Patent application number | Description | Published |
20120115878 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO- [2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF - This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salts thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same. | 05-10-2012 |
20130217698 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO- [2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF - This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salts thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same. | 08-22-2013 |
20130225571 | MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES - The invention relates to new crystalline forms of processes for manufacturing a compound of formula 5, | 08-29-2013 |
20130274279 | CRYSTALLINE FORMS OF 5-CHLORO-N2-(2-ISOPROPOXY-5-METHYL-4-PIPERIDIN-4-YL-PHENYL)-N4-[2-(PROPAN- E-2-SULFONYL)-PHENYL]-PYRIMIDINE-2, 4-DIAMINE - The present invention describes specific crystalline forms of 5-chloro-N-(2-isopropoxy-5-methyl-4-(piperidin-4-ylphenyl)-N-2-(isopropylsulfonyl)phenyl)-2,4-diamine. The present invention further relates to methods for preparing said crystalline forms, pharmaceutical compositions comprising said crystalline forms, and methods of using said crystalline forms and pharmaceutical compositions to treat disease. | 10-17-2013 |
20140200246 | COMPOUNDS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH DGAT1 ACTIVITY - The present invention relates to novel crystalline forms of salts of 2-((1R,4R)-4-(4-(5-(benzo[d]oxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl)acetic acid and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans. | 07-17-2014 |
Patent application number | Description | Published |
20110041197 | Promoter-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 02-17-2011 |
20130312128 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 11-21-2013 |
20130312129 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 11-21-2013 |
20140075586 | Parental Cell Lines for Making Cassette-Free F1 Progeny - Non-human totipotent or pluripotent cells are provided comprising at a genomic locus a self-excisable, recombinase expression cassette flanked with recombination recognition sites, wherein a recombinase gene is operably linked to a promoter that is active in a post-meiotic spermatid stage when cytoplasmic bridging occurs between spermatids. Compositions and methods are provided for making cassette-deleted F1 non-human animals, wherein the methods comprise employing totipotent or pluripotent cells containing a self-excisable, recombinase expression cassette. | 03-13-2014 |
20140199761 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 07-17-2014 |
20140221734 | CLONED NON-HUMAN ANIMALS FREE OF SELECTIVE MARKERS - Genetically modified somatic cells of a non-human animal are provided that are engineered to contain a self-excisable, recombinase expression cassette comprising a site-specific recombinase gene operably linked to an ES cell-specific promoter. Compositions and methods for producing a genetically modified, cloned non-human animal that is free of a selective marker gene and a recombinase gene are provided, wherein a targeting construct comprising a self-excisable recombinase gene operably linked to an ES cell-specific promoter is introduced into differentiated somatic cells. The genetically modified genome of the somatic cells is transferred into an enucleated host oocyte. The artificially created zygote is then cultured in vitro until the blastocyst embryonic stage and subsequently implanted into a uterus of a surrogate mother to form a genetically modified, cloned non-human animal free of selective marker and recombinase genes. | 08-07-2014 |
20150047062 | lincRNA-DEFICIENT NON-HUMAN ANIMALS - Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. | 02-12-2015 |
Patent application number | Description | Published |
20100014722 | METHODS INVOLVING OPTIMIZING AND MAPPING IMAGES - A method for optimizing images, the method comprising, receiving a designation of a first feature of interest, receiving a designation of a second feature of interest, receiving a target image, receiving an atlas image including labels of first and second features of interest of the target image and a first optimization parameter associated with the first feature of interest and a second optimization parameter associated with the second feature of interest, mapping the atlas image onto the target image resulting in a global mapped image, defining an area of the first feature of interest and an area of the second feature of interest, mapping the reference image onto the area of the first feature of interest on the global mapped image using the first optimization parameter, and mapping the reference image onto the area of the second feature of interest on the global mapped image using the second optimization parameter. | 01-21-2010 |
20100054525 | SYSTEM AND METHOD FOR AUTOMATIC RECOGNITION AND LABELING OF ANATOMICAL STRUCTURES AND VESSELS IN MEDICAL IMAGING SCANS - A system and method for recognizing and labeling anatomical structures in an image includes creating a list of objects such that one or more objects on the list appear before a target object and setting the image as a context for a first object on the list. The first object is detected and labeled by subtracting a background of the image. A local context is set for a next object on the list using the first object. The next object is detected and labeled by registration using the local context. Setting a local context and detecting and labeling the next object are repeated until the target object is detected and labeled. Labeling of the target object is refined using region growing. | 03-04-2010 |
20120281904 | SYSTEM AND METHOD FOR AUTOMATIC RECOGNITION AND LABELING OF ANATOMICAL STRUCTURES AND VESSELS IN MEDICAL IMAGING SCANS - A system and method for recognizing and labeling anatomical structures in an image includes creating a list of objects such that one or more objects on the list appear before a target object and setting the image as a context for a first object on the list. The first object is detected and labeled by subtracting a background of the image. A local context is set for a next object on the list using the first object. The next object is detected and labeled by registration using the local context. Setting a local context and detecting and labeling the next object are repeated until the target object is detected and labeled. Labeling of the target object is refined using region growing. | 11-08-2012 |
Patent application number | Description | Published |
20100238351 | Scene recognition methods for virtual insertions - A method of adding a virtual insertion to an image, according to an embodiment, includes extracting dynamic features from an input image, associating the dynamic extracted features with dynamic reference features in a reference feature database, generating a camera model based on the associations, mixing a virtual insertion into the input image based on the camera model, and outputting an image containing both the input image and the virtual insertion. According to another embodiment, a method of adding a virtual insertion to an image includes generating a biased camera model using a statistically selected subset of a plurality of non-fixed regions of the image, locating fixed reference objects in the image, using the biased camera model as an entry point for a search, generating a corrected camera model using the fixed reference objects in the image, and adding a virtual insertion to the image using the corrected camera model. | 09-23-2010 |
20110102678 | Key Generation Through Spatial Detection of Dynamic Objects - A method, apparatus, and computer program product are described that utilizes spatial modeling to represent foreground objects of an event to allow virtual graphics to be integrated into a background of the event in the presence of dynamic objects. The present invention detects a presence of dynamic objects within a region of interest from a video depicting the event. The present invention produces a suppression key corresponding to the dynamic object when present in the video or a suppression key with a default value when and where no dynamic object is present in the video. | 05-05-2011 |
20130051763 | AUTOMATIC CAMERA IDENTIFICATION FROM A MULTI-CAMERA VIDEO STREAM - An apparatus and method for receiving a current video frame of a program video having a plurality of scene cuts switching between video segments originating from respective cameras of a plurality of cameras and automatically identifying the camera from which the current video frame originated. The apparatus having a feature database storing predetermined features for a plurality of cameras filming a program video originating from the plurality of cameras, a recognition unit receiving a current video frame of the program video, extracting features from the current video frame, and comparing the features to the previously stored features and a camera model estimator computing an estimated camera model based on corresponding feature pairs and previously stored features, wherein if the estimated camera model is within a predetermined threshold of a stored camera model for one of the plurality of cameras, that camera is identified as originating the current video frame. | 02-28-2013 |
20140327830 | MULTIPLE-INPUT CONFIGURATION AND PLAYBACK VIDEO ENHANCEMENT - A system and method for delaying a first version of a video feed from a video camera according to a first delay to generate a second version of the feed, supplying the first version to an insertion system, wherein the insertion system inserts an indicia into the first version to create an enhanced version with a second delay substantially matching the first delay and supplying the enhanced version and the second version to a production switcher, wherein the enhanced version and the second version supplied to the production switcher are synchronized with one another. | 11-06-2014 |
Patent application number | Description | Published |
20110117909 | METHOD AND SYSTEM FOR DYNAMICALLY SELECTING AND CONFIGURING VIRTUAL MODEMS (VMS) BASED ON PERFORMANCE METRICS IN A MULTI-SIM MULTI-STANDBY COMMUNICATION DEVICE - A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. The access to radio resources in the single radio resource unit is controlled via a virtual modem controller (VMC). The VMC collects performance metrics such as requested service type and signal quality associated with each of the VMs. A VM is selected based on the collected performance metrics to perform a requested service. A serving VM is switched among the VMs based on the collected performance metrics. VM capabilities are dynamically configured based on the collected performance metrics. According to the collected performance metrics such as associated navigation information and requested service type, one or more VMs may be turned on or off, and certain VM capabilities may be enabled or disabled to save resources. | 05-19-2011 |
20130150014 | Background Paging Monitoring For Multiple SIM User Equipment - Systems and methods are presented to support operation of a multiple subscriber identity module (SIM) device. A first SIM may monitor paging indicators while a second SIM performs a data transfer or voice call. During the second SIM's data transfer or voice call, paging transition times are identified to transition communication resources to the first SIM for use in monitoring paging indicators. The transition time may be short so as to limit the impact on the second SIM's data transfer or voice call. When the first SIM receives a paging indicator indicating an incoming call, the device may retrieve caller identification information of the incoming call and automatically reject the incoming call. The communication resource may be returned to the second SIM to continue the data transfer or voice call. | 06-13-2013 |
20130150032 | Controlled Idle Mode Behavior in User Equipment Supporting Multiple Radio Access Techniques - User equipment includes techniques that may improve operation by selectively controlling access to particular radio access technologies (RATs) for the user equipment while it is operating in certain modes, such as idle mode. Once the user equipment is in a connected mode, and operating with significant uplink and\or downlink traffic activity, inter-RAT procedures can provide the benefits of access to multiple RATs. This technique is useful in many different environments, such as an environment that is predominantly 2G or 3G with 4G hot spot coverage. This technique may also be useful for providing enhanced operations in 2G/3G capable dual SIM user equipment running in a camped mode or other modes. The technique is not limited to 2G/3G/4G or any other particular standards, but may apply to any standards in a sequence of evolving or incrementally improving standards. | 06-13-2013 |
Patent application number | Description | Published |
20090049314 | Method and System for Dynamic Voltage and Frequency Scaling (DVFS) - Methods and systems for dynamic voltage and frequency scaling (DVFS) may include monitoring change in resource utilization of an electronic device. If the change is greater than a threshold amount, a frequency of at least one clock and/or voltage for at least one voltage island may be adjusted. The resource utilization may be measured as, for example, a number of instructions executed per second. The frequency and/or voltage adjustment may depend on one or more operating points that may correspond to a power management state. An interrupt received in a power management state may also indicate an operating point. If resource utilization has increased, the frequency/voltage may be increased. Similarly, in cases where resource utilization has decreased, the frequency/voltage may be decreased. Voltage to circuits using the clock may be increased prior to increasing the clock frequency, and the voltage may be decreased after decreasing the clock frequency. | 02-19-2009 |
20090201894 | PIPELINE ARCHITECTURE FOR MULTI-SLOT WIRELESS LINK PROCESSING - A wireless communication device processes N Radio Frequency (RF) bursts contained within N slots of a digital communications time divided frame, wherein N is a positive integer greater than one. The wireless communication device includes an RF front end, a baseband processor, and an equalizer module. The RF front end is operable to receive the plurality of received RF bursts and to convert the RF bursts to corresponding baseband signals. The baseband processor is operable to receive the baseband signals, to pre-equalization process the baseband signals to produce processed baseband signals, and to post-equalization process soft decisions. The equalizer is operable to equalize the processed baseband signals to produce the soft decisions. These RF bursts may be contained in adjacent slots or, in non-adjacent slots, or in a combination of adjacent slots and non-adjacent slots. | 08-13-2009 |
20110117944 | METHOD AND SYSTEM FOR TASK-LEVEL ACCESS ARBITRATION BETWEEN VIRTUAL MODEMS IN A MULTI-SIM MULTI-STANDBY COMMUNICATION DEVICE - A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. The access to radio resources in the single radio resource unit is controlled for each VM task via a virtual modem controller (VMC). Upon receiving requests for tasks to access radio resources in the single radio resource unit, the VMC arbitrates the access based on task priority information, current activities associated with one or more of the plurality of VMs, and the radio resources available in the single radio resource unit. The access may be immediately accepted, accepted with a delay or rejected. With an immediate access, current activities may be suspended and then resumed once radio resources become available. With a delayed access, the VMC determines what time instants the access may be accepted. | 05-19-2011 |
20110117962 | METHOD AND SYSTEM FOR MULTI-STANDBY OPERATION FOR A MULTI-SIM MULTI-STANDBY COMMUNICATION DEVICE - A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit that is shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. Traffic related to the SIM cards are concurrently handled utilizing corresponding VMs. Available radio resource in the single radio resource unit are shared by the VMs based on corresponding VM states, namely, an active state, an idle state and a suspended state. VMs in an idle state concurrently monitor paging events and concurrently perform idle mode procedures such as location updating. VMs not related to an intended traffic are suspended. A VM related to the intended traffic is transitioned from an idle state to an active state to enable the communication for the intended traffic. Once the communication is complete, the suspended VMs are resumed to continue idle mode activities. | 05-19-2011 |
20110117963 | METHOD AND SYSTEM FOR A FAST CELL RECOVERY ON SUSPENDED VIRTUAL MODEMS WITHIN A MULTI-SIM MULTI-STANDBY COMMUNICATION DEVICE - A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit shared by a plurality of virtual modems (VMs). A first VM in an active state monitors its own associated cells and cells associated with remaining VMs in a suspended state. The active VM measures signal strength on available cells to track cell information such as cell quality and cell timing information for associated cells for the first active VM and for the remaining suspended VMs. When the suspended VMs are resumed, the single radio resource unit is synchronized to corresponding serving cells in an order determined based on the tracked cell timing information. With a synchronized serving cell, a suspended VM may bypass cell selection or reselection and directly camp on its serving cell. Otherwise, the suspended VM performs a cell selection or reselection selectively based on tracked cell information for a cell to camp on. | 05-19-2011 |
20110117965 | METHOD AND SYSTEM FOR TASK SCHEDULING IN AN OPERATING SYSTEM FOR VIRTUAL MODEMS WITHIN A MULTI-SIM MULTI-STANDBY COMMUNICATION DEVICE - A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single operating system (OS) and a single radio resource unit that is shared by multiple virtual modems (VMs) within a virtual modem framework (VMF). The OS maps VM tasks of the multiple VM to OS resource spaces according to corresponding VM IDs. The single OS may run the mapped VM tasks utilizing OS resources in the OS resource spaces. VM ID information is embedded in global variables and/or static variables that are utilized in the single OS to access OS resources. The OS may run VM tasks utilizing OS resources in OS resource spaces identified by corresponding VM IDs. The OS may re-use OS resources for VM tasks of different VMs, when needed, without duplicating the OS resources. VM tasks are scheduled to run on the single OS according to task priorities, which are determined based on corresponding VM environment. | 05-19-2011 |
20120015653 | METHOD AND SYSTEM FOR MITIGATION OF UNLISTED CELL IMPACTS IN IDLE MODE OF CELLULAR SYSTEMS - A UE, in an idle mode, receives pilot signals and synchronization signals from a serving cell and neighbor cells comprising neighbor cells listed and/or unlisted in a neighboring cell list. The UE validates each of the serving cell, the listed neighbor cells and the unlisted neighbor cells from the received signals. The UE performs cell measurement on the listed cells as well as the unlisted cells for multipath profiles and associated power levels. In instances where number of attempts of the cell measurements on the unlisted cells exceeds a threshold value, the UE may validate presence of the unlisted cells. The best available cell is selected from the listed cells and the unlisted for the UE to camp on. I/Q samples of the received signals are stored while measuring or monitoring the cells. The stored I/Q samples may be utilized to carry out baseband procedures through offline processing. | 01-19-2012 |
20130301507 | Idle mode power consumption reduction in wireless communications - Idle mode power consumption reduction in wireless communications. Within a wireless communication device that is operative to communicate with any one of a number of servicing cells, paging broadcasts from more than one of these servicing cells are received and undergo only a limited amount of processing before being stored for use in subsequent processing that may be performed later. This partitioned processing allows the turning off of certain components that are not needed and/or no longer needed for determining the system frame numbers associated with various servicing cells to effectuate timing synchronization. Certain modules within such a wireless communication device may perform processing using the full capabilities of the wireless communication device to generate initially processed signal, and then after such signals are stored, then only partial processing capability of the wireless communication device may be employed, even though perhaps being slower, to complete the processing. | 11-14-2013 |