIM) is arranged between the axial end portions of adjacent ones of the plurality of permanent magnets. | 02-13-2014 |
20140070635 | PERMANENT MAGNET ELECTRIC MACHINE INCLUDING PERMANENT MAGNETS HAVING A SLEEVE FORMED FROM A THERMAL INTERFACE MATERIAL - An electric machine includes a housing, a stator fixedly mounted relative to the housing, and a rotor assembly rotatably mounted relative to the stator. The rotor assembly includes a plurality of rotor laminations forming a rotor body, one or more permanent magnets provided in the rotor body, and a sleeve extending around the one or more permanent magnets. The sleeve provides a thermal interface between the one or more permanent magnets and the rotor body. | 03-13-2014 |
20140070636 | ELECTRO-DYNAMIC MACHINE - An electro-dynamic machine is provided and includes stator assembly end turns and a coolant chargeable bladder disposable to contact the end turns. | 03-13-2014 |
20140070637 | THERMAL MANAGEMENT OF AN IPM MOTOR WITH CONTAINERIZED FLUID - A rotor of an electric machine includes a rotor core having a plurality of longitudinally extending magnet channels each containing a permanent magnet, and a plurality of moldable containers each containing a heat transfer material and each being contiguous with portions of the respective permanent magnet and its magnet channel. A method of thermal management of an internal permanent magnet (IPM) rotor includes installing, into at least one longitudinally extending magnet channel of a rotor core, a permanent magnet having opposite lateral ends. The method also includes installing a moldable container, enclosing a heat transfer material, into the magnet channel adjacent one of the lateral ends of the permanent magnet. The method further includes transferring heat from the magnet through the container into the rotor core. | 03-13-2014 |
20140070654 | PERMANENT MAGNET ELECTRIC MACHINE HAVING MAGNETS PROVIDED WITH A THERMAL ENHANCEMENT BONDING COATING - A rotor assembly for a permanent magnet electric machine includes a plurality of rotor laminations joined to form a rotor body. Each of the plurality of rotor laminations includes a plurality of slots. One or more permanent magnets are mounted within respective ones of the plurality of slots. Each of the one or more permanent magnets includes a thermal enhancement bonding coating. A method of forming a rotor assembly is also disclosed. | 03-13-2014 |
20140070658 | LAMINATION ASSEMBLY INCLUDING AN INTER-LAMINATION THERMAL TRANSFER MEMBER FOR AN ELECTRIC MACHINE - A lamination assembly having a lamination stack including a plurality of lamination members, and at least one inter-lamination thermal transfer member coupled to at least one of the plurality of lamination members. The at least one inter-lamination thermal transfer member establishes a heat dissipation path from the lamination stack. | 03-13-2014 |
20140077632 | ELECTRIC MACHINE WITH THERMAL TRANSFER BY LIQUID - A rotor of an internal permanent magnet (IPM) electric machine includes a core having first and second axial ends, longitudinal channels extending between the ends, and a plurality of permanent magnets disposed in the channels. A first conical spring washer having a circumferential edge is secured to the first axial end and a second conical spring washer having a circumferential edge is secured to the second axial end. Space between the first conical spring washer and the first axial end is in fluid communication, via the channels, with space between the second conical spring washer and the second axial end. A method includes stacking and aligning laminations on a shaft to thereby form a rotor core, placing a conical spring washer onto the shaft at each axial end of the lamination stack, and tightening the conical spring washers onto the shaft, whereby the conical spring washers compress the lamination stack. A method of cooling magnets of an internal permanent magnet (IPM) electric machine includes enclosing each axial end of a rotor core with a conical spring washer to form two respective end cavities, and transferring coolant between the end cavities, thereby passing the coolant by the magnets. | 03-20-2014 |
20140091652 | ELECTRIC MACHINE INCLUDING A HOUSING HAVING MATERIALLY INTEGRALLY FORMED COOLANT CHANNELS AND AN OUTER SLEEVE - An electric machine housing includes a housing body having an outer surface provided with a plurality of materially integrally formed ribs defining a plurality of coolant channels. Each of the plurality of materially integrally formed ribs has an outer surface portion. A sleeve is provided on the housing body extending about the outer surface. The sleeve has an inner surface section that is matingly engaged with the outer surface portion of each of the materially integrally formed ribs. | 04-03-2014 |
20140132094 | THERMAL MANAGEMENT OF AN IPM MOTOR WITH NON-MAGNETIC BARS - A rotor of an electric machine includes a lamination stack having a plurality of longitudinally extending magnet channels each having a magnet space and longitudinally extending gaps on each lateral end of the magnet space. A plurality of permanent magnets are respectively disposed in ones of the magnet channels, substantially non-magnetic bars are disposed in each longitudinally extending gap, and a thermally conductive filler material secures the magnets and the bars within the channels. A method of thermal management of an internal permanent magnet (IPM) rotor includes installing, into at least one longitudinally extending magnet channel of a lamination stack, a pair of substantially non-magnetic bars adjacent opposite lateral ends of a longitudinally extending permanent magnet, and transferring heat from the magnet through the bars into the lamination stack. | 05-15-2014 |
20140175916 | ROTOR ASSEMBLY HAVING LIQUID COOLING - A liquid-cooled rotor assembly for a rotary electric machine, including a shaft provided with a fluid passageway receivable of a liquid coolant, and a substantially cylindrical rotor core rotatable in unison with the shaft. The rotor core is provided with a plurality of passages each terminating at a void in a rotor core axial end. Permanent magnets are disposed in rotor core passages, a gap is defined between each magnet and its respective rotor core passage. The shaft fluid passageway is in fluid communication with the rotor core end voids through the gaps, whereby the rotor core and the magnets are convectively cooled by liquid coolant receivable by the shaft fluid passageway and delivered to a rotor core end through the rotor core passages. Also, a method for liquid cooling a rotor assembly. | 06-26-2014 |
Patent application number | Description | Published |
20100300460 | EARPLUG - An earplug is provided and includes a tip for use in forward and lateral sealing, which is formed to define a rearward recessed cavity, and a stem. The stem includes a user graspable elongate portion configured with a stiffness in a first direction that is greater than a stiffness in a second direction, which is transverse to the first direction, and a member, disposed at a forward end of the elongate portion and configured to be insertable into the cavity, the member including a surface to be adhered to an interior facing surface of the cavity and on which a channel is defined to allow for outflow from the cavity, and the member being formed with a shape to complement that of the cavity to axially and circumferentially align the tip and the stem. | 12-02-2010 |
20120104014 | DISPENSER WITH WASTE COLLECTION SPOOL, AND METHOD OF USING - Herein are disclosed methods for liberating one or more packaged devices from a packaging web, and a dispenser for performing such methods. The packaging web is separated into first and second waste webs which are co-wound onto a common collection spool. | 05-03-2012 |
20130019880 | EARPLUG - An earplug is provided and includes a tip for use in forward and lateral sealing, which is formed to define a rearward recessed cavity, and a stem. The stem includes a user graspable elongate portion configured with a stiffness in a first direction that is greater than a stiffness in a second direction, which is transverse to the first direction, and a member, disposed at a forward end of the elongate portion and configured to be insertable into the cavity, the member including a surface to be adhered to an interior facing surface of the cavity and on which a channel is defined to allow for outflow from the cavity, and the member being formed with a shape to complement that of the cavity to axially and circumferentially align the tip and the stem. | 01-24-2013 |
20140014121 | PUSH-IN EARPLUG - A push-in earplug including an elongate core and outer layer is disclosed. The outer layer includes a sound attenuating portion having a first average density and a stem portion having a second average density, and the second average density is greater than the first average density. | 01-16-2014 |
20140015157 | METHOD OF MAKING AN EARPLUG - A method of making personal protective equipment, such as a push-in earplug, is disclosed. The method includes the steps of covering a substrate with an outer layer that includes an unactivated foaming agent, positioning at least a portion of the outer layer in a mold, and activating the foaming agent such that a portion of the outer layer expands. | 01-16-2014 |
20140017492 | FOAMABLE ARTICLE - A foamable article is disclosed. The article includes a substrate and an outer layer covering at least a portion of the substrate and including an unactivated expandable sphere foaming agent and an unactivated chemical foaming agent. The unactivated foaming agents may be activated to increase the volume of the outer layer. | 01-16-2014 |
20140230830 | EARPLUG WITH TIP CAVITY AND METHODS OF MANUFACTURING THE SAME - Hearing protection devices, e.g., push-to-fit earplugs, having a tip cavity in the sound attenuating body and methods of manufacturing the hearing protection devices are described herein. | 08-21-2014 |
Patent application number | Description | Published |
20080311601 | Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy - The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF as a biomarker for multi-kinase inhibitors. | 12-18-2008 |
20080311604 | Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy - The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of soluble VEGF-R2 as a biomarker for multi-kinase inhibitors. | 12-18-2008 |
20090221010 | Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy - The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF-165 as a biomarker for multi-kinase inhibitors. | 09-03-2009 |
20090286268 | Assays for Cancer Patient Monitoring Based on Levels of Analyte Components of the Plasminogen Activator System in Body Fluid Samples - The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. As a result of performing the method, an increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient. | 11-19-2009 |
20100167324 | Quantitative Assays for Ras p21 in Body Fluids - The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total ras p21 in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for preneoplastic/neoplastic diseases, and useful to select therapies for patients with preneoplastic/neoplastic diseases. The disclosed methods are further useful to monitor the status of a patient's preneoplastic/neoplastic disease, and/or to monitor how a patient is responding to an anticancer therapy. | 07-01-2010 |
20120220524 | ASSAYS FOR CANCER PATIENT MONITORING BASED ON LEVELS OF ANALYTE COMPONENTS OF THE PLASMINOGEN ACTIVATOR SYSTEM IN BODY FLUID SAMPLES - The present invention describes methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. An increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression. | 08-30-2012 |
20140093890 | QUANTITATIVE ASSAYS FOR RAS P21 IN BODY FLUIDS - The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitating total ras p21 in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for preneoplastic/neoplastic diseases, and useful to select therapies for patients with preneoplastic/neoplastic diseases. The disclosed methods are further useful to monitor the status of a patient's preneoplastic/neoplastic disease, and/or to monitor how a patient is responding to an anticancer therapy. | 04-03-2014 |