Patent application number | Description | Published |
20080219891 | PORTABLE SENSOR ARRAY SYSTEM - A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. | 09-11-2008 |
20090093063 | Color Changing and Coverage Indicating Hand Sanitizer - The present invention includes compositions and methods for detection of the effectiveness of a substance for cleaning that include an electrophilic dye, wherein the electrophilic dye is colorless before exposure to a nucleophilic agent, and an nucleophilic agent, wherein the electrophilic dye, the nucleophilic agent or both are encapsulated and wherein exposure to one or more cognate target or condition triggers the release of the electrophilic dye, the nucleophilic agent or both from encapsulation. It also includes compositions and methods for detection of the effectiveness of a substance for cleaning by a recognitive dye, wherein the dye is colorless before exposure to its cognate target, changes color upon exposure to its cognate target and reverts to being colorless after a predetermined period of time by exposure to one or more environmental agents. | 04-09-2009 |
20090215646 | SYSTEM AND METHOD OF ANALYTE DETECTION USING DIFFERENTIAL RECEPTORS - Methods and systems for detecting the presence of analytes are described. A fluid or gas sample containing one or more analytes may pass through a particle-based sensor array. Detection and analysis techniques may be applied to determine the identity and quantity of the analytes. | 08-27-2009 |
20090258791 | Fluid Based Analysis of Multiple Analytes by a Sensor Array - A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. | 10-15-2009 |
20090269765 | Compositions And Methods For Detection Of Small Molecules Using Dyes Derivatized with Analyte Responsive Receptors in a Chemiluminescent Assay - Compositions, methods, and systems for detecting small molecules using chemiluminescent signaling assay technology are provided. One system provided herein comprises a chromophore; an oxalate ester, a peroxide, and a modulating agent, wherein the modulating agent will perturb a chemiluminescent signal generated by an interaction among the chromophore, the oxalate ester, and a peroxide; and the perturbation will occur in response to an analyte. One method provided herein comprises combining a chromophore, an oxalate ester, a peroxide, and a modulating agent, wherein: the modulating agent will perturb a chemiluminescent signal generate by an interaction among the chromophore, the oxalate ester, and a peroxide; and the perturbation will occur in response to an analyte. Another method provides a calorimetric or fluorometric signal response in the presence of an analyte. | 10-29-2009 |
20110251075 | SYSTEM AND METHOD FOR THE ANALYSIS OF BODILY FLUIDS - A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. | 10-13-2011 |
20120122228 | Compositions And Methods For The Detection Of Chemical Warfare Agents - Compositions for detection of chemical warfare agents that comprise oximate anion reactive sites and fluorophore cores. Methods for detecting a chemical warfare agents that comprise providing a detector molecule comprising an oximate anion reactive site and a fluorophore core and detecting fluorescence from the detector molecule. Methods for enhancing the reactivity of an oximate nucleophile that comprise introducing an oxime into an aprotic solvent and deprotonating the oxime to form the oximate nucleophile with a base that creates noncoordinating anions. | 05-17-2012 |
20130302903 | FLUORESCENT NITRIC OXIDE PROBES AND ASSOCIATED METHODS - Nitric oxide probes comprising a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided. | 11-14-2013 |
20140120574 | FLUORESCENT NITRIC OXIDE PROBES AND ASSOCIATED METHODS - Nitric oxide probes comprising a compound represented by Formula I are provided. Methods of using this nitric oxide probes to detect nitric oxide are also provided. | 05-01-2014 |
20140179014 | FLUORESCENT NITRIC OXIDE PROBES AND ASSOCIATED METHODS - Nitric oxide probes including a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided. | 06-26-2014 |
Patent application number | Description | Published |
20140208656 | VEHICLE DOOR AND DOOR MODULE WITH MULTI-PORTION DOOR CARRIER - A vehicle door comprising an outer door panel an inner door panel and a door Module. The inner door panel is joined to the outer door panel so as to define a door cavity between the inner and outer door panels. The inner door panel has an aperture providing access to the door cavity. The door module includes a plurality of carrier portions including a first carrier portion that holds at least one functional door hardware component and a second carrier portion that holds at least one other functional door hardware component. The plurality of carrier portions are mounted to the inner panel to seal the aperture thereby defining a wet side of the door module facing towards the door cavity and a dry side of the door module facing away from the door cavity. | 07-31-2014 |
20150019083 | METHOD AND SYSTEM FOR HANDS-FREE OPERATION OF A POWER WINDOW OF A VEHICLE - A method for hands-free operation of a power window of a vehicle, comprising: determining an order of activation of a first sensor and a second sensor, the first sensor and the second sensor being spaced apart and located inside the vehicle proximate the power window; when the first sensor is activated before the second sensor, controlling a window pane of the power window to move toward a first position; when the second sensor is activated before the first sensor, controlling the window pane to move toward a second position; and, when the first sensor and the second sensor are activated simultaneously or approximately simultaneously while the window pane is moving, controlling the window pane to stop moving. | 01-15-2015 |
20150035320 | DRIVE SYSTEM FOR SUNROOF ASSEMBLY - In an aspect, a sunroof assembly is provided for a vehicle, and comprises a sunroof panel, a final gear and a drive arm. The sunroof panel has a longitudinal axis and which is mounted to the vehicle for longitudinal movement between an open position and a closed position. The final gear is mounted to a stationary member of the vehicle, and is pivotable about a pivot axis between a first position and a second position. The drive arm is pivotable with the final gear about the pivot axis and which has a drive end that is laterally movable relative to the sunroof panel but that is operatively connected to the sunroof panel to drive the sunroof panel longitudinally between the open and closed positions during pivoting movement of the final gear between the first and second positions. | 02-05-2015 |
Patent application number | Description | Published |
20090258388 | METHODS OF ENHANCED HETEROLOGOUS PROTEIN SECRETION - A method of enhancing heterologous protein secretion in a yeast cell is disclosed. In one embodiment, the method comprising the steps of engineering a yeast cell to overexpress at last one gene selected from the group consisting of CCW12, CWP2, SED1, RPP0, ERO1 and their homologs, supplying the yeast cell with a nucleic acid encoding a heterologous protein and obtaining increased expression of the heterologous protein, wherein the expression is increased relative to the protein expression in a yeast cell that does not overexpress a gene selected from the group consisting of CCW12, CWP2, SED1, RPP0, ERO1 and their homologs. | 10-15-2009 |
20100137158 | GFABS: GFP-based biosensors possessing the binding properties of antibodies - A family of GFP scaffolds capable of accommodating two proximal, randomized binding loops is disclosed. GFP-based binders binding with nanomolar affinity are developed from a library of these GFP scaffolds. | 06-03-2010 |
20100209425 | Blood-Brain Barrier Targeting Anti-bodies - This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies. | 08-19-2010 |
20110262460 | BLOOD-BRAIN BARRIER TARGETING ANTIBODIES - This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies. | 10-27-2011 |
20110312018 | Blood-Brain Barrier Model - A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells. | 12-22-2011 |
20120015395 | Human Blood-Brain Barrier Endothelial Cells Derived From Pluripotent Stem Cells and Blood-Brain Barrier Model Thereof - A model blood brain barrier obtained from hPSCs is disclosed. | 01-19-2012 |
20120277122 | GFABS: GFP-Based Biosensors Possessing the Binding Properties of Antibodies - A family of GFP scaffolds capable of accommodating two proximal, randomized binding loops is disclosed. GFP-based binders binding with nanomolar affinity are developed from a library of these GFP scaffolds. | 11-01-2012 |
20130029419 | Blood-Brain Barrier Model - A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells. | 01-31-2013 |
20140127800 | Retinoic Acid Enhanced Human Stem Cell Derived Blood Brain Barrier Model - In one embodiment, the present invention is a method of creating a fully-human blood-brain barrier (BBB) model, comprising the steps of (a) obtaining a mixture of neural cells and brain microvascular endothelial cells (BMECs), wherein the neural cells and BMECs that comprise the mixture were produced from the differentiation of human pluripotent stem cells (hPSCs); (b) purifying BMECs from the mixture of neural cells and BMECs of step (a); and (c) co-culturing the purified BMECs with a cell type selected from the group consisting of pericytes, astrocytes and differentiated neural progenitor cells (NPCs), wherein a blood brain barrier model is created. | 05-08-2014 |
20150196663 | Blood-Brain Barrier Targeting Antibodies - A BBB-selective antibody comprising a protein encoded by SEQ ID NO:1 or 3 or comprising a peptide encoded by CDR H1, CDR H2, CDR H3, CDRL1, CDRL2 or CDRL3 of SEQ ID NO:1 or CDR H1, CDR H2, CDR H3, CDRL1, CDRL2, or CDRL3 of SEQ ID NO: 3 is disclosed. | 07-16-2015 |