Godler
David Godler, Victoria AU
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20120094288 | ASSAY FOR DETERMINING EPIGENETIC PROFILES OF MARKERS OF FRAGILE X ALLELES - The present invention relates generally to an assay for the determination of epigenetic profiles, particularly epigenetic profiles associated with a pathological condition. Even more particularly, the present invention provides an assay to detect epigenetic profiles within the Fragile X Mental Retardation (FMR) genetic locus indicative of a pathoneurological condition such as pathoneurodevelopmental and pathoneurodegenerative conditions. The epigenetic profiles can also identify potential non-neurological conditions. Kits and assays for medicaments also form part of the present invention as do computer programs to monitor changes in epigenetic patterns and methods for screening for agents which modulate epigenetic modification. | 04-19-2012 |
David Godler, Hughesdale, Victoria AU
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20160083792 | AN ASSAY FOR QUANTITATING THE EXTENT OF METHYLATION OF A TARGET SITE - An assay quantifies the extent of methylation in a DNA sample. Kits and clinical diagnostic assays include assays to determine clinical phenotypes based on extent of methylation of a DNA target site. | 03-24-2016 |
David Eugeny Godler, Ormond AU
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20130210007 | TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS - The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. The epigenetic profiles can be from an intron, an intron/exon boundary or a splicing region. Epigenetic profiles are disclosed from the following sites in the FMR locus: FREES, intron 2 of FMR1, the genomic FREE2 region as a whole or specific FREE2 fragments including FREE2 (D) or FREE2 (E). Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles. Further enabled herein is a method for screening for agents which can reduce or mask the adverse effects of epigenetic modification and the use of these agents in therapy and prophylaxis. | 08-15-2013 |
20130338032 | ASSAY FOR DETERMINING EPIGENETIC PROFILES OF MARKERS OF FRAGILE X ALLELES - The present invention relates generally to an assay for the determination of epigenetic profiles, particularly epigenetic profiles associated with a pathological condition. Even more particularly, the present invention provides an assay to detect epigenetic profiles within the Fragile X Mental Retardation (FMR) genetic locus indicative of a pathoneurological condition such as pathoneurodevelopmental and pathoneurodegenerative conditions. The epigenetic profiles can also identify potential non-neurological conditions. Kits and assays for medicaments also form part of the present invention as do computer programs to monitor changes in epigenetic patterns and methods for screening for agents which modulate epigenetic modification. | 12-19-2013 |
20160053326 | TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS - The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. The epigenetic profiles can be from an intron, an intron/exon boundary or a splicing region. Epigenetic profiles are disclosed from the following sites in the FMR locus: FREE3, intron 2 of FMR1, the genomic FREE2 region as a whole or specific FREE2 fragments including FREE2 (D) or FREE2 (E). Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles. Further enabled herein is a method for screening for agents which can reduce or mask the adverse effects of epigenetic modification and the use of these agents in therapy and prophylaxis. | 02-25-2016 |
David Eugeny Godler, Hughesdale AU
Patent application number | Description | Published |
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20140212873 | TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS - The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. Epigenetic profiles are disclosed from the following sites in the FMR1 gene: FREE3, intron 2, an intron, intron/exon boundary and/or splicing region downstream of intron 2, and a site within the FREE2 portion of intron 1 in combination with a FM. Epigenetic profiles are also disclosed from a region in the FMR genetic locus selected from an intron, intron/exon boundary, a splicing region or an intragenic region in combination with an expansion mutation. Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles. Further enabled herein is a method for screening for agents which can reduce or mask the adverse effects of epigenetic modification and the use of these agents in therapy and prophylaxis. | 07-31-2014 |
Ivan Godler, Kitakyushu JP
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20090249903 | Motion Conversion Device - Rotary to linear and linear to rotary motion conversion devices that consist of rotational elements, at least two flexible linking elements, and motion elements are disclosed. Rotary elements and motion elements are connected by the flexible linking members, which twist around each other when rotational elements rotate and thus produce pulling force on the motion elements. A methodology to design the motion conversion devices and robotic joints incorporating the motion conversion devices are disclosed. | 10-08-2009 |
20110199038 | Drive Unit for Legged Robots and Control Method Thereof - A drive unit comprising of a driving motor and of at least two flexible linking members, which twist on each other when a rotational shaft of the driving motor rotates and thus produce a pulling force on a motion element that is attached to or is a part of link of a legged robot's leg mechanism is disclosed. A control method to control the invented drive unit so that a passive, a passive-dynamic or an active walking modes and transition between the modes of a legged robot is achieved without any additional mechanical means is disclosed. | 08-18-2011 |