Patent application number | Description | Published |
20100261640 | SOLUBLE AND MEMBRANE ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS - The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses. | 10-14-2010 |
20140377740 | SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS - Soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins are disclosed, as well as diagnostic and preventative methods using these compositions. Also disclosed are methods including preparation of vaccines, factors (e.g. small molecules) that inhibit LASV infectivity, and diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses. | 12-25-2014 |
Patent application number | Description | Published |
20080312319 | Modulation of Bacterial Quorum Sensing with Synthetic Ligands - The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups. | 12-18-2008 |
20100305182 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA - The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds. | 12-02-2010 |
20110212860 | Modulation of Bacterial Quorum Sensing With Synthetic Ligands - The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups. | 09-01-2011 |
20150080349 | MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS - The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups. | 03-19-2015 |
Patent application number | Description | Published |
20080283070 | METHOD OF, AND APPARATUS FOR, FORMING PORTIONS OF FIBROUS MATERIAL AND REMOVING THE SAME - A method and apparatus of forming portions of tobacco, and of removing the same by an conveyor having at least one path of holders for a respective portion, in which the holders are filled with individual portions of the contents at least two filling lines of one or more filling stations, and, prior to the individual filling operations, individual portions of the contents are weighed and weighed portions that satisfy the predetermined conditions—acceptable portions—are filled cyclically into the holders and weighed portions that do not satisfy the predetermined conditions are detected and ejected as defective portions, characterized by components and steps of (a) following detection of a defective portion, that holder which the filling line originally predetermined for filling this holder would have filled with the contents portion, on which the defective portion is based, had the contents portion satisfied the predetermined conditions—defective-portion holder—is sensed, and a filling line other than that originally predetermined for filling the defective-portion holder—compensating filling line—fills the defective-portion holder, preferably outside the original filling cycle thereof, with an acceptable portion that satisfies the predetermined conditions. | 11-20-2008 |
20100262273 | Method and apparatus for the manufacture of pouches - The invention relates to a method for the manufacture of pouches ( | 10-14-2010 |
Patent application number | Description | Published |
20100096665 | InGaAsSbN PHOTODIODE ARRAYS - Embodiments of detectors made using lattice matched photoabsorbing layers are disclosed. A photodiode apparatus in accordance with one or more embodiments of the present invention comprises an indium phosphide substrate, and a photoabsorbing region comprising at least an indium gallium arsenide antimonide nitride (InGaAsSbN) layer, wherein the InGaAsSbN layer has a thickness of at least 100 nanometers and is nominally lattice-matched to the indium phosphide substrate. | 04-22-2010 |
20110169048 | InGaAsSbN PHOTODIODE ARRAYS - Embodiments of detectors made using lattice matched photoabsorbing layers are disclosed. A photodiode apparatus in accordance with one or more embodiments of the present invention comprises an indium phosphide substrate, and a photoabsorbing region comprising at least an indium gallium arsenide antimonide nitride (InGaAsSbN) layer, wherein the InGaAsSbN layer has a thickness of at least 100 nanometers and is nominally lattice-matched to the indium phosphide substrate. | 07-14-2011 |
20120106585 | HIGH FILL-FACTOR EFFICIENT VERTICAL-CAVITY SURFACE EMITTING LASER ARRAYS - An array of vertical-cavity surface emitting lasers (VCSELs) may be fabricated with very high fill-factors, thereby enabling very high output power densities during pulse, quasi-continuous wave (QCW), and continuous wave (CW) operation. This high fill-factor is achieved using asymmetrical pillars in a rectangular packing scheme as opposed prior art pillar shapes and packing schemes. The use of asymmetrical pillars maintains high efficiency operation of VCSELs by maintaining minimal current injection distance from the metal contacts to the laser active region and by maintaining efficient waste heat extraction from the VCSEL. This packing scheme for very high fill-factor VCSEL arrays is directly applicable for next generation high-power, substrate removed, VCSEL arrays. | 05-03-2012 |
20120248288 | DUAL WELL READ-OUT INTEGRATED CIRCUIT (ROIC) - Embodiments of the invention describe solutions directed towards having a single camera capable of capturing high speed laser return pulses for a target, as well as provide imaging information on the background of the target. This capability is enabled by having a read-out integrated circuit (ROIC) capable of extracting both types of information from a pixel of a focal plane array (FPA). | 10-04-2012 |
20130194787 | MULTI-WAVELENGTH VCSEL ARRAY TO REDUCE SPECKLE - Embodiments of the invention describe an illuminator having a light source to originate an illumination beam, wherein the light source further comprises a set of vertical-cavity surface emitting lasers (VCSELs), including a first VCSEL having a first laser emission wavelength, and a second VCSEL having a second laser emission wavelength different than the first laser emission wavelength. Thus, by varying laser emission wavelengths of VCSELs in a VCSEL array, embodiments of the invention produce low-contrast speckle, and do not limit the imaging capabilities of the host illumination system. In some embodiments of the invention, vertical external cavity surface emitting lasers (VECSELs) are utilized to produce the above described varying laser emission wavelengths. | 08-01-2013 |
20140010254 | HIGH FILL-FACTOR EFFICIENT VERTICAL-CAVITY SURFACE EMITTING LASER ARRAYS - An array of vertical-cavity surface emitting lasers (VCSELs) may be fabricated with very high fill-factors, thereby enabling very high output power densities during pulse, quasi-continuous wave (QCW), and continuous wave (CW) operation. This high fill-factor is achieved using asymmetrical pillars in a rectangular packing scheme as opposed prior art pillar shapes and packing schemes. The use of asymmetrical pillars maintains high efficiency operation of VCSELs by maintaining minimal current injection distance from the metal contacts to the laser active region and by maintaining efficient waste heat extraction from the VCSEL. This packing scheme for very high fill-factor VCSEL arrays is directly applicable for next generation high-power, substrate removed, VCSEL arrays. | 01-09-2014 |
20140269796 | MULTI-WAVELENGTH VCSEL ARRAY TO REDUCE SPECKLE - Embodiments of the invention describe an illuminator having a light source to originate an illumination beam, wherein the light source further comprises a set of vertical-cavity surface emitting lasers (VCSELs), including a first VCSEL having a first laser emission wavelength, and a second VCSEL having a second laser emission wavelength different than the first laser emission wavelength. Thus, by varying laser emission wavelengths of VCSELs in a VCSEL array, embodiments of the invention produce low-contrast speckle, and do not limit the imaging capabilities of the host illumination system. In some embodiments of the invention, vertical external cavity surface emitting lasers (VECSELs) are utilized to produce the above described varying laser emission wavelengths. | 09-18-2014 |
20150198295 | SCALABLE LASER WITH SELECTABLE DIVERGENCE - A laser illuminator/pointer can have an array of diode lasers for providing laser beams. A beam shaping optic can shape each of the laser beams. A movable, substantially transparent window can be in a path of the laser beams. A plurality of diffusers can be disposed on the window and can be positioned to vary a divergence of at least one of the laser beams when the window is moved. | 07-16-2015 |
Patent application number | Description | Published |
20090077483 | System And Method For Accessing And Using A Supercomputer - Systems and methods form and control a supercomputer based upon a parallel processing architecture such as a Howard cascade. A graphical user interface allows a user to interact with one or more virtual power centers of the supercomputer facility. A plurality of processing nodes self-organize into one or more virtual power centers. The processing nodes utilize overlapped input and output for improved communication. | 03-19-2009 |
20120029330 | Cable cross talk suppression - Systems, methods, and devices are provided for suppressing cross-talk noise due to capacitive and/or inductive coupling in a medical sensor signal. For example, an embodiment of a patient monitor may include driving circuitry, an amplifier, and transient current discharge circuitry. When the driving circuitry drives an emitter to emit light into a patient, a detector may detect a portion of the light that passes through the patient, generating a detector signal. Cross-talk between the emitter driving signals and the detector signal may generate interference in the form of a transient current in the detector signal. Before the amplifier receives the detector signal, transient current discharge circuitry may discharge the transient current. | 02-02-2012 |
20120136257 | SNR Through Ambient Light Cancellation - Systems, methods, and devices for improved patient monitor signal processing with higher signal-to-noise ratio (SNR) are provided. In accordance with an embodiment, an electronic patient monitor may include drive circuitry, a current-to-voltage converter, and feedback circuitry. The drive circuitry may drive an emitter of a medical sensor with dark periods during which the emitter does not emit light, and the current-to-voltage converter may receive and amplify a photocurrent signal from a detector of the sensor. The feedback circuitry may provide a feedback signal to the current-to-voltage converter. The feedback signal, based at least in part on the output of the current-to-voltage converter during the dark periods, may cause the current-to-voltage converter to substantially exclude an ambient light component of the photocurrent. As a result, the current-to-voltage converter may employ a higher transimpedance without distorting the output voltage signal due to oversaturation, and thus may achieve a higher SNR. | 05-31-2012 |
20130137946 | MEDICAL DEVICE WITH CONDITIONAL POWER CONSUMPTION - Embodiments of the present disclosure relate to a system and method for reducing power consumption of a medical device based on one or more physiological parameters. For example, the medical device may be operated in a low power mode if a physiological parameter trend is above a certain threshold. In the low power mode, the processing power may be reduced relative to a high power mode. The low power mode may be associated with reduced processing and output rate. | 05-30-2013 |
Patent application number | Description | Published |
20110183297 | POROUS, SILICATE, CERAMIC BODY, DENTAL RESTORATIONS AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a porous, silicate, ceramic body, possibly with different colors, with a first density, which can be sintered into a silicate, ceramic body with a second density, wherein the ratio of the first density to the second density is 2/5 to 98/100, and the three-point bending strength of the porous, silicate ceramic body with a first density, measured according to ISO 6872, amounts to 25 to 180 MPa. | 07-28-2011 |
20140070435 | POROUS, SILICATE, CERAMIC BODY, DENTAL RESTORATION AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a porous, silicate, ceramic body, possibly with different colors, with a first density, which can be sintered into a silicate, ceramic body with a second density, wherein the ratio of the first density to the second density is 2/5 to 98/100, and the three-point bending strength of the porous, silicate ceramic body with a first density, measured according to ISO 6872, amounts to 25 to 180 MPa. | 03-13-2014 |
20150050619 | POROUS, SILICATE, CERAMIC BODY, DENTAL RESTORATIONS AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a porous, silicate, ceramic body, possibly with different colors, with a first density, which can be sintered into a silicate, ceramic body with a second density, wherein the ratio of the first density to the second density is 2/5 to 98/100, and the three-point bending strength of the porous, silicate ceramic body with a first density, measured according to ISO 6872, amounts to 25 to 180 MPa. | 02-19-2015 |