Patent application number | Description | Published |
20090093426 | RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 04-09-2009 |
20090170141 | GHRELIN O-ACYLTRANSFERASE (GOAT) BIOCHEMICAL ASSAY - Ghrelin is acylated ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase. | 07-02-2009 |
20100086955 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase - Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition. | 04-08-2010 |
20100184829 | RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 07-22-2010 |
20110184047 | RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 07-28-2011 |
20110318807 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase - Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition. | 12-29-2011 |
20130274310 | RNAi MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 10-17-2013 |
Patent application number | Description | Published |
20090040509 | OPTICAL TOPOLOGY FOR MULTIMODE AND SINGLEMODE OTDR - A network test instrument for singlemode and multimode OTDR testing employs an optical topology providing for combined singlemode and multimode use of a detector for reduced cost and instrument size. | 02-12-2009 |
20100225901 | PON TESTER - A high resolution optical fiber length meter, live fiber detector, and reflectance tester (instrument) for single mode applications using a low power, long wavelength laser for generating wide and narrow optical pulses that are launched into a single mode fiber under test. The laser output fiber pigtail is fusion spliced to a singlemode coupler whose output is coupled to the instrument bulkhead connector. A PIN photodiode is fusion spliced to the singlemode coupler to receive the reflected light from the fiber under test. The high resolution hand-held instrument is useful in examining singlemode passive optical networks (PON). | 09-09-2010 |
20130194566 | FIELD TESTER FOR TOPOLOGIES UTILIZING ARRAY CONNECTORS AND MULTI-WAVELENGTH FIELD TESTER FOR TOPOLOGIES UTILIZING ARRAY CONNECTORS - A test instrument comprises plural first optical signal sources at a first wavelength and a distributor coupled to the plural first optical signal sources to supply the signals produced to a multi-fiber test port. Additional second wavelength signal sources may be provided, and a second test instrument for use at a second end of the link under test may be provided, to effect testing of the optical link. | 08-01-2013 |
20130293874 | OPTICAL LIGHT SOURCE WITH CONTROLLED LAUNCH CONDITIONS - A system, apparatus and method for providing controlled launch conditions to an optical light source comprises adjustable fiber bending/deforming apparatus to allow adjustment of the device such that multimode launch conditions can be accurately controlled. Both LED light source and OTDR/laser implementations are provided | 11-07-2013 |