Patent application number | Description | Published |
20080317736 | Methods for enlarging the diameter of a biological conduit in a human subject - The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. | 12-25-2008 |
20090060893 | Methods for enlarging the diameter of a biological conduit in a human subject - The invention provides methods for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. | 03-05-2009 |
20090060897 | Systems for enlarging the diameter of a biological conduit in a human subject - The invention provides systems for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. | 03-05-2009 |
20090162343 | RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 06-25-2009 |
20090196865 | Methods for the treatment and prevention of diseases of biological conduits - Methods for treating or preventing disease in biological conduits are provided herein. In certain embodiments, the methods relate to reducing or preventing vasospasm in blood vessel walls. In other embodiments, the methods described herein relate to reducing the accumulation of intimal hyperplasia in blood vessel walls after vascular procedures, including surgery. The methods encompass the use of agents that are useful for dilating biological conduits, but in dosages lower than are effective to achieve dilation of biological conduits. | 08-06-2009 |
20100203034 | METHODS FOR THE TREATMENT AND PREVENTION OF DISEASES OF BIOLOGICAL CONDUITS - Methods are described for dilating biological conduits by removing elastin and remodeling collagens in the wall of the conduit. Methods include the use of agents that increase the release of endogenous elastase and collagenase in the wall of the conduit, either by cells that are normally present in the wall of the conduit or by inflammatory cells that are attracted to the conduit, thereby providing additional conduit dilation. Methods also include the use of agents that increase conduit wall permeability and expose elastin and collagen fibers. Methods also include removing components of the extracellular matrix of arteries and veins leading to an inhibition of intimal hyperplasia in the wall of the vessels by decreasing biomechanical stimuli directed toward the cells in the wall of the vessel. Methods further include the use of agent that degrade microfibers, in addition to elastin, in order to decrease the resynthesis of elastin. Methods also include the use of agent that stabilize the diameter of aneurysmal arteries by blocking cell surface receptors in the wall of the aneurysmal artery that are important in the recruitment of inflammatory cells. | 08-12-2010 |
20110008315 | RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 01-13-2011 |
20110081705 | RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 04-07-2011 |
20110160682 | MEDICAL DEVICE - A medical device for the delivery of fluids into or through the wall of a biological space or conduit is described. The medical device comprises one or more actuators, which may exist in a constrained configuration which is substantially parallel to the longitudinal axis of the device or an unconstrained configuration in which at least a portion of the one or more actuators is oriented substantially non-parallel to the longitudinal axis of the device. The device further comprises tissue penetrators, which may be attached to the actuators or contained within the actuators. Upon positioning of the device at the target treatment site within a biological space or conduit, the operator may release the actuators from their constrained position, allowing the actuators to adopt their unconstrained position and make contact with an adjacent wall of a biological space or conduit. The actuators are configured to minimize the physical contact between the device and the target tissue, thereby permitting uniform and enhanced delivery of fluids into less compressed tissue, with reduced tissue trauma. | 06-30-2011 |
20110182876 | Methods of Treatment with Elastase - The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. | 07-28-2011 |
20130336956 | RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 12-19-2013 |
20140004098 | METHODS OF TREATMENT WITH ELASTASE | 01-02-2014 |