Patent application number | Description | Published |
20080234946 | PREDICTIVE RADIOSENSITIVITY NETWORK MODEL - This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2/3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer. | 09-25-2008 |
20090076734 | Gene Signature for the Prediction of Radiation Therapy Response - Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor. | 03-19-2009 |
20100240540 | GENOTYPIC TUMOR PROGRESSION CLASSIFIER AND PREDICTOR - Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the number of mitotic cells in a histological slide prepared from the tumor and assessed by a trained pathologist. Disclosed is a method for using cumulative information from a series of expressed genes to determine tumor prognosis. This cumulative information can be used to categorize tumor samples into high mitotic states or low mitotic states using a mathematical algorithm and gene expression data derived from microarrays or quantitative-Polymerase Chain Reaction (Q-PCR) data. The specific mathematical description outlines how the algorithm assesses the most informative subset of genes from the full list of genes during the assessment of each sample. | 09-23-2010 |
20120041908 | Predictive Radiosensitivity Network Model - This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2/3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer. | 02-16-2012 |
20130344169 | GENE SIGNATURE FOR THE PREDICTION OF RADIATION THERAPY RESPONSE - Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor. | 12-26-2013 |
20140336945 | GENE SIGNATURE FOR THE PREDICTION OF RADIATION THERAPY RESPONSE - Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor. | 11-13-2014 |
Patent application number | Description | Published |
20120193988 | HYBRID INVERTER GENERATOR - A hybrid engine and battery generator and a method of operating the same. The generator is controlled to operate in at least three modes: a battery-only mode, a battery charging mode, and a boost mode. In the battery-only mode, the engine is off and an internal battery of the generator is used by an inverter to generate AC output. In the battery charging mode, the engine generates DC power, via an alternator and rectifier, which is used to charge the battery and to supply power to the inverter to generate AC output. In the boost mode, the battery and the engine generate DC power that is used by the inverter to generate an AC output with increased wattage, relative to the battery-only mode and battery charging mode. The generator automatically switches between the modes based on battery level and load demand. | 08-02-2012 |
20120294746 | CYLINDER HEAD FOR A PUMP - A cylinder head for a pump. The pump includes a piston and a cylinder block at least partially defining a cylinder chamber receiving the piston. The cylinder head is couplable to the cylinder block. The cylinder head includes an inlet manifold formed as a single piece, an outlet manifold formed as a single piece separate from the inlet manifold, and a pressure chamber positioned fluidly between the inlet manifold and the outlet manifold formed as a single piece separate from the inlet manifold and separate from the outlet manifold. The pressure chamber is formed of a first material, and at least one of the inlet manifold and the outlet manifold is formed of a second material different than the first material. | 11-22-2012 |
20140109867 | MULTI-FUNCTION CHOKE SWITCH - A choke assembly for an internal combustion engine comprising a user interface, a fuel valve, and a choke valve. The choke assembly further comprising an off position, in which the user interface is in a first position, the fuel valve is in a closed position, and the choke valve is in a closed position; a start position, in which the user interface is in a second position, the fuel valve is in an open position, and the choke valve is in the closed position; and a run position, in which the user interface is in a third position, the fuel valve is in the open position, and the choke valve is in an open position. | 04-24-2014 |